DK0975597T3 - Chinolinderivater som inhibitorer af HIV-integrase - Google Patents
Chinolinderivater som inhibitorer af HIV-integraseInfo
- Publication number
- DK0975597T3 DK0975597T3 DK98920581T DK98920581T DK0975597T3 DK 0975597 T3 DK0975597 T3 DK 0975597T3 DK 98920581 T DK98920581 T DK 98920581T DK 98920581 T DK98920581 T DK 98920581T DK 0975597 T3 DK0975597 T3 DK 0975597T3
- Authority
- DK
- Denmark
- Prior art keywords
- aryl
- group
- different
- alkyl
- substituents
- Prior art date
Links
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title abstract 3
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title abstract 2
- 108010002459 HIV Integrase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002391 heterocyclic compounds Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- -1 -N(Q)-(CH2)m- Chemical group 0.000 abstract 1
- 239000004593 Epoxy Substances 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9704289A FR2761687B1 (fr) | 1997-04-08 | 1997-04-08 | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
| PCT/FR1998/000701 WO1998045269A1 (fr) | 1997-04-08 | 1998-04-07 | Derives de quinoleines en tant qu'inhibiteurs de la vih integrase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0975597T3 true DK0975597T3 (da) | 2009-11-02 |
Family
ID=9505648
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98920581T DK0975597T3 (da) | 1997-04-08 | 1998-04-07 | Chinolinderivater som inhibitorer af HIV-integrase |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6670377B1 (https=) |
| EP (1) | EP0975597B1 (https=) |
| JP (1) | JP4697679B2 (https=) |
| AT (1) | ATE441634T1 (https=) |
| CA (1) | CA2286385C (https=) |
| CY (1) | CY1109553T1 (https=) |
| DE (1) | DE69841119D1 (https=) |
| DK (1) | DK0975597T3 (https=) |
| ES (1) | ES2332434T3 (https=) |
| FR (1) | FR2761687B1 (https=) |
| PT (1) | PT975597E (https=) |
| WO (1) | WO1998045269A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2321348A1 (en) * | 2000-09-27 | 2002-03-27 | Blaise Magloire N'zemba | Aromatic derivatives with hiv integrase inhibitory properties |
| FR2819507B1 (fr) | 2001-01-17 | 2007-09-28 | Inst Rech Developpement Ird | Quinoleines substituees pour le traitement de co-infections a protozoaires et a retrovirus |
| JP3616628B2 (ja) | 2001-03-01 | 2005-02-02 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
| FR2830863B1 (fr) * | 2001-10-12 | 2004-01-30 | Bioalliance Pharma | Derives de quinoleine, procede de synthese, et medicaments renfermant ces derives |
| FR2839646B1 (fr) * | 2002-05-17 | 2008-04-11 | Bioalliance Pharma | Utilisation de derives de quinoleine a effet anti-integrase et ses applications |
| ATE404537T1 (de) | 2002-08-13 | 2008-08-15 | Shionogi & Co | Heterocyclische verbindungen mit hiv-integrase- hemmender wirkung |
| SK2662004A3 (sk) | 2002-11-20 | 2005-06-02 | Japan Tobacco, Inc. | Zlúčenina s obsahom 4-oxochinolínu a jej použitie ako inhibítora integráz |
| RU2275361C3 (ru) * | 2002-11-20 | 2021-10-01 | Джапан Тобакко Инк. | Соединение 4-оксохинолина и его применение в качестве ингибитора вич интегразы |
| US7531554B2 (en) | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| KR100866296B1 (ko) * | 2004-05-20 | 2008-11-11 | 니뽄 다바코 산교 가부시키가이샤 | ４―옥소퀴놀린 화합물의 안정한 결정체 |
| MY134672A (en) * | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| WO2006129134A1 (en) * | 2005-06-01 | 2006-12-07 | Bioalliance Pharma | Synergic combinations comprising a styrylquinoline compound and other hiv infection therapeutic agents |
| ES2531190T3 (es) | 2006-03-06 | 2015-03-11 | Japan Tobacco Inc | Método para producir un compuesto de 4-oxoquinolina |
| MX2009013332A (es) | 2007-06-08 | 2010-01-25 | Mannkind Corp | Inhibidores de ire-1 alfa. |
| ES2402322T3 (es) * | 2007-11-15 | 2013-04-30 | Gilead Sciences, Inc. | Inhibidores de la replicación del virus de la inmunodeficiencia humana |
| ATE541841T1 (de) * | 2007-11-15 | 2012-02-15 | Boehringer Ingelheim Int | Inhibitoren der replikation des human immunodeficiency virus |
| ES2463720T3 (es) * | 2007-11-16 | 2014-05-29 | Gilead Sciences, Inc. | Inhibidores de la replicación del virus de inmunodeficiencia humana |
