DK0957972T3 - Anordning og fremgangsmåde til at forøge transdermal middelflux - Google Patents

Anordning og fremgangsmåde til at forøge transdermal middelflux

Info

Publication number
DK0957972T3
DK0957972T3 DK97951729T DK97951729T DK0957972T3 DK 0957972 T3 DK0957972 T3 DK 0957972T3 DK 97951729 T DK97951729 T DK 97951729T DK 97951729 T DK97951729 T DK 97951729T DK 0957972 T3 DK0957972 T3 DK 0957972T3
Authority
DK
Denmark
Prior art keywords
increasing transdermal
mean flux
increasing
transdermal
flux
Prior art date
Application number
DK97951729T
Other languages
Danish (da)
English (en)
Inventor
Felix Theeuwes
Armand P Neukermans
Michel J N Cormier
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DK0957972T3 publication Critical patent/DK0957972T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body
DK97951729T 1996-12-20 1997-12-16 Anordning og fremgangsmåde til at forøge transdermal middelflux DK0957972T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3344096P 1996-12-20 1996-12-20
PCT/US1997/023274 WO1998028037A1 (en) 1996-12-20 1997-12-16 Device and method for enhancing transdermal agent flux

Publications (1)

Publication Number Publication Date
DK0957972T3 true DK0957972T3 (da) 2003-07-21

Family

ID=21870407

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97951729T DK0957972T3 (da) 1996-12-20 1997-12-16 Anordning og fremgangsmåde til at forøge transdermal middelflux

Country Status (11)

Country Link
EP (1) EP0957972B1 (ko)
JP (1) JP4153999B2 (ko)
KR (1) KR100453132B1 (ko)
CN (1) CN1133472C (ko)
AT (1) ATE234649T1 (ko)
AU (1) AU722574B2 (ko)
CA (1) CA2271167C (ko)
DE (1) DE69720057T2 (ko)
DK (1) DK0957972T3 (ko)
ES (1) ES2195190T3 (ko)
WO (1) WO1998028037A1 (ko)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3316820B2 (ja) 1995-12-28 2002-08-19 シィグナス インコーポレィティド 被験者の生理的分析物の継続モニタリング装置及び方法
ATE302041T1 (de) 1997-12-11 2005-09-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
EP1911488A3 (en) 1997-12-11 2008-12-03 Alza Corporation Device for enhancing transdermal agent flux
EP1037687B8 (en) * 1997-12-11 2008-10-22 Alza Corporation Device for enhancing transdermal agent flux
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
ATE280615T1 (de) * 1998-08-31 2004-11-15 Johnson & Johnson Consumer Elektrotransportvorrichtung mit klingen
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
CZ303515B6 (cs) 1999-04-19 2012-11-07 Smithkline Beecham Biologicals S. A. Adjuvantní prostredek
US6558670B1 (en) 1999-04-19 2003-05-06 Smithkline Beechman Biologicals S.A. Vaccine adjuvants
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
EP1187653B1 (en) * 1999-06-04 2010-03-31 Georgia Tech Research Corporation Devices for enhanced microneedle penetration of biological barriers
ATE324922T1 (de) * 1999-06-08 2006-06-15 Altea Therapeutics Corp Vorrichtung zur mikroporation eines biologischen gewebes mittels einer filmgewebe schnittstellenvorrichtung und verfahren
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
WO2001041863A1 (en) 1999-12-10 2001-06-14 Alza Corporation Device and method for enhancing microprotrusion skin piercing
WO2001041864A1 (en) * 1999-12-10 2001-06-14 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery
US6622035B1 (en) 2000-01-21 2003-09-16 Instrumentarium Corp. Electrode for measurement of weak bioelectrical signals
US7404815B2 (en) 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
AU2001283469B2 (en) * 2000-08-24 2006-07-06 Alza Corporation Method for transdermal nucleic acid sampling
DE60129585T2 (de) 2000-09-08 2008-04-17 Alza Corp., Mountain View Transdermale vorrichtung
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
PL360998A1 (en) * 2000-10-13 2004-09-20 Alza Corporation Apparatus and method for piercing skin with microprotrusions
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
IL155389A0 (en) 2000-10-13 2003-11-23 Alza Corportion Microprotrusion member retainer for impact applicator
RU2277390C2 (ru) 2000-10-13 2006-06-10 Алза Корпорейшн Аппликатор для силового воздействия комплектом микроножей
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
PT1889630E (pt) 2000-10-18 2012-02-29 Glaxosmithkline Biolog Sa Vacinas compreendendo o antigénio mage ligado a um fragmento da proteína d
MXPA03003815A (es) 2000-10-26 2004-08-12 Johnson & Johnson Dispositivos de suministro transdermico de farmaco que tienen microrresaltos recubiertos.
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002050584A2 (en) 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Microneedle array systems
US6855372B2 (en) 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
EP3251722B1 (en) 2001-04-20 2020-06-17 ALZA Corporation Microprojection array having a beneficial agent containing coating and method of forming the coating thereon
IL158480A0 (en) 2001-04-20 2004-05-12 Alza Corp Microprojection array having a beneficial agent containing coating
WO2003024507A2 (en) 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
AU2002330083A1 (en) 2001-09-21 2003-04-01 Biovalve Technologies, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
ES2701884T3 (es) * 2002-03-11 2019-02-26 Nitto Denko Corp Sistema de parche de administración transdérmica de fármacos
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
BRPI0412029A (pt) 2003-06-30 2006-09-05 Alza Corp formulações para microprojeções revestidas contendo contra-ìons não-voláteis
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
WO2005042054A2 (en) 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
WO2005044139A2 (en) 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
EP1680154B1 (en) 2003-10-31 2012-01-04 ALZA Corporation Self-actuating applicator for microprojection array
CN1886171A (zh) * 2003-11-28 2006-12-27 艾克若克斯Dds有限公司 快速经皮施用的方法和系统
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2006020841A2 (en) * 2004-08-11 2006-02-23 Alza Corporation Apparatus and method for transdermal delivery of natriuretic peptides
ES2472441T3 (es) 2004-09-22 2014-07-01 Glaxosmithkline Biologicals S.A. Composición inmunog�nica para uso en vacunación contra estafilococos
CA2597931A1 (en) * 2005-02-16 2006-08-24 Alza Corporation Apparatus and method for transdermal delivery of erythropoetin-based agents
CA2602814A1 (en) * 2005-03-28 2006-10-05 Alza Corporation Microprojections with capillary control features and method
EP1896115B2 (en) * 2005-06-27 2020-01-22 3M Innovative Properties Company Microneedle cartridge assembly
AR058707A1 (es) 2005-12-22 2008-02-20 Glaxosmithkline Biolog Sa Vacuna, procedimiento para fabricarla y su uso
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
AU2006336187A1 (en) 2005-12-28 2007-07-26 Alza Corporation Stable therapeutic formulations
JP2009531387A (ja) 2006-03-30 2009-09-03 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物
US20090171314A1 (en) * 2006-04-20 2009-07-02 Ferguson Dennis E Molded articles comprising microneedle arrays
DE102006028987A1 (de) * 2006-06-24 2007-12-27 Lts Lohmann Therapie-Systeme Ag Ultraschallverstärktes transdermales therapeutisches System
