US6881570B1
(en)
*
|
1998-12-15 |
2005-04-19 |
Fuji Photo Film Co., Ltd. |
Test piece and quantitative method and apparatus for an organism-oriented substance
|
US6255476B1
(en)
*
|
1999-02-22 |
2001-07-03 |
Pe Corporation (Ny) |
Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports
|
JP3957118B2
(ja)
*
|
1999-05-18 |
2007-08-15 |
富士フイルム株式会社 |
試験片およびこの試験片からの画像情報読取装置
|
AU5285800A
(en)
|
1999-05-24 |
2000-12-12 |
Invitrogen Corporation |
Method for deblocking of labeled oligonucleotides
|
US7183405B2
(en)
*
|
1999-06-25 |
2007-02-27 |
Syn Gen, Inc. |
Compositions and methods for labeling oligonucleotides
|
US7211390B2
(en)
|
1999-09-16 |
2007-05-01 |
454 Life Sciences Corporation |
Method of sequencing a nucleic acid
|
US7244559B2
(en)
|
1999-09-16 |
2007-07-17 |
454 Life Sciences Corporation |
Method of sequencing a nucleic acid
|
US6451588B1
(en)
*
|
2000-06-30 |
2002-09-17 |
Pe Corporation (Ny) |
Multipartite high-affinity nucleic acid probes
|
JP3398366B2
(ja)
*
|
2000-08-09 |
2003-04-21 |
富士写真フイルム株式会社 |
Dna分析用マイクロアレイの製造方法
|
US6559279B1
(en)
|
2000-09-08 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Process for preparing peptide derivatized oligomeric compounds
|
DE60140317D1
(de)
*
|
2000-12-14 |
2009-12-10 |
Gen Probe Inc |
Verfahren und kits zur verbesserung der hybridisierungsraten von polynukleotiden
|
US6534646B2
(en)
|
2001-06-04 |
2003-03-18 |
Barrskogen, Inc. |
Oligonucleotide labeling reagents
|
US6448016B1
(en)
*
|
2001-06-12 |
2002-09-10 |
The United States Of America As Represented By The Secretary Of The Army |
Nucleotide sequences for detection of Bacillus anthracis
|
US20050009022A1
(en)
*
|
2001-07-06 |
2005-01-13 |
Weiner Michael P. |
Method for isolation of independent, parallel chemical micro-reactions using a porous filter
|
US20030054396A1
(en)
*
|
2001-09-07 |
2003-03-20 |
Weiner Michael P. |
Enzymatic light amplification
|
US6902921B2
(en)
|
2001-10-30 |
2005-06-07 |
454 Corporation |
Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
|
US6956114B2
(en)
|
2001-10-30 |
2005-10-18 |
'454 Corporation |
Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
|
US20050124022A1
(en)
*
|
2001-10-30 |
2005-06-09 |
Maithreyan Srinivasan |
Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase
|
US6946245B2
(en)
|
2001-12-04 |
2005-09-20 |
Quest Diagnostics Investments Incorporated |
Oligonucleotides and methods for detecting hepatitis C viral nucleic acids
|
US6686162B2
(en)
|
2001-12-04 |
2004-02-03 |
Quest Diagnostics Investments, Incorporated |
Oligonucleotides and methods for detecting Borrelia burgdorferi
|
DE10206616A1
(de)
*
|
2002-02-15 |
2003-09-04 |
Qiagen Gmbh |
Verfahren zur Reduktion der Background-Kontamination nach Markierungsreaktionen
|
CA2498320A1
(en)
*
|
2002-09-20 |
2004-04-01 |
Integrated Dna Technologies, Inc. |
Anthraquinone quencher dyes, their methods of preparation and use
|
US6913890B2
(en)
*
|
2002-12-18 |
2005-07-05 |
Palo Alto Research Center Incorporated |
Process for preparing albumin protein conjugated oligonucleotide probes
|
US20060292438A1
(en)
*
|
2002-12-23 |
2006-12-28 |
Applera Corporation; Applied Biosystems Group |
Heteroconfigurational Polynucleotides and Methods of Use
|
US20080015349A1
(en)
*
|
2003-01-24 |
2008-01-17 |
Third Wave Technologies, Inc. |
Oligonucleotide production
|
JP4480715B2
(ja)
*
|
2003-01-29 |
2010-06-16 |
454 コーポレーション |
二重末端シーケンシング
|
US7575865B2
(en)
*
|
2003-01-29 |
2009-08-18 |
454 Life Sciences Corporation |
Methods of amplifying and sequencing nucleic acids
|
EP1466919A1
(en)
*
|
2003-04-05 |
2004-10-13 |
Roche Diagnostics GmbH |
Nucleotide analogs with six membered rings
|
CA2463719A1
(en)
*
|
2003-04-05 |
2004-10-05 |
F. Hoffmann-La Roche Ag |
Nucleotide analogs with six membered rings
|
US7439341B2
(en)
*
|
2003-11-14 |
2008-10-21 |
Integrated Dna Technologies, Inc. |
Fluorescence quenching azo dyes, their methods of preparation and use
|
US20050153300A1
(en)
*
|
2004-01-09 |
2005-07-14 |
Quest Diagnostics Incorporated |
Methods and compositions for the detection of mucolipidosis IV mutations
|
US20050214779A1
(en)
*
|
2004-03-29 |
2005-09-29 |
Peck Bill J |
Methods for in situ generation of nucleic acid arrays
|
EP1627926A1
(en)
*
|
2004-08-19 |
2006-02-22 |
Roche Diagnostics GmbH |
A method to reduce false positive results
|
WO2006052842A2
(en)
|
2004-11-09 |
2006-05-18 |
The Trustees Of The University Of Pennsylvania |
Methods for diagnosis of myelodysplastic syndromes (mds)
|
CA2601554A1
(en)
*
|
2005-05-20 |
2006-11-30 |
Integrated Dna Technologies, Inc. |
Compounds and methods for labeling oligonucleotides
|
WO2007024798A2
(en)
|
2005-08-22 |
2007-03-01 |
Applera Corporation |
Apparatus, system, and method using immiscible-fluid-discrete-volumes
|
ES2332139T3
(es)
|
2005-11-23 |
2010-01-27 |
F. Hoffmann-La Roche Ag |
Polinucleotidos con mimetico de fosfato.
|
WO2007106907A2
(en)
*
|
2006-03-15 |
2007-09-20 |
Integrated Dna Technologies, Inc. |
Nucleic acid monomers with 2'-chemical moieties
|
EP2001871B1
(en)
*
|
2006-03-31 |
2014-07-16 |
Applied Biosystems, LLC |
Rhodamine-labeled oligonucleotides
|
CA2649770C
(en)
|
2006-04-18 |
2017-08-15 |
The Trustees Of The University Of Pennsylvania |
Mutated acvr1 for diagnosis and treatment of fibrodysplasia ossificans progressiva (fop)
|
US8859752B2
(en)
|
2006-04-18 |
2014-10-14 |
The Trustees Of The University Of Pennsylvania |
SIRNA-based therapy of Fibrodyplasia Ossificans Progressiva (FOP)
|
US7759062B2
(en)
*
|
2006-06-09 |
2010-07-20 |
Third Wave Technologies, Inc. |
T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
|
US20080153135A1
(en)
*
|
2006-12-20 |
2008-06-26 |
Liu Timothy Z |
Methods and apparatus for conducting amplification reactions on high density hydrophilic patterned microplates
|
US20080153134A1
(en)
*
|
2006-12-22 |
2008-06-26 |
Willy Wiyatno |
Methods and apparatus for generating hydrophilic patterning of high density microplates using an amphiphilic polymer
|
US20080268440A1
(en)
*
|
2007-04-26 |
2008-10-30 |
Liu Timothy Z |
Biomolecule immobilization on surface via hydrophobic interactions
|
EP2036897B1
(en)
*
|
2007-09-04 |
2017-10-18 |
Roche Diagnostics GmbH |
Stable rhodamine labeling reagent
|
JP2010540900A
(ja)
|
2007-09-18 |
2010-12-24 |
アプライド バイオシステムズ インコーポレイテッド |
集光機構のための方法、システムおよび装置
|
US20090139311A1
(en)
*
|
2007-10-05 |
2009-06-04 |
Applied Biosystems Inc. |
Biological Analysis Systems, Devices, and Methods
|
JP5365005B2
(ja)
*
|
2008-01-17 |
2013-12-11 |
富士通株式会社 |
中性で切断可能な核酸合成用レジン
|
WO2009117327A2
(en)
|
2008-03-15 |
2009-09-24 |
Hologic, Inc. |
Compositions and methods for analysis of nucleic acid molecules during amplification reactions
|
JP5438922B2
(ja)
*
|
2008-06-25 |
2014-03-12 |
日東電工株式会社 |
核酸の製造方法
|
US8097412B2
(en)
*
|
2008-07-12 |
2012-01-17 |
Biodiagnostics, Inc. |
DNA-based test for detection of annual and intermediate ryegrass
|
EP2192198A1
(en)
|
2008-12-01 |
2010-06-02 |
Biotype AG |
Novel combination of fluorescent dyes for the detection of nucleic acids
|
US9347092B2
(en)
*
|
2009-02-25 |
2016-05-24 |
Roche Molecular System, Inc. |
Solid support for high-throughput nucleic acid analysis
|
US20110146418A1
(en)
*
|
2009-10-02 |
2011-06-23 |
Brevnov Maxim G |
Sample Preparation Devices and Methods
|
WO2011066330A2
(en)
*
|
2009-11-24 |
2011-06-03 |
Life Technologies Corporation |
Selective amplification of polynucleotide sequences
|
US9506057B2
(en)
|
2010-03-26 |
2016-11-29 |
Integrated Dna Technologies, Inc. |
Modifications for antisense compounds
|
EP2553123B1
(en)
|
2010-03-26 |
2016-08-24 |
Integrated DNA Technologies, Inc. |
Methods for enhancing nucleic acid hybridization
|
EP3578205A1
(en)
|
2010-08-06 |
2019-12-11 |
ModernaTX, Inc. |
A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
|
WO2012033848A1
(en)
|
2010-09-07 |
2012-03-15 |
Integrated Dna Technologies, Inc. |
Modifications for antisense compounds
|
HUE058896T2
(hu)
|
2010-10-01 |
2022-09-28 |
Modernatx Inc |
N1-metil-pszeudo-uracilt tartalmazó ribonukleinsavak és azok felhasználásai
|
JP2014511687A
(ja)
|
2011-03-31 |
2014-05-19 |
モデルナ セラピューティクス インコーポレイテッド |
工学操作された核酸の送達および製剤
|
US9777332B2
(en)
|
2011-03-31 |
2017-10-03 |
St. Jude Children's Research Hospital |
Methods and compositions for identifying minimal residual disease in acute lymphoblastic leukemia
