DK0712827T3 - Fremgangsmåde til fremstilling af D-chiro-inositol - Google Patents
Fremgangsmåde til fremstilling af D-chiro-inositolInfo
- Publication number
- DK0712827T3 DK0712827T3 DK94923085T DK94923085T DK0712827T3 DK 0712827 T3 DK0712827 T3 DK 0712827T3 DK 94923085 T DK94923085 T DK 94923085T DK 94923085 T DK94923085 T DK 94923085T DK 0712827 T3 DK0712827 T3 DK 0712827T3
- Authority
- DK
- Denmark
- Prior art keywords
- chiro
- inositol
- resin
- type
- column packed
- Prior art date
Links
- CDAISMWEOUEBRE-LKPKBOIGSA-N 1D-chiro-inositol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-LKPKBOIGSA-N 0.000 title abstract 7
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 2
- 230000002378 acidificating effect Effects 0.000 abstract 5
- 239000000243 solution Substances 0.000 abstract 4
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 239000003456 ion exchange resin Substances 0.000 abstract 3
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 3
- 239000011347 resin Substances 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- PVTHJAPFENJVNC-MHRBZPPQSA-N kasugamycin Chemical compound N[C@H]1C[C@H](NC(=N)C(O)=O)[C@@H](C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O PVTHJAPFENJVNC-MHRBZPPQSA-N 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
- C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
- C07C35/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with more than one hydroxy group bound to the ring
- C07C35/16—Inositols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5217926A JP3053510B2 (ja) | 1993-08-11 | 1993-08-11 | Ｄ−キロ−イノシトールの製造法 |
| JP05288827A JP3113770B2 (ja) | 1993-10-26 | 1993-10-26 | Ｄ−キロ−イノシトールの製造方法 |
| JP06152181A JP3113776B2 (ja) | 1994-07-04 | 1994-07-04 | Ｄ−キロ−イノシトールの製造方法 |
| PCT/JP1994/001304 WO1995004711A1 (fr) | 1993-08-11 | 1994-08-08 | Procede de production de d-chiro-inositol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0712827T3 true DK0712827T3 (da) | 1999-09-20 |
Family
ID=27320233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94923085T DK0712827T3 (da) | 1993-08-11 | 1994-08-08 | Fremgangsmåde til fremstilling af D-chiro-inositol |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5714643A (de) |
| EP (1) | EP0712827B1 (de) |
| KR (1) | KR100332144B1 (de) |
| CN (1) | CN1072637C (de) |
| AT (1) | ATE176779T1 (de) |
| CA (1) | CA2168953A1 (de) |
| DE (1) | DE69416594T2 (de) |
| DK (1) | DK0712827T3 (de) |
| ES (1) | ES2130440T3 (de) |
| TW (1) | TW350837B (de) |
| WO (1) | WO1995004711A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2203680A1 (en) * | 1994-11-10 | 1996-05-23 | David A. Riley | Improved processes for the preparation of d-chiro-inositol |
| US5932774A (en) * | 1995-11-06 | 1999-08-03 | Abbott Laboratories | Processes for the preparation of D-chiro-inositol |
| JP2001215294A (ja) * | 1999-11-22 | 2001-08-10 | Japan Organo Co Ltd | 復水脱塩装置 |
| US6342645B2 (en) * | 1999-12-30 | 2002-01-29 | Insmed Pharmaceuticals, Inc. | Methods for the production and isolation of D-chiro-inositol from kasugamycin and the use of D-chiro-inositol obtained therefrom |
| US6660891B2 (en) | 2000-05-15 | 2003-12-09 | Insmed Incorporated | Methods for the production of D-chiro-inositol and the use of D-chiro inositol obtained therefrom |
| US6408277B1 (en) * | 2000-06-21 | 2002-06-18 | Banter Limited | System and method for automatic task prioritization |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| ZA200704872B (en) * | 2004-11-17 | 2008-12-31 | Mclaurin Joanne | Compositions comprising scyllo-inositol derivatives and methods to treat disorders of protein aggregation |
| WO2007119108A2 (en) * | 2005-10-13 | 2007-10-25 | Waratah Pharmaceuticals Inc. | Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence |
| US20070197452A1 (en) * | 2006-02-17 | 2007-08-23 | Mclaurin Joanne | Treatment of amyloid-related diseases |
| WO2007101353A1 (en) * | 2006-03-09 | 2007-09-13 | Waratah Pharmaceuticals Inc. | A cyclohexane polyalcohol formulation for treatment of disorders of protein aggregation |
| US20110028719A1 (en) * | 2006-05-19 | 2011-02-03 | Jacek Slon-Usakiewicz | Screening methods for amyloid beta modulators |
| US20100173960A1 (en) * | 2006-09-21 | 2010-07-08 | Antonio Cruz | The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases |
| US20090214474A1 (en) * | 2006-11-01 | 2009-08-27 | Barbara Brooke Jennings | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| US20080103116A1 (en) * | 2006-11-01 | 2008-05-01 | Jennings-Spring Barbara L | Method of treatment and compositions of D-chiro inositol and phosphates thereof |
| JP2010510254A (ja) * | 2006-11-24 | 2010-04-02 | ワラタ ファーマシューティカルズ， インコーポレイテッド | アルツハイマー病および関連の神経変性疾患のための併用処置 |
| ES2425264T3 (es) * | 2007-04-12 | 2013-10-14 | Waratah Pharmaceuticals, Inc. | Uso de derivados de ciclohexanohexol en el tratamiento de enfermedades oculares |
| US20100144891A1 (en) * | 2007-04-12 | 2010-06-10 | Mclaurin Joanne | Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis |
| US20100331267A1 (en) * | 2007-04-12 | 2010-12-30 | Mclaurin Joanne | Use of cyclohexanehexol derivatives in the treatment of alpha-synucleinopathies |
| US20110105626A1 (en) * | 2007-04-12 | 2011-05-05 | Mclaurin Joanne | Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases |
| WO2010040232A1 (en) * | 2008-10-09 | 2010-04-15 | Waratah Pharmaceuticals Inc. | Use of scyllo-inositols for the treatment of macular degeneration-related disorders |
| KR101447579B1 (ko) | 2012-09-26 | 2014-10-15 | 주식회사 디와이내츄럴 | 미생물을 이용한 ｄ-카이로 이노시톨의 생산 방법 |
| CN104961628A (zh) * | 2015-06-30 | 2015-10-07 | 天津科技大学 | 一种由d-松醇转化为d-手性肌醇的方法 |
| CN105669376B (zh) * | 2016-02-27 | 2019-03-12 | 诸城市浩天药业有限公司 | 制备高结晶度、粒径大的肌醇的结晶工艺及应用 |
| CN111065462A (zh) * | 2017-12-21 | 2020-04-24 | 奥加诺株式会社 | 非水液状物质的精制方法和带外部气体阻隔部件的离子交换树脂填充筒 |
| KR20220004056A (ko) * | 2019-05-03 | 2022-01-11 | 보노 앤드 디타 에스.피.에이. | 캐롭 추출물로부터 피니톨의 분리를 위한 방법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS572381B2 (de) * | 1974-11-18 | 1982-01-16 | ||
| US5091596A (en) * | 1990-12-20 | 1992-02-25 | Univ. Of Va. Alumni Patents Foundation | Method for producing chiro-inositol |
-
1994
- 1994-08-08 DE DE69416594T patent/DE69416594T2/de not_active Expired - Fee Related
- 1994-08-08 KR KR1019960700719A patent/KR100332144B1/ko not_active IP Right Cessation
- 1994-08-08 ES ES94923085T patent/ES2130440T3/es not_active Expired - Lifetime
- 1994-08-08 US US08/596,131 patent/US5714643A/en not_active Expired - Fee Related
- 1994-08-08 CA CA002168953A patent/CA2168953A1/en not_active Abandoned
- 1994-08-08 EP EP94923085A patent/EP0712827B1/de not_active Expired - Lifetime
- 1994-08-08 WO PCT/JP1994/001304 patent/WO1995004711A1/ja active IP Right Grant
- 1994-08-08 AT AT94923085T patent/ATE176779T1/de not_active IP Right Cessation
- 1994-08-08 DK DK94923085T patent/DK0712827T3/da active
- 1994-08-08 CN CN94193030A patent/CN1072637C/zh not_active Expired - Fee Related
- 1994-09-02 TW TW083108097A patent/TW350837B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| KR100332144B1 (ko) | 2002-11-13 |
| KR960703836A (ko) | 1996-08-31 |
| EP0712827A1 (de) | 1996-05-22 |
| DE69416594T2 (de) | 1999-09-23 |
| ATE176779T1 (de) | 1999-03-15 |
| CA2168953A1 (en) | 1995-02-16 |
| US5714643A (en) | 1998-02-03 |
| WO1995004711A1 (fr) | 1995-02-16 |
| TW350837B (en) | 1999-01-21 |
| CN1072637C (zh) | 2001-10-10 |
| CN1128986A (zh) | 1996-08-14 |
| DE69416594D1 (de) | 1999-03-25 |
| EP0712827B1 (de) | 1999-02-17 |
| EP0712827A4 (de) | 1996-11-06 |
| ES2130440T3 (es) | 1999-07-01 |
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