MX9504954A - Nuevo procedimiento altamente selectivo para la fabricacion de derivados del acido 1,4-dihidropiridin-3,5-dicarboxilico, sustituidos por fenilo, de enantiomeros puros. - Google Patents

Nuevo procedimiento altamente selectivo para la fabricacion de derivados del acido 1,4-dihidropiridin-3,5-dicarboxilico, sustituidos por fenilo, de enantiomeros puros.

Info

Publication number
MX9504954A
MX9504954A MX9504954A MX9504954A MX9504954A MX 9504954 A MX9504954 A MX 9504954A MX 9504954 A MX9504954 A MX 9504954A MX 9504954 A MX9504954 A MX 9504954A MX 9504954 A MX9504954 A MX 9504954A
Authority
MX
Mexico
Prior art keywords
dihydropyridine
phenyl
substituted
dicarboxylic acid
highly selective
Prior art date
Application number
MX9504954A
Other languages
English (en)
Inventor
Joachim Mittendorf
Peter Fey
Bodo Junge
Johannes Kaulen
Kai Van Laak
Heinrich Meier
Rudolf Schohe-Loop
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of MX9504954A publication Critical patent/MX9504954A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invencion se refiere a un nuevo procedimiento altamente selectivo para la fabricacion de ésteres del ácido 1,4-dihidropiridin-3,5-dicarboxílico, sustituidos por halogeno-fenilo, de enantiomeros puros, de la formula general (I): en donde R1 hasta R3 tienen los significados indicados en la descripcion.
MX9504954A 1994-12-05 1995-11-28 Nuevo procedimiento altamente selectivo para la fabricacion de derivados del acido 1,4-dihidropiridin-3,5-dicarboxilico, sustituidos por fenilo, de enantiomeros puros. MX9504954A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4443168A DE4443168A1 (de) 1994-12-05 1994-12-05 Neues hochselektives Verfahren zur Herstellung von enantiomerenreinen phenylsubstituierten 1,4-Dihydropyridin-3,5-dicarbonsäurederivaten

Publications (1)

Publication Number Publication Date
MX9504954A true MX9504954A (es) 1997-01-31

Family

ID=6534908

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9504954A MX9504954A (es) 1994-12-05 1995-11-28 Nuevo procedimiento altamente selectivo para la fabricacion de derivados del acido 1,4-dihidropiridin-3,5-dicarboxilico, sustituidos por fenilo, de enantiomeros puros.

Country Status (27)

Country Link
US (4) US5700948A (es)
EP (2) EP1443043A3 (es)
JP (1) JP3891500B2 (es)
KR (1) KR100396011B1 (es)
CN (5) CN1079793C (es)
AT (1) ATE322482T1 (es)
AU (1) AU702274B2 (es)
CA (1) CA2164276C (es)
CZ (1) CZ296438B6 (es)
DE (2) DE4443168A1 (es)
DK (1) DK0716081T3 (es)
ES (1) ES2262138T3 (es)
FI (1) FI115908B (es)
HU (1) HU214683B (es)
IL (1) IL116225A (es)
MX (1) MX9504954A (es)
MY (1) MY112938A (es)
NO (1) NO312832B1 (es)
NZ (1) NZ280578A (es)
PL (1) PL183604B1 (es)
PT (1) PT716081E (es)
RU (1) RU2155752C2 (es)
SG (1) SG73352A1 (es)
SI (1) SI0716081T1 (es)
SK (1) SK282428B6 (es)
TW (1) TW310324B (es)
ZA (1) ZA9510263B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102533154B1 (ko) 2022-09-22 2023-05-17 임태형 안전계단 난간대

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932646A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
JPS6058239B2 (ja) * 1978-07-20 1985-12-19 山之内製薬株式会社 新規セフアロスポリン誘導体
DE2911029C2 (de) * 1979-03-21 1985-03-14 Kombi-Lift Montage- Und Handelsgesellschaft Mbh, 5650 Solingen Vorrichtung zum Haltern der Führungsrollen für die Lastseile eines Fassadenseilaufzuges in einem oben am Gebäude fest angeordneten Gehäuse
GR850872B (es) * 1984-04-16 1985-11-25 Yamanouchi Pharma Co Ltd
US4539302A (en) * 1984-04-30 1985-09-03 E. I. Du Pont De Nemours And Company Recovery of zerovalent nickel complexes
DE3423105A1 (de) * 1984-06-22 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung optisch aktiver 1,4-dihydropyridine

