DK0949268T3 - Nye derivater af 2-fluor-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribohexopyranosyl)-oxy)-6-O-methyl-3-oxo-erythromycin, fremgangsmåde til deres fremstilling af deres anvendelse til syntese af aktive stoffer i medikamenter - Google Patents

Nye derivater af 2-fluor-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribohexopyranosyl)-oxy)-6-O-methyl-3-oxo-erythromycin, fremgangsmåde til deres fremstilling af deres anvendelse til syntese af aktive stoffer i medikamenter

Info

Publication number
DK0949268T3
DK0949268T3 DK99400843T DK99400843T DK0949268T3 DK 0949268 T3 DK0949268 T3 DK 0949268T3 DK 99400843 T DK99400843 T DK 99400843T DK 99400843 T DK99400843 T DK 99400843T DK 0949268 T3 DK0949268 T3 DK 0949268T3
Authority
DK
Denmark
Prior art keywords
methyl
dideoxy
oxy
oxo
fluoro
Prior art date
Application number
DK99400843T
Other languages
Danish (da)
English (en)
Inventor
Alain Bonnet
Francoise Gambier
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of DK0949268T3 publication Critical patent/DK0949268T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK99400843T 1998-04-08 1999-04-07 Nye derivater af 2-fluor-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribohexopyranosyl)-oxy)-6-O-methyl-3-oxo-erythromycin, fremgangsmåde til deres fremstilling af deres anvendelse til syntese af aktive stoffer i medikamenter DK0949268T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9804366A FR2777282B1 (fr) 1998-04-08 1998-04-08 Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments

Publications (1)

Publication Number Publication Date
DK0949268T3 true DK0949268T3 (da) 2004-03-29

Family

ID=9524992

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99400843T DK0949268T3 (da) 1998-04-08 1999-04-07 Nye derivater af 2-fluor-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribohexopyranosyl)-oxy)-6-O-methyl-3-oxo-erythromycin, fremgangsmåde til deres fremstilling af deres anvendelse til syntese af aktive stoffer i medikamenter

Country Status (12)

Country Link
US (1) US6121432A (ko)
EP (1) EP0949268B1 (ko)
JP (1) JP4707785B2 (ko)
KR (1) KR100633835B1 (ko)
CN (1) CN1130370C (ko)
AT (1) ATE256139T1 (ko)
DE (1) DE69913413T2 (ko)
DK (1) DK0949268T3 (ko)
ES (1) ES2210999T3 (ko)
FR (1) FR2777282B1 (ko)
HU (1) HU227562B1 (ko)
PT (1) PT949268E (ko)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200102128T2 (tr) * 1999-01-27 2001-12-21 Pfizer Products Inc. Ketolid antibiyotikler
ATE340183T1 (de) 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
AU4354900A (en) 1999-04-16 2000-11-02 Kosan Biosciences, Inc. Ketolide antibacterials
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
CA2373117C (en) * 1999-05-24 2006-02-28 Pfizer Products Inc. 13-methyl-erythromycin derivatives
JP2001261694A (ja) * 2000-03-06 2001-09-26 Pfizer Prod Inc ケトライド抗生物質
ATE271062T1 (de) 2000-06-30 2004-07-15 Pfizer Prod Inc Makrolid-antibiotika
ES2552682T3 (es) 2003-03-10 2015-12-01 Merck Sharp & Dohme Corp. Agentes antibacterianos novedosos
CN105732745A (zh) * 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
ES2565083T3 (es) 2008-10-24 2016-03-31 Cempra Pharmaceuticals, Inc. Biodefensas usando macrólidos que contienen triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN102724874B (zh) 2009-09-10 2018-06-01 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
MY162411A (en) 2010-03-22 2017-06-15 Cempra Pharmaceuticals Inc Crystalline forms of a macrolide, and uses therefor
JP6184319B2 (ja) 2010-05-20 2017-08-23 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド類およびケトライド類ならびにその中間体を調製するための工程
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES
JP5851516B2 (ja) * 2010-12-09 2016-02-03 ウォックハート リミテッド ケトライド化合物
KR20140139083A (ko) 2012-03-27 2014-12-04 셈프라 파마슈티컬스, 인크. 마크롤라이드계 항생제를 투여하기 위한 비경구 제제
JP6426696B2 (ja) 2013-03-14 2018-11-21 センプラ ファーマシューティカルズ，インコーポレイテッド 呼吸器疾患の治療のための方法および製剤
WO2014145210A1 (en) 2013-03-15 2014-09-18 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN106518939B (zh) * 2015-09-14 2019-12-31 江苏奥赛康药业有限公司 一种制备Solithromycin化合物的方法
CN106554381A (zh) * 2015-09-25 2017-04-05 苏州鹏旭医药科技有限公司 酮内酯类抗生素中间体及其制备方法和应用
EP3190122A1 (en) 2016-01-08 2017-07-12 LEK Pharmaceuticals d.d. A novel synthetic pathway towards solithromycin and purification thereof
CN106432383A (zh) * 2016-09-14 2017-02-22 重庆两江药物研发中心有限公司 索利霉素及其中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742049A (en) * 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
US4740502A (en) * 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
AU662420B2 (en) * 1992-04-22 1995-08-31 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide A derivative
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose

Also Published As

Publication number Publication date
JPH11310591A (ja) 1999-11-09
JP4707785B2 (ja) 2011-06-22
EP0949268A1 (fr) 1999-10-13
HU9900958D0 (en) 1999-06-28
HU227562B1 (en) 2011-08-29
DE69913413D1 (de) 2004-01-22
US6121432A (en) 2000-09-19
PT949268E (pt) 2004-04-30
FR2777282B1 (fr) 2001-04-20
HUP9900958A3 (en) 2000-04-28
ATE256139T1 (de) 2003-12-15
DE69913413T2 (de) 2004-12-02
HUP9900958A1 (hu) 1999-11-29
EP0949268B1 (fr) 2003-12-10
FR2777282A1 (fr) 1999-10-15
ES2210999T3 (es) 2004-07-01
KR19990082977A (ko) 1999-11-25
KR100633835B1 (ko) 2006-10-13
CN1130370C (zh) 2003-12-10
CN1235162A (zh) 1999-11-17

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