DK1208086T3 - Benzamidformulering med histondeacetylaseinhibitoraktivitet - Google Patents
Benzamidformulering med histondeacetylaseinhibitoraktivitetInfo
- Publication number
- DK1208086T3 DK1208086T3 DK00956496T DK00956496T DK1208086T3 DK 1208086 T3 DK1208086 T3 DK 1208086T3 DK 00956496 T DK00956496 T DK 00956496T DK 00956496 T DK00956496 T DK 00956496T DK 1208086 T3 DK1208086 T3 DK 1208086T3
- Authority
- DK
- Denmark
- Prior art keywords
- histone deacetylase
- deacetylase inhibitor
- inhibitor activity
- benzamide
- formulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24244499A JP2001081031A (ja) | 1999-08-30 | 1999-08-30 | 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1208086T3 true DK1208086T3 (da) | 2006-06-19 |
Family
ID=17089193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00956496T DK1208086T3 (da) | 1999-08-30 | 2000-08-29 | Benzamidformulering med histondeacetylaseinhibitoraktivitet |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6638530B1 (no) |
| EP (1) | EP1208086B1 (no) |
| JP (2) | JP2001081031A (no) |
| KR (1) | KR100712640B1 (no) |
| CN (1) | CN1147472C (no) |
| AR (1) | AR025434A1 (no) |
| AT (1) | ATE318258T1 (no) |
| AU (1) | AU773617B2 (no) |
| BG (1) | BG65544B1 (no) |
| BR (1) | BR0013648A (no) |
| CA (1) | CA2382886C (no) |
| CZ (1) | CZ301737B6 (no) |
| DE (1) | DE60026144T2 (no) |
| DK (1) | DK1208086T3 (no) |
| EE (1) | EE05063B1 (no) |
| ES (1) | ES2259289T3 (no) |
| HK (1) | HK1046277B (no) |
| HR (1) | HRP20020182B1 (no) |
| HU (1) | HUP0203330A3 (no) |
| IL (2) | IL148357A0 (no) |
| MX (1) | MXPA02002090A (no) |
| NO (1) | NO322532B1 (no) |
| NZ (1) | NZ517520A (no) |
| PL (1) | PL201274B1 (no) |
| PT (1) | PT1208086E (no) |
| RU (1) | RU2260428C2 (no) |
| SI (1) | SI1208086T1 (no) |
| SK (1) | SK287252B6 (no) |
| TW (1) | TWI268778B (no) |
| UA (1) | UA72541C2 (no) |
| WO (1) | WO2001016106A1 (no) |
| ZA (1) | ZA200201424B (no) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8119159B2 (en) * | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| WO2002078669A1 (fr) * | 2001-03-30 | 2002-10-10 | Takeda Chemical Industries, Ltd. | Solutions medicinales |
| US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| AU2006252047B2 (en) * | 2001-09-14 | 2010-02-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| EP1429765A2 (en) | 2001-09-14 | 2004-06-23 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US6706686B2 (en) | 2001-09-27 | 2004-03-16 | The Regents Of The University Of Colorado | Inhibition of histone deacetylase as a treatment for cardiac hypertrophy |
| EP1443928B1 (en) | 2001-10-16 | 2011-07-27 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
| JPWO2003070691A1 (ja) * | 2002-02-21 | 2005-06-09 | 財団法人大阪産業振興機構 | Ｎ−ヒドロキシカルボキサミド誘導体 |
| BR0308250A (pt) | 2002-03-04 | 2005-01-11 | Aton Pharma Inc | Métodos de indução de diferenciação terminal |
| US7456219B2 (en) | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
| US7148257B2 (en) | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
| JP2005518817A (ja) | 2002-03-07 | 2005-06-30 | ユニバーシティー、オブ、デラウェア | ヒストン・デアセチラーゼ・インヒビタ、ラムダファージベータ蛋白、またはヒドロキシウレアを含む組成物を使用してオリゴヌクレオチド媒介性核酸配列改変を高める方法、組成物およびキット |
| GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| DE10233412A1 (de) * | 2002-07-23 | 2004-02-12 | 4Sc Ag | Neue Verbindungen als Histondeacetylase-Inhibitoren |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| GB0226855D0 (en) * | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
| US7244751B2 (en) * | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
| CA2518318A1 (en) | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CN100455564C (zh) * | 2003-09-12 | 2009-01-28 | 深圳微芯生物科技有限责任公司 | 组蛋白去乙酰化酶抑制剂及其药用制剂的制备和应用 |
| CN1882529A (zh) * | 2003-09-24 | 2006-12-20 | 梅特希尔基因公司 | 组蛋白脱乙酰基酶抑制剂 |
