DK1156059T3 - Selektivt spaltelige linkere baseret på en methioningruppe og en estergruppe - Google Patents

Selektivt spaltelige linkere baseret på en methioningruppe og en estergruppe

Info

Publication number
DK1156059T3
DK1156059T3 DK01114395T DK01114395T DK1156059T3 DK 1156059 T3 DK1156059 T3 DK 1156059T3 DK 01114395 T DK01114395 T DK 01114395T DK 01114395 T DK01114395 T DK 01114395T DK 1156059 T3 DK1156059 T3 DK 1156059T3
Authority
DK
Denmark
Prior art keywords
group
methionine
cleavable linkers
ester group
linkers based
Prior art date
Application number
DK01114395T
Other languages
Danish (da)
English (en)
Inventor
Michal Lebl
Viktor Krchnak
Petr Kocis
Kit S Lam
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK1156059T3 publication Critical patent/DK1156059T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fertilizers (AREA)
  • Medicinal Preparation (AREA)
DK01114395T 1993-06-21 1994-06-21 Selektivt spaltelige linkere baseret på en methioningruppe og en estergruppe DK1156059T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8038893A 1993-06-21 1993-06-21
US8199793A 1993-06-23 1993-06-23
PCT/US1994/007012 WO1995000165A1 (en) 1993-06-21 1994-06-21 Selectively cleavable linkers based on iminodiacetic acid ester bonds

Publications (1)

Publication Number Publication Date
DK1156059T3 true DK1156059T3 (da) 2007-11-12

Family

ID=26763448

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01114395T DK1156059T3 (da) 1993-06-21 1994-06-21 Selektivt spaltelige linkere baseret på en methioningruppe og en estergruppe
DK94920294T DK0751779T3 (da) 1993-06-21 1994-06-21 Selektivt kløvbare linkere som er baseret på iminodieddikesyreester-bindinger

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK94920294T DK0751779T3 (da) 1993-06-21 1994-06-21 Selektivt kløvbare linkere som er baseret på iminodieddikesyreester-bindinger

Country Status (11)

Country Link
US (1) US5635598A (es)
EP (2) EP1156059B1 (es)
JP (2) JP3469579B2 (es)
AT (2) ATE210993T1 (es)
AU (1) AU689116B2 (es)
DE (2) DE69435011T2 (es)
DK (2) DK1156059T3 (es)
ES (2) ES2165880T3 (es)
NZ (1) NZ268292A (es)
PT (2) PT1156059E (es)
WO (1) WO1995000165A1 (es)

