DK0784613T3 - Colchicinderivater og den terapeutiske anvendelse deraf - Google Patents

Colchicinderivater og den terapeutiske anvendelse deraf

Info

Publication number
DK0784613T3
DK0784613T3 DK95935393T DK95935393T DK0784613T3 DK 0784613 T3 DK0784613 T3 DK 0784613T3 DK 95935393 T DK95935393 T DK 95935393T DK 95935393 T DK95935393 T DK 95935393T DK 0784613 T3 DK0784613 T3 DK 0784613T3
Authority
DK
Denmark
Prior art keywords
colchicine derivatives
therapeutic use
derivatives
colchicine
antitumoral
Prior art date
Application number
DK95935393T
Other languages
Danish (da)
English (en)
Inventor
Ezio Bombardelli
Bruno Gabetta
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Application granted granted Critical
Publication of DK0784613T3 publication Critical patent/DK0784613T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DK95935393T 1994-10-05 1995-09-27 Colchicinderivater og den terapeutiske anvendelse deraf DK0784613T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI942026A IT1270124B (it) 1994-10-05 1994-10-05 Derivati della colchicina e loro impiego terapeutico
PCT/EP1995/003823 WO1996011184A1 (en) 1994-10-05 1995-09-27 Colchicine derivatives and the therapeutical use thereof

Publications (1)

Publication Number Publication Date
DK0784613T3 true DK0784613T3 (da) 1999-11-15

Family

ID=11369650

Family Applications (2)

Application Number Title Priority Date Filing Date
DK95935393T DK0784613T3 (da) 1994-10-05 1995-09-27 Colchicinderivater og den terapeutiske anvendelse deraf
DK98121484T DK0909763T3 (da) 1994-10-05 1995-09-27 Colchicin-derivater og terapeutisk anvendelse deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK98121484T DK0909763T3 (da) 1994-10-05 1995-09-27 Colchicin-derivater og terapeutisk anvendelse deraf

Country Status (23)

Country Link
US (1) US5843910A (fi)
EP (2) EP0784613B1 (fi)
JP (1) JP2921990B2 (fi)
KR (1) KR100255074B1 (fi)
CN (2) CN1075059C (fi)
AT (2) ATE181060T1 (fi)
AU (1) AU692624B2 (fi)
CA (1) CA2201723C (fi)
CZ (1) CZ290309B6 (fi)
DE (2) DE69510212T2 (fi)
DK (2) DK0784613T3 (fi)
ES (2) ES2131863T3 (fi)
FI (1) FI120452B (fi)
GR (1) GR3030449T3 (fi)
HK (2) HK1001394A1 (fi)
HU (1) HU223779B1 (fi)
IT (1) IT1270124B (fi)
NO (1) NO308030B1 (fi)
PL (1) PL182204B1 (fi)
PT (1) PT909763E (fi)
RU (1) RU2145598C1 (fi)
SK (1) SK281831B6 (fi)
WO (1) WO1996011184A1 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
FR2779147B1 (fr) * 1998-05-27 2000-06-30 Synthelabo Derive de thiocolchicoside sa preparation et son application en therapeutique
US6433187B1 (en) 1998-12-17 2002-08-13 Tularik Inc. Certain polycyclic compounds useful as tubulin-binding agents
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
US6399093B1 (en) 1999-05-19 2002-06-04 Advanced Medical Instruments Method and composition to treat musculoskeletal disorders
US6720323B2 (en) * 2000-07-07 2004-04-13 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
AU6623301A (en) * 2000-07-07 2002-01-21 Angiogene Pharm Ltd Colchinol derivatives as vascular damaging agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.
PL2128170T3 (pl) * 2008-05-28 2011-05-31 Indena Spa Sposób glikozydacji kolchicyny i tiokolchicyny
WO2011022805A1 (en) 2009-08-26 2011-03-03 Alberta Health Services Novel colchicine derivatives, methods and uses thereof
EP3207026B1 (en) 2014-10-14 2018-12-12 Council of Scientific and Industrial Research 10-substituted colchicinoids as potent anticancer agents
WO2023077977A1 (zh) * 2021-11-08 2023-05-11 天津市昕晨投资发展有限公司 秋水仙碱衍生物的制备方法及其用途
CN114907228B (zh) * 2022-06-27 2023-11-28 深圳市锦泰医药科技合伙企业(有限合伙) 一种秋水仙碱和厚朴酚复合物及其合成方法以及在抗新冠病毒方面的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH513119A (de) * 1968-02-23 1971-09-30 Merck Patent Gmbh Verfahren zur Herstellung neuer Halogencolchicinderivate
GB1345991A (en) * 1972-05-05 1974-02-06 Roussel Uclaf Thiocolchicine derivatives
EP0356137B1 (en) * 1988-08-24 1994-10-26 Advance Biofactures Corporation Carbonates of 3-demethylthiocolchicine and N-acyl analogs

Also Published As

Publication number Publication date
HK1001394A1 (en) 1998-06-19
ES2224322T3 (es) 2005-03-01
PL319455A1 (en) 1997-08-04
NO308030B1 (no) 2000-07-10
DE69533267D1 (de) 2004-08-19
US5843910A (en) 1998-12-01
ATE271061T1 (de) 2004-07-15
ATE181060T1 (de) 1999-06-15
PT909763E (pt) 2004-10-29
AU3743295A (en) 1996-05-02
KR100255074B1 (ko) 2000-05-01
CZ290309B6 (cs) 2002-07-17
DE69510212D1 (de) 1999-07-15
WO1996011184A1 (en) 1996-04-18
ITMI942026A1 (it) 1996-04-05
CA2201723C (en) 2003-03-25
AU692624B2 (en) 1998-06-11
CN1075059C (zh) 2001-11-21
RU2145598C1 (ru) 2000-02-20
EP0909763B1 (en) 2004-07-14
FI971364A (fi) 1997-05-30
ITMI942026A0 (it) 1994-10-05
NO971503D0 (no) 1997-04-03
EP0909763A2 (en) 1999-04-21
EP0909763A3 (en) 2003-01-22
CN1159801A (zh) 1997-09-17
FI120452B (fi) 2009-10-30
SK281831B6 (sk) 2001-08-06
NO971503L (no) 1997-05-14
HK1017361A1 (en) 1999-11-19
CN1308059A (zh) 2001-08-15
EP0784613A1 (en) 1997-07-23
DK0909763T3 (da) 2004-11-22
DE69510212T2 (de) 1999-11-11
CZ101597A3 (en) 1997-10-15
GR3030449T3 (en) 1999-09-30
CN1127480C (zh) 2003-11-12
CA2201723A1 (en) 1996-04-18
SK42497A3 (en) 1997-11-05
IT1270124B (it) 1997-04-28
HU223779B1 (hu) 2005-01-28
FI971364A0 (fi) 1997-04-03
PL182204B1 (en) 2001-11-30
ES2131863T3 (es) 1999-08-01
DE69533267T2 (de) 2005-08-04
HUT77223A (hu) 1998-03-02
JP2921990B2 (ja) 1999-07-19
JPH10507169A (ja) 1998-07-14
EP0784613B1 (en) 1999-06-09

Similar Documents

Publication Publication Date Title
IS1846B (is) Setin N-(indól-2-karbónýl)-b-alaninamíð, notkun þeirra og lyfjaefnablöndur
DK0784613T3 (da) Colchicinderivater og den terapeutiske anvendelse deraf
NO306398B1 (no) Substituerte N-(indol-2-karbonyl) glycinamider, anvendelse derav, mellomprodukt og farmasöytisk preparat
IS1812B (is) Meðferðaefnasambönd, lyfjafræðilega hæf sölt og samsetningar sem innihalda efnasamböndin, ásamt notkun þeirra
NO20016198L (no) Orale farmasöytiske sammensetninger som inneholder taxaner og fremgangsmåter for anvendelse av samme i behandling
NO307092B1 (no) Sordaridin-derivater, anvendelse derav og farmasoeytisk blanding
NO308533B1 (no) Heteroarylaminer, anvendelse derav og farmasøytisk preparat
ATE261972T1 (de) 2,5-diazabicyclo(2.2.1)heptanderivate, deren herstellung und deren verwendung in heilkunde
NO972451D0 (no) 2-heterocyklyloksy og tiometyl-1,2,5-tiadiazolidin-3-on 1,1-dioksider og preparater og fremgangsmåte for anvendelse derav
IT219016Z2 (it) "pinza per saldatura perfezionata ad anidride carbonica"
DE69312319T2 (de) Tachyquinin antagonisten, ihre herstellung und ihre verwendung in pharmazeutischen formulierungen
NO302170B1 (no) Enantiomerisk 1-fenyl-2-(2-pyridinyl)etylamin, farmasöytisk formulering og anvendelse derav
ITMI911470A0 (it) N-(5-tioxo-l-prolil)-l-cisteina e suoi derivati, loro preparazione ed impiego terapeutico
FR2779429B1 (fr) Derives d'oxindole, leurs preparations et leurs applications en therapeutique
IS6159A (is) Fjölgervingar af kristölluðu asabísýkló (2,2,2) oktan-3-amín sítrati og lyfjasamsetningar
EE9600197A (et) Uudsed 1,1-bis(heteroasolüül)alkaani derivaadid ja nende kasutamine neuroprotektiivsete ainetena
FR2672796B1 (fr) Arc facial orthodontique perfectionne.
IS2024B (is) Indól og 2,3-díhýdróindól afleiður, framleiðsla þeirra og notkun
ITMO920074A1 (it) Spazzolino da denti perfezionato
DE69111530D1 (de) Pyridincarbonsäure-Amid-Derivate und diese enthaltende pharmazeutische Zusammensetzungen.
FR2710832B1 (fr) Articulateur dentaire.
ITVI960022V0 (it) Dispositivo perfezionato per la depurazione e l'ossigenazione dell'aria ambiente.
IT234739Y1 (it) Testiera senza morzo da usare al posto della classica imboccatura per i cavalli
ITMI940711A0 (it) Specchio orale da dentista
NO952658D0 (no) Tann-og munnpleiemiddel og fremgangsmåte til fremstilling derav