DK0752854T3 - Pyrimidin- eller triazincarboxylsyrederivater til anvendelse som lægemiddel - Google Patents

Pyrimidin- eller triazincarboxylsyrederivater til anvendelse som lægemiddel

Info

Publication number
DK0752854T3
DK0752854T3 DK95914301T DK95914301T DK0752854T3 DK 0752854 T3 DK0752854 T3 DK 0752854T3 DK 95914301 T DK95914301 T DK 95914301T DK 95914301 T DK95914301 T DK 95914301T DK 0752854 T3 DK0752854 T3 DK 0752854T3
Authority
DK
Denmark
Prior art keywords
pyrimidine
drug
carboxylic acid
acid derivatives
pct
Prior art date
Application number
DK95914301T
Other languages
Danish (da)
English (en)
Inventor
Ernst Baumann
Joachim Rheinheimer
Uwe Josef Vogelbacher
Claus Bollschweiler
Liliane Unger
Dagmar Klinge
Manfred Raschack
Wolfgang Wernet
Hartmut Riechers
Burkhard Kroeger
Siegfried Bialojan
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0752854T3 publication Critical patent/DK0752854T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK95914301T 1994-03-31 1995-03-23 Pyrimidin- eller triazincarboxylsyrederivater til anvendelse som lægemiddel DK0752854T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4411225A DE4411225A1 (de) 1994-03-31 1994-03-31 Verwendung von Carbonsäurederivaten als Arzneimittel
PCT/EP1995/001099 WO1995026716A1 (de) 1994-03-31 1995-03-23 Pyrimidin- oder triazincarbonsäurederivate zur verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DK0752854T3 true DK0752854T3 (da) 2001-10-08

Family

ID=6514334

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95914301T DK0752854T3 (da) 1994-03-31 1995-03-23 Pyrimidin- eller triazincarboxylsyrederivater til anvendelse som lægemiddel

Country Status (28)

Country Link
US (1) US5840722A (ja)
EP (1) EP0752854B1 (ja)
JP (2) JP4001622B2 (ja)
KR (1) KR100365629B1 (ja)
CN (1) CN1070701C (ja)
AT (1) ATE204471T1 (ja)
AU (1) AU695193B2 (ja)
BR (1) BR9507231A (ja)
CA (1) CA2186784C (ja)
CZ (1) CZ290684B6 (ja)
DE (2) DE4411225A1 (ja)
DK (1) DK0752854T3 (ja)
ES (1) ES2162916T3 (ja)
FI (1) FI118589B (ja)
GR (1) GR3036606T3 (ja)
HR (1) HRP950115B1 (ja)
HU (1) HU228063B1 (ja)
IL (1) IL113137A (ja)
NO (1) NO310497B1 (ja)
NZ (1) NZ283333A (ja)
PL (1) PL179580B1 (ja)
PT (1) PT752854E (ja)
RU (1) RU2163808C2 (ja)
SI (1) SI9520048A (ja)
TW (1) TW382594B (ja)
UA (1) UA44734C2 (ja)
WO (1) WO1995026716A1 (ja)
ZA (1) ZA952614B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4411225A1 (de) * 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel
DE19533023B4 (de) 1994-10-14 2007-05-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19536891A1 (de) * 1995-10-04 1997-04-10 Basf Ag Neue Aminosäurederivate, ihre Herstellung und Verwendung
DE19614533A1 (de) 1996-04-12 1997-10-16 Basf Ag Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung
DE19636046A1 (de) 1996-09-05 1998-03-12 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten
US6030975A (en) * 1997-03-14 2000-02-29 Basf Aktiengesellschaft Carboxylic acid derivatives, their preparation and use in treating cancer
DE19726146A1 (de) * 1997-06-19 1998-12-24 Basf Ag Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten
ID25620A (id) * 1997-09-04 2000-10-19 Basf Ag Turunan-turunan asam karboksilat baru, pembuatannya dan penggunaannya sebagai campuran reseptor antagonis et a/et b
SK4592000A3 (en) 1997-10-31 2000-12-11 Basf Ag Novel carboxylic acid derivatives which carry amide side chains, production of said carboxylic acid derivatives and their use as endothelin receptor antagonists
DE19806438A1 (de) * 1998-02-17 1999-08-19 Basf Ag Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung
DE19809144A1 (de) * 1998-03-04 1999-09-09 Basf Ag Neue unsymmetrisch substituierte Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶LAMBDA¶/ET¶B¶-Rezeptorantagonisten
DE19809635A1 (de) 1998-03-06 1999-09-09 Basf Ag Verfahren zur Darstellung von Endothelinrezeptorantagonisten vom Sulfanyltyp
US7566452B1 (en) 1999-05-04 2009-07-28 New York University Cancer treatment with endothelin receptor antagonists
WO2002064573A1 (de) * 2001-02-14 2002-08-22 Abbott Gmbh & Co. Kg Neue carbonsäurederivate mit alkylsubstituierten triazinen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten
US20040204422A1 (en) 2003-04-14 2004-10-14 Abbott Gmbh & Co. Kg. N-[(Piperazinyl)hetaryl]arylsulfonamide compounds
WO2008097468A2 (en) * 2007-02-02 2008-08-14 Concert Pharmaceuticals, Inc. Selective endothelin type-a antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69226813T2 (de) * 1991-06-07 1999-02-18 Ube Industries, Ltd., Ube, Yamaguchi Pyrimidin- oder Triazin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Herbizide
DE4313412A1 (de) * 1993-04-23 1994-10-27 Basf Ag 3-(Het)aryl-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE4411225A1 (de) * 1994-03-31 1995-10-05 Basf Ag Verwendung von Carbonsäurederivaten als Arzneimittel

Also Published As

Publication number Publication date
AU2135695A (en) 1995-10-23
PL179580B1 (pl) 2000-09-29
HUT75305A (en) 1997-05-28
HRP950115A2 (en) 1997-10-31
CA2186784C (en) 2007-02-20
KR100365629B1 (ko) 2003-04-10
SI9520048A (en) 1997-02-28
TW382594B (en) 2000-02-21
PT752854E (pt) 2002-02-28
JP4001622B2 (ja) 2007-10-31
DE59509537D1 (de) 2001-09-27
UA44734C2 (uk) 2002-03-15
EP0752854A1 (de) 1997-01-15
JP2007131645A (ja) 2007-05-31
PL316563A1 (en) 1997-01-20
ATE204471T1 (de) 2001-09-15
RU2163808C2 (ru) 2001-03-10
NO964121L (no) 1996-11-26
BR9507231A (pt) 1997-09-16
NZ283333A (en) 1997-02-24
FI963885A (fi) 1996-11-26
GR3036606T3 (en) 2001-12-31
HU9602695D0 (en) 1996-11-28
HU228063B1 (en) 2012-09-28
CZ290684B6 (cs) 2002-09-11
ZA952614B (en) 1996-09-30
WO1995026716A1 (de) 1995-10-12
HRP950115B1 (en) 2001-12-31
KR970702042A (ko) 1997-05-13
FI118589B (fi) 2008-01-15
CN1148807A (zh) 1997-04-30
CZ287396A3 (en) 1997-04-16
DE4411225A1 (de) 1995-10-05
US5840722A (en) 1998-11-24
ES2162916T3 (es) 2002-01-16
IL113137A (en) 1999-10-28
IL113137A0 (en) 1995-06-29
NO310497B1 (no) 2001-07-16
JP4769742B2 (ja) 2011-09-07
FI963885A0 (fi) 1996-09-27
NO964121D0 (no) 1996-09-27
EP0752854B1 (de) 2001-08-22
AU695193B2 (en) 1998-08-06
CA2186784A1 (en) 1995-10-12
CN1070701C (zh) 2001-09-12
JPH09510984A (ja) 1997-11-04
MX9604448A (es) 1997-07-31

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