DK0866720T3 - OB-protein til forögelse af mager kropsmasse - Google Patents

OB-protein til forögelse af mager kropsmasse

Info

Publication number
DK0866720T3
DK0866720T3 DK96938773T DK96938773T DK0866720T3 DK 0866720 T3 DK0866720 T3 DK 0866720T3 DK 96938773 T DK96938773 T DK 96938773T DK 96938773 T DK96938773 T DK 96938773T DK 0866720 T3 DK0866720 T3 DK 0866720T3
Authority
DK
Denmark
Prior art keywords
protein
body mass
lean body
increasing lean
increasing
Prior art date
Application number
DK96938773T
Other languages
Danish (da)
English (en)
Inventor
Christopher Francis Toombs
Mary Ann Pelleymounter
Michael Benjamin Mann
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK0866720T3 publication Critical patent/DK0866720T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
DK96938773T 1995-11-22 1996-11-04 OB-protein til forögelse af mager kropsmasse DK0866720T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56173295A 1995-11-22 1995-11-22
PCT/US1996/017718 WO1997018833A1 (en) 1995-11-22 1996-11-04 Methods of increasing lean tissue mass using ob protein compositions

Publications (1)

Publication Number Publication Date
DK0866720T3 true DK0866720T3 (da) 2004-06-14

Family

ID=24243198

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96938773T DK0866720T3 (da) 1995-11-22 1996-11-04 OB-protein til forögelse af mager kropsmasse

Country Status (15)

Country Link
EP (3) EP0866720B1 (ja)
JP (2) JP4173914B2 (ja)
AT (2) ATE455554T1 (ja)
AU (3) AU7607496A (ja)
CA (2) CA2358862A1 (ja)
DE (2) DE69638119D1 (ja)
DK (1) DK0866720T3 (ja)
ES (2) ES2217327T3 (ja)
IL (2) IL124442A0 (ja)
MX (1) MX9803992A (ja)
NZ (3) NZ527007A (ja)
PT (1) PT866720E (ja)
SI (1) SI0866720T1 (ja)
WO (1) WO1997018833A1 (ja)
ZA (1) ZA969605B (ja)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
US20030040467A1 (en) 1998-06-15 2003-02-27 Mary Ann Pelleymounter Ig/ob fusions and uses thereof.
EP0866720B1 (en) * 1995-11-22 2004-02-11 Amgen Inc., Ob protein for increasing lean tissue mass
US6936439B2 (en) 1995-11-22 2005-08-30 Amgen Inc. OB fusion protein compositions and methods
US6620413B1 (en) 1995-12-27 2003-09-16 Genentech, Inc. OB protein-polymer chimeras
US7074397B1 (en) 1996-01-08 2006-07-11 Genentech, Inc. Method for enhancing proliferation or differentiation of a cell using ob protein
US6541604B1 (en) 1996-01-08 2003-04-01 Genentech, Inc. Leptin receptor having a WSX motif
US20050019325A1 (en) 1996-01-08 2005-01-27 Carter Paul J. WSX receptor agonist antibodies
EP0877627A1 (en) * 1996-01-25 1998-11-18 Eli Lilly And Company Obesity protein analog compounds and formulations thereof
WO1997039767A1 (en) * 1996-04-19 1997-10-30 Zymogenetics, Inc. Methods for inducing bone formation
JP4175668B2 (ja) * 1996-12-20 2008-11-05 アムジエン・インコーポレーテツド Ｏｂ融合タンパク質組成物および方法
JP2001507228A (ja) * 1996-12-20 2001-06-05 イーライ・リリー・アンド・カンパニー 抗肥満タンパク質
US20020019352A1 (en) * 1997-04-17 2002-02-14 David N. Brems Stable, active, human ob protein compositions and methods
EP0950417A3 (en) 1998-02-23 2000-02-23 Pfizer Products Inc. Treatment of skeletal disorders
WO1999053939A1 (en) * 1998-04-20 1999-10-28 Mayo Foundation For Medical Education And Research Treatment of osteoporosis with leptin
US6210924B1 (en) 1998-08-11 2001-04-03 Amgen Inc. Overexpressing cyclin D 1 in a eukaryotic cell line
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
WO2000024418A1 (en) * 1998-10-27 2000-05-04 Eli Lilly And Company Prevention of muscle mass loss with leptin receptor ligands
EP1151102B1 (en) * 1999-02-12 2006-04-19 Amgen Inc. Glycosylated leptin compositions and related methods
US8106098B2 (en) 1999-08-09 2012-01-31 The General Hospital Corporation Protein conjugates with a water-soluble biocompatible, biodegradable polymer
ES2418954T3 (es) 2001-10-22 2013-08-19 Amgen, Inc. Uso de la leptina para el tratamiento de la lipoatrofia humana y método para determinar la predisposición a dicho tratamiento
NZ534757A (en) 2002-03-12 2006-07-28 Merck & Co Inc Substituted amides
US7579444B2 (en) * 2004-06-30 2009-08-25 Nektar Therapeutics Al, Corporation Polymer-factor IX moiety conjugates
US8394765B2 (en) 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
CN101094689B (zh) 2004-11-01 2013-06-12 安米林药品有限责任公司 治疗肥胖以及肥胖相关疾病和病症的方法
WO2008048691A2 (en) * 2006-10-18 2008-04-24 Amylin Pharmaceuticals, Inc. Use of leptin for treating post-lipectomy ectopic fat deposition and other post-lipectomy associated disorders
WO2009149379A2 (en) 2008-06-05 2009-12-10 Regents Of The University Of Michigan Use of leptin for the treatment of fatty liver diseases and conditions
ES2630031T3 (es) 2010-09-28 2017-08-17 Aegerion Pharmaceuticals, Inc. Un polipéptido de leptina pinnípedo-humano quimérico con solubilidad aumentada
PL2900230T3 (pl) 2012-09-27 2019-02-28 The Children's Medical Center Corporation Związki do leczenia otyłości i sposoby ich zastosowania
ES2709976T3 (es) 2013-11-26 2019-04-22 Childrens Medical Ct Corp Compuestos para el tratamiento de la obesidad y procedimientos de uso de los mismos
WO2015153933A1 (en) 2014-04-03 2015-10-08 The Children's Medical Center Corporation Hsp90 inhibitors for the treatment of obesity and methods of use thereof
BR112019004715A2 (pt) 2016-09-12 2019-07-16 Aegerion Pharmaceuticals Inc métodos para detectar anticorpos neutralizantes anti-leptina

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1228925B (it) * 1987-08-07 1991-07-10 Eniricerche Spa Procedimento per la preparazione dell'ormone della crescita umano
DK173142B1 (da) * 1988-08-24 2000-02-07 Natinco Nv Fremgangsmåde til forbedring af kødkvaliteten og foderomsætningseffektiviteten for grise
US5028440A (en) * 1990-01-30 1991-07-02 Iowa State University Research Foundation, Inc. Method of raising meat producing animals to increase lean tissue development
JPH09503973A (ja) * 1993-08-13 1997-04-22 プッツマイスター・ヴェルク マシーネンファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング 大型対象物の表面を処理する方法および装置
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
GB9511935D0 (en) * 1995-06-13 1995-08-09 Smithkline Beecham Plc Novel compound
EP0866720B1 (en) * 1995-11-22 2004-02-11 Amgen Inc., Ob protein for increasing lean tissue mass
BR9612359A (pt) * 1995-12-27 1999-07-13 Genentech Inc Derivado covalente de uma proteína ob composição polipeptídeo quimérico sequência de ácido nucleico vetor de express o replicável célula hospedeira e métodos associados aos mesmos
JP4175668B2 (ja) * 1996-12-20 2008-11-05 アムジエン・インコーポレーテツド Ｏｂ融合タンパク質組成物および方法
JP4086908B2 (ja) * 1997-04-17 2008-05-14 アムジエン・インコーポレーテツド 安定かつ活性なヒトＯＢタンパク質と抗体Ｆｃ鎖とのコンジュゲートを含む組成物および方法

Also Published As

Publication number Publication date
AU763769B2 (en) 2003-07-31
DE69631544D1 (de) 2004-03-18
AU763755B2 (en) 2003-07-31
EP1285664B1 (en) 2010-01-20
DE69638119D1 (de) 2010-03-11
ES2339846T3 (es) 2010-05-26
ZA969605B (en) 1997-06-02
AU4265200A (en) 2000-09-21
JP2002206000A (ja) 2002-07-23
IL127926A (en) 2006-08-20
SI0866720T1 (en) 2004-10-31
NZ527007A (en) 2005-01-28
IL124442A0 (en) 1998-12-06
WO1997018833A1 (en) 1997-05-29
CA2358862A1 (en) 1997-05-29
IL127926A0 (en) 1999-11-30
PT866720E (pt) 2004-06-30
DE69631544T2 (de) 2004-12-23
NZ512083A (en) 2003-02-28
CA2236163A1 (en) 1997-05-29
ATE259243T1 (de) 2004-02-15
EP1285664A3 (en) 2003-07-30
EP1285664A2 (en) 2003-02-26
ATE455554T1 (de) 2010-02-15
EP0866720A1 (en) 1998-09-30
JP4227325B2 (ja) 2009-02-18
EP0866720B1 (en) 2004-02-11
MX9803992A (es) 1998-09-30
ES2217327T3 (es) 2004-11-01
JP2000500492A (ja) 2000-01-18
AU7607496A (en) 1997-06-11
NZ511617A (en) 2003-08-29
AU4265300A (en) 2000-09-07
JP4173914B2 (ja) 2008-10-29
EP0956862A1 (en) 1999-11-17

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