DE69823657D1 - Zur herstellung von sulfurierten oligonukleotidanaloga - Google Patents

Zur herstellung von sulfurierten oligonukleotidanaloga

Info

Publication number
DE69823657D1
DE69823657D1 DE69823657T DE69823657T DE69823657D1 DE 69823657 D1 DE69823657 D1 DE 69823657D1 DE 69823657 T DE69823657 T DE 69823657T DE 69823657 T DE69823657 T DE 69823657T DE 69823657 D1 DE69823657 D1 DE 69823657D1
Authority
DE
Germany
Prior art keywords
analogs
sulfured
oligonucleotid
production
oligonucleotide analog
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69823657T
Other languages
English (en)
Other versions
DE69823657T2 (de
Inventor
S Cheruvallath
C Capaldi
T Ravikumar
L Cole
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of DE69823657D1 publication Critical patent/DE69823657D1/de
Application granted granted Critical
Publication of DE69823657T2 publication Critical patent/DE69823657T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/12—Dithiocarbonic acids; Derivatives thereof
    • C07C329/14—Esters of dithiocarbonic acids
DE69823657T 1997-03-03 1998-03-03 Reagens, das zur Herstellung von geschwefelten Oligonukleotidanaloga geeignet ist Expired - Fee Related DE69823657T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US811233 1985-12-20
US08/811,233 US5902881A (en) 1997-03-03 1997-03-03 Reagent useful for synthesizing sulfurized oligonucleotide analogs
PCT/US1998/004111 WO1998039290A1 (en) 1997-03-03 1998-03-03 Reagent useful for synthesizing sulfurized oligonucleotide analogs

Publications (2)

Publication Number Publication Date
DE69823657D1 true DE69823657D1 (de) 2004-06-09
DE69823657T2 DE69823657T2 (de) 2005-04-07

Family

ID=25205965

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69823657T Expired - Fee Related DE69823657T2 (de) 1997-03-03 1998-03-03 Reagens, das zur Herstellung von geschwefelten Oligonukleotidanaloga geeignet ist

Country Status (7)

Country Link
US (3) US5902881A (de)
EP (1) EP0983233B1 (de)
JP (1) JP2000510872A (de)
AT (1) ATE266001T1 (de)
AU (1) AU6680498A (de)
DE (1) DE69823657T2 (de)
WO (1) WO1998039290A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902881A (en) 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs
US6242591B1 (en) * 1997-10-15 2001-06-05 Isis Pharmaceuticals, Inc. Synthesis of sulfurized 2'-substituted oligonucleotides
US6124484A (en) 1998-07-17 2000-09-26 Isis Pharmaceuticals, Inc. Recovery of triarylmethyl halide protecting groups cleaved during oligonucleotide synthesis
US6069243A (en) * 1998-10-06 2000-05-30 Isis Pharmaceuticals, Inc. Process for oligonucleotide synthesis
WO2002081476A1 (en) * 2001-04-06 2002-10-17 Micrologix Biotech, Inc. Thiophosphate nucleic acid-based compounds
US20040241665A1 (en) * 2003-05-30 2004-12-02 Bass Jay K. Methods and devices for identifying a fluid on a substrate surface
WO2005097817A2 (en) 2004-04-05 2005-10-20 Alnylam Pharmaceuticals, Inc. Process and reagents for oligonucleotide synthesis and purification
WO2012059510A1 (en) 2010-11-02 2012-05-10 Girindus America, Inc. Back pressure control during solid-phase synthesis on polymeric supports
US11597744B2 (en) 2017-06-30 2023-03-07 Sirius Therapeutics, Inc. Chiral phosphoramidite auxiliaries and methods of their use

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DE3301833A1 (de) * 1983-01-20 1984-07-26 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verfahren zur simultanen synthese mehrerer oligonocleotide an fester phase
US4522735A (en) * 1983-06-17 1985-06-11 The B. F. Goodrich Company Polyphosphoramidite oligomers and stabilizer compositions thereof
DE3329892A1 (de) * 1983-08-18 1985-03-07 Köster, Hubert, Prof. Dr., 2000 Hamburg Verfahren zur herstellung von oligonucleotiden
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US5449769A (en) * 1989-03-06 1995-09-12 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
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US5003097A (en) * 1989-10-02 1991-03-26 The United States Of America As Represented By The Department Of Health And Human Services Method for the sulfurization of phosphorous groups in compounds
NL8902521A (nl) * 1989-10-11 1991-05-01 Rijksuniversiteit Werkwijze voor het bereiden van fosforothioaatesters.
US5218088A (en) * 1989-11-02 1993-06-08 Purdue Research Foundation Process for preparing dithiophosphate oligonucleotide analogs via nucleoside thiophosphoramidite intermediates
US5359051A (en) * 1990-01-11 1994-10-25 Isis Pharmaceuticals Compounds useful in the synthesis of nucleic acids capable of cleaning RNA
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US5292875A (en) * 1990-04-20 1994-03-08 Lynx Therapeutics, Inc. Method of synthesizing sulfurized oligonucleotide analogs
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US5614621A (en) * 1993-07-29 1997-03-25 Isis Pharmaceuticals, Inc. Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents
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US5514789A (en) * 1994-04-21 1996-05-07 Barrskogen, Inc. Recovery of oligonucleotides by gas phase cleavage
US5510476A (en) * 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
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US5760209A (en) * 1997-03-03 1998-06-02 Isis Pharmaceuticals, Inc. Protecting group for synthesizing oligonucleotide analogs
US5902881A (en) * 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs

Also Published As

Publication number Publication date
US6040438A (en) 2000-03-21
US5902881A (en) 1999-05-11
AU6680498A (en) 1998-09-22
ATE266001T1 (de) 2004-05-15
EP0983233B1 (de) 2004-05-06
EP0983233A1 (de) 2000-03-08
DE69823657T2 (de) 2005-04-07
EP0983233A4 (de) 2002-03-20
WO1998039290A1 (en) 1998-09-11
JP2000510872A (ja) 2000-08-22
US6399831B1 (en) 2002-06-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee