DE60005646D1 - Synthese von markierten oligonucleotiden auf festphasenträgern - Google Patents

Synthese von markierten oligonucleotiden auf festphasenträgern

Info

Publication number
DE60005646D1
DE60005646D1 DE60005646T DE60005646T DE60005646D1 DE 60005646 D1 DE60005646 D1 DE 60005646D1 DE 60005646 T DE60005646 T DE 60005646T DE 60005646 T DE60005646 T DE 60005646T DE 60005646 D1 DE60005646 D1 DE 60005646D1
Authority
DE
Germany
Prior art keywords
solid
support
label
acid
labelled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60005646T
Other languages
English (en)
Other versions
DE60005646T2 (de
Inventor
S Vinayak
G Lee
B Mullah
B Rosenblum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp filed Critical Applera Corp
Publication of DE60005646D1 publication Critical patent/DE60005646D1/de
Application granted granted Critical
Publication of DE60005646T2 publication Critical patent/DE60005646T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE60005646T 1999-02-22 2000-02-18 Synthese von markierten oligonucleotiden auf festphasenträgern Expired - Lifetime DE60005646T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/256,340 US6255476B1 (en) 1999-02-22 1999-02-22 Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports
US256340 1999-02-22
PCT/US2000/004213 WO2000050432A2 (en) 1999-02-22 2000-02-18 Synthesis of labelled oligonucleotides on solid-supports

Publications (2)

Publication Number Publication Date
DE60005646D1 true DE60005646D1 (de) 2003-11-06
DE60005646T2 DE60005646T2 (de) 2004-08-05

Family

ID=22971883

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60005646T Expired - Lifetime DE60005646T2 (de) 1999-02-22 2000-02-18 Synthese von markierten oligonucleotiden auf festphasenträgern

Country Status (10)

Country Link
US (5) US6255476B1 (de)
EP (1) EP1155027B1 (de)
JP (4) JP4634615B2 (de)
AT (1) ATE251174T1 (de)
AU (1) AU773864B2 (de)
CA (1) CA2353047C (de)
DE (1) DE60005646T2 (de)
DK (1) DK1155027T3 (de)
ES (1) ES2204537T3 (de)
WO (1) WO2000050432A2 (de)

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Also Published As

Publication number Publication date
US6835827B2 (en) 2004-12-28
JP2007131641A (ja) 2007-05-31
US20030191303A1 (en) 2003-10-09
ATE251174T1 (de) 2003-10-15
DE60005646T2 (de) 2004-08-05
CA2353047A1 (en) 2000-08-31
US6255476B1 (en) 2001-07-03
WO2000050432A2 (en) 2000-08-31
WO2000050432A3 (en) 2001-02-01
US6316610B2 (en) 2001-11-13
ES2204537T3 (es) 2004-05-01
JP4634615B2 (ja) 2011-02-16
JP2007131642A (ja) 2007-05-31
EP1155027B1 (de) 2003-10-01
US20010014735A1 (en) 2001-08-16
JP2002537401A (ja) 2002-11-05
EP1155027A2 (de) 2001-11-21
DK1155027T3 (da) 2003-12-29
US20020165389A1 (en) 2002-11-07
US6525183B2 (en) 2003-02-25
US20050191660A1 (en) 2005-09-01
JP2011084573A (ja) 2011-04-28
AU3369100A (en) 2000-09-14
AU773864B2 (en) 2004-06-10
CA2353047C (en) 2009-01-20

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