EA015817B1 (ru) 2006-10-12 2011-12-30 Глаксосмитклайн Байолоджикалс С.А. Иммуногенная композиция, содержащая адъювант в виде эмульсии "масло в воде"
EP2086582B1 (en) 2006-10-12 2012-11-14 GlaxoSmithKline Biologicals s.a. Vaccine comprising an oil in water emulsion adjuvant
AU2008245585B2 (en) 2007-04-27 2011-10-06 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
EP2152304B1 (en) 2007-05-02 2018-08-22 The Regents of the University of Michigan Nanoemulsion therapeutic compositions and methods of using the same
WO2008139648A1 (ja) 2007-05-15 2008-11-20 Hisamitsu Pharmaceutical Co., Inc. マイクロニードルのコーティング方法
EA200901578A1 (ru) 2007-06-26 2010-08-30 Глаксосмитклайн Байолоджикалс С.А. Вакцина, содержащая конъюгаты капсульных полисахаридов streptococcus pneumoniae
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
AU2009212106B9 (en) 2008-02-07 2014-05-22 Vaxxas Pty Limited Patch production
GB0802447D0 (en) 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
WO2009127676A1 (en) 2008-04-16 2009-10-22 Glaxosmithkline Biologicals S.A. Vaccine
AU2009250341A1 (en) * 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
US20100092526A1 (en) 2008-09-26 2010-04-15 Nanobio Corporation Nanoemulsion therapeutic compositions and methods of using the same
CA2743904A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
CN102264429B (zh) 2008-12-26 2014-01-08 久光制药株式会社 微针装置
EP2392378B1 (en) 2009-01-30 2017-03-15 Hisamitsu Pharmaceutical Co., Inc. Microneedle device
WO2010143689A1 (ja) 2009-06-10 2010-12-16 久光製薬株式会社 マイクロニードルデバイス
ES2566646T3 (es) 2009-06-16 2016-04-14 The Regents Of The University Of Michigan Vacunas en nanoemulsión
JP5620911B2 (ja) 2009-07-23 2014-11-05 久光製薬株式会社 マイクロニードルアレイ
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
CA2790923C (en) 2010-02-24 2017-10-31 Toshiyuki Matsudo Micro-needle device and preparation method
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
CN102917751A (zh) 2010-05-28 2013-02-06 久光制药株式会社 具有带有微小突起的阵列的装置
CN102917752A (zh) 2010-05-28 2013-02-06 久光制药株式会社 带微小突起的阵列
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
JP5675952B2 (ja) 2011-02-24 2015-02-25 久光製薬株式会社 マイクロニードルデバイス用ｇｌｐ−１アナログ組成物
US8696637B2 (en) * 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
AR086405A1 (es) 2011-05-17 2013-12-11 Glaxosmithkline Biolog Sa Vacuna de streptococcus pneumoniae
CA2851606C (en) 2011-10-12 2020-08-04 3M Innovative Properties Company Integrated microneedle array delivery system
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
JP2013153959A (ja) * 2012-01-30 2013-08-15 Toppan Printing Co Ltd 針状体の構造
CN103356243A (zh) * 2012-03-27 2013-10-23 马广 新型皮肤采样器
DK2912186T3 (da) 2012-10-24 2021-02-22 Platelet Targeted Therapeutics Llc Behandling rettet mod blodplader
WO2015017561A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-profile microneedle patch applicator
EP3063171B1 (en) 2013-11-01 2019-07-24 University Of Oslo Albumin variants and uses thereof
US9993541B2 (en) 2013-11-13 2018-06-12 University Of Oslo Outer membrane vesicles and uses thereof
WO2015071763A2 (en) 2013-11-15 2015-05-21 Oslo Universitetssykehus Hf Ctl peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof
US11083788B2 (en) 2014-10-10 2021-08-10 The Regents Of The University Of Michigan Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
AR102547A1 (es) 2014-11-07 2017-03-08 Takeda Vaccines Inc Vacunas contra la enfermedad de manos, pies y boca y métodos de fabricación y su uso
AU2015252119A1 (en) 2014-11-07 2016-05-26 Takeda Vaccines, Inc. Hand, foot, and mouth vaccines and methods of manufacture and use thereof
EP4218892A1 (en) 2015-02-02 2023-08-02 Vaxxas Pty Limited Microprojection array applicator
WO2016141320A2 (en) 2015-03-05 2016-09-09 Northwestern University Non-neuroinvasive viruses and uses thereof
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
WO2017201390A1 (en) 2016-05-19 2017-11-23 The Regents Of The University Of Michigan Novel adjuvant compositions
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
JP6685432B2 (ja) 2016-12-26 2020-04-22 久光製薬株式会社 マイクロニードルデバイス
EP3586906A4 (en) 2017-02-24 2020-12-30 Hisamitsu Pharmaceutical Co., Inc. MICRO-NEEDLE DEVICE
JP7152787B2 (ja) 2017-03-31 2022-10-13 ヴァクザス ピーティーワイ リミテッド 表面をコーティングするための装置および方法
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
EP3641828B1 (en) 2017-06-23 2023-11-22 Affinivax, Inc. Immunogenic compositions
EP3661587A4 (en) 2017-08-04 2021-06-09 Vaxxas Pty Limited COMPACT HIGH MECHANICAL ENERGY STORAGE AND LOW RELEASE FORCE ACTUATOR FOR MICROPROJECTION NETWORK (PRM) PATCH DELIVERY
WO2019048936A1 (en) 2017-09-07 2019-03-14 University Of Oslo VACCINE MOLECULES
JP2020533338A (ja) 2017-09-07 2020-11-19 ユニバーシティ オブ オスロＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｏｓｌｏ ワクチン分子
BR112020008652A2 (pt) 2017-11-03 2020-11-10 Takeda Vaccines, Inc. vacinas e composições imunogênicas contra zika e métodos de uso das mesmas
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
JP7399295B2 (ja) 2020-04-06 2023-12-15 イルロン カンパニー リミテッド 化粧品吸収誘導用微細針が取り付けられた化粧品注入器及びその制作方法
US20230233667A1 (en) 2021-09-08 2023-07-27 Affinivax, Inc. Coronavirus vaccine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
CA2079315C (en) 1990-03-30 2003-04-15 Joseph Bradley Phipps Device and method for iontophoretic drug delivery
ZA918528B (en) 1990-10-29 1992-08-26 Alza Corp Iontophoretic delivery device and method of hydrating same
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
CA2205444A1 (en) * 1994-12-09 1996-06-13 Novartis Ag Transdermal system
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem

Also Published As

Publication number Publication date
DE69720057T2 (de) 2003-09-25
CA2271167C (en) 2007-01-09
AU722574B2 (en) 2000-08-10
AU5529498A (en) 1998-07-17
EP0957972B1 (en) 2003-03-19
ES2195190T3 (es) 2003-12-01
ATE234649T1 (de) 2003-04-15
JP4153999B2 (ja) 2008-09-24
WO1998028037A1 (en) 1998-07-02
JP2001506904A (ja) 2001-05-29
CA2271167A1 (en) 1998-07-02
DE69720057D1 (de) 2003-04-24
KR20000053006A (ko) 2000-08-25
CN1133472C (zh) 2004-01-07
CN1233967A (zh) 1999-11-03
EP0957972A1 (en) 1999-11-24
KR100453132B1 (ko) 2004-10-15

Similar Documents

Publication Publication Date Title
DK0957972T3 (da) Anordning og fremgangsmåde til at forøge transdermal middelflux
DK1037687T3 (da) Anordning til at forbedre et middels transdermale strömning
IT1277860B1 (it) Dispositivo simmetrizzatore e procedimento per la sua progettazione.
NO911720D0 (no) Fremgangsmaate og innretning for avviksboring.
DE3773624D1 (de) Geraet sowie anschlussteil dafuer.
AU7802298A (en) Fluid jet blood sampling device and methods
DK0775007T3 (da) Blodbehandlingsindretning med forbedret udbytte, og som har en vinklet grænsestyreflade
NO865081D0 (no) Tale- og hoereinnretning for pusteapparat.
NO983703D0 (no) Aktiveringsanordning for hjerteventil, og aktivert hjerteventil
NL1006031A1 (nl) Lineaire vermogensversterkingsinrichting en -werkwijze.
DK1138205T3 (da) Indretning til at modtage og frigive slagtede dyr eller dele heraf
NO865068D0 (no) System, fremgangsmaate og apparat til fraksjonering av blod in situ.
IT8720296A0 (it) Procedimento e dispositivo per cordonare.
TR199700116A2 (tr) Garnitürlerin taslanmasi icin cihaz ve yöntem.
DE3784160T2 (de) Dampfdruck-messgeraet und -verfahren.
NO901271D0 (no) Fremgangsmaate og anordning for gassopploesning.
IT1288494B1 (it) Metodo e dispositivo per il controllo senza contatto diretto delle teste delle sigarette, o simili.
NO990955D0 (no) FremgangsmÕte for Õ pÕvise hudkreft hos mennesker og dyr, og anordning for Õ ut°ve fremgangsmÕten
NO901504D0 (no) Isolerings- og fjaerelementer eller klemmelementer for festing av skinner.
NO862428D0 (no) Fremgangsmaate og anordning for gassdektering.
NO883685D0 (no) Utpressingsfremgangsmaate og -apparat.
DK667587A (da) Indretning og fremgangsmaade til at stikke hul paa gaspatroner
EP0216630A3 (en) Ear tag applicator tool
IT8621826A1 (it) Procedimento per guidare pezzi su assottigliatrici, e dispositivo di guida per attuare il procedimento
NL1007214A1 (nl) Invrieswerkwijze en een inrichting hiervoor.