DK0716081T3 - Höjselektiv fremgangsmåde til fremstilling af enantiomerrene phenylsubstituerede 1,4-dihydropyridin-3,5-dicarboxylsyrederivater - Google Patents

Höjselektiv fremgangsmåde til fremstilling af enantiomerrene phenylsubstituerede 1,4-dihydropyridin-3,5-dicarboxylsyrederivater

Info

Publication number
DK0716081T3
DK0716081T3 DK95118359T DK95118359T DK0716081T3 DK 0716081 T3 DK0716081 T3 DK 0716081T3 DK 95118359 T DK95118359 T DK 95118359T DK 95118359 T DK95118359 T DK 95118359T DK 0716081 T3 DK0716081 T3 DK 0716081T3
Authority
DK
Denmark
Prior art keywords
formula
enantiomerically pure
alkyl
esters
iiia
Prior art date
Application number
DK95118359T
Other languages
Danish (da)
English (en)
Inventor
Peter Dr Fey
Bodo Dr Junge
Joachim Dr Mittendorf
Johannes Dr Kaulen
Laak Kai Dr Van
Rudolf Dr Schohe-Loop
Heinrich Dr Meier
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Application granted granted Critical
Publication of DK0716081T3 publication Critical patent/DK0716081T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK95118359T 1994-12-05 1995-11-22 Höjselektiv fremgangsmåde til fremstilling af enantiomerrene phenylsubstituerede 1,4-dihydropyridin-3,5-dicarboxylsyrederivater DK0716081T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4443168A DE4443168A1 (de) 1994-12-05 1994-12-05 Neues hochselektives Verfahren zur Herstellung von enantiomerenreinen phenylsubstituierten 1,4-Dihydropyridin-3,5-dicarbonsäurederivaten

Publications (1)

Publication Number Publication Date
DK0716081T3 true DK0716081T3 (da) 2006-08-07

Family

ID=6534908

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95118359T DK0716081T3 (da) 1994-12-05 1995-11-22 Höjselektiv fremgangsmåde til fremstilling af enantiomerrene phenylsubstituerede 1,4-dihydropyridin-3,5-dicarboxylsyrederivater

Country Status (27)

Country Link
US (4) US5700948A (zh)
EP (2) EP1443043A3 (zh)
JP (1) JP3891500B2 (zh)
KR (1) KR100396011B1 (zh)
CN (5) CN1079793C (zh)
AT (1) ATE322482T1 (zh)
AU (1) AU702274B2 (zh)
CA (1) CA2164276C (zh)
CZ (1) CZ296438B6 (zh)
DE (2) DE4443168A1 (zh)
DK (1) DK0716081T3 (zh)
ES (1) ES2262138T3 (zh)
FI (1) FI115908B (zh)
HU (1) HU214683B (zh)
IL (1) IL116225A (zh)
MX (1) MX9504954A (zh)
MY (1) MY112938A (zh)
NO (1) NO312832B1 (zh)
NZ (1) NZ280578A (zh)
PL (1) PL183604B1 (zh)
PT (1) PT716081E (zh)
RU (1) RU2155752C2 (zh)
SG (1) SG73352A1 (zh)
SI (1) SI0716081T1 (zh)
SK (1) SK282428B6 (zh)
TW (1) TW310324B (zh)
ZA (1) ZA9510263B (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102533154B1 (ko) 2022-09-22 2023-05-17 임태형 안전계단 난간대

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932646A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
JPS6058239B2 (ja) * 1978-07-20 1985-12-19 山之内製薬株式会社 新規セフアロスポリン誘導体
DE2911029C2 (de) * 1979-03-21 1985-03-14 Kombi-Lift Montage- Und Handelsgesellschaft Mbh, 5650 Solingen Vorrichtung zum Haltern der Führungsrollen für die Lastseile eines Fassadenseilaufzuges in einem oben am Gebäude fest angeordneten Gehäuse
GR850872B (zh) * 1984-04-16 1985-11-25 Yamanouchi Pharma Co Ltd
US4539302A (en) * 1984-04-30 1985-09-03 E. I. Du Pont De Nemours And Company Recovery of zerovalent nickel complexes
DE3423105A1 (de) * 1984-06-22 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung optisch aktiver 1,4-dihydropyridine

Also Published As

Publication number Publication date
MX9504954A (es) 1997-01-31
NO312832B1 (no) 2002-07-08
ZA9510263B (en) 1996-06-12
SI0716081T1 (sl) 2006-06-30
AU702274B2 (en) 1999-02-18
KR960022463A (ko) 1996-07-18
EP0716081A1 (de) 1996-06-12
FI955825A (fi) 1996-06-06
MY112938A (en) 2001-10-31
NZ280578A (en) 1996-10-28
CN1094486C (zh) 2002-11-20
JPH08225529A (ja) 1996-09-03
EP1443043A2 (de) 2004-08-04
EP1443043A3 (de) 2005-02-02
CN1269358A (zh) 2000-10-11
CA2164276C (en) 2007-04-10
JP3891500B2 (ja) 2007-03-14
US5700948A (en) 1997-12-23
USRE36607E (en) 2000-03-07
IL116225A (en) 2000-06-29
CN1105102C (zh) 2003-04-09
NO954885L (no) 1996-06-06
DE59511043D1 (de) 2006-05-18
SG73352A1 (en) 2000-06-20
CN1094926C (zh) 2002-11-27
AU3915095A (en) 1996-06-13
US5910593A (en) 1999-06-08
EP0716081B1 (de) 2006-04-05
RU2155752C2 (ru) 2000-09-10
NO954885D0 (no) 1995-12-01
CZ296438B6 (cs) 2006-03-15
ES2262138T3 (es) 2006-11-16
PL311539A1 (en) 1996-06-10
CN1269357A (zh) 2000-10-11
CN1131664A (zh) 1996-09-25
HUT74292A (en) 1996-11-28
HU214683B (hu) 1998-04-28
US5849924A (en) 1998-12-15
CZ320595A3 (en) 1996-06-12
IL116225A0 (en) 1996-03-31
FI115908B (fi) 2005-08-15
TW310324B (zh) 1997-07-11
HU9503438D0 (en) 1996-01-29
PT716081E (pt) 2006-08-31
CA2164276A1 (en) 1996-06-06
CN1216054C (zh) 2005-08-24
DE4443168A1 (de) 1996-06-13
KR100396011B1 (ko) 2003-11-10
SK152695A3 (en) 1996-06-05
FI955825A0 (fi) 1995-12-04
CN1269359A (zh) 2000-10-11
ATE322482T1 (de) 2006-04-15
CN1269362A (zh) 2000-10-11
CN1079793C (zh) 2002-02-27
PL183604B1 (pl) 2002-06-28
SK282428B6 (sk) 2002-01-07

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