DK0920431T3 - Thienopyrimidiner. - Google Patents

Thienopyrimidiner.

Info

Publication number
DK0920431T3
DK0920431T3 DK97940047T DK97940047T DK0920431T3 DK 0920431 T3 DK0920431 T3 DK 0920431T3 DK 97940047 T DK97940047 T DK 97940047T DK 97940047 T DK97940047 T DK 97940047T DK 0920431 T3 DK0920431 T3 DK 0920431T3
Authority
DK
Denmark
Prior art keywords
thienopyrimidines
Prior art date
Application number
DK97940047T
Other languages
Danish (da)
English (en)
Inventor
Jonas Rochus
Pierre Schelling
Franz-Werner Kluxen
Maria Christadler
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK0920431T3 publication Critical patent/DK0920431T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK97940047T 1996-08-12 1997-07-30 Thienopyrimidiner. DK0920431T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19632423A DE19632423A1 (de) 1996-08-12 1996-08-12 Thienopyrimidine
PCT/EP1997/004139 WO1998006722A1 (de) 1996-08-12 1997-07-30 Thienopyrimidine

Publications (1)

Publication Number Publication Date
DK0920431T3 true DK0920431T3 (da) 2003-06-02

Family

ID=7802392

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97940047T DK0920431T3 (da) 1996-08-12 1997-07-30 Thienopyrimidiner.

Country Status (29)

Country Link
US (1) US6110920A (es)
EP (1) EP0920431B1 (es)
JP (1) JP4405593B2 (es)
KR (1) KR100502271B1 (es)
CN (1) CN1081638C (es)
AR (1) AR009052A1 (es)
AT (1) ATE233265T1 (es)
AU (1) AU725227B2 (es)
BR (1) BR9711062A (es)
CA (1) CA2263561C (es)
CZ (1) CZ287772B6 (es)
DE (2) DE19632423A1 (es)
DK (1) DK0920431T3 (es)
ES (1) ES2191192T3 (es)
HK (1) HK1021731A1 (es)
HU (1) HUP0001607A3 (es)
IL (1) IL128504A (es)
NO (1) NO990643L (es)
NZ (1) NZ334600A (es)
PL (1) PL190174B1 (es)
PT (1) PT920431E (es)
RU (1) RU2199541C2 (es)
SI (1) SI0920431T1 (es)
SK (1) SK282823B6 (es)
TR (1) TR199900308T2 (es)
TW (1) TW359672B (es)
UA (1) UA55421C2 (es)
WO (1) WO1998006722A1 (es)
ZA (1) ZA977156B (es)

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US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
WO2000059912A1 (fr) * 1999-03-30 2000-10-12 Nippon Soda Co., Ltd. Composes de thienopyrimidine et leurs sels, et procede de preparation desdits composes et sels
US6399826B1 (en) 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
DE10031585A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 2-Aminoalkyl-thieno[2,3-d]pyrimidine
JPWO2002026745A1 (ja) * 2000-09-29 2004-02-05 日本曹達株式会社 チエノピリミジン化合物とその塩並びに製造方法
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US6610887B2 (en) 2001-04-13 2003-08-26 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
US6849638B2 (en) * 2001-04-30 2005-02-01 Bayer Pharmaceuticals Corporation 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions
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US7153412B2 (en) 2001-12-28 2006-12-26 Kabushiki Kaisha Toyota Chuo Kenkyusho Electrodes, electrochemical elements, gas sensors, and gas measurement methods
US7208516B2 (en) 2002-03-20 2007-04-24 Celgene Corporation Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
US6962940B2 (en) 2002-03-20 2005-11-08 Celgene Corporation (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
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US7276529B2 (en) 2002-03-20 2007-10-02 Celgene Corporation Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
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DE10351436A1 (de) * 2003-11-04 2005-06-09 Merck Patent Gmbh Verwendung von Thienopyrimidinen
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TWI417095B (zh) * 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
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US20100227853A1 (en) * 2008-04-18 2010-09-09 Trustees Of Boston College Inhibitors of cyclic amp phosphodiesterases
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AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
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BRPI0921333A2 (pt) 2008-11-28 2015-12-29 Addex Pharmaceuticals Sa derivados de indol e benzoxazina como moduladores de receptores de glutamato metabotrópicos
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
KR101753826B1 (ko) 2009-05-12 2017-07-04 얀센 파마슈티칼즈, 인코포레이티드 1,２,４―트리아졸로［４,３―ａ］피리딘 유도체 및 신경정신 질환의 치료 또는 예방을 위한 이들의 용도
ES2536433T3 (es) 2010-11-08 2015-05-25 Janssen Pharmaceuticals, Inc. Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2
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US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
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Also Published As

Publication number Publication date
AU725227B2 (en) 2000-10-12
NZ334600A (en) 2000-07-28
PL331538A1 (en) 1999-07-19
NO990643D0 (no) 1999-02-11
CA2263561C (en) 2007-02-20
CZ287772B6 (en) 2001-01-17
PL190174B1 (pl) 2005-11-30
HUP0001607A3 (en) 2002-09-30
JP2000516223A (ja) 2000-12-05
CA2263561A1 (en) 1998-02-19
CZ44899A3 (cs) 1999-05-12
KR20000029932A (ko) 2000-05-25
DE19632423A1 (de) 1998-02-19
HUP0001607A2 (hu) 2000-10-28
TW359672B (en) 1999-06-01
CN1227560A (zh) 1999-09-01
JP4405593B2 (ja) 2010-01-27
EP0920431A1 (de) 1999-06-09
BR9711062A (pt) 1999-08-17
IL128504A0 (en) 2000-01-31
UA55421C2 (uk) 2003-04-15
ATE233265T1 (de) 2003-03-15
CN1081638C (zh) 2002-03-27
PT920431E (pt) 2003-07-31
DE59709404D1 (en) 2003-04-03
ZA977156B (en) 1998-02-19
SK282823B6 (sk) 2002-12-03
HK1021731A1 (en) 2000-06-30
AU4203597A (en) 1998-03-06
WO1998006722A1 (de) 1998-02-19
SK16499A3 (en) 1999-06-11
US6110920A (en) 2000-08-29
KR100502271B1 (ko) 2005-07-22
NO990643L (no) 1999-02-11
AR009052A1 (es) 2000-03-08
ES2191192T3 (es) 2003-09-01
TR199900308T2 (xx) 1999-04-21
SI0920431T1 (en) 2003-08-31
IL128504A (en) 2003-01-12
RU2199541C2 (ru) 2003-02-27
EP0920431B1 (de) 2003-02-26

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