DK0854723T3 - Substituerede pyrazolyl-benzensulfonamider til anvendelse ved veterinære terapier som antiinflammatoriske midler - Google Patents
Substituerede pyrazolyl-benzensulfonamider til anvendelse ved veterinære terapier som antiinflammatoriske midlerInfo
- Publication number
- DK0854723T3 DK0854723T3 DK96936018T DK96936018T DK0854723T3 DK 0854723 T3 DK0854723 T3 DK 0854723T3 DK 96936018 T DK96936018 T DK 96936018T DK 96936018 T DK96936018 T DK 96936018T DK 0854723 T3 DK0854723 T3 DK 0854723T3
- Authority
- DK
- Denmark
- Prior art keywords
- inflammatory agents
- veterinary therapies
- pyrazolylbenzenesulfonamides
- substituted
- substituted pyrazolylbenzenesulfonamides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/536,318 US5756529A (en) | 1995-09-29 | 1995-09-29 | Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies |
PCT/US1996/015538 WO1997011704A1 (fr) | 1995-09-29 | 1996-09-27 | Pyrazolyl benzenesulfonamides substitues destines a etre utilises dans des therapies veterinaires comme agents anti-inflammatoires |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0854723T3 true DK0854723T3 (da) | 2003-08-11 |
Family
ID=24138015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96936018T DK0854723T3 (da) | 1995-09-29 | 1996-09-27 | Substituerede pyrazolyl-benzensulfonamider til anvendelse ved veterinære terapier som antiinflammatoriske midler |
Country Status (21)
Country | Link |
---|---|
US (1) | US5756529A (fr) |
EP (1) | EP0854723B1 (fr) |
JP (1) | JPH11514991A (fr) |
KR (1) | KR100498730B1 (fr) |
CN (1) | CN1202828A (fr) |
AT (1) | ATE238058T1 (fr) |
AU (1) | AU718300B2 (fr) |
BR (1) | BR9610974A (fr) |
CA (1) | CA2233620C (fr) |
CZ (1) | CZ297183B6 (fr) |
DE (1) | DE69627683T2 (fr) |
DK (1) | DK0854723T3 (fr) |
ES (1) | ES2197954T3 (fr) |
IL (1) | IL123635A (fr) |
NO (1) | NO321157B1 (fr) |
NZ (1) | NZ320919A (fr) |
PL (1) | PL191934B1 (fr) |
PT (1) | PT854723E (fr) |
RO (1) | RO120408B1 (fr) |
RU (1) | RU2253456C2 (fr) |
WO (1) | WO1997011704A1 (fr) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6492411B1 (en) * | 1993-11-30 | 2002-12-10 | G. D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation |
EP0828718A1 (fr) | 1995-06-02 | 1998-03-18 | G.D. SEARLE & CO. | Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase |
US6087381A (en) * | 1997-05-22 | 2000-07-11 | G. D. Searle & Company | Pyrazole derivatives as p38 kinase inhibitors |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
TNSN99111A1 (fr) * | 1998-06-11 | 2005-11-10 | Pfizer | Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant. |
US6294558B1 (en) | 1999-05-31 | 2001-09-25 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
US6727238B2 (en) * | 1998-06-11 | 2004-04-27 | Pfizer Inc. | Sulfonylbenzene compounds as anti-inflammatory/analgesic agents |
SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
EP1158977B1 (fr) * | 1999-03-10 | 2005-10-12 | G.D. Searle LLC | Composition se rapportant a l'administration d'un inhibiteur de la cyclo-oxygenase-2 aux animaux |
ATE361748T1 (de) | 1999-06-16 | 2007-06-15 | Univ Temple | 1-(4-sulfamylphenyl)-3-trifluormethyl-5-aryl-2- pyrazoline als cyclooxygenase-2 inhibitoren |
DK1104758T3 (da) * | 1999-12-03 | 2003-10-20 | Pfizer Prod Inc | Acetylenderivativer som anti-inflammatoriske/analgesiske lægemidler |
CA2392931A1 (fr) | 1999-12-03 | 2001-06-07 | Pfizer Products Inc. | Derive heterocyclo-alkylsulfonyle pyrazole en tant qu'agents anti-inflammatoires/analgesiques |
ES2208227T3 (es) | 1999-12-03 | 2004-06-16 | Pfizer Products Inc. | Compuestos de heteroarilfenilpirazol como agentes antiinflamatorios/analgesicos. |
DE60001623T2 (de) | 1999-12-03 | 2003-12-18 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
CZ20012875A3 (cs) * | 1999-12-08 | 2002-02-13 | Pharmacia Corporation | Polymorfní krystalické formy celecoxibu |
KR100793668B1 (ko) * | 1999-12-08 | 2008-01-10 | 파마시아 코포레이션 | 강화된 생체이용률을 지닌 고체상 형태의 셀레콕시브 |
PT1239857E (pt) * | 1999-12-22 | 2006-07-31 | Pharmacia Corp | Composicoes de libertacao dupla de um inibidor de ciclo-oxigenase-2 |
AU2001253418A1 (en) * | 2000-04-12 | 2001-10-30 | Smith Kline Beecham Corporation | Compounds and methods |
CA2406226A1 (fr) * | 2000-04-18 | 2001-10-25 | Pharmacia Corporation | Formulation a effet therapeutique rapide contenant un inhibiteur selectif de la cyclooxygenase-2 |
WO2001081332A2 (fr) * | 2000-04-25 | 2001-11-01 | Pharmacia Corporation | Composes de 2-fluorobenzenesulfonyle utilises pour le traitement d'inflammations |
PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
US20030219461A1 (en) * | 2000-09-12 | 2003-11-27 | Britten Nancy J. | Parenteral combination therapy for infective conditions |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
US7695736B2 (en) | 2001-04-03 | 2010-04-13 | Pfizer Inc. | Reconstitutable parenteral composition |
US6673818B2 (en) | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
ES2241964T3 (es) | 2001-07-05 | 2005-11-01 | Pfizer Products Inc. | Heterocicloalquilsulfufonilpirazoles como agentes antiinflamatorios/abnalgesicos. |
US7076539B2 (en) * | 2001-07-30 | 2006-07-11 | Hewlett-Packard Development Company, L.P. | Network connectivity establishment at user log-in |
UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
EP1427706B1 (fr) * | 2001-09-19 | 2007-05-30 | Pharmacia Corporation | Composes de pyrazolo substitues pour le traitement de l'inflammation |
JP2005506983A (ja) | 2001-09-19 | 2005-03-10 | ファルマシア・コーポレーション | 炎症の治療のための置換ピラゾリル化合物 |
GT200200183A (es) | 2001-09-28 | 2003-05-23 | Procedimiento para preparar derivados de heterocicloalquilsulfonil pirazol | |
WO2003037330A1 (fr) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Sulfonylpyrazoles et sulfonyl-heteroaryl pyrazoles presentant un substituant hydrazinyle ou oxyde d'azote en position 5, servant d'inhibiteurs de la cyclooxygenase |
CA2464944A1 (fr) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Procede efficace de synthese de pyrazoles contenant cinq heteroatomes |
WO2003037351A1 (fr) | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Heterocyclo-alkylsulfonyle pyrazoles et leur utilisation comme inhibiteurs de cox-2 |
WO2003037335A1 (fr) * | 2001-11-02 | 2003-05-08 | Pfizer Products Inc. | Pyrazoles substitues a 5 heteroatomes |
EP1499597A4 (fr) * | 2002-04-08 | 2006-01-25 | Univ Ohio State Res Found | Composes et methodes permettant d'induire l'apoptose chez des cellules de proliferation |
EP1539679A4 (fr) | 2002-06-28 | 2007-07-04 | Nitromed Inc | Inhibiteurs a selectivite cyclooxygenase-2 nitrosiles et/ou nitroses contenant une oxime et/ou une hydrazone, compositions et methodes d'utilisation correspondantes |
UA79804C2 (en) | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
US7803787B2 (en) * | 2002-10-16 | 2010-09-28 | Arthrodynamic Technologies, Animal Health Division, Inc. | Composition and method for treating connective tissue damage by transmucosal administration |
US8455458B2 (en) | 2002-10-16 | 2013-06-04 | Arthrodynamic Technologies, Animal Health Division, Inc. | Composition and method for treating connective tissue damage |
US20080003258A1 (en) * | 2002-10-16 | 2008-01-03 | Marcum Frank D | Composition and Method for Treating Rheumatoid Arthritis |
US20080153894A1 (en) * | 2002-12-19 | 2008-06-26 | Pharmacia Corporation | Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis |
US20050009931A1 (en) * | 2003-03-20 | 2005-01-13 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
US20050004098A1 (en) * | 2003-03-20 | 2005-01-06 | Britten Nancy Jean | Dispersible formulation of an anti-inflammatory agent |
DK1608407T3 (da) * | 2003-03-20 | 2006-12-04 | Pharmacia Corp | Dispergébar formulering af et antiinflammatorisk middel |
US20040214753A1 (en) * | 2003-03-20 | 2004-10-28 | Britten Nancy Jean | Dispersible pharmaceutical composition for treatment of mastitis and otic disorders |
EP1534305B9 (fr) | 2003-05-07 | 2007-03-07 | Osteologix A/S | Sels de strontium hydrosolubles pour le traitement d'affections de cartilage et/ou d'os |
US20050131028A1 (en) * | 2003-09-11 | 2005-06-16 | Pharmacia Corporation | Methods and compositions for the extended duration treatment of pain, inflammation and inflammation-related disorders |
US7659426B2 (en) * | 2003-12-01 | 2010-02-09 | Reverse Proteomics Research Institute Co., Ltd. | Target protein of anticancer agent and novel anticancer agent (spnal) corresponding thereto |
US7250434B2 (en) | 2003-12-22 | 2007-07-31 | Janssen Pharmaceutica N.V. | CCK-1 receptor modulators |
ITMI20041032A1 (it) * | 2004-05-24 | 2004-08-24 | Neuroscienze S C A R L | Compositi farmaceutici |
US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
US8128460B2 (en) * | 2006-09-14 | 2012-03-06 | The Material Works, Ltd. | Method of producing rust inhibitive sheet metal through scale removal with a slurry blasting descaling cell |
TW200911240A (en) * | 2007-06-11 | 2009-03-16 | Kyowa Hakko Kogyo Kk | Anti-tumor agent |
US9186375B2 (en) | 2007-06-21 | 2015-11-17 | Arthrodynamic Technologies, Animal Health Division, Inc. | Glycosaminoglycan compositions in combination with stem cells |
EP2560966B1 (fr) | 2010-03-30 | 2021-01-06 | Verseon International Corporation | Composés aromatiques multisubstitués utilisés comme inhibiteurs de la thrombine |
CA2825519A1 (fr) * | 2011-02-03 | 2012-09-08 | Lupin Limited | Derives de pyrazole utilises comme modulateurs de nachr alpha-7 |
CN103242233B (zh) * | 2012-02-08 | 2014-07-30 | 北京博爱汇康医药科技有限责任公司 | 制备塞来昔布的新方法 |
WO2014012074A2 (fr) * | 2012-07-12 | 2014-01-16 | Euclises Pharmaceuticals, Inc. | Agents anticancéreux de coxib liés à un sulfonamide (liaison à l'azote) de nonoate à libération de no |
LT2968297T (lt) | 2013-03-15 | 2019-01-10 | Verseon Corporation | Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai |
EP2970141B1 (fr) | 2013-03-15 | 2020-02-26 | Verseon Corporation | Halogénopyrazoles en tant qu'inhibiteurs de la thrombine |
EP2886104A1 (fr) | 2013-12-11 | 2015-06-24 | Patir, Suleyman | Gel intra-articulaire |
CA2960790A1 (fr) | 2014-09-17 | 2016-03-24 | Verseon Corporation | Composes de pyridone substituee par pyrazolyl en tant qu'inhibiteurs de serine protease |
EP3261639B1 (fr) | 2015-02-27 | 2022-08-24 | Verseon International Corporation | Composés pyrazole substitués à utiliser en tant qu'inhibiteurs de sérine protéase |
CN107686465B (zh) * | 2017-09-02 | 2020-10-27 | 东北农业大学 | 地拉考昔的制备方法 |
CN114292235B (zh) * | 2021-12-29 | 2023-04-14 | 江苏天和制药有限公司 | 一种地拉考昔的制备和提纯方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3940418A (en) * | 1972-04-07 | 1976-02-24 | G. D. Searle & Co. | Esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds |
GB8814587D0 (en) * | 1988-06-20 | 1988-07-27 | Erba Carlo Spa | Condensed pyrazole 3-oxo-propanenitrile derivatives & process for their preparation |
PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
US5134155A (en) * | 1991-08-08 | 1992-07-28 | Ortho Pharmaceutical Corporation | Tetrahydroindazole, tetrahydrocyclopentapyrazole, and hexahydrocycloheptapyrazole compounds and their use as HMG-coA reductase inhibitors |
IL104311A (en) * | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
US5434178A (en) * | 1993-11-30 | 1995-07-18 | G.D. Searle & Co. | 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation |
ES2193609T3 (es) * | 1993-11-30 | 2003-11-01 | Searle & Co | Pirazolil-bencenosulfonamidas sustituidas y su uso como inhibidores de la ciclooxigenasa ii. |
US5475018A (en) * | 1993-11-30 | 1995-12-12 | G. D. Searle & Co. | 1,5-diphenyl pyrazole compounds for treatment of inflammation |
US5466823A (en) * | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
US5401765A (en) * | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
-
1995
- 1995-09-29 US US08/536,318 patent/US5756529A/en not_active Expired - Lifetime
-
1996
- 1996-09-27 ES ES96936018T patent/ES2197954T3/es not_active Expired - Lifetime
- 1996-09-27 WO PCT/US1996/015538 patent/WO1997011704A1/fr active IP Right Grant
- 1996-09-27 JP JP9513685A patent/JPH11514991A/ja not_active Abandoned
- 1996-09-27 DE DE69627683T patent/DE69627683T2/de not_active Expired - Lifetime
- 1996-09-27 AT AT96936018T patent/ATE238058T1/de active
- 1996-09-27 KR KR10-1998-0702346A patent/KR100498730B1/ko not_active IP Right Cessation
- 1996-09-27 CN CN96198561A patent/CN1202828A/zh active Pending
- 1996-09-27 PL PL325952A patent/PL191934B1/pl unknown
- 1996-09-27 NZ NZ320919A patent/NZ320919A/en not_active IP Right Cessation
- 1996-09-27 AU AU73768/96A patent/AU718300B2/en not_active Expired
- 1996-09-27 DK DK96936018T patent/DK0854723T3/da active
- 1996-09-27 PT PT96936018T patent/PT854723E/pt unknown
- 1996-09-27 IL IL12363596A patent/IL123635A/xx not_active IP Right Cessation
- 1996-09-27 CA CA2233620A patent/CA2233620C/fr not_active Expired - Lifetime
- 1996-09-27 EP EP96936018A patent/EP0854723B1/fr not_active Expired - Lifetime
- 1996-09-27 CZ CZ0089798A patent/CZ297183B6/cs not_active IP Right Cessation
- 1996-09-27 RU RU98107643/13A patent/RU2253456C2/ru active
- 1996-09-27 RO RO98-00799A patent/RO120408B1/ro unknown
-
1998
- 1998-03-27 NO NO19981392A patent/NO321157B1/no not_active IP Right Cessation
- 1998-03-30 BR BR9610974A patent/BR9610974A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CZ297183B6 (cs) | 2006-09-13 |
DE69627683T2 (de) | 2003-12-18 |
IL123635A0 (en) | 1998-10-30 |
ES2197954T3 (es) | 2004-01-16 |
AU7376896A (en) | 1997-04-17 |
NO981392L (no) | 1998-05-25 |
RO120408B1 (ro) | 2006-01-30 |
CN1202828A (zh) | 1998-12-23 |
PT854723E (pt) | 2003-08-29 |
EP0854723A1 (fr) | 1998-07-29 |
US5756529A (en) | 1998-05-26 |
RU2253456C2 (ru) | 2005-06-10 |
WO1997011704A1 (fr) | 1997-04-03 |
NO321157B1 (no) | 2006-03-27 |
EP0854723B1 (fr) | 2003-04-23 |
IL123635A (en) | 2003-06-24 |
BR9610974A (pt) | 1999-07-13 |
KR100498730B1 (ko) | 2005-09-09 |
CA2233620C (fr) | 2011-11-22 |
PL325952A1 (en) | 1998-08-17 |
NZ320919A (en) | 1999-10-28 |
NO981392D0 (no) | 1998-03-27 |
DE69627683D1 (de) | 2003-05-28 |
PL191934B1 (pl) | 2006-07-31 |
CZ89798A3 (cs) | 1999-04-14 |
AU718300B2 (en) | 2000-04-13 |
JPH11514991A (ja) | 1999-12-21 |
KR19990063874A (ko) | 1999-07-26 |
ATE238058T1 (de) | 2003-05-15 |
CA2233620A1 (fr) | 1997-04-03 |
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