DK0991658T3 - Dolastatin 15-derivater - Google Patents

Dolastatin 15-derivater

Info

Publication number
DK0991658T3
DK0991658T3 DK98935531T DK98935531T DK0991658T3 DK 0991658 T3 DK0991658 T3 DK 0991658T3 DK 98935531 T DK98935531 T DK 98935531T DK 98935531 T DK98935531 T DK 98935531T DK 0991658 T3 DK0991658 T3 DK 0991658T3
Authority
DK
Denmark
Prior art keywords
dolastatin
derivatives
Prior art date
Application number
DK98935531T
Other languages
Danish (da)
English (en)
Inventor
Bernd Janssen
Thomas Zierke
Andreas Kling
Teresa Barlozzari
Andreas Haupt
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Application granted granted Critical
Publication of DK0991658T3 publication Critical patent/DK0991658T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK98935531T 1997-07-18 1998-07-07 Dolastatin 15-derivater DK0991658T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/896,394 US6143721A (en) 1997-07-18 1997-07-18 Dolastatin 15 derivatives

Publications (1)

Publication Number Publication Date
DK0991658T3 true DK0991658T3 (da) 2006-05-15

Family

ID=25406130

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98935531T DK0991658T3 (da) 1997-07-18 1998-07-07 Dolastatin 15-derivater

Country Status (33)

Country Link
US (6) US6143721A (pt)
EP (1) EP0991658B1 (pt)
JP (4) JP4508413B2 (pt)
KR (1) KR100579748B1 (pt)
CN (1) CN1268636C (pt)
AR (1) AR018501A1 (pt)
AT (1) ATE314387T1 (pt)
AU (1) AU750120B2 (pt)
BG (1) BG65212B1 (pt)
BR (1) BR9810911A (pt)
CA (1) CA2296036C (pt)
CO (1) CO4990967A1 (pt)
CY (1) CY1107047T1 (pt)
CZ (1) CZ303045B6 (pt)
DE (1) DE69832982T2 (pt)
DK (1) DK0991658T3 (pt)
ES (1) ES2258819T3 (pt)
HK (1) HK1029125A1 (pt)
HR (1) HRP980397A2 (pt)
HU (1) HU228996B1 (pt)
ID (1) ID24669A (pt)
IL (1) IL133784A (pt)
MY (1) MY135057A (pt)
NO (1) NO326827B1 (pt)
NZ (1) NZ502296A (pt)
PL (1) PL197884B1 (pt)
PT (1) PT991658E (pt)
RU (1) RU2195462C2 (pt)
SK (1) SK286581B6 (pt)
TR (2) TR200000132T2 (pt)
TW (1) TW533217B (pt)
WO (1) WO1999003879A1 (pt)
ZA (1) ZA986358B (pt)

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US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6686336B2 (en) 2000-02-08 2004-02-03 Federal Government As Represented By The Department Of Veterans Affaires N-terminal D(-)-penicillamine peptides as aldehyde sequestration agents
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
AU2003228354B8 (en) * 2002-03-22 2010-03-04 Eisai R&D Management Co., Ltd. Hemiasterlin derivatives and uses thereof in the treatment of cancer
US7659241B2 (en) 2002-07-31 2010-02-09 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
BR122018071808B8 (pt) 2003-11-06 2020-06-30 Seattle Genetics Inc conjugado
JP2008522624A (ja) * 2004-12-09 2008-07-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘミアスタリン（ｈｅｍｉａｓｔｅｒｌｉｎ）アナログを使用する癌治療におけるチューブリンのアイソタイプのスクリーニング
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
US8163792B2 (en) 2006-05-16 2012-04-24 Pharmascience Inc. IAP BIR domain binding compounds
ES2579323T3 (es) 2007-07-16 2016-08-09 Genentech, Inc. Anticuerpos anti-CD79B e inmunoconjugados y métodos de uso
AU2008276128B2 (en) 2007-07-16 2013-10-10 Genentech, Inc. Humanized anti-CD79b antibodies and immunoconjugates and methods of use
DE102007039706A1 (de) 2007-08-22 2009-02-26 Erhard Prof. Dr.-Ing. Kohn Chemischer Sensor auf Diamantschichten
CL2009000062A1 (es) 2008-01-31 2010-05-14 Genentech Inc Anticuerpo humanizado anti cd79b; con modificaciones de cisterna libre; inmunoconjugado que contiene dicho anticuerpo y una droga; polinucleotido que codifica el anticuerpo; vector, celula huesped; composicion farmaceutica y uso de dicha composicion para tratar cancer, preferentemente linfomas.
MX2012006877A (es) * 2009-12-18 2012-08-31 Idenix Pharmaceuticals Inc Inhibidores de virus de hepatitis c de arileno o heteroarileno 5, 5 - fusionado.
CN105001334A (zh) 2010-02-10 2015-10-28 伊缪诺金公司 Cd20抗体及其用途
SG10201501095WA (en) 2010-02-12 2015-04-29 Pharmascience Inc Iap bir domain binding compounds
WO2014080251A1 (en) 2012-11-24 2014-05-30 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
ES2960619T3 (es) 2014-02-28 2024-03-05 Hangzhou Dac Biotech Co Ltd Enlazadores cargados y sus usos para la conjugación
EP3689910A3 (en) 2014-09-23 2020-12-02 F. Hoffmann-La Roche AG Method of using anti-cd79b immunoconjugates
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
CN110099682B (zh) 2016-11-14 2023-03-31 杭州多禧生物科技有限公司 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用
MX2024002571A (es) 2021-09-03 2024-03-20 Toray Industries Composicion farmaceutica para tratamiento y/o prevencion de cancer.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
DK0934950T3 (da) * 1991-08-09 2002-07-29 Teikoku Hormone Mfg Co Ltd Tetrapeptidderivat
US5448045A (en) * 1992-02-26 1995-09-05 Clark; Paul C. System for protecting computers via intelligent tokens or smart cards
US5533097A (en) * 1992-02-26 1996-07-02 Motorola, Inc. Portable communication system comprising a local and wide area communication units which can store a communication when the wide area communication system is not available
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
CZ292612B6 (cs) * 1992-05-20 2003-11-12 Abbott Gmbh & Co. Kg Peptid s protirakovinnou aktivitou, jeho použití a farmaceutický prostředek s obsahem takového peptidu
HUT72067A (en) * 1992-12-16 1996-03-28 Basf Ag Dolostatin analog
US5554993A (en) * 1994-01-04 1996-09-10 Panasonic Technologies, Inc. Global position determining system and method
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters
US5554725A (en) * 1994-09-14 1996-09-10 Arizona Board Of Regents Acting On Behalf Of Arizona State University Synthesis of dolastatin 15
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
US5618232A (en) * 1995-03-23 1997-04-08 Martin; John R. Dual mode gaming device methods and systems
US5970143A (en) * 1995-11-22 1999-10-19 Walker Asset Management Lp Remote-auditing of computer generated outcomes, authenticated billing and access control, and software metering system using cryptographic and other protocols
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
WO1998030297A1 (en) * 1997-01-10 1998-07-16 Silicon Gaming, Inc. Method and apparatus for providing authenticated, secure on-line communication between remote locations
US6143721A (en) 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6554705B1 (en) * 1997-08-22 2003-04-29 Blake Cumbers Passive biometric customer identification and tracking system
US6629591B1 (en) * 2001-01-12 2003-10-07 Igt Smart token
US6438382B1 (en) * 2001-02-14 2002-08-20 Telefonaktiebolaget Lm Ericsson (Publ.) Expedited location determination in analog service areas

