DE60018070D1 - Verfahren zur herstellung von morphine-6-glucuronide und derivate unter verwendung von haloglucuronatester - Google Patents

Verfahren zur herstellung von morphine-6-glucuronide und derivate unter verwendung von haloglucuronatester

Info

Publication number
DE60018070D1
DE60018070D1 DE60018070T DE60018070T DE60018070D1 DE 60018070 D1 DE60018070 D1 DE 60018070D1 DE 60018070 T DE60018070 T DE 60018070T DE 60018070 T DE60018070 T DE 60018070T DE 60018070 D1 DE60018070 D1 DE 60018070D1
Authority
DE
Germany
Prior art keywords
morphine
haloglucuronate
formula
glucuronides
sitter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60018070T
Other languages
English (en)
Other versions
DE60018070T2 (de
Inventor
Feodor Scheinmann
Valentine Stachulski
John Ferguson
Louise Law
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UFC Ltd
Original Assignee
UFC Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UFC Ltd filed Critical UFC Ltd
Publication of DE60018070D1 publication Critical patent/DE60018070D1/de
Application granted granted Critical
Publication of DE60018070T2 publication Critical patent/DE60018070T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE60018070T 1999-06-21 2000-06-20 Verfahren zur herstellung von morphine-6-glucuronide und derivate unter verwendung von haloglucuronatester Expired - Fee Related DE60018070T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9914382 1999-06-21
GBGB9914382.8A GB9914382D0 (en) 1999-06-21 1999-06-21 New process for the manufacture of morphine-6-glucuronide and its analogues and also to a manufacture of new intermediaries
PCT/GB2000/002232 WO2000078764A1 (en) 1999-06-21 2000-06-20 Process for making morphine-6-glucuronide and its analogues using haloglucuronate ester intermediates

Publications (2)

Publication Number Publication Date
DE60018070D1 true DE60018070D1 (de) 2005-03-17
DE60018070T2 DE60018070T2 (de) 2005-12-29

Family

ID=10855704

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60018070T Expired - Fee Related DE60018070T2 (de) 1999-06-21 2000-06-20 Verfahren zur herstellung von morphine-6-glucuronide und derivate unter verwendung von haloglucuronatester

Country Status (9)

Country Link
US (1) US6642366B1 (de)
EP (1) EP1200441B1 (de)
JP (1) JP2003502427A (de)
AT (1) ATE288917T1 (de)
AU (1) AU5413400A (de)
CA (1) CA2375274A1 (de)
DE (1) DE60018070T2 (de)
GB (1) GB9914382D0 (de)
WO (1) WO2000078764A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7667167B2 (en) 2005-12-08 2010-02-23 Graphic Packaging International, Inc. Microwave food heating package with removable portion
FR2939436B1 (fr) * 2008-12-10 2010-12-17 Sanofi Aventis Synthese de morphine-6-glucuronide ou de l'un de ses derives
EP2717057A1 (de) * 2012-10-04 2014-04-09 Cisbio Bioassays Morphin-6-glucuronid-Derivate, Immunogene und Immunassay

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5218097A (en) * 1988-12-07 1993-06-08 Ciba-Geigy Corporation Process for the preparation of protected mono-sugar and oligo-sugar halides
GB9116909D0 (en) * 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB9325065D0 (en) * 1993-12-07 1994-02-02 Salford Ultrafine Chem & Res An enzymatic process for making morphine-6-glucuronide or substituted morphine-6-glucuronide
US5908927A (en) * 1996-05-22 1999-06-01 High Standard Products Corporation Synthesis of deuterated opiate glucuronides
GB2339196B (en) * 1997-04-14 2001-11-07 Salford Ultrafine Chem & Res Morphine derivatives
CA2319833A1 (en) * 1998-02-02 1999-08-05 Lev Yudovitch Glycosidation of 4,5-epoxymorphinan-6-ols
WO1999064430A2 (en) * 1998-06-06 1999-12-16 Cenes Limited Morphine-6-glucuronide synthesis

Also Published As

Publication number Publication date
EP1200441B1 (de) 2005-02-09
ATE288917T1 (de) 2005-02-15
JP2003502427A (ja) 2003-01-21
CA2375274A1 (en) 2000-12-28
EP1200441A1 (de) 2002-05-02
WO2000078764A1 (en) 2000-12-28
GB9914382D0 (en) 1999-08-18
AU5413400A (en) 2001-01-09
US6642366B1 (en) 2003-11-04
DE60018070T2 (de) 2005-12-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee