NO983864L - Morfin- og diamorfinsalter av anioniske, ikke-narkotiske analgetika av den substituerte karboksyltypen - Google Patents

Morfin- og diamorfinsalter av anioniske, ikke-narkotiske analgetika av den substituerte karboksyltypen

Info

Publication number
NO983864L
NO983864L NO983864A NO983864A NO983864L NO 983864 L NO983864 L NO 983864L NO 983864 A NO983864 A NO 983864A NO 983864 A NO983864 A NO 983864A NO 983864 L NO983864 L NO 983864L
Authority
NO
Norway
Prior art keywords
morphine
salts
anionic
narcotic analgesics
substituted carboxyl
Prior art date
Application number
NO983864A
Other languages
English (en)
Other versions
NO983864D0 (no
Inventor
Bodo Asmussen
Walter Mueller
Walter Riess
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Publication of NO983864D0 publication Critical patent/NO983864D0/no
Publication of NO983864L publication Critical patent/NO983864L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Det er beskrevet morfin- og diamorfinsalter av anioniske, ikke-narkotiske analgetika av den substituerte karboksylsyretypen, fortrinnsvis morfin- og diamorfmsaltene av diklorfenac (formel 1) R -O H Formel l (formel la: R=H) (formel lb: CH3CO) fremgangsmåter for deres fremstilling, anvendelse av disse saltene for behandling av sykdommer, samt farmasøytiske preparater som inneholder disse saltene.
NO983864A 1996-02-28 1998-08-21 Morfin- og diamorfinsalter av anioniske, ikke-narkotiske analgetika av den substituerte karboksyltypen NO983864L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19607395A DE19607395C2 (de) 1996-02-28 1996-02-28 Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate
PCT/EP1997/000711 WO1997031918A1 (de) 1996-02-28 1997-02-15 Morphin- und diamorphinsalze anionischer nicht-narkotischer analgetika vom typ der substituierten carbonsäuren

Publications (2)

Publication Number Publication Date
NO983864D0 NO983864D0 (no) 1998-08-21
NO983864L true NO983864L (no) 1998-08-21

Family

ID=7786595

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983864A NO983864L (no) 1996-02-28 1998-08-21 Morfin- og diamorfinsalter av anioniske, ikke-narkotiske analgetika av den substituerte karboksyltypen

Country Status (20)