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US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties
DE69632989T2 (de) * 1995-10-17 2005-08-25 Combichem, Inc., San Diego Matrize für die Synthese kombinatorischer Bibliotheken in Lösung
US6475807B1 (en) * 1996-04-08 2002-11-05 Smithkline Beecham Corporation Mass-based encoding and qualitative analysis of combinatorial libraries
DE19626762A1 (de) * 1996-07-03 1998-01-08 Basf Ag Enzymatisch spaltbare Linker für Festphasensynthesen
US6453246B1 (en) 1996-11-04 2002-09-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing proximity data in a multi-dimensional space
AU722989B2 (en) * 1996-11-04 2000-08-17 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for the visualization and interactive processing and analysis of chemical data
US6571227B1 (en) * 1996-11-04 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Method, system and computer program product for non-linear mapping of multi-dimensional data
DE19782096T1 (de) 1996-11-06 2000-03-23 Sequenom Inc Immobiliserung von Nucleinsäuren in hoher Dichte
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
US5958703A (en) * 1996-12-03 1999-09-28 Glaxo Group Limited Use of modified tethers in screening compound libraries
US6168913B1 (en) * 1997-10-14 2001-01-02 Abbott Laboratories Coding combinatorial libraries with fluorine tags
WO1999025752A1 (en) * 1997-11-18 1999-05-27 Aventis Pharmaceuticals Products Inc. Functionalized resin for the synthesis of amides and peptides
CA2260472A1 (en) * 1998-02-11 1999-08-11 Xiao-Yi Xiao Safety-catch linkers
US7094943B2 (en) 1998-04-27 2006-08-22 Hubert Köster Solution phase biopolymer synthesis
GB9912911D0 (en) * 1999-06-04 1999-08-04 Zeneca Ltd Chemical process
US6309889B1 (en) 1999-12-23 2001-10-30 Glaxo Wellcome Inc. Nano-grid micro reactor and methods
US7416524B1 (en) 2000-02-18 2008-08-26 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. System, method and computer program product for fast and efficient searching of large chemical libraries
EP1259823A2 (en) * 2000-02-23 2002-11-27 Xenoport, Inc. Self-encoded combinatorial synthesis of compound multiplets
AU2001241800A1 (en) 2000-02-29 2001-09-12 3-Dimensional Pharmaceuticals, Inc. Method and computer program product for designing combinatorial arrays
AU2001247627A1 (en) 2000-03-22 2001-10-03 3-Dimensional Pharmaceuticals, Inc. System, method, and computer program product for representing object relationships in a multidimensional space
WO2001075790A2 (en) 2000-04-03 2001-10-11 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for representing object relationships in a multidimensional space
EP1350193A2 (en) * 2000-08-22 2003-10-08 3-Dimensional Pharmaceuticals, Inc. Method, system, and computer program product for determining properties of combinatorial library products from features of library building blocks
US6678619B2 (en) * 2000-09-20 2004-01-13 Victor S. Lobanov Method, system, and computer program product for encoding and building products of a virtual combinatorial library
US7054757B2 (en) * 2001-01-29 2006-05-30 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Method, system, and computer program product for analyzing combinatorial libraries
US7262269B2 (en) * 2001-10-26 2007-08-28 The Regents Of University Of California Method for screening combinational bead library; ligands for cancer cells
US6670142B2 (en) 2001-10-26 2003-12-30 The Regents Of The University Of California Method for screening combinatorial bead library, capturing cells from body fluids, and ligands for cancer cells
US7291456B2 (en) 2002-01-24 2007-11-06 The Regents Of The University Of California Method for determining differences in molecular interactions and for screening a combinatorial library
US20040185499A1 (en) * 2003-03-20 2004-09-23 Jolley Michael E. Method of epitope scanning using fluorescence polarization
EP1807092B1 (en) 2004-11-05 2016-09-07 The Children's Hospital of Philadelphia Biodegradable linkers for molecular therapies
EP2592103A1 (en) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymer aldehyde derivatives
CN105254576A (zh) * 2014-02-26 2016-01-20 中国科学院长春应用化学研究所 一种谷氨酸二酮哌嗪的制备方法
KR20170109046A (ko) * 2015-02-02 2017-09-27 투 포어 가이즈, 인코포레이티드 바이오마커 검출용 불안정성 링커
DK3650458T3 (da) * 2015-02-24 2023-09-04 Hope City Platforme til screening af kemisk kodede, rumligt adresserede biblioteker
DE102015117567B4 (de) 2015-10-15 2017-05-11 Stochastic Combinatorics GbR (vertretungsberechtigter Gesellschafter: Dr. Alexander Nesterov-Müller, 76661 Philippsburg) Ultra-hochdichte Oligomerarrays und Verfahren zu deren Herstellung
CA3068254A1 (en) 2017-06-20 2018-12-27 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
EP3866794A4 (en) 2018-10-17 2022-07-20 Imbria Pharmaceuticals, Inc. METHODS OF TREATING RHEUMATIC DISEASES USING TRIMETAZIDINE COMPOUNDS
CA3158746A1 (en) * 2019-11-14 2021-05-20 Bcd Bioscience, Inc. High-yield peroxide quench-controlled polysaccharide depolymerization and compositions thereof
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine
WO2023102255A1 (en) * 2021-12-03 2023-06-08 Massachusetts Institute Of Technology Peptide-encoded libraries of small molecules for de novo drug discovery

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US3963701A (en) * 1972-04-17 1976-06-15 Richardson-Merrell Inc. Substituted benzhydryl lactamimide derivatives
FR2595695B1 (fr) * 1986-03-12 1988-12-02 Synthelabo Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique
EP0273895A3 (en) * 1986-12-24 1988-12-21 Monsanto Company Solid phase peptide synthesis
EP0322348B1 (de) * 1987-12-22 1994-02-02 Hoechst Aktiengesellschaft Säurelabile Ankergruppen zur Synthese von Peptidamiden mittels Festphasenmethode
JP2815362B2 (ja) * 1988-02-29 1998-10-27 中外製薬株式会社 ベンズヒドリルアミン誘導体及びその製法
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
DE69020143T2 (de) * 1989-02-17 1996-01-25 Chiron Mimotopes Pty Ltd Verfahren zur verwendung und herstellung von peptiden.
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
NL9002611A (nl) * 1990-11-29 1992-06-16 Crown Gear Bv Gereedschap voor het vervaardigen van kroonwielen, alsmede werkwijze voor het vervaardigen van een dergelijk gereedschap.
CS103091A3 (en) * 1991-04-12 1992-10-14 Ustav Organicke Chemie A Bioch Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use

Also Published As

Publication number Publication date
ES2165880T3 (es) 2002-04-01
EP1156059B1 (en) 2007-08-08
JP3469579B2 (ja) 2003-11-25
PT1156059E (pt) 2007-10-19
NZ268292A (en) 1997-09-22
DE69429542D1 (de) 2002-01-31
ES2291245T3 (es) 2008-03-01
EP0751779A1 (en) 1997-01-08
JP3672558B2 (ja) 2005-07-20
AU7114594A (en) 1995-01-17
JPH09500111A (ja) 1997-01-07
ATE210993T1 (de) 2002-01-15
AU689116B2 (en) 1998-03-26
US5635598A (en) 1997-06-03
WO1995000165A1 (en) 1995-01-05
DE69435011D1 (de) 2007-09-20
JP2003327597A (ja) 2003-11-19
EP1156059A1 (en) 2001-11-21
EP0751779B1 (en) 2001-12-19
EP0751779A4 (en) 1998-12-09
PT751779E (pt) 2002-05-31
DE69429542T2 (de) 2002-08-08
DK0751779T3 (da) 2002-04-15
ATE369376T1 (de) 2007-08-15
DE69435011T2 (de) 2008-10-23

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