ES2130440T3 - Proceso para producir d-(quiro)-inositol. - Google Patents

Proceso para producir d-(quiro)-inositol.

Info

Publication number
ES2130440T3
ES2130440T3 ES94923085T ES94923085T ES2130440T3 ES 2130440 T3 ES2130440 T3 ES 2130440T3 ES 94923085 T ES94923085 T ES 94923085T ES 94923085 T ES94923085 T ES 94923085T ES 2130440 T3 ES2130440 T3 ES 2130440T3
Authority
ES
Spain
Prior art keywords
inositol
chiro
solution
resin
ion exchange
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94923085T
Other languages
English (en)
Inventor
Kiyoshi Sato
Makoto Yoshida
Kenji Kanbe
Kiyoshi Hirazawa
Tomio Takeuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Hokko Chemical Industry Co Ltd
Original Assignee
Microbial Chemistry Research Foundation
Hokko Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5217926A external-priority patent/JP3053510B2/ja
Priority claimed from JP05288827A external-priority patent/JP3113770B2/ja
Priority claimed from JP06152181A external-priority patent/JP3113776B2/ja
Application filed by Microbial Chemistry Research Foundation, Hokko Chemical Industry Co Ltd filed Critical Microbial Chemistry Research Foundation
Application granted granted Critical
Publication of ES2130440T3 publication Critical patent/ES2130440T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
    • C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
    • C07C35/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with more than one hydroxy group bound to the ring
    • C07C35/16—Inositols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

SE PRESENTA UN PROCESO PARA PRODUCIR D-QUIRO-INOSITOL QUE COMPRENDE BIEN LA MEZCLA DE UNA SOLUCION ACUOSA DE CASUGAMICINA O UNA SAL DE LA MISMA CON UNA RESINA DE INTERCAMBIO DE IONES FUERTEMENTE ACIDICO (DEL TIPO H+) EN UN REACTOR O BIEN LA PUESTA EN CONTACTO DE LA SOLUCION ACUOSA CON LA RESINA EN UNA COLUMNA EMPAQUETADA CON LA MISMA, CALENTANDO LA SOLUCION ACUOSA Y LA RESINA BAJO UNA PRESION NORMAL O AMPLIADA PARA EFECTUAR LA HIDROLISIS DE LA CASUGAMICINA PARA PREPARAR DE ESTA FORMA UNA SOLUCION DE REACCION ACIDICA QUE CONTENGA D-QUIRO-INOSITOL, POSTERIORMENTE SE SEPARA LA SOLUCION DE LA REACCION ACIDICA DE LA RESINA, Y SE RECUPERA D-QUIRO-INOSITOL DE LA SOLUCION. EN ESTA ETAPA, ES POSIBLE OBTENER D-QUIRO-INOSITOL DE FORMA EFICIENTE Y CON UNA ALTA PUREZA PASANDO LA SOLUCION DE REACCION ACIDICA PRIMERO A TