DK0996470T3 - Fremgangsmåde til forögelse af mikroindkapslede gassers ekkogenicitet og formindskelse af dæmpning - Google Patents

Fremgangsmåde til forögelse af mikroindkapslede gassers ekkogenicitet og formindskelse af dæmpning

Info

Publication number
DK0996470T3
DK0996470T3 DK98932957T DK98932957T DK0996470T3 DK 0996470 T3 DK0996470 T3 DK 0996470T3 DK 98932957 T DK98932957 T DK 98932957T DK 98932957 T DK98932957 T DK 98932957T DK 0996470 T3 DK0996470 T3 DK 0996470T3
Authority
DK
Denmark
Prior art keywords
microparticles
diameter
polymers
imaging
applications
Prior art date
Application number
DK98932957T
Other languages
Danish (da)
English (en)
Inventor
Julie Ann Straub
Charles C Church
Howard Bernstein
Henry T Brush
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acusphere Inc filed Critical Acusphere Inc
Application granted granted Critical
Publication of DK0996470T3 publication Critical patent/DK0996470T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Acoustics & Sound (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Drying Of Gases (AREA)
DK98932957T 1997-06-30 1998-06-30 Fremgangsmåde til forögelse af mikroindkapslede gassers ekkogenicitet og formindskelse af dæmpning DK0996470T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/885,933 US6045777A (en) 1997-06-30 1997-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
PCT/US1998/013514 WO1999000149A1 (en) 1997-06-30 1998-06-30 Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases

Publications (1)

Publication Number Publication Date
DK0996470T3 true DK0996470T3 (da) 2007-05-21

Family

ID=25388026

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98932957T DK0996470T3 (da) 1997-06-30 1998-06-30 Fremgangsmåde til forögelse af mikroindkapslede gassers ekkogenicitet og formindskelse af dæmpning

Country Status (22)

Country Link
US (1) US6045777A (zh)
EP (1) EP0996470B1 (zh)
JP (1) JP2002507214A (zh)
KR (1) KR100637022B1 (zh)
CN (1) CN1268397C (zh)
AT (1) ATE352322T1 (zh)
AU (1) AU740728B2 (zh)
BR (1) BR9810371A (zh)
CA (1) CA2294199C (zh)
CY (1) CY1107593T1 (zh)
DE (1) DE69836961T2 (zh)
DK (1) DK0996470T3 (zh)
ES (1) ES2280094T3 (zh)
HK (1) HK1029273A1 (zh)
IL (1) IL133595A (zh)
MY (1) MY122120A (zh)
NO (1) NO316614B1 (zh)
NZ (1) NZ501830A (zh)
PT (1) PT996470E (zh)
TW (1) TW360521B (zh)
WO (1) WO1999000149A1 (zh)
ZA (1) ZA985705B (zh)

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IT239807Y1 (it) * 1996-09-11 2001-03-13 Lgl Electronics Spa Dispositivo perfezionato di separazione delle spire di filato perapparecchi alimentatori di trama
DE19882362T1 (de) * 1997-04-30 2000-05-18 Point Biomedical Corp Mikropartikel, geeignet als Ultraschallkontrastmittel und zum Transport von Arzneimitteln in den Blutstrom
AU1705300A (en) * 1998-10-12 2000-05-01 Mallinckrodt, Inc. Novel ultrasound contrast agents
EP1202670A4 (en) 1999-08-13 2004-11-10 Point Biomedical Corp HOLLOW MICROSPHERES WITH CONTROLLED FRAGILITY FOR MEDICAL USE
US6626854B2 (en) 2000-12-27 2003-09-30 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
US6645162B2 (en) 2000-12-27 2003-11-11 Insightec - Txsonics Ltd. Systems and methods for ultrasound assisted lipolysis
IL159624A0 (en) 2001-06-29 2004-06-01 Medgraft Microtech Inc Biodegradable injectable implants and related methods of manufacture and use
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US20030215394A1 (en) * 2002-05-17 2003-11-20 Short Robert E. Microparticles having a matrix interior useful for ultrasound triggered delivery of drugs into the bloodstream
US20040185108A1 (en) * 2003-03-18 2004-09-23 Short Robert E. Method of preparing gas-filled polymer matrix microparticles useful for delivering drug
WO2005041897A2 (en) 2003-10-31 2005-05-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents
WO2005118016A1 (en) * 2004-05-27 2005-12-15 Medtronic, Inc. Medical device comprising a biologically active agent
US8012457B2 (en) * 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
CA2569134C (en) * 2004-06-04 2010-11-23 Acusphere, Inc. Ultrasound contrast agent dosage formulation
DE602004026164D1 (de) * 2004-06-04 2010-05-06 Acusphere Inc Ultraschallkontrastmittel
EP1714642A1 (en) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
US20070037215A1 (en) * 2005-08-11 2007-02-15 Patton Wayne F Assay particles and methods of use
US7955281B2 (en) * 2006-09-07 2011-06-07 Nivasonix, Llc External ultrasound lipoplasty
US8262591B2 (en) * 2006-09-07 2012-09-11 Nivasonix, Llc External ultrasound lipoplasty
US8697098B2 (en) 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
KR101061224B1 (ko) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 Ｘ 선을 이용한 유동정보 측정용 캡슐
US9177543B2 (en) 2009-08-26 2015-11-03 Insightec Ltd. Asymmetric ultrasound phased-array transducer for dynamic beam steering to ablate tissues in MRI
EP2489034B1 (en) 2009-10-14 2016-11-30 Insightec Ltd. Mapping ultrasound transducers
US8331194B1 (en) * 2010-04-26 2012-12-11 The United States Of America As Represented By The Secretary Of The Navy Underwater acoustic waveguide
US9852727B2 (en) 2010-04-28 2017-12-26 Insightec, Ltd. Multi-segment ultrasound transducers
CN103945830B (zh) 2011-02-25 2017-06-06 南达科他州立大学 缀合蛋白的聚合物胶束
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
JP2011140527A (ja) * 2011-04-20 2011-07-21 Acusphere Inc 超音波造影剤の投薬処方物
US10357450B2 (en) 2012-04-06 2019-07-23 Children's Medical Center Corporation Process for forming microbubbles with high oxygen content and uses thereof
US20160067276A1 (en) * 2013-03-15 2016-03-10 Children's Medical Center Corporation Hollow particles encapsulating a biological gas and methods of use
US10577554B2 (en) 2013-03-15 2020-03-03 Children's Medical Center Corporation Gas-filled stabilized particles and methods of use
WO2015156359A1 (ja) * 2014-04-10 2015-10-15 シャープ株式会社 粘性気泡液およびその製造方法、その製造装置、その保管方法
CN107952085A (zh) * 2016-10-17 2018-04-24 北京凯莱天成医药科技有限公司 一种超声造影剂及其制备方法和用途
WO2018160752A1 (en) 2017-02-28 2018-09-07 Children's Medical Center Corporation Stimuli-responsive particles encapsulating a gas and methods of use

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US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5334381A (en) * 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
EP0586524B2 (en) * 1991-06-03 2000-11-02 Nycomed Imaging As Improvements in or relating to contrast agents
DE4219723A1 (de) * 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
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US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents

Also Published As

Publication number Publication date
TW360521B (en) 1999-06-11
JP2002507214A (ja) 2002-03-05
CN1261809A (zh) 2000-08-02
CA2294199A1 (en) 1999-01-07
NO316614B1 (no) 2004-03-08
BR9810371A (pt) 2000-09-05
CA2294199C (en) 2009-01-20
MY122120A (en) 2006-03-31
NO996512L (no) 2000-02-29
NO996512D0 (no) 1999-12-28
CY1107593T1 (el) 2013-03-13
ES2280094T3 (es) 2007-09-01
ZA985705B (en) 1999-08-04
HK1029273A1 (en) 2001-03-30
IL133595A0 (en) 2001-04-30
DE69836961D1 (de) 2007-03-15
CN1268397C (zh) 2006-08-09
AU8273198A (en) 1999-01-19
WO1999000149A1 (en) 1999-01-07
KR20010014300A (ko) 2001-02-26
ATE352322T1 (de) 2007-02-15
EP0996470B1 (en) 2007-01-24
PT996470E (pt) 2007-03-30
DE69836961T2 (de) 2007-10-18
AU740728B2 (en) 2001-11-15
IL133595A (en) 2004-06-01
US6045777A (en) 2000-04-04
EP0996470A1 (en) 2000-05-03
KR100637022B1 (ko) 2006-10-20
NZ501830A (en) 2003-01-31

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