ES2006988A6 - Procedimiento de preparar hidrocloruro cloruro-2-(2-aminotiazol-4-il)-2-metoxiiminoacetil-sulfito-dimetilformiminio y procedimiento de utilizacion del mismo para obtencion de amidas. - Google Patents

Procedimiento de preparar hidrocloruro cloruro-2-(2-aminotiazol-4-il)-2-metoxiiminoacetil-sulfito-dimetilformiminio y procedimiento de utilizacion del mismo para obtencion de amidas.

Info

Publication number
ES2006988A6
ES2006988A6 ES8801910A ES8801910A ES2006988A6 ES 2006988 A6 ES2006988 A6 ES 2006988A6 ES 8801910 A ES8801910 A ES 8801910A ES 8801910 A ES8801910 A ES 8801910A ES 2006988 A6 ES2006988 A6 ES 2006988A6
Authority
ES
Spain
Prior art keywords
intermediates therefor
preparing cephalosporins
cephalosporins
preparing
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8801910A
Other languages
English (en)
Inventor
Meseguer Jose Diago
Bianchini Asuncion Esteve
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz Industrial Products SA
Original Assignee
Gema SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gema SA filed Critical Gema SA
Priority to ES8801910A priority Critical patent/ES2006988A6/es
Publication of ES2006988A6 publication Critical patent/ES2006988A6/es
Priority to DE68919282T priority patent/DE68919282T2/de
Priority to AT89111004T priority patent/ATE113939T1/de
Priority to ES89111004T priority patent/ES2065944T3/es
Priority to EP89111004A priority patent/EP0347777B1/en
Priority to JP1158126A priority patent/JPH0245478A/ja
Priority to US07/367,656 priority patent/US5037988A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCEDIMIENTO DE PREPARAR HIDROCLORURO CLORURO-2-(2-AMINOTIAZOL-4-IL)-2-METAXIIMINOACETIL-SULFITO-DIMETILFORMIMINIO (DE FORMULA I) Y PROCEDIMIENTO DE UTILIZACION DEL MISMO PARA OBTENCION DE AMIDAS, EN QUE EL PRIMER PROCEDIMIENTO ESTA BASADO EN LA REACCION DELCLORURO-CLOROSULFITO DE DIMETILFORMINIO CON EL ACIDO 2-(2-AMINOTIAZOL-4-IL)-2-METOXIIMINIO-ACETICO, DE DONDE RESULTA EL COMPUESTO DE FORMULA I. ESTE COMPUESTO, POR REACCION CON UNA AMINA, R1-NH2, ES UTILIZADO PARA LA OBTENCION DE AMIDAS DE FORMULA
ES8801910A 1988-06-20 1988-06-20 Procedimiento de preparar hidrocloruro cloruro-2-(2-aminotiazol-4-il)-2-metoxiiminoacetil-sulfito-dimetilformiminio y procedimiento de utilizacion del mismo para obtencion de amidas. Expired ES2006988A6 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES8801910A ES2006988A6 (es) 1988-06-20 1988-06-20 Procedimiento de preparar hidrocloruro cloruro-2-(2-aminotiazol-4-il)-2-metoxiiminoacetil-sulfito-dimetilformiminio y procedimiento de utilizacion del mismo para obtencion de amidas.
DE68919282T DE68919282T2 (de) 1988-06-20 1989-06-16 Verfahren zur Herstellung von Cephalosporin und Zwischenverbindungen.
AT89111004T ATE113939T1 (de) 1988-06-20 1989-06-16 Verfahren zur herstellung von cephalosporin und zwischenverbindungen.
ES89111004T ES2065944T3 (es) 1988-06-20 1989-06-16 Proceso para preparar cefalosporinas e intermedios para las mismas.
EP89111004A EP0347777B1 (en) 1988-06-20 1989-06-16 Process for preparing cephalosporins and intermediates therefor
JP1158126A JPH0245478A (ja) 1988-06-20 1989-06-19 セファロスポリン類の製法および中間体
US07/367,656 US5037988A (en) 1988-06-20 1989-06-19 Process for preparing cephalosporins and intermediates therefor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES8801910A ES2006988A6 (es) 1988-06-20 1988-06-20 Procedimiento de preparar hidrocloruro cloruro-2-(2-aminotiazol-4-il)-2-metoxiiminoacetil-sulfito-dimetilformiminio y procedimiento de utilizacion del mismo para obtencion de amidas.

