DK0802909T3 - Substituerede oxazolidiner som calpain- og/eller cathepsin B-inhibitorer - Google Patents

Substituerede oxazolidiner som calpain- og/eller cathepsin B-inhibitorer

Info

Publication number
DK0802909T3
DK0802909T3 DK95943478T DK95943478T DK0802909T3 DK 0802909 T3 DK0802909 T3 DK 0802909T3 DK 95943478 T DK95943478 T DK 95943478T DK 95943478 T DK95943478 T DK 95943478T DK 0802909 T3 DK0802909 T3 DK 0802909T3
Authority
DK
Denmark
Prior art keywords
calpain
cathepsin
inhibitors
substituted oxazolidines
oxazolidines
Prior art date
Application number
DK95943478T
Other languages
Danish (da)
English (en)
Inventor
Norton P Peet
Shujaath Mehdi
Matthew D Linnik
Michael R Angelastro
Hwa-Ok Kim
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK0802909T3 publication Critical patent/DK0802909T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK95943478T 1995-01-11 1995-12-15 Substituerede oxazolidiner som calpain- og/eller cathepsin B-inhibitorer DK0802909T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37119295A 1995-01-11 1995-01-11
PCT/US1995/016565 WO1996021655A2 (en) 1995-01-11 1995-12-15 Substituted oxazolidine calpain and/or cathepsin b inhibitors

Publications (1)

Publication Number Publication Date
DK0802909T3 true DK0802909T3 (da) 2002-01-28

Family

ID=23462894

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95943478T DK0802909T3 (da) 1995-01-11 1995-12-15 Substituerede oxazolidiner som calpain- og/eller cathepsin B-inhibitorer

Country Status (23)

Country Link
US (1) US5691368A (de)
EP (1) EP0802909B1 (de)
JP (1) JP4157601B2 (de)
KR (1) KR100393701B1 (de)
CN (1) CN1088456C (de)
AR (1) AR001787A1 (de)
AT (1) ATE206413T1 (de)
AU (1) AU692044B2 (de)
CA (1) CA2210258C (de)
DE (1) DE69523072T2 (de)
DK (1) DK0802909T3 (de)
ES (1) ES2165441T3 (de)
FI (1) FI972935A0 (de)
HU (1) HUT77649A (de)
IL (1) IL116724A (de)
MX (1) MX9705235A (de)
NO (1) NO309267B1 (de)
NZ (1) NZ298999A (de)
PT (1) PT802909E (de)
SI (1) SI0802909T1 (de)
TW (1) TW454001B (de)
WO (1) WO1996021655A2 (de)
ZA (1) ZA96100B (de)

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TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
US6506733B1 (en) 1999-03-15 2003-01-14 Axys Pharmaceuticals, Inc. Compounds and compositions as protease inhibitors
US6420364B1 (en) * 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
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ATE318809T1 (de) * 1999-11-05 2006-03-15 Sod Conseils Rech Applic Heterocyclische verbindungen und ihre verwendung als medikamente
AU2001278084A1 (en) * 2000-07-31 2002-02-13 The Regents Of The University Of California Model for alzheimer's disease and other neurodegenerative diseases
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
MXPA03005601A (es) 2000-12-22 2004-12-02 Axys Pharm Inc Nuevos compuestos y composiciones como inhibidores de catepsina.
RU2316546C2 (ru) 2001-09-14 2008-02-10 Авентис Фармасьютикалз Инк. Новые соединения в качестве ингибиторов катепсина, фармацевтическая композиция на их основе, их применение и способ их получения
CA2467391A1 (en) 2001-11-14 2003-05-22 Aventis Pharmaceuticals Inc. Oligopeptides and compositions containing them as cathepsin s inhibitors
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US7384970B2 (en) * 2003-03-24 2008-06-10 Irm Llc Inhibitors of cathepsin S
US7109243B2 (en) * 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
WO2004089395A2 (en) * 2003-04-01 2004-10-21 Aventis Pharmaceuticals Inc. Use of an inhibitor of cathepsin-s or -b to treat or prevent chronic obstructive pulmonary disease
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US7173051B2 (en) * 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
US7256207B2 (en) * 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
FR2863268B1 (fr) * 2003-12-09 2006-02-24 Sod Conseils Rech Applic Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
EP2481408A3 (de) 2007-03-01 2013-01-09 Probiodrug AG Neue Verwendung von Inhibitoren der Glutaminyl Cyclase
EP2865670B1 (de) 2007-04-18 2017-01-11 Probiodrug AG Thioharnstoffderivative als Glutaminylcyclaseinhibitoren
EP2300000A1 (de) * 2008-07-03 2011-03-30 University of Massachusetts Verfahren und zusammensetzungen zur entzündungsminderung und behandlung von entzündungserkrankungen
EP2475428B1 (de) 2009-09-11 2015-07-01 Probiodrug AG Heterocyclische derivate als glutaminylcyclase-hemmer
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
CN102791704B (zh) 2010-03-10 2015-11-25 前体生物药物股份公司 谷氨酰胺酰环化酶(qc, ec 2.3.2.5)的杂环抑制剂
EP2560953B1 (de) 2010-04-21 2016-01-06 Probiodrug AG Hemmer der glutaminylzyklase
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
WO2024018245A1 (en) 2022-07-22 2024-01-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of calpain inhibitors for the treatment of the diabetic kidney disease

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Also Published As

Publication number Publication date
WO1996021655A3 (en) 1996-09-06
CA2210258A1 (en) 1996-07-18
EP0802909B1 (de) 2001-10-04
PT802909E (pt) 2002-03-28
AR001787A1 (es) 1997-12-10
DE69523072D1 (en) 2001-11-08
WO1996021655A2 (en) 1996-07-18
US5691368A (en) 1997-11-25
ES2165441T3 (es) 2002-03-16
TW454001B (en) 2001-09-11
IL116724A (en) 2000-08-31
JP4157601B2 (ja) 2008-10-01
AU4473196A (en) 1996-07-31
AU692044B2 (en) 1998-05-28
SI0802909T1 (en) 2002-02-28
ATE206413T1 (de) 2001-10-15
FI972935A (fi) 1997-07-10
MX9705235A (es) 1997-10-31
CN1088456C (zh) 2002-07-31
FI972935A0 (fi) 1997-07-10
KR100393701B1 (ko) 2003-11-28
ZA96100B (en) 1996-07-24
JPH10512257A (ja) 1998-11-24
EP0802909A2 (de) 1997-10-29
DE69523072T2 (de) 2002-06-20
NZ298999A (en) 1999-01-28
NO973216L (no) 1997-09-09
CA2210258C (en) 2002-10-01
HUT77649A (hu) 1998-07-28
CN1173174A (zh) 1998-02-11
IL116724A0 (en) 1996-05-14
NO309267B1 (no) 2001-01-08
NO973216D0 (no) 1997-07-10

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