DK0883619T3 - Morfin- og diamorfinsalte af anioniske ikke-narkotiske analgetika af substitueret carboxylsyretype - Google Patents

Morfin- og diamorfinsalte af anioniske ikke-narkotiske analgetika af substitueret carboxylsyretype

Info

Publication number
DK0883619T3
DK0883619T3 DK97903288T DK97903288T DK0883619T3 DK 0883619 T3 DK0883619 T3 DK 0883619T3 DK 97903288 T DK97903288 T DK 97903288T DK 97903288 T DK97903288 T DK 97903288T DK 0883619 T3 DK0883619 T3 DK 0883619T3
Authority
DK
Denmark
Prior art keywords
salts
substituted carboxylic
morphine
pct
narcotic analgesics
Prior art date
Application number
DK97903288T
Other languages
Danish (da)
English (en)
Inventor
Bodo Asmussen
Walter Mueller
Walter Riess
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Application granted granted Critical
Publication of DK0883619T3 publication Critical patent/DK0883619T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK97903288T 1996-02-28 1997-02-15 Morfin- og diamorfinsalte af anioniske ikke-narkotiske analgetika af substitueret carboxylsyretype DK0883619T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19607395A DE19607395C2 (de) 1996-02-28 1996-02-28 Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate
PCT/EP1997/000711 WO1997031918A1 (de) 1996-02-28 1997-02-15 Morphin- und diamorphinsalze anionischer nicht-narkotischer analgetika vom typ der substituierten carbonsäuren

Publications (1)

Publication Number Publication Date
DK0883619T3 true DK0883619T3 (da) 2002-04-29

Family

ID=7786595

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97903288T DK0883619T3 (da) 1996-02-28 1997-02-15 Morfin- og diamorfinsalte af anioniske ikke-narkotiske analgetika af substitueret carboxylsyretype

Country Status (20)

Country Link
US (1) US6156764A (ko)
EP (1) EP0883619B1 (ko)
JP (1) JP4624497B2 (ko)
KR (1) KR100422276B1 (ko)
CN (1) CN1064363C (ko)
AT (1) ATE212024T1 (ko)
AU (1) AU712255B2 (ko)
CZ (1) CZ294401B6 (ko)
DE (2) DE19607395C2 (ko)
DK (1) DK0883619T3 (ko)
ES (1) ES2171886T3 (ko)
HU (1) HU225268B1 (ko)
IL (1) IL125819A (ko)
NO (1) NO983864D0 (ko)
NZ (1) NZ331485A (ko)
PL (1) PL185915B1 (ko)
PT (1) PT883619E (ko)
SK (1) SK104398A3 (ko)
WO (1) WO1997031918A1 (ko)
ZA (1) ZA971740B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200000653T2 (tr) * 1997-09-25 2000-07-21 Lts Lohmann Therapie-Systeme Ag Asit katılmış morfin alkoloidlerinin tuzları ve bunların kullanımı.
KR20040014544A (ko) * 2001-06-05 2004-02-14 컨트롤 딜리버리 시스템즈 인코포레이티드 서방 진통제 화합물
JP2005509631A (ja) * 2001-10-18 2005-04-14 ノバルティス アクチエンゲゼルシャフト Ａｔ１−レセプターアンタゴニストと心臓血管薬から形成される塩
JP2005518354A (ja) * 2001-11-19 2005-06-23 コントロール・デリバリー・システムズ・インコーポレイテッド コドラッグを含有する医薬組成物
MXPA04006875A (es) * 2002-01-18 2004-12-06 Control Delivery Sys Inc Sistema de gel polimerico para suministro controlado de cofarmacos.
US8557291B2 (en) * 2002-07-05 2013-10-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opioids and other drugs
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8840928B2 (en) * 2002-07-05 2014-09-23 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US7399488B2 (en) * 2002-07-05 2008-07-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opiods and other drugs
TW200500067A (en) * 2003-01-21 2005-01-01 Control Delivery Sys Inc Salts of codrugs and uses related thereto
DE602004016995D1 (de) * 2003-06-26 2008-11-20 Control Delivery Sys Inc In-situ gelierendes arzneimittelabgabesystem
CA2530113C (en) * 2003-06-26 2013-08-13 Control Delivery Systems, Inc. Bioerodible sustained release drug delivery systems
EP1686963A1 (en) * 2003-10-27 2006-08-09 PSivida Inc. Suspension delivery system for the sustained and controlled local release of pharmaceuticals
PT1765292T (pt) * 2004-06-12 2017-12-29 Collegium Pharmaceutical Inc Formulações de fármacos dissuasoras de abuso
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404209A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and sulindac
GB8319546D0 (en) * 1983-07-20 1983-08-24 Euro Celtique Sa Pharmaceutical active salts
ZA893422B (en) * 1988-02-24 1991-01-30 Adcock Ingram Lab Ltd Pharmaceutical composition
TW225536B (ko) * 1990-08-23 1994-06-21 Ciba Geigy Ag
CA2104684A1 (en) * 1991-03-04 1992-09-05 Mahdi B. Fawzi Salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms
US5256669A (en) * 1992-08-07 1993-10-26 Aminotek Sciences, Inc. Methods and compositions for treating acute or chronic pain and drug addiction
SE9301057L (sv) * 1993-03-30 1994-10-01 Pharmacia Ab Beredning med kontrollerad frisättning
FR2708611B1 (fr) * 1993-07-29 1995-10-27 Meram Lab Sel de codéine de l'acide 2-(3-benzoylphényl)propionique, procédé d'obtention et compositions pharmaceutiques le contenant.
GB9319568D0 (en) * 1993-09-22 1993-11-10 Euro Celtique Sa Pharmaceutical compositions and usages
US5460826A (en) * 1994-06-27 1995-10-24 Alza Corporation Morphine therapy

Also Published As

Publication number Publication date
NZ331485A (en) 1999-03-29
ATE212024T1 (de) 2002-02-15
AU712255B2 (en) 1999-11-04
DE19607395A1 (de) 1997-09-04
HUP9900568A2 (hu) 1999-06-28
IL125819A0 (en) 1999-04-11
JP4624497B2 (ja) 2011-02-02
NO983864L (no) 1998-08-21
CN1064363C (zh) 2001-04-11
CZ265798A3 (cs) 1998-11-11
EP0883619A1 (de) 1998-12-16
US6156764A (en) 2000-12-05
CZ294401B6 (cs) 2004-12-15
DE59706015D1 (de) 2002-02-21
KR100422276B1 (ko) 2004-07-30
PT883619E (pt) 2002-07-31
EP0883619B1 (de) 2002-01-16
NO983864D0 (no) 1998-08-21
PL328712A1 (en) 1999-02-15
KR19990087343A (ko) 1999-12-27
ZA971740B (en) 1997-09-04
IL125819A (en) 2002-04-21
AU1769597A (en) 1997-09-16
DE19607395C2 (de) 2002-11-21
HU225268B1 (en) 2006-08-28
JP2000505463A (ja) 2000-05-09
ES2171886T3 (es) 2002-09-16
HUP9900568A3 (en) 2001-08-28
WO1997031918A1 (de) 1997-09-04
PL185915B1 (pl) 2003-08-29
CN1212698A (zh) 1999-03-31
SK104398A3 (en) 1998-12-02

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