NO20020952L - Benzamid-formulering med histon-deacetylase- inhibitoraktivitet - Google Patents

Benzamid-formulering med histon-deacetylase- inhibitoraktivitet

Info

Publication number
NO20020952L
NO20020952L NO20020952A NO20020952A NO20020952L NO 20020952 L NO20020952 L NO 20020952L NO 20020952 A NO20020952 A NO 20020952A NO 20020952 A NO20020952 A NO 20020952A NO 20020952 L NO20020952 L NO 20020952L
Authority
NO
Norway
Prior art keywords
histone deacetylase
deacetylase inhibitor
inhibitor activity
benzamide
formulation
Prior art date
Application number
NO20020952A
Other languages
English (en)
Other versions
NO20020952D0 (no
NO322532B1 (no
Inventor
Masahiko Ishibashi
Masahiro Sakabe
Ikuo Sakai
Tsuneji Suzuki
Tomoyuki Ando
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20020952D0 publication Critical patent/NO20020952D0/no
Publication of NO20020952L publication Critical patent/NO20020952L/no
Publication of NO322532B1 publication Critical patent/NO322532B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
NO20020952A 1999-08-30 2002-02-27 Farmasoytisk formulering omfattende benzamidderivat. NO322532B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24244499A JP2001081031A (ja) 1999-08-30 1999-08-30 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤
PCT/EP2000/008421 WO2001016106A1 (en) 1999-08-30 2000-08-29 Benzamide formulation with histone deacetylase inhibitor activity

Publications (3)

Publication Number Publication Date
NO20020952D0 NO20020952D0 (no) 2002-02-27
NO20020952L true NO20020952L (no) 2002-03-20
NO322532B1 NO322532B1 (no) 2006-10-23

Family

ID=17089193

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020952A NO322532B1 (no) 1999-08-30 2002-02-27 Farmasoytisk formulering omfattende benzamidderivat.

Country Status (32)

Country Link
US (1) US6638530B1 (no)
EP (1) EP1208086B1 (no)
JP (2) JP2001081031A (no)
KR (1) KR100712640B1 (no)
CN (1) CN1147472C (no)
AR (1) AR025434A1 (no)
AT (1) ATE318258T1 (no)
AU (1) AU773617B2 (no)
BG (1) BG65544B1 (no)
BR (1) BR0013648A (no)
CA (1) CA2382886C (no)
CZ (1) CZ301737B6 (no)
DE (1) DE60026144T2 (no)
DK (1) DK1208086T3 (no)
EE (1) EE05063B1 (no)
ES (1) ES2259289T3 (no)
HK (1) HK1046277B (no)
HR (1) HRP20020182B1 (no)
HU (1) HUP0203330A3 (no)
IL (2) IL148357A0 (no)
MX (1) MXPA02002090A (no)
NO (1) NO322532B1 (no)
NZ (1) NZ517520A (no)
PL (1) PL201274B1 (no)
PT (1) PT1208086E (no)
RU (1) RU2260428C2 (no)
SI (1) SI1208086T1 (no)
SK (1) SK287252B6 (no)
TW (1) TWI268778B (no)
UA (1) UA72541C2 (no)
WO (1) WO2001016106A1 (no)
ZA (1) ZA200201424B (no)

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US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
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US6706686B2 (en) 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
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US7456219B2 (en) 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
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TWI415603B (zh) 2005-05-20 2013-11-21 Merck Sharp & Dohme １，８－辛二醯基苯胺羥胺酸（ｓｕｂｅｒｏｙｌａｎｉｌｉｄｅ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄ）之調配物及其製配方法
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US20070292512A1 (en) * 2006-06-09 2007-12-20 Merrion Research Ii Limited Solid Oral Dosage Form Containing an Enhancer
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Also Published As

Publication number Publication date
CA2382886A1 (en) 2001-03-08
HK1046277B (zh) 2004-11-26
HUP0203330A3 (en) 2004-03-01
SK2612002A3 (en) 2002-09-10
CZ2002724A3 (cs) 2002-07-17
BG65544B1 (bg) 2008-11-28
PL201274B1 (pl) 2009-03-31
AU6841600A (en) 2001-03-26
TWI268778B (en) 2006-12-21
DE60026144T2 (de) 2006-11-16
PT1208086E (pt) 2006-07-31
DE60026144D1 (de) 2006-04-27
CZ301737B6 (cs) 2010-06-09
EP1208086B1 (en) 2006-02-22
US6638530B1 (en) 2003-10-28
BR0013648A (pt) 2002-05-07
ES2259289T3 (es) 2006-10-01
MXPA02002090A (es) 2003-08-20
WO2001016106A1 (en) 2001-03-08
HRP20020182B1 (en) 2007-08-31
NO20020952D0 (no) 2002-02-27
CA2382886C (en) 2009-06-09
CN1147472C (zh) 2004-04-28
EE05063B1 (et) 2008-08-15
UA72541C2 (en) 2005-03-15
EE200200097A (et) 2003-04-15
KR20020023424A (ko) 2002-03-28
PL353063A1 (en) 2003-10-06
BG106439A (en) 2002-11-29
HK1046277A1 (en) 2003-01-03
DK1208086T3 (da) 2006-06-19
RU2260428C2 (ru) 2005-09-20
JP2003508386A (ja) 2003-03-04
CN1371366A (zh) 2002-09-25
JP2001081031A (ja) 2001-03-27
SI1208086T1 (sl) 2006-08-31
ATE318258T1 (de) 2006-03-15
AU773617B2 (en) 2004-05-27
HRP20020182A2 (en) 2004-02-29
SK287252B6 (sk) 2010-04-07
IL148357A (en) 2006-12-10
AR025434A1 (es) 2002-11-27
NO322532B1 (no) 2006-10-23
NZ517520A (en) 2003-05-30
ZA200201424B (en) 2002-11-27
KR100712640B1 (ko) 2007-05-02
HUP0203330A2 (hu) 2003-02-28
IL148357A0 (en) 2002-09-12
EP1208086A1 (en) 2002-05-29

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