Also Published As

Publication number Publication date
NO312832B1 (no) 2002-07-08
ZA9510263B (en) 1996-06-12
SI0716081T1 (sl) 2006-06-30
AU702274B2 (en) 1999-02-18
KR960022463A (ko) 1996-07-18
EP0716081A1 (de) 1996-06-12
FI955825A (fi) 1996-06-06
MY112938A (en) 2001-10-31
NZ280578A (en) 1996-10-28
DK0716081T3 (da) 2006-08-07
CN1094486C (zh) 2002-11-20
JPH08225529A (ja) 1996-09-03
EP1443043A2 (de) 2004-08-04
EP1443043A3 (de) 2005-02-02
CN1269358A (zh) 2000-10-11
CA2164276C (en) 2007-04-10
JP3891500B2 (ja) 2007-03-14
US5700948A (en) 1997-12-23
USRE36607E (en) 2000-03-07
IL116225A (en) 2000-06-29
CN1105102C (zh) 2003-04-09
NO954885L (no) 1996-06-06
DE59511043D1 (de) 2006-05-18
SG73352A1 (en) 2000-06-20
CN1094926C (zh) 2002-11-27
AU3915095A (en) 1996-06-13
US5910593A (en) 1999-06-08
EP0716081B1 (de) 2006-04-05
RU2155752C2 (ru) 2000-09-10
NO954885D0 (no) 1995-12-01
CZ296438B6 (cs) 2006-03-15
ES2262138T3 (es) 2006-11-16
PL311539A1 (en) 1996-06-10
CN1269357A (zh) 2000-10-11
CN1131664A (zh) 1996-09-25
HUT74292A (en) 1996-11-28
HU214683B (hu) 1998-04-28
US5849924A (en) 1998-12-15
CZ320595A3 (en) 1996-06-12
IL116225A0 (en) 1996-03-31
FI115908B (fi) 2005-08-15
TW310324B (es) 1997-07-11
HU9503438D0 (en) 1996-01-29
PT716081E (pt) 2006-08-31
CA2164276A1 (en) 1996-06-06
CN1216054C (zh) 2005-08-24
DE4443168A1 (de) 1996-06-13
KR100396011B1 (ko) 2003-11-10
SK152695A3 (en) 1996-06-05
FI955825A0 (fi) 1995-12-04
CN1269359A (zh) 2000-10-11
ATE322482T1 (de) 2006-04-15
CN1269362A (zh) 2000-10-11
CN1079793C (zh) 2002-02-27
PL183604B1 (pl) 2002-06-28
SK282428B6 (sk) 2002-01-07

Similar Documents

Publication Publication Date Title
BG105515A (en) Substituted 2-phenylbenzimidazoles, the production thereof and their use
RS65604A (en) Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals
MX9700273A (es) Benzamidinas sustituidas, su preparacion y empleo como sustancias medicamentosas.
MX9705726A (es) Amidas del acido alcoximinoacetico.
ZA9410181B (en) Arylacetic acid derivatives.
YU12000A (sh) Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3-benzazocin -10-oli, postupak za njihovo pripremanje i njihova primena kao lekova
AU7556591A (en) Microbial production of a novel compound 7,10-dihydroxy-8-octadecenoic acid from oleic acid
MX9504954A (es) Nuevo procedimiento altamente selectivo para la fabricacion de derivados del acido 1,4-dihidropiridin-3,5-dicarboxilico, sustituidos por fenilo, de enantiomeros puros.
HUT72040A (en) Process for the manufacture of aminomethanephosphonic acid
ES8502435A1 (es) Un metodo para preparar 2(1h)-piridinonas
AU3011295A (en) Use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters as medicaments
ATE182140T1 (de) Optisch aktive 1,4-dihydropyridinderivate sowie verfahren zu ihrer herstellung
BG105326A (en) Novel benzoylguanadine derivatives with advantageous properties, method for producing them and their use in the production of medicaments
DE69518252D1 (de) Verfahren zur herstellung von 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalin-derivaten
DE3777464D1 (de) Fluorine enthaltende vitamin-d3-derivate und verfahren zu ihrer herstellung.
AU7206898A (en) Method for producing 1,3-di-substituted 2-nitroguanidines
CA2331758A1 (en) Method for the stereochemically controlled production of isomerically pure highly substituted azacyclic compounds
NZ332245A (en) Substituted benzo-oxazolol carboxylic acid derivatives, process for their production and medicaments containing them
YU37902A (sh) Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3- benzazocini i njihova primena kao lekova
ES8608887A1 (es) Procedimiento para la obtencion de preparados combinados antihipertensores y antianginicos a base de dihidropiridina y bloquear beta.
AU1552701A (en) Process for the production of 5-oxy-7-oxabicyclo-(4.1.0)hept-3-E NE-3-carboxylic acid esters
BG105780A (en) Method for producing derivatives of biphenyl-2-carboxylic acid
YU35500A (sh) Novi uretani, njihovi tio- i ditio-analozi, njihove soli, lekovi koji sadrže ova jedinjenja i njihova primena, kao i postupak za njihovo pripremanje
IE840151L (en) £(3, 4-methylenedioxy-ó-hydroxybenzyl| pyrrolidine¹antihypertensives
HU9702339D0 (en) Process for producing intermediates of phenyl-substituted 1,4-dihydro-pyridine-3,5-dicarboxylic acid derivatives and the intermediate compounds