Country Link
US (1) US6156764A (no)
EP (1) EP0883619B1 (no)
JP (1) JP4624497B2 (no)
KR (1) KR100422276B1 (no)
CN (1) CN1064363C (no)
AT (1) ATE212024T1 (no)
AU (1) AU712255B2 (no)
CZ (1) CZ294401B6 (no)
DE (2) DE19607395C2 (no)
DK (1) DK0883619T3 (no)
ES (1) ES2171886T3 (no)
HU (1) HU225268B1 (no)
IL (1) IL125819A (no)
NO (1) NO983864L (no)
NZ (1) NZ331485A (no)
PL (1) PL185915B1 (no)
PT (1) PT883619E (no)
SK (1) SK104398A3 (no)
WO (1) WO1997031918A1 (no)
ZA (1) ZA971740B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL134787A (en) * 1997-09-25 2007-05-15 Lohmann Therapie Syst Lts Acid addition salts of morphine alkaloids, their preparation and pharmaceutical compositions containing them for trandermal and transmucosal application
IL158882A0 (en) * 2001-06-05 2004-05-12 Control Delivery Sys Inc Sustained-release analgesic compounds
CN1571668A (zh) * 2001-10-18 2005-01-26 诺瓦提斯公司 At1－受体拮抗剂和心血管药物形成的盐
AU2002350207A1 (en) * 2001-11-19 2003-06-10 Control Delivery Systems, Inc. Topical delivery of codrugs
CA2472188C (en) * 2002-01-18 2011-06-21 Control Delivery Systems, Inc. Polymeric gel system for the controlled delivery of codrugs
US8840928B2 (en) 2002-07-05 2014-09-23 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
AU2003247876B2 (en) 2002-07-05 2006-10-05 Collegium Pharmaceutical, Inc Abuse-deterrent pharmaceutical compositions of opiods and other drugs
US8557291B2 (en) 2002-07-05 2013-10-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opioids and other drugs
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
TW200500067A (en) * 2003-01-21 2005-01-01 Control Delivery Sys Inc Salts of codrugs and uses related thereto
PL1635875T3 (pl) * 2003-06-26 2009-03-31 Psivida Inc System dostarczania leków poprzez żelowanie w warunkach in-situ
WO2005000268A2 (en) * 2003-06-26 2005-01-06 Control Delivery Systems, Inc. Bioerodible sustained release drug delivery systems
EP1686963A1 (en) * 2003-10-27 2006-08-09 PSivida Inc. Suspension delivery system for the sustained and controlled local release of pharmaceuticals
PT1765292T (pt) 2004-06-12 2017-12-29 Collegium Pharmaceutical Inc Formulações de fármacos dissuasoras de abuso
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404209A (en) * 1982-06-30 1983-09-13 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and sulindac
GB8319546D0 (en) * 1983-07-20 1983-08-24 Euro Celtique Sa Pharmaceutical active salts
ZA893422B (en) * 1988-02-24 1991-01-30 Adcock Ingram Lab Ltd Pharmaceutical composition
TW225536B (no) * 1990-08-23 1994-06-21 Ciba Geigy Ag
WO1992015332A1 (en) * 1991-03-04 1992-09-17 Warner-Lambert Company Novel salts/ion pairs of non-steroidal anti-inflammatory drugs in various dosage forms
US5256669A (en) * 1992-08-07 1993-10-26 Aminotek Sciences, Inc. Methods and compositions for treating acute or chronic pain and drug addiction
SE9301057L (sv) * 1993-03-30 1994-10-01 Pharmacia Ab Beredning med kontrollerad frisättning
FR2708611B1 (fr) * 1993-07-29 1995-10-27 Meram Lab Sel de codéine de l'acide 2-(3-benzoylphényl)propionique, procédé d'obtention et compositions pharmaceutiques le contenant.
GB9319568D0 (en) * 1993-09-22 1993-11-10 Euro Celtique Sa Pharmaceutical compositions and usages
US5460826A (en) * 1994-06-27 1995-10-24 Alza Corporation Morphine therapy

Also Published As

Publication number Publication date
NO983864D0 (no) 1998-08-21
DE19607395C2 (de) 2002-11-21
SK104398A3 (en) 1998-12-02
EP0883619A1 (de) 1998-12-16
ATE212024T1 (de) 2002-02-15
PT883619E (pt) 2002-07-31
JP4624497B2 (ja) 2011-02-02
HUP9900568A2 (hu) 1999-06-28
PL328712A1 (en) 1999-02-15
IL125819A (en) 2002-04-21
IL125819A0 (en) 1999-04-11
DE59706015D1 (de) 2002-02-21
HU225268B1 (en) 2006-08-28
AU712255B2 (en) 1999-11-04
WO1997031918A1 (de) 1997-09-04
CN1064363C (zh) 2001-04-11
DE19607395A1 (de) 1997-09-04
HUP9900568A3 (en) 2001-08-28
CN1212698A (zh) 1999-03-31
KR100422276B1 (ko) 2004-07-30
ZA971740B (en) 1997-09-04
DK0883619T3 (da) 2002-04-29
CZ294401B6 (cs) 2004-12-15
CZ265798A3 (cs) 1998-11-11
EP0883619B1 (de) 2002-01-16
NZ331485A (en) 1999-03-29
KR19990087343A (ko) 1999-12-27
PL185915B1 (pl) 2003-08-29
AU1769597A (en) 1997-09-16
ES2171886T3 (es) 2002-09-16
JP2000505463A (ja) 2000-05-09
US6156764A (en) 2000-12-05

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