|
JP5808025B2
(ja)
*
|
2011-08-12 |
2015-11-10 |
国立研究開発法人産業技術総合研究所 |
アミノ化オリゴヌクレオチド用固相担体
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
RU2648950C2
(ru)
|
2011-10-03 |
2018-04-02 |
Модерна Терапьютикс, Инк. |
Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
|
EP2791160B1
(en)
|
2011-12-16 |
2022-03-02 |
ModernaTX, Inc. |
Modified mrna compositions
|
WO2013119956A1
(en)
|
2012-02-09 |
2013-08-15 |
Life Technologies Corporation |
Conjugated polymeric particle and method of making same
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
AU2013243951A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of secreted proteins
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
US8859098B2
(en)
*
|
2012-05-18 |
2014-10-14 |
Lord Corporation |
Acrylic adhesion promoters
|
EP2906725A4
(en)
|
2012-10-15 |
2016-07-20 |
Sudhir Sinha |
METHOD FOR GENETIC DETECTION WITH MIXED GENETIC ELEMENTS: MULTIPLEXED DNA ANALYSIS SYSTEM
|
EP2922554B1
(en)
|
2012-11-26 |
2022-02-23 |
ModernaTX, Inc. |
Terminally modified rna
|
WO2014158628A1
(en)
|
2013-03-14 |
2014-10-02 |
Hologic, Inc. |
Compositions and methods for analysis of nucleic acid molecules
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
WO2015034928A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
WO2015048744A2
(en)
|
2013-09-30 |
2015-04-02 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding immune modulating polypeptides
|
EA201690675A1
(ru)
|
2013-10-03 |
2016-08-31 |
Модерна Терапьютикс, Инк. |
Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
|
US20150132256A1
(en)
*
|
2013-10-19 |
2015-05-14 |
Trovagene, Inc. |
Detecting and monitoring mutations in histiocytosis
|
CA2926722A1
(en)
*
|
2013-10-19 |
2015-04-23 |
Trovagene, Inc. |
Detecting mutations in disease over time
|
EP3146094B1
(en)
*
|
2014-05-23 |
2019-08-28 |
Centrillion Technology Holdings Corporation |
Oligonucleotide probe inversion process for in situ synthesized probe arrays
|
US20170204152A1
(en)
|
2014-07-16 |
2017-07-20 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
WO2016014846A1
(en)
|
2014-07-23 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of intrabodies
|
EP3317426B1
(en)
|
2015-07-02 |
2020-01-15 |
Life Technologies Corporation |
Conjugation of carboxyl functional hydrophilic beads
|
WO2017007774A1
(en)
*
|
2015-07-06 |
2017-01-12 |
Life Technologies Corporation |
Substrates and methods useful in sequencing
|
US10695735B2
(en)
|
2015-08-18 |
2020-06-30 |
Centrillion Technology Holdings Corporation |
Probe inversion process for in situ synthesized probe arrays
|
CN106467913B
(zh)
*
|
2015-08-18 |
2021-07-20 |
生捷科技控股公司 |
用于原位合成探针阵列的探针倒转方法
|
BR112020021218A2
(pt)
|
2018-04-18 |
2021-03-02 |
St. Jude Children's Research Hospital |
ensaios de genotipagem para identificar mutações em xaf1
|
US11384376B2
(en)
|
2018-05-31 |
2022-07-12 |
Roche Molecular Systems, Inc. |
Reagents and methods for post-synthetic modification of nucleic acids
|
BR112022026056A2
(pt)
*
|
2020-06-22 |
2023-03-07 |
Illumina Cambridge Ltd |
Nucleosídeos e nucleotídeos com grupo bloqueador 3? acetal
|
KR20230056683A
(ko)
|
2020-07-23 |
2023-04-27 |
라이프 테크놀로지스 코포레이션 |
생물학적 분석에 사용하기 위한 에너지 전달 염료 접합체
|
CN116323965A
(zh)
|
2020-07-23 |
2023-06-23 |
生命技术公司 |
使用染料的用于生物分析的组合物、系统和方法
|
CN116333006A
(zh)
*
|
2023-04-07 |
2023-06-27 |
苏州欧利生物医药科技有限公司 |
一种带有荧光标记物的寡核苷酸的固相合成方法
|