Also Published As

Publication number Publication date
CZ2000176A3 (en) 2001-06-13
CA2296036A1 (en) 1999-01-28
SK286581B6 (sk) 2009-01-07
BG104089A (en) 2000-12-29
US7662786B2 (en) 2010-02-16
US20130046077A1 (en) 2013-02-21
HK1029125A1 (en) 2001-03-23
ID24669A (id) 2000-07-27
US20060270606A1 (en) 2006-11-30
DE69832982D1 (de) 2006-02-02
ES2258819T3 (es) 2006-09-01
US8163698B2 (en) 2012-04-24
NO326827B1 (no) 2009-02-23
CZ303045B6 (cs) 2012-03-07
IL133784A (en) 2005-09-25
PL197884B1 (pl) 2008-05-30
JP2012211164A (ja) 2012-11-01
BG65212B1 (bg) 2007-07-31
AU750120B2 (en) 2002-07-11
KR20010021998A (ko) 2001-03-15
JP2001515010A (ja) 2001-09-18
NO20000231L (no) 2000-01-17
WO1999003879A1 (en) 1999-01-28
JP5122429B2 (ja) 2013-01-16
ZA986358B (en) 2000-01-17
TR200103545T2 (tr) 2002-06-21
JP2009137968A (ja) 2009-06-25
CN1264388A (zh) 2000-08-23
HUP0004234A2 (hu) 2001-05-28
ATE314387T1 (de) 2006-01-15
HUP0004234A3 (en) 2001-08-28
CO4990967A1 (es) 2000-12-26
US6143721A (en) 2000-11-07
CN1268636C (zh) 2006-08-09
CA2296036C (en) 2007-05-01
TW533217B (en) 2003-05-21
HRP980397A2 (en) 1999-04-30
IL133784A0 (en) 2001-04-30
PT991658E (pt) 2006-05-31
AU8475898A (en) 1999-02-10
NO20000231D0 (no) 2000-01-17
EP0991658A1 (en) 2000-04-12
JP5047935B2 (ja) 2012-10-10
AR018501A1 (es) 2001-11-28
US6458765B1 (en) 2002-10-01
BR9810911A (pt) 2000-08-01
KR100579748B1 (ko) 2006-05-15
DE69832982T2 (de) 2006-08-24
SK187999A3 (en) 2000-09-12
HU228996B1 (hu) 2013-07-29
US20030153505A1 (en) 2003-08-14
US7084110B2 (en) 2006-08-01
US20100099843A1 (en) 2010-04-22
RU2195462C2 (ru) 2002-12-27
PL338144A1 (en) 2000-09-25
CY1107047T1 (el) 2012-09-26
TR200000132T2 (tr) 2000-05-22
JP4508413B2 (ja) 2010-07-21
JP2009137967A (ja) 2009-06-25
EP0991658B1 (en) 2005-12-28
NZ502296A (en) 2002-02-01
MY135057A (en) 2008-01-31

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