DK1023279T3 - Forbindelser og fremgangsmåde til fremstilling af substituerede 4-phenyl-4-cyanocyclohexansyrer - Google Patents

Forbindelser og fremgangsmåde til fremstilling af substituerede 4-phenyl-4-cyanocyclohexansyrer

Info

Publication number
DK1023279T3
DK1023279T3 DK98908534T DK98908534T DK1023279T3 DK 1023279 T3 DK1023279 T3 DK 1023279T3 DK 98908534 T DK98908534 T DK 98908534T DK 98908534 T DK98908534 T DK 98908534T DK 1023279 T3 DK1023279 T3 DK 1023279T3
Authority
DK
Denmark
Prior art keywords
phenyl
compounds
processes
preparing substituted
cyanocyclohexanoic
Prior art date
Application number
DK98908534T
Other languages
Danish (da)
English (en)
Inventor
Andrew Allen
Ann Marie Diederich
Li Liu
Wilford Mendelson
Original Assignee
Smithkline Beecham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham filed Critical Smithkline Beecham
Application granted granted Critical
Publication of DK1023279T3 publication Critical patent/DK1023279T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/21Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
DK98908534T 1997-02-12 1998-02-12 Forbindelser og fremgangsmåde til fremstilling af substituerede 4-phenyl-4-cyanocyclohexansyrer DK1023279T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3760897P 1997-02-12 1997-02-12
PCT/US1998/002749 WO1998034584A2 (en) 1997-02-12 1998-02-12 Compounds and method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (1)

Publication Number Publication Date
DK1023279T3 true DK1023279T3 (da) 2003-07-21

Family

ID=21895265

Family Applications (2)

Application Number Title Priority Date Filing Date
DK04078092T DK1524268T3 (da) 1997-02-12 1998-02-12 Forbindelser og fremgangsmåde til fremstilling af substituerede 4-phenyl-4-cyanocyclohexansyrer
DK98908534T DK1023279T3 (da) 1997-02-12 1998-02-12 Forbindelser og fremgangsmåde til fremstilling af substituerede 4-phenyl-4-cyanocyclohexansyrer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK04078092T DK1524268T3 (da) 1997-02-12 1998-02-12 Forbindelser og fremgangsmåde til fremstilling af substituerede 4-phenyl-4-cyanocyclohexansyrer

Country Status (38)

Country Link
US (1) US6337408B1 (uk)
EP (1) EP1023279B8 (uk)
JP (4) JP3786971B2 (uk)
KR (1) KR100412008B1 (uk)
CN (2) CN1301982C (uk)
AP (1) AP1215A (uk)
AR (2) AR012550A1 (uk)
AT (2) ATE237603T1 (uk)
AU (1) AU725484B2 (uk)
BG (1) BG63541B1 (uk)
BR (1) BR9808637A (uk)
CA (1) CA2279951A1 (uk)
CO (1) CO4950534A1 (uk)
CY (1) CY2478B1 (uk)
DE (3) DE69836928T2 (uk)
DK (2) DK1524268T3 (uk)
DZ (1) DZ2423A1 (uk)
EA (1) EA001783B1 (uk)
ES (3) ES2246373T3 (uk)
HK (1) HK1037613A1 (uk)
HU (1) HUP0001801A3 (uk)
ID (1) ID23527A (uk)
IL (7) IL131270A (uk)
MA (1) MA24471A1 (uk)
MY (1) MY118813A (uk)
NO (1) NO993863L (uk)
NZ (1) NZ337084A (uk)
OA (1) OA11144A (uk)
PL (1) PL193366B1 (uk)
PT (2) PT1524268E (uk)
SI (2) SI1524268T1 (uk)
SK (1) SK108899A3 (uk)
TR (1) TR199901920T2 (uk)
TW (1) TW442455B (uk)
UA (1) UA58533C2 (uk)
UY (2) UY24882A1 (uk)
WO (1) WO1998034584A2 (uk)
ZA (1) ZA981125B (uk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA67753C2 (uk) * 1997-10-10 2004-07-15 Смітклайн Бічам Корпорейшн Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
US20040220424A1 (en) * 1999-08-06 2004-11-04 Smithkline Beecham Corporation Process for preparing acids via alpha-chloroepoxy esters
UY26268A1 (es) * 1999-08-06 2001-01-31 Smithkline Beecham Corp Procedimiento para preparar acidos a traves de alfa-cloroep xi- esteres ley 17164 art 127
GB9920152D0 (en) 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
EP2258689A1 (en) 2000-03-16 2010-12-08 Biolipox AB Benzylated PDE4 inhibitors
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
SK279958B6 (sk) * 1992-04-02 1999-06-11 Smithkline Beecham Corporation Zlúčeniny s protialergickým a protizápalovým účink
EP0634930A4 (en) * 1992-04-02 1995-02-22 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases.

Also Published As

Publication number Publication date
JP2004269546A (ja) 2004-09-30
JP4093967B2 (ja) 2008-06-04
HK1037613A1 (en) 2002-02-15
IL166184A0 (en) 2006-01-15
EP1023279A2 (en) 2000-08-02
IL150955A (en) 2006-07-05
IL131270A0 (en) 2001-01-28
IL166188A0 (en) 2006-01-15
DE69831022D1 (de) 2005-09-01
HUP0001801A3 (en) 2001-12-28
BG103651A (en) 2000-02-29
IL166186A0 (en) 2006-01-15
AR012550A1 (es) 2000-11-08
SI1524268T1 (sl) 2007-04-30
ES2280008T3 (es) 2007-09-01
IL131270A (en) 2005-05-17
NZ337084A (en) 2001-04-27
DE69813596T2 (de) 2004-02-12
PL193366B1 (pl) 2007-02-28
SI1295869T1 (sl) 2005-12-31
OA11144A (en) 2003-04-17
EA199900735A1 (ru) 2000-02-28
JP2001510482A (ja) 2001-07-31
EA001783B1 (ru) 2001-08-27
NO993863D0 (no) 1999-08-11
AU725484B2 (en) 2000-10-12
AP9901618A0 (en) 1999-09-30
PT1524268E (pt) 2007-03-30
KR100412008B1 (ko) 2003-12-24
AP1215A (en) 2003-10-14
EP1023279B1 (en) 2003-04-16
NO993863L (no) 1999-08-11
ATE300517T1 (de) 2005-08-15
DE69836928D1 (de) 2007-03-08
IL166185A0 (en) 2006-01-15
JP2004149546A (ja) 2004-05-27
WO1998034584A3 (en) 1998-11-19
BR9808637A (pt) 2000-07-04
US6337408B1 (en) 2002-01-08
CA2279951A1 (en) 1998-08-13
TW442455B (en) 2001-06-23
UY24882A1 (es) 2001-08-27
JP2004292460A (ja) 2004-10-21
DE69831022T2 (de) 2006-04-20
UY25127A1 (es) 1998-11-27
KR20000070927A (ko) 2000-11-25
ZA981125B (en) 1998-08-21
CN1246855A (zh) 2000-03-08
UA58533C2 (uk) 2003-08-15
MA24471A1 (fr) 1998-10-01
ES2246373T3 (es) 2006-02-16
MY118813A (en) 2005-01-31
PT1023279E (pt) 2003-08-29
EP1023279A4 (en) 2000-10-04
SK108899A3 (en) 2000-01-18
WO1998034584A2 (en) 1998-08-13
CN1854131A (zh) 2006-11-01
CY2478B1 (en) 2005-06-03
DE69813596D1 (de) 2003-05-22
DE69836928T2 (de) 2007-11-08
CO4950534A1 (es) 2000-09-01
CN1301982C (zh) 2007-02-28
DK1524268T3 (da) 2007-05-14
TR199901920T2 (xx) 1999-11-22
JP4053023B2 (ja) 2008-02-27
PL335031A1 (en) 2000-03-27
IL166187A0 (en) 2006-01-15
ID23527A (id) 2000-04-27
BG63541B1 (bg) 2002-04-30
DZ2423A1 (fr) 2003-01-04
EP1023279B8 (en) 2003-08-13
JP4053024B2 (ja) 2008-02-27
ES2196551T3 (es) 2003-12-16
JP3786971B2 (ja) 2006-06-21
HUP0001801A2 (hu) 2000-10-28
ATE237603T1 (de) 2003-05-15
AU6654498A (en) 1998-08-26
AR050308A2 (es) 2006-10-18

Similar Documents

Publication Publication Date Title
DK0885968T3 (da) Fremgangsmåde til fremstilling af vanillin
DK1011309T3 (da) Fremgangsmåde til tilvejebringelse af forøget fotosyntese
DK1032566T5 (da) Fremgangsmåde til fremstilling af citalopram
DK1038008T3 (da) Fremgangsmåde til fremstilling af EGIII-lignende enzymer
ATE281927T1 (de) Giessverfahren
DK0911416T3 (da) Fremgangsmåde til fremstilling af protein
DK1005517T3 (da) Fremgangsmåde til fremstilling af diglycerider
DK0991666T3 (da) Alfa-1-antitrypsin-præparat og fremgangsmåde til fremstilling heraf
DK0917879T3 (da) Forbedret fremgangsmåde til stabilisering af proteiner
DK1053217T3 (da) Fremgangsmåde til fremstilling af n-propanol
DK1003383T4 (da) Smagsforstærkende N-ethyl-p-menthan-3-carboxamidindeholdende forbindelser og fremgangsmåde til fremstilling og anvendelse deraf
DK1027315T3 (da) Fremgangsmåde til fremstilling af n-butanol
DK1327637T3 (da) Fremgangsmåde til fremstilling af L-Ribose
DK1028960T3 (da) Fremgangsmåde til fremstilling af thiazolidinedion
DK0970939T3 (da) Fremgangsmåde til fremstilling af methanol
DK0946514T3 (da) Fremgangsmåde til fremstilling af n-substituerede 3-hydroxypyrazoler
DK1524268T3 (da) Forbindelser og fremgangsmåde til fremstilling af substituerede 4-phenyl-4-cyanocyclohexansyrer
DK0864564T3 (da) Særlig fremgangsmåde til fremstillingen af alfa-bromlactamderivater
DK1308454T3 (da) Fremgangsmåde til fremstilling af platinforbindelse
DK0978502T3 (da) Fremgangsmåde til omestering af alfa-ketocarboxylsyrer
NO20003080D0 (no) Polymerisasjon-oppstartningsprosess
DK0970073T3 (da) Fremgangsmåde til fremstilling af eprosartan
DK1036319T3 (da) Fremgangsmåde til opnåelse af L-dihydroorotsyre og anvendelse deraf
DK1012152T3 (da) Fremgangsmåde til fremstilling af oxazaphosphorin-2-aminer
DK0923565T3 (da) Fremgangsmåde til fremstilling af paclitaxel