| EP1663953A1 (en) * | 2003-09-24 | 2006-06-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| HUE028490T2 (en) | 2003-12-02 | 2016-12-28 | Univ Ohio State Res Found | Short-chain fatty acids fixed to the Zn2-chelating motif as a new class of histone deacetylase inhibitors |
| EP1697538A1 (en) * | 2003-12-18 | 2006-09-06 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Method for identifying histone deacetylase inhibitors |
| US7253204B2 (en) | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
| EP1824831A2 (en) | 2004-12-16 | 2007-08-29 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20100087328A1 (en) * | 2005-03-01 | 2010-04-08 | The Regents Of The University Of Michigan | Brm expression and related diagnostics |
| US7604939B2 (en) * | 2005-03-01 | 2009-10-20 | The Regents Of The University Of Michigan | Methods of identifying active BRM expression-promoting HDAC inhibitors |
| JP2008540574A (ja) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| TWI415603B (zh) | 2005-05-20 | 2013-11-21 | Merck Sharp & Dohme | １，８－辛二醯基苯胺羥胺酸（ｓｕｂｅｒｏｙｌａｎｉｌｉｄｅ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄ）之調配物及其製配方法 |
| CA2615105A1 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| WO2007017728A2 (en) * | 2005-08-05 | 2007-02-15 | Orchid Research Laboratories Limited | Novel heterocyclic compounds |
| ES2426445T3 (es) * | 2006-04-07 | 2013-10-23 | Merrion Research Iii Limited | Forma de dosificación oral sólida que contiene un potenciador |
| JP5554988B2 (ja) | 2006-04-07 | 2014-07-23 | メチルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| CA2654566A1 (en) * | 2006-06-09 | 2007-12-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| US20100056522A1 (en) | 2007-03-28 | 2010-03-04 | Santen Pharmaceutical Co., Ltd. | Intraocular pressure-lowering agent comprising compound having histone deacetylase inhibitor effect as active ingredient |
| US20110044952A1 (en) * | 2007-11-27 | 2011-02-24 | Ottawa Health Research Institute | Amplification of cancer-specific oncolytic viral infection by histone deacetylase inhibitors |
| WO2009126662A1 (en) * | 2008-04-08 | 2009-10-15 | Syndax Pharmaceuticals, Inc. | Administration of an inhibitor of hdac, an inhibitor of her-2, and a selective estrogen receptor modulator |
| US8999383B2 (en) * | 2008-05-07 | 2015-04-07 | Merrion Research Iii Limited | Compositions of GnRH related compounds and processes of preparation |
| WO2009140164A1 (en) * | 2008-05-16 | 2009-11-19 | Chipscreen Biosciences Ltd. | 6-aminonicotinamide derivatives as potent and selective histone deacetylase inhibitors |
| WO2010011700A2 (en) | 2008-07-23 | 2010-01-28 | The Brigham And Women's Hospital, Inc. | Treatment of cancers characterized by chromosomal rearrangement of the nut gene |
| CA2751854A1 (en) * | 2009-02-25 | 2010-09-02 | Merrion Research Iii Limited | Composition and drug delivery of bisphosphonates |
| US9089484B2 (en) | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
| WO2012094598A2 (en) | 2011-01-07 | 2012-07-12 | Merrion Research Iii Limited | Pharmaceutical compositions of iron for oral administration |
| CN103172540B (zh) * | 2013-03-18 | 2015-07-01 | 潍坊博创国际生物医药研究院 | 苯甘氨酸类组蛋白去乙酰酶抑制剂及其制备方法和应用 |
| WO2015051035A1 (en) | 2013-10-01 | 2015-04-09 | The J. David Gladstone Institutes | Compositions, systems and methods for gene expression noise drug screening and uses thereof |
| US10265384B2 (en) | 2015-01-29 | 2019-04-23 | Novo Nordisk A/S | Tablets comprising GLP-1 agonist and enteric coating |
| DK3317281T3 (da) | 2015-07-02 | 2020-06-15 | Acerta Pharma Bv | Faste former og formuleringer af (s)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-n-(pyridin-2-yl)benzamid |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| JP2019524879A (ja) * | 2016-07-08 | 2019-09-05 | ラネディス ファーマシューティカルズ リミテッド ライアビリティ カンパニー | リソソーム蓄積症およびその他の単一遺伝子代謝疾患を処置および／または予防するための組成物および方法 |
| WO2018222572A1 (en) * | 2017-06-01 | 2018-12-06 | Warner Babcock Institute For Green Chemistry, Llc | Non-covalent derivatives and methods of treatment |
| WO2018226939A1 (en) * | 2017-06-07 | 2018-12-13 | Ranedis Pharmaceuticals, Llc | Compositions and methods of treating and/or preventing cancer |
| EP3960240B1 (en) | 2019-04-25 | 2024-03-27 | Fuji Pharma Co., Ltd. | Pharmaceutical preparation and method for producing same |
| CN112294810B (zh) * | 2019-07-29 | 2024-03-01 | 深圳微芯生物科技股份有限公司 | 含有西达本胺和表面活性剂的药物组合物 |
| EP4238565A1 (en) | 2020-10-28 | 2023-09-06 | KinoPharma, Inc. | Pharmaceutical composition for preventing or treating viral perivaginal disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ513800A (en) * | 1996-08-12 | 2001-09-28 | Welfide Corp | Treatment of diseases using Rho kinase inhibitors |
| JP3354090B2 (ja) * | 1996-09-30 | 2002-12-09 | シエーリング アクチエンゲゼルシャフト | 分化誘導剤 |
| US6174905B1 (en) * | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| JP4405602B2 (ja) | 1998-04-16 | 2010-01-27 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | ヒストン脱アセチル化酵素阻害剤 |
| JP2000256194A (ja) * | 1999-01-06 | 2000-09-19 | Mitsui Chemicals Inc | 核内レセプタ作動薬およびその効果増強剤 |
| JP2001064177A (ja) * | 1999-08-16 | 2001-03-13 | Schering Ag | ベンズアミド誘導体を有効成分とする製剤 |
-
1999
- 1999-08-30 JP JP24244499A patent/JP2001081031A/ja active Pending
-
2000
- 2000-08-29 WO PCT/EP2000/008421 patent/WO2001016106A1/en active IP Right Grant
- 2000-08-29 BR BR0013648-4A patent/BR0013648A/pt not_active Application Discontinuation
- 2000-08-29 MX MXPA02002090A patent/MXPA02002090A/es active IP Right Grant
- 2000-08-29 JP JP2001519675A patent/JP2003508386A/ja not_active Withdrawn
- 2000-08-29 SK SK261-2002A patent/SK287252B6/sk not_active IP Right Cessation
- 2000-08-29 IL IL14835700A patent/IL148357A0/xx active IP Right Grant
- 2000-08-29 UA UA2002032271A patent/UA72541C2/uk unknown
- 2000-08-29 SI SI200030851T patent/SI1208086T1/sl unknown
- 2000-08-29 EP EP00956496A patent/EP1208086B1/en not_active Expired - Lifetime
- 2000-08-29 AR ARP000104493A patent/AR025434A1/es unknown
- 2000-08-29 CZ CZ20020724A patent/CZ301737B6/cs not_active IP Right Cessation
- 2000-08-29 TW TW089117485A patent/TWI268778B/zh not_active IP Right Cessation
- 2000-08-29 EE EEP200200097A patent/EE05063B1/xx not_active IP Right Cessation
- 2000-08-29 HU HU0203330A patent/HUP0203330A3/hu unknown
- 2000-08-29 DK DK00956496T patent/DK1208086T3/da active
- 2000-08-29 NZ NZ517520A patent/NZ517520A/en not_active IP Right Cessation
- 2000-08-29 CA CA002382886A patent/CA2382886C/en not_active Expired - Fee Related
- 2000-08-29 AU AU68416/00A patent/AU773617B2/en not_active Ceased
- 2000-08-29 PL PL353063A patent/PL201274B1/pl not_active IP Right Cessation
- 2000-08-29 DE DE60026144T patent/DE60026144T2/de not_active Expired - Lifetime
- 2000-08-29 KR KR1020027002163A patent/KR100712640B1/ko not_active IP Right Cessation
- 2000-08-29 US US10/069,582 patent/US6638530B1/en not_active Expired - Fee Related
- 2000-08-29 RU RU2002107992/15A patent/RU2260428C2/ru active IP Right Revival
- 2000-08-29 AT AT00956496T patent/ATE318258T1/de active
- 2000-08-29 ES ES00956496T patent/ES2259289T3/es not_active Expired - Lifetime
- 2000-08-29 PT PT00956496T patent/PT1208086E/pt unknown
- 2000-08-29 CN CNB008122849A patent/CN1147472C/zh not_active Expired - Fee Related
-
2002
- 2002-02-20 ZA ZA200201424A patent/ZA200201424B/en unknown
- 2002-02-25 IL IL148357A patent/IL148357A/en not_active IP Right Cessation
- 2002-02-26 BG BG106439A patent/BG65544B1/bg unknown
- 2002-02-27 NO NO20020952A patent/NO322532B1/no not_active IP Right Cessation
- 2002-02-27 HR HR20020182A patent/HRP20020182B1/xx not_active IP Right Cessation
- 2002-10-22 HK HK02107642.5A patent/HK1046277B/zh not_active IP Right Cessation
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