DK125021B - Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydro-4-phenyl-isoquinolinderivater eller syreadditionssalte deraf eller de tilsvarende optisk aktive forbindelser. - Google Patents
Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydro-4-phenyl-isoquinolinderivater eller syreadditionssalte deraf eller de tilsvarende optisk aktive forbindelser.Info
- Publication number
- DK125021B DK125021B DK2571AA DK2571A DK125021B DK 125021 B DK125021 B DK 125021B DK 2571A A DK2571A A DK 2571AA DK 2571 A DK2571 A DK 2571A DK 125021 B DK125021 B DK 125021B
- Authority
- DK
- Denmark
- Prior art keywords
- tetrahydro
- phenyl
- preparation
- acid addition
- addition salts
- Prior art date
Links
- OSZMNJRKIPAVOS-UHFFFAOYSA-N 4-phenyl-1,2,3,4-tetrahydroisoquinoline Chemical class C1NCC2=CC=CC=C2C1C1=CC=CC=C1 OSZMNJRKIPAVOS-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH10370A CH527194A (de) | 1970-01-06 | 1970-01-06 | Verfahren zur Herstellung von Isochinolin-Derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK125021B true DK125021B (da) | 1972-12-18 |
Family
ID=4179328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK2571AA DK125021B (da) | 1970-01-06 | 1971-01-05 | Analogifremgangsmåde til fremstilling af 1,2,3,4-tetrahydro-4-phenyl-isoquinolinderivater eller syreadditionssalte deraf eller de tilsvarende optisk aktive forbindelser. |
Country Status (19)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA844402B (en) * | 1983-06-23 | 1986-01-29 | Mcneil Pharmaceutical | Hexahydropyrrolo(2,1-a)isoquinoline derivatives |
| US4719216A (en) * | 1983-06-23 | 1988-01-12 | Mcneilab, Inc. | Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressants |
| US4595688A (en) * | 1983-06-23 | 1986-06-17 | Mcneilab, Inc. | Hexahydropyrrolo[2,1-a]isoquinoline derivatives and antidepressant use thereof |
| GB2271566A (en) * | 1992-10-14 | 1994-04-20 | Merck & Co Inc | HIV integrase inhibitors |
| BR0015307A (pt) * | 1999-11-03 | 2002-07-09 | Albany Molecular Res Inc | Composto, composição, composição farmacêutica, métodos para tratar um distúrbio que é criado pela ou é dependente da disponibilidade diminuìda de serotonina, norepinefrina ou dopamina, e para inibir a absorção de norepinefrina sináptica, de serotonina sináptica e de dopamina sináptica em um paciente em necessidade destas, e, conjunto |
| US7163949B1 (en) * | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
| CN1414953A (zh) | 1999-11-03 | 2003-04-30 | 阿尔巴尼分子研究公司 | 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和5－羟色胺重摄取的用途 |
| EP1113007A1 (en) * | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
| WO2002004455A2 (en) | 2000-07-11 | 2002-01-17 | Albany Molecular Research, Inc | 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
| NZ552397A (en) | 2004-07-15 | 2011-04-29 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| JP2008543880A (ja) | 2005-06-17 | 2008-12-04 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ナフチリジン化合物 |
| KR101594898B1 (ko) | 2005-07-15 | 2016-02-18 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| AR071997A1 (es) | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| CN102595902B (zh) | 2009-05-12 | 2015-04-29 | 阿尔巴尼分子研究公司 | 7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉及其用途 |
| WO2010132487A1 (en) | 2009-05-12 | 2010-11-18 | Bristol-Myers Squibb Company | CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF |
| MX2011011901A (es) | 2009-05-12 | 2012-01-20 | Albany Molecular Res Inc | Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670694B2 (de) * | 1966-05-05 | 1976-07-22 | Hoechst Ag, 6000 Frankfurt | Verfahren zur herstellung von tetrahydroisochinolinen |
-
1970
- 1970-01-06 CH CH10370A patent/CH527194A/de not_active IP Right Cessation
- 1970-01-06 CH CH1011872A patent/CH538477A/de not_active IP Right Cessation
- 1970-12-16 SE SE17063/70A patent/SE368401B/xx unknown
- 1970-12-16 SE SE7313623A patent/SE386672B/xx unknown
- 1970-12-16 DE DE2062001A patent/DE2062001C2/de not_active Expired
- 1970-12-21 ZA ZA708590A patent/ZA708590B/xx unknown
- 1970-12-28 IL IL35916A patent/IL35916A/xx unknown
- 1970-12-29 NL NLAANVRAGE7018956,A patent/NL171444C/xx not_active IP Right Cessation
- 1970-12-31 FI FI703519A patent/FI49503C/fi active
-
1971
- 1971-01-04 IE IE6/71A patent/IE34859B1/xx unknown
- 1971-01-05 BE BE761219A patent/BE761219A/xx not_active IP Right Cessation
- 1971-01-05 NO NO7121A patent/NO135315C/no unknown
- 1971-01-05 ES ES387016A patent/ES387016A1/es not_active Expired
- 1971-01-05 FR FR7100097A patent/FR2081412B1/fr not_active Expired
- 1971-01-05 GB GB45471A patent/GB1335261A/en not_active Expired
- 1971-01-05 AT AT4571A patent/AT303041B/de not_active IP Right Cessation
- 1971-01-05 DK DK2571AA patent/DK125021B/da not_active IP Right Cessation
- 1971-01-06 CA CA102,060A patent/CA999866A/en not_active Expired
- 1971-01-06 JP JP7194A patent/JPS5515476B1/ja active Pending
- 1971-01-06 YU YU19/71A patent/YU33660B/xx unknown
- 1971-01-07 PH PH12087*UA patent/PH9682A/en unknown
-
1973
- 1973-10-05 SE SE7313622A patent/SE399879B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH527194A (de) | 1972-08-31 |
| SE399879B (sv) | 1978-03-06 |
| YU33660B (en) | 1977-12-31 |
| SE386672B (sv) | 1976-08-16 |
| NL7018956A (enrdf_load_html_response) | 1971-07-08 |
| NO135315B (enrdf_load_html_response) | 1976-12-13 |
| IE34859B1 (en) | 1975-09-03 |
| FI49503B (enrdf_load_html_response) | 1975-04-01 |
| FR2081412A1 (enrdf_load_html_response) | 1971-12-03 |
| YU1971A (en) | 1977-06-30 |
| NO135315C (enrdf_load_html_response) | 1977-03-23 |
| NL171444B (nl) | 1982-11-01 |
| CA999866A (en) | 1976-11-16 |
| FR2081412B1 (enrdf_load_html_response) | 1974-04-12 |
| JPS5515476B1 (enrdf_load_html_response) | 1980-04-23 |
| FI49503C (fi) | 1975-07-10 |
| DE2062001C2 (de) | 1986-10-16 |
| GB1335261A (en) | 1973-10-24 |
| NL171444C (nl) | 1983-04-05 |
| AT303041B (de) | 1972-11-10 |
| IE34859L (en) | 1971-07-06 |
| CH538477A (de) | 1973-06-30 |
| PH9682A (en) | 1976-02-10 |
| ZA708590B (en) | 1971-09-29 |
| DE2062001A1 (de) | 1971-07-15 |
| IL35916A0 (en) | 1971-02-25 |
| ES387016A1 (es) | 1976-05-01 |
| SE368401B (enrdf_load_html_response) | 1974-07-01 |
| BE761219A (fr) | 1971-07-05 |
| IL35916A (en) | 1973-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |