DK0835316T3 - Phenyl-acetyl-ligase ud fra Penicillium chysogenum - Google Patents

Phenyl-acetyl-ligase ud fra Penicillium chysogenum

Info

Publication number
DK0835316T3
DK0835316T3 DK96923946T DK96923946T DK0835316T3 DK 0835316 T3 DK0835316 T3 DK 0835316T3 DK 96923946 T DK96923946 T DK 96923946T DK 96923946 T DK96923946 T DK 96923946T DK 0835316 T3 DK0835316 T3 DK 0835316T3
Authority
DK
Denmark
Prior art keywords
ligase
acetyl
phenyl
penicillium
chysogenum
Prior art date
Application number
DK96923946T
Other languages
English (en)
Inventor
Linden-Smithkline Bee Gledhill
Philip Andrew-Smithkli Greaves
John Patrick-Smithklin Griffin
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of DK0835316T3 publication Critical patent/DK0835316T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/02—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin in presence of phenylacetic acid or phenylacetamide or their derivatives not to be used

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK96923946T 1995-06-30 1996-06-26 Phenyl-acetyl-ligase ud fra Penicillium chysogenum DK0835316T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9513403.7A GB9513403D0 (en) 1995-06-30 1995-06-30 Novel product
PCT/EP1996/002799 WO1997002349A1 (en) 1995-06-30 1996-06-26 PHENYLACETYL-CoA LIGASE FROM PENICILLIUM CHRYSOGENUM

Publications (1)

Publication Number Publication Date
DK0835316T3 true DK0835316T3 (da) 2003-08-25

Family

ID=10776961

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96923946T DK0835316T3 (da) 1995-06-30 1996-06-26 Phenyl-acetyl-ligase ud fra Penicillium chysogenum

Country Status (17)

Country Link
US (1) US6245524B1 (da)
EP (1) EP0835316B1 (da)
JP (1) JP3819429B2 (da)
KR (1) KR100455054B1 (da)
CN (1) CN1145699C (da)
AT (1) ATE239081T1 (da)
AU (1) AU6417396A (da)
DE (1) DE69627856T2 (da)
DK (1) DK0835316T3 (da)
ES (1) ES2198493T3 (da)
GB (1) GB9513403D0 (da)
HK (1) HK1010213A1 (da)
MX (1) MX9800212A (da)
PL (2) PL186765B1 (da)
PT (1) PT835316E (da)
SI (1) SI0835316T1 (da)
WO (1) WO1997002349A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010085A1 (en) 1994-09-28 1996-04-04 Gist-Brocades B.V. PROCESS OF PRODUCING β-LACTAM ANTIBIOTICS APPLYING MICROORGANISMS WITH INCREASED LIGASE ACTIVITY
ES2108651B1 (es) 1996-03-18 1998-07-16 Antibioticos Sa Procedimiento para incrementar la produccion de penicilina g (bencilpenicilina) en penicillium chrysogenum mediante la expresion del gen pcl.
ES2220176B1 (es) * 2002-05-27 2006-02-16 Universidad De Extremadura Nuevo enzima protelotico, procedimiento para su obtencion y aplicaciones.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996010085A1 (en) * 1994-09-28 1996-04-04 Gist-Brocades B.V. PROCESS OF PRODUCING β-LACTAM ANTIBIOTICS APPLYING MICROORGANISMS WITH INCREASED LIGASE ACTIVITY

Also Published As

Publication number Publication date
CN1194002A (zh) 1998-09-23
US6245524B1 (en) 2001-06-12
JP3819429B2 (ja) 2006-09-06
MX9800212A (es) 1998-04-30
PL324225A1 (en) 1998-05-11
WO1997002349A1 (en) 1997-01-23
SI0835316T1 (en) 2003-12-31
HK1010213A1 (en) 1999-06-17
PL186765B1 (pl) 2004-02-27
GB9513403D0 (en) 1995-09-06
DE69627856T2 (de) 2004-03-11
CN1145699C (zh) 2004-04-14
KR19990028533A (ko) 1999-04-15
JPH11508450A (ja) 1999-07-27
ES2198493T3 (es) 2004-02-01
EP0835316A1 (en) 1998-04-15
AU6417396A (en) 1997-02-05
PL188190B1 (pl) 2004-12-31
ATE239081T1 (de) 2003-05-15
PT835316E (pt) 2003-08-29
EP0835316B1 (en) 2003-05-02
DE69627856D1 (de) 2003-06-05
KR100455054B1 (ko) 2005-01-17

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