| EA019259B1 (ru) * | 2007-11-16 | 2014-02-28 | Джилид Сайенсиз, Инк. | Ингибиторы репликации вируса иммунодефицита человека |
| EP2149557A1 (en) | 2008-07-23 | 2010-02-03 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
| EP2147912A1 (en) | 2008-07-23 | 2010-01-27 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
| EP2147913A1 (en) * | 2008-07-23 | 2010-01-27 | BioAlliance Pharma | Styrylquinolines, their process of preparation and their therapeutic uses |
| EP2588455B1 (en) * | 2010-07-02 | 2018-04-04 | Gilead Sciences, Inc. | 2-quinolinyl-acetic acid derivatives as hiv antiviral compounds |
| US9731001B2 (en) | 2011-12-22 | 2017-08-15 | Universite Laval | Three-dimensional cavities of dendritic cell immunoreceptor (DCIR), compounds binding thereto and therapeutic applications related to inhibition of human immunodeficiency virus type-1 (HIV-1) |
| SG10201802911RA (en) | 2013-03-15 | 2018-05-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| EA202092627A1 (ru) | 2013-11-18 | 2021-09-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| TWI825524B (zh) | 2016-05-12 | 2023-12-11 | 美商全球血液治療公司 | 用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法 |
| CR20210175A (es) | 2018-09-18 | 2021-06-01 | Nikang Therapeutics Inc | Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2 (shp2) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59152891A (ja) * | 1983-02-18 | 1984-08-31 | Yamada Kagaku Kogyo Kk | 発色性記録材料 |
| IE861607L (en) * | 1985-06-18 | 1986-12-18 | Bunce Roger A | 2-substituted quinolines |
| EP0219307A3 (en) * | 1985-10-16 | 1987-10-14 | Merck Frosst Canada Inc. | 2-substituted quinolines |
| JPS61189988A (ja) * | 1986-08-11 | 1986-08-23 | Yamada Kagaku Kogyo Kk | 発色性記録材料 |
| JPH01199979A (ja) * | 1987-04-07 | 1989-08-11 | Kanebo Ltd | 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤 |
| EP0318093A3 (en) * | 1987-11-25 | 1990-12-05 | Merck Frosst Canada Inc. | Diarylquinoline diacids and their use as medicaments |
| US5438141A (en) * | 1993-05-21 | 1995-08-01 | Merck Frosst Canada, Inc. | Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists |
| EP0643045B1 (de) * | 1993-09-10 | 2000-03-08 | Novartis AG | Chinolin-Verbindungen als Leukotriene Antagonisten |
| GB9414590D0 (en) * | 1994-07-20 | 1994-09-07 | Leo Pharm Prod Ltd | Chemical compounds |
| ES2103180B1 (es) * | 1994-08-01 | 1998-04-01 | Menarini Lab | Fenilacetamidas con accion antagonista de los leucotrienos. |
| EP0725063A1 (de) * | 1995-02-01 | 1996-08-07 | Ciba-Geigy Ag | Chinolin-Derivate |
| US6310211B1 (en) * | 1996-09-10 | 2001-10-30 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
-
1997
- 1997-04-08 FR FR9704289A patent/FR2761687B1/fr not_active Expired - Fee Related
-
1998
- 1998-04-07 PT PT98920581T patent/PT975597E/pt unknown
- 1998-04-07 EP EP98920581A patent/EP0975597B1/fr not_active Expired - Lifetime
- 1998-04-07 ES ES98920581T patent/ES2332434T3/es not_active Expired - Lifetime
- 1998-04-07 DE DE69841119T patent/DE69841119D1/de not_active Expired - Lifetime
- 1998-04-07 CA CA2286385A patent/CA2286385C/fr not_active Expired - Fee Related
- 1998-04-07 WO PCT/FR1998/000701 patent/WO1998045269A1/fr not_active Ceased
- 1998-04-07 DK DK98920581T patent/DK0975597T3/da active
- 1998-04-07 AT AT98920581T patent/ATE441634T1/de active
- 1998-04-07 US US09/402,858 patent/US6670377B1/en not_active Expired - Fee Related
- 1998-04-07 JP JP54245998A patent/JP4697679B2/ja not_active Expired - Fee Related
-
2009
- 2009-12-01 CY CY20091101257T patent/CY1109553T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998045269A1 (fr) | 1998-10-15 |
| JP4697679B2 (ja) | 2011-06-08 |
| CA2286385C (fr) | 2011-02-01 |
| ES2332434T3 (es) | 2010-02-04 |
| DE69841119D1 (de) | 2009-10-15 |
| JP2001518890A (ja) | 2001-10-16 |
| FR2761687B1 (fr) | 2000-09-15 |
| PT975597E (pt) | 2010-01-04 |
| EP0975597B1 (fr) | 2009-09-02 |
| CA2286385A1 (fr) | 1998-10-15 |
| ATE441634T1 (de) | 2009-09-15 |
| CY1109553T1 (el) | 2014-08-13 |
| FR2761687A1 (fr) | 1998-10-09 |
| EP0975597A1 (fr) | 2000-02-02 |
| US6670377B1 (en) | 2003-12-30 |
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