DK0869791T3 - 4-substituerede piperidinanaloger og deres anvendelse som subtypeselektive NMDA-receptorantagonister - Google Patents
4-substituerede piperidinanaloger og deres anvendelse som subtypeselektive NMDA-receptorantagonisterInfo
- Publication number
- DK0869791T3 DK0869791T3 DK96944537T DK96944537T DK0869791T3 DK 0869791 T3 DK0869791 T3 DK 0869791T3 DK 96944537 T DK96944537 T DK 96944537T DK 96944537 T DK96944537 T DK 96944537T DK 0869791 T3 DK0869791 T3 DK 0869791T3
- Authority
- DK
- Denmark
- Prior art keywords
- substituted piperidine
- pct
- piperidine analogs
- sec
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US919295P | 1995-12-22 | 1995-12-22 | |
PCT/US1996/020766 WO1997023214A1 (fr) | 1995-12-22 | 1996-12-20 | Analogues de piperidine a substitution en position 4 et utilisation de ces derniers en tant qu'antagonistes selectivement actifs contre les sous-types du recepteurs de nmda |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0869791T3 true DK0869791T3 (da) | 2003-06-10 |
Family
ID=21736135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96944537T DK0869791T3 (da) | 1995-12-22 | 1996-12-20 | 4-substituerede piperidinanaloger og deres anvendelse som subtypeselektive NMDA-receptorantagonister |
Country Status (22)
Country | Link |
---|---|
US (4) | US6130234A (fr) |
EP (1) | EP0869791B1 (fr) |
JP (1) | JP2000502352A (fr) |
AT (1) | ATE239473T1 (fr) |
AU (1) | AU719430B2 (fr) |
BG (1) | BG63424B1 (fr) |
BR (1) | BR9612153A (fr) |
CA (1) | CA2240038A1 (fr) |
CZ (1) | CZ177898A3 (fr) |
DE (1) | DE69628035T2 (fr) |
DK (1) | DK0869791T3 (fr) |
EA (1) | EA001133B1 (fr) |
ES (1) | ES2196196T3 (fr) |
IL (1) | IL125060A (fr) |
MX (1) | MX9805032A (fr) |
NO (1) | NO312028B1 (fr) |
NZ (1) | NZ325735A (fr) |
PL (1) | PL327413A1 (fr) |
PT (1) | PT869791E (fr) |
SK (1) | SK82398A3 (fr) |
WO (1) | WO1997023214A1 (fr) |
ZA (1) | ZA9610741B (fr) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
WO1998010757A2 (fr) * | 1996-09-11 | 1998-03-19 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Utilisation d'antagonistes fonctionnels du n-methyl-d-aspartate pour reduire ou prevenir l'ototoxicite induite par l'aminoglucoside |
GB9704948D0 (en) * | 1997-03-11 | 1997-04-30 | Knoll Ag | Therapeutic agents |
IL134363A0 (en) | 1997-10-24 | 2001-04-30 | Warner Lambert Co | Method for treating disease-related or drug-induced dyskinesias |
US6960577B2 (en) * | 1998-05-22 | 2005-11-01 | Eli Lilly And Company | Combination therapy for treatment of refractory depression |
PE20000728A1 (es) * | 1998-06-26 | 2000-08-21 | Cocensys Inc | Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda |
US7214711B2 (en) * | 1998-12-23 | 2007-05-08 | Neurotherapeutics Pharma Llc | Method of treating migraine headache without aura |
US8722668B2 (en) * | 1998-12-23 | 2014-05-13 | Daryl W. Hochman | Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders |
US20060025387A1 (en) * | 1998-12-23 | 2006-02-02 | Cytoscan Sciences Llc | Compositions and methods for the treatment of disorders of the central and peripheral nervous systems |
US8008283B2 (en) * | 1998-12-23 | 2011-08-30 | Neurotherapeutics Pharma, Inc. | Methods and compositions for the treatment of neuropsychiatric disorders |