Publications (1)

Publication Number Publication Date
ES2006988A6 true ES2006988A6 (es) 1989-05-16

Family

ID=8256891

Family Applications (2)

Application Number Title Priority Date Filing Date
ES8801910A Expired ES2006988A6 (es) 1988-06-20 1988-06-20 Procedimiento de preparar hidrocloruro cloruro-2-(2-aminotiazol-4-il)-2-metoxiiminoacetil-sulfito-dimetilformiminio y procedimiento de utilizacion del mismo para obtencion de amidas.
ES89111004T Expired - Lifetime ES2065944T3 (es) 1988-06-20 1989-06-16 Proceso para preparar cefalosporinas e intermedios para las mismas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES89111004T Expired - Lifetime ES2065944T3 (es) 1988-06-20 1989-06-16 Proceso para preparar cefalosporinas e intermedios para las mismas.

Country Status (6)

Country Link
US (1) US5037988A (es)
EP (1) EP0347777B1 (es)
JP (1) JPH0245478A (es)
AT (1) ATE113939T1 (es)
DE (1) DE68919282T2 (es)
ES (2) ES2006988A6 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423459D0 (en) * 1994-11-21 1995-01-11 Biochemie Gmbh Silylation process
AT402928B (de) * 1994-12-23 1997-09-25 Biochemie Gmbh Neues verfahren zur herstellung von cefotaxim
IN181459B (es) * 1995-12-26 1998-06-20 Lupin Lab Ltd
EP0791597B1 (en) * 1996-02-21 2000-07-12 Lupin Laboratories Limited Method for manufacture of cephalosporins and intermediates thereof
EP0791596A1 (en) * 1996-02-21 1997-08-27 Lupin Laboratories Limited Method for manufacture of cephalosporins and intermediates thereof
US6610845B1 (en) 2002-01-04 2003-08-26 Orchid Chemicals & Pharmaceuticals Limited, India Thioester derivatives of thiazolyl acetic acid and their use in the preparation of cephalosporin compounds
WO2004058695A1 (en) * 2002-12-26 2004-07-15 Lupin Limited Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates
EP1704153A2 (en) * 2004-01-16 2006-09-27 Wockhardt Limited Improved process for the production of cefotaxime sodium
CN102702233A (zh) * 2012-05-18 2012-10-03 苏州中联化学制药有限公司 头孢曲松钠的制备方法
CN109503630A (zh) * 2018-12-14 2019-03-22 河北合佳医药科技集团股份有限公司 一种去乙酰头孢噻肟的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2060460A5 (es) * 1968-12-21 1971-06-18 Coll Antonio
US4871860A (en) * 1976-04-12 1989-10-03 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3,7-disubstituted-3-cephem-4-caroxylic acid compounds and processes for the preparation thereof
FR2462439A1 (fr) * 1979-07-26 1981-02-13 Roussel Uclaf Nouveau procede de preparation de produits derives de l'acide 7-/(2-aryl) 2-hydroxyimino acetamido/cephalosporanique
DE3419015A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von cephalosporinen
DE3542644A1 (de) * 1985-12-03 1987-06-04 Hoechst Ag Verfahren zur herstellung von cefodizim

Also Published As

Publication number Publication date
DE68919282D1 (de) 1994-12-15
DE68919282T2 (de) 1995-05-24
EP0347777A3 (en) 1991-08-28
JPH0245478A (ja) 1990-02-15
EP0347777B1 (en) 1994-11-09
ES2065944T3 (es) 1995-03-01
US5037988A (en) 1991-08-06
EP0347777A2 (en) 1989-12-27
ATE113939T1 (de) 1994-11-15

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Owner name: BIOCHEMIE S.A.