DK1045849T3 - Purinderivater, der har phosphodiesterase IV inhiberingsaktivitet - Google Patents

Purinderivater, der har phosphodiesterase IV inhiberingsaktivitet

Info

Publication number
DK1045849T3
DK1045849T3 DK98963053T DK98963053T DK1045849T3 DK 1045849 T3 DK1045849 T3 DK 1045849T3 DK 98963053 T DK98963053 T DK 98963053T DK 98963053 T DK98963053 T DK 98963053T DK 1045849 T3 DK1045849 T3 DK 1045849T3
Authority
DK
Denmark
Prior art keywords
compound
formula
group
reacting
effective amount
Prior art date
Application number
DK98963053T
Other languages
Danish (da)
English (en)
Inventor
David Cavalla
Mark Chasin
Peter Hofer
Andre Gehrig
Peter Wintergerst
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of DK1045849T3 publication Critical patent/DK1045849T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK98963053T 1997-12-12 1998-12-11 Purinderivater, der har phosphodiesterase IV inhiberingsaktivitet DK1045849T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6937197P 1997-12-12 1997-12-12
PCT/US1998/026293 WO1999031102A1 (en) 1997-12-12 1998-12-11 Purine derivatives having phosphodiesterase iv inhibition activity

Publications (1)

Publication Number Publication Date
DK1045849T3 true DK1045849T3 (da) 2003-10-27

Family

ID=22088545

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98963053T DK1045849T3 (da) 1997-12-12 1998-12-11 Purinderivater, der har phosphodiesterase IV inhiberingsaktivitet

Country Status (19)

Country Link
US (5) US6037470A (de)
EP (3) EP1044201A4 (de)
JP (5) JP2002508377A (de)
KR (3) KR100349385B1 (de)
CN (3) CN1294590A (de)
AT (1) ATE244243T1 (de)
AU (5) AU1722899A (de)
BR (3) BR9815170A (de)
CA (3) CA2313004A1 (de)
DE (3) DE19882892T1 (de)
DK (1) DK1045849T3 (de)
ES (1) ES2202924T3 (de)
GB (2) GB2346878B (de)
HU (3) HUP0301166A2 (de)
NO (1) NO20002998L (de)
PL (1) PL341108A1 (de)
PT (1) PT1045849E (de)
TR (1) TR200001706T2 (de)
WO (5) WO1999031103A1 (de)

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DE60014915T2 (de) * 1999-08-12 2005-10-13 Euro-Celtique S.A. Hypoxanthin- und thiohypxanthin-verbindungen
WO2002098878A1 (en) * 2001-02-08 2002-12-12 Memory Pharmaceuticals Corporation Trifluoromethylpurines as phosphodiesterase 4 inhibitors
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Also Published As

Publication number Publication date
WO1999031105A1 (en) 1999-06-24
BR9815169A (pt) 2000-10-10
CN1284077A (zh) 2001-02-14
ES2202924T3 (es) 2004-04-01
EP1045849A1 (de) 2000-10-25
EP1045850A1 (de) 2000-10-25
CN1294590A (zh) 2001-05-09
JP2002508378A (ja) 2002-03-19
US6057445A (en) 2000-05-02
BR9815171A (pt) 2000-10-10
HUP0100417A3 (en) 2002-04-29
BR9815170A (pt) 2000-10-10
TR200001706T2 (tr) 2000-11-21
CA2314335A1 (en) 1999-06-24
EP1045850A4 (de) 2001-10-31
DE19882893T1 (de) 2001-02-22
EP1045849A4 (de) 2001-10-31
GB2346878B (en) 2002-12-04
US6040447A (en) 2000-03-21
KR20010032979A (ko) 2001-04-25
AU747366B2 (en) 2002-05-16
EP1044201A4 (de) 2001-10-31
US6211367B1 (en) 2001-04-03
KR100349385B1 (ko) 2002-08-24
EP1044201A1 (de) 2000-10-18
JP2002508377A (ja) 2002-03-19
GB0013780D0 (en) 2000-07-26
DE69816127D1 (de) 2003-08-07
WO1999031102A1 (en) 1999-06-24
NO20002998L (no) 2000-07-19
EP1045849B1 (de) 2003-07-02
CA2313150A1 (en) 1999-06-17
ATE244243T1 (de) 2003-07-15
GB0013781D0 (en) 2000-07-26
KR20010032681A (ko) 2001-04-25
AU1722899A (en) 1999-07-05
KR20010033049A (ko) 2001-04-25
US6228859B1 (en) 2001-05-08
AU1815999A (en) 1999-07-05
HUP0301166A2 (en) 2003-08-28
CN1281458A (zh) 2001-01-24
US6037470A (en) 2000-03-14
JP2002508379A (ja) 2002-03-19
GB2346879A (en) 2000-08-23
JP3504234B2 (ja) 2004-03-08
WO1999031104A1 (en) 1999-06-24
CA2313004A1 (en) 1999-06-24
AU1722999A (en) 1999-07-05
DE69816127T2 (de) 2004-04-22
AU1820899A (en) 1999-06-28
GB2346878A (en) 2000-08-23
WO1999031103A1 (en) 1999-06-24
JP2001525412A (ja) 2001-12-11
PT1045849E (pt) 2003-11-28
JP2002508376A (ja) 2002-03-19
GB2346879B (en) 2002-12-04
PL341108A1 (en) 2001-03-26
NO20002998D0 (no) 2000-06-09
AU1723099A (en) 1999-07-05
HUP0100305A2 (hu) 2002-01-28
WO1999029694A1 (en) 1999-06-17
DE19882892T1 (de) 2001-02-22
HUP0100417A2 (hu) 2001-12-28

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