US6316474B1 (en) * | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
US6824981B2 (en) * | 2000-08-11 | 2004-11-30 | Agilix Corporation | Ultra-sensitive detection systems using alterable peptide tags |
EP1186303A3 (fr) * | 2000-09-06 | 2003-12-10 | Pfizer Products Inc. | Combinaisons pharmaceutiques pour le traitement des accidents cerebrovasculaires, contenant un facteur inhibitant la neutrophile et un antagoniste selectif du NMDA-NR2B |
EP1674087A1 (fr) | 2000-10-02 | 2006-06-28 | Pfizer Products Inc. | Utilisation prophylactique d'antagonistes des récepteurs du N-méthyl-D-aspartate (NMDA) |
ZA200108038B (en) * | 2000-10-02 | 2003-04-01 | Pfizer Prod Inc | Prophylactic use of n-methyl-d-asparrate (NMDA) antagonists. |
IL145584A0 (en) * | 2000-10-02 | 2002-06-30 | Pfizer Prod Inc | Nmda nr2b antagonists for treatment |
WO2002050070A2 (fr) | 2000-12-21 | 2002-06-27 | Warner-Lambert Company Llc | Derives de piperidine en tant qu'antagonistes vis-a-vis de n-methyl-d-aspartate (nmda), avec selectivite en termes de sous-type |
EP1409477B1 (fr) | 2001-07-24 | 2008-09-17 | Richter Gedeon NYRT | Derives de piperidine utilises en tant qu'antagonistes du recepteur n-methyl-d-aspartate (nmda) |
EP1420644B1 (fr) * | 2001-08-23 | 2006-05-31 | Bayer CropScience S.A. | Amines propargyliques substituees |
WO2003035641A1 (fr) * | 2001-10-22 | 2003-05-01 | Shionogi & Co., Ltd. | Nouveau derive carbamoyl-pyrrolidone |
JP2005514603A (ja) * | 2001-11-06 | 2005-05-19 | アジリックス・コーポレイション | 高感度コード化検出システム |
DE10201550A1 (de) * | 2002-01-17 | 2003-07-31 | Merck Patent Gmbh | Phenoxy-Piperidine |
WO2005037286A1 (fr) | 2003-03-25 | 2005-04-28 | Vasopharm Biotech Gmbh | Utilisation de derives de pteridine pour le traitement de l'augmentation de la pression intracranienne et de l'ischemie secondaire |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
EP1689721B1 (fr) * | 2003-11-26 | 2010-07-14 | Pfizer Products Inc. | Derives d'aminopyrazole en tant qu'inhibiteurs de la gsk-3 |
CA2596117A1 (fr) * | 2005-02-03 | 2006-08-10 | Perkinelmer Las, Inc. | Systemes de detection ultrasensible utilisant des signaux multidimensionnels |
EP1864666B1 (fr) * | 2005-03-31 | 2012-08-15 | Asahi Glass Company, Limited | Agent protecteur pour la cellule neuronale retinienne contenant un derive de prostaglandine f2 alpha comme ingredient actif |
JPWO2006112313A1 (ja) * | 2005-04-13 | 2008-12-11 | 宇部興産株式会社 | インダゾール誘導体を有効成分として含む網膜神経細胞保護剤 |
SI1899322T1 (sl) | 2005-06-28 | 2010-01-29 | Sanofi Aventis | Izokinolinski derivati kot inhibitorji Rho-kinaze |
PL1912949T3 (pl) | 2005-07-26 | 2012-01-31 | Sanofi Sa | Pochodne cykloheksyloaminoizochinolonu jako inhibitory kinazy RHO |
BRPI0613861B8 (pt) | 2005-07-26 | 2021-05-25 | Sanofi Aventis | derivados de isoquinolona piperidinil-substituídos como inibidores de rho-cinase |
JP2009511629A (ja) * | 2005-10-17 | 2009-03-19 | ニューロセラピューティクス ファーマ, インコーポレイテッド | 中枢神経系疾患の調節に有用な利尿薬様化合物類似体 |
EP2089383B1 (fr) | 2006-11-09 | 2015-09-16 | Probiodrug AG | Dérivés 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one utiles en tant qu' inhibiteurs de la glutaminyl-cyclase dans le traitement des ulcères, du cancer et d'autres maladies |
ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
CN101578266B (zh) | 2006-12-27 | 2013-10-30 | 塞诺菲-安万特股份有限公司 | 环烷基胺取代的异喹啉和异喹啉酮衍生物 |
CA2673916C (fr) | 2006-12-27 | 2015-02-17 | Sanofi-Aventis | Derives d'isoquinoline et d'isoquinolinone substitues inhibiteurs de la rho-kinase |
MX2009005966A (es) | 2006-12-27 | 2009-06-15 | Sanofi Aventis | Derivados de isoquinolona sustituidos con cicloalquilamina. |
AU2007338410B2 (en) | 2006-12-27 | 2012-08-16 | Sanofi-Aventis | Cycloalkylamine substituted isoquinoline derivatives |
RU2009128690A (ru) | 2006-12-27 | 2011-02-10 | Санофи-Авентис (Fr) | Новые замещенные производные изохинолина и изохинолинона |
MX2009006517A (es) | 2006-12-27 | 2009-06-26 | Sanofi Aventis | Nuevos derivados de isoquinolina e isoquinolinona sustituidos. |
CA2679446C (fr) | 2007-03-01 | 2016-05-17 | Probiodrug Ag | Nouvelle utilisation d'inhibiteurs de la glutaminyl cyclase |
EP2142514B1 (fr) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase |
CN102131785B (zh) | 2008-06-24 | 2014-10-29 | 赛诺菲-安万特 | 6-取代的异喹啉和异喹啉酮 |
MX2010013867A (es) | 2008-06-24 | 2011-02-24 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona bi- y policiclicos sustituidos. |
CA2728137C (fr) | 2008-06-24 | 2016-10-18 | Sanofi-Aventis | Isoquinolines et isoquinolinones substituees utilisees comme inhibiteurs de rho-kinase |
CA2772488C (fr) | 2009-09-11 | 2018-04-17 | Probiodrug Ag | Derives heterocycliques en tant qu'inhibiteurs de glutaminyle cyclase |
ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
EP2545047B9 (fr) | 2010-03-10 | 2015-06-10 | Probiodrug AG | Inhibiteurs hétérocycliques de la glutaminyl cyclase (qc, ec 2.3.2.5) |
US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
ES2570167T3 (es) | 2011-03-16 | 2016-05-17 | Probiodrug Ag | Derivados de benzimidazol como inhibidores de glutaminil ciclasa |
WO2012151139A1 (fr) * | 2011-05-03 | 2012-11-08 | Merck Sharp & Dohme Corp. | Dérivés alcyne benzotriazoles |
CN108042517A (zh) | 2011-11-22 | 2018-05-18 | 加利福尼亚大学董事会 | 用于治疗缺血性损伤的半胱胺和/或胱胺 |
EP3090260A1 (fr) * | 2014-01-02 | 2016-11-09 | John P. Jasper | Procédé de surveillance continue de processus chimiques ou biologiques |
US11066366B2 (en) | 2015-09-03 | 2021-07-20 | Allegheny-Singer Research Institute | Hydrophilic fentanyl derivatives |
SI25272A (sl) * | 2016-09-23 | 2018-03-30 | Univerza V Ljubljani | Disubstituirani azetidini, pirolidini, piperidini in azepani kot zaviralci monoamin oksidaze B za zdravljenje nevrodegenerativnih bolezni |
EP3461819B1 (fr) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibiteurs de la glutaminyl-cyclase |
CN108250058B (zh) * | 2018-01-19 | 2022-02-11 | 上海怡立舍生物技术有限公司 | Ppar激动剂及其在治疗老年痴呆及其他疾病中的用途 |
WO2022251280A1 (fr) * | 2021-05-25 | 2022-12-01 | Vividion Therapeutics, Inc. | Composés sélectifs pour jak1 et procédés d'utilisation |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
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CA696999A (en) | 1964-11-03 | Ayerst, Mckenna And Harrison | Therapeutic compounds and their preparation | |
US3255196A (en) | 1966-06-07 | Phenoxyalkyl piperidine derivatives | ||
GB1052302A (fr) * | 1963-04-22 | |||
GB1055548A (en) | 1965-08-23 | 1967-01-18 | Acraf | New substituted 1-aryl-3-aminopropynes and process for their preparation |
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-
1996
- 1996-12-19 ZA ZA9610741A patent/ZA9610741B/xx unknown
- 1996-12-20 SK SK823-98A patent/SK82398A3/sk unknown
- 1996-12-20 NZ NZ325735A patent/NZ325735A/en unknown
- 1996-12-20 CA CA002240038A patent/CA2240038A1/fr not_active Abandoned
- 1996-12-20 IL IL12506096A patent/IL125060A/xx not_active IP Right Cessation
- 1996-12-20 US US09/091,594 patent/US6130234A/en not_active Expired - Fee Related
- 1996-12-20 EP EP96944537A patent/EP0869791B1/fr not_active Expired - Lifetime
- 1996-12-20 EA EA199800591A patent/EA001133B1/ru not_active IP Right Cessation
- 1996-12-20 AT AT96944537T patent/ATE239473T1/de not_active IP Right Cessation
- 1996-12-20 JP JP09523881A patent/JP2000502352A/ja not_active Ceased
- 1996-12-20 DK DK96944537T patent/DK0869791T3/da active
- 1996-12-20 CZ CZ981778A patent/CZ177898A3/cs unknown
- 1996-12-20 WO PCT/US1996/020766 patent/WO1997023214A1/fr not_active Application Discontinuation
- 1996-12-20 ES ES96944537T patent/ES2196196T3/es not_active Expired - Lifetime
- 1996-12-20 DE DE69628035T patent/DE69628035T2/de not_active Expired - Fee Related
- 1996-12-20 PL PL96327413A patent/PL327413A1/xx unknown
- 1996-12-20 BR BR9612153-0A patent/BR9612153A/pt not_active Application Discontinuation
- 1996-12-20 AU AU14310/97A patent/AU719430B2/en not_active Ceased
- 1996-12-20 PT PT96944537T patent/PT869791E/pt unknown
-
1998
- 1998-06-19 BG BG102561A patent/BG63424B1/bg unknown
- 1998-06-19 MX MX9805032A patent/MX9805032A/es not_active IP Right Cessation
- 1998-06-19 NO NO19982869A patent/NO312028B1/no unknown
-
2000
- 2000-06-13 US US09/592,883 patent/US6448270B1/en not_active Expired - Fee Related
-
2002
- 2002-07-29 US US10/206,578 patent/US20030105133A1/en not_active Abandoned
- 2002-08-06 US US10/172,525 patent/US20030100018A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE239473T1 (de) | 2003-05-15 |
EA199800591A1 (ru) | 1999-02-25 |
NO982869D0 (no) | 1998-06-19 |
MX9805032A (es) | 1998-11-30 |
DE69628035T2 (de) | 2004-02-12 |
WO1997023214A1 (fr) | 1997-07-03 |
US6130234A (en) | 2000-10-10 |
SK82398A3 (en) | 1999-03-12 |
ES2196196T3 (es) | 2003-12-16 |
EA001133B1 (ru) | 2000-10-30 |
EP0869791A1 (fr) | 1998-10-14 |
PT869791E (pt) | 2003-08-29 |
US20030105133A1 (en) | 2003-06-05 |
AU719430B2 (en) | 2000-05-11 |
PL327413A1 (en) | 1998-12-07 |
IL125060A0 (en) | 1999-01-26 |
CA2240038A1 (fr) | 1997-07-03 |
NO982869L (no) | 1998-08-24 |
AU1431097A (en) | 1997-07-17 |
IL125060A (en) | 2003-07-31 |
NO312028B1 (no) | 2002-03-04 |
BG63424B1 (bg) | 2002-01-31 |
BR9612153A (pt) | 1999-12-28 |
US20030100018A1 (en) | 2003-05-29 |
US6448270B1 (en) | 2002-09-10 |
BG102561A (en) | 1999-04-30 |
JP2000502352A (ja) | 2000-02-29 |
ZA9610741B (en) | 1997-06-24 |
NZ325735A (en) | 2000-02-28 |
DE69628035D1 (de) | 2003-06-12 |
CZ177898A3 (cs) | 1998-12-16 |
EP0869791A4 (fr) | 1999-04-28 |
EP0869791B1 (fr) | 2003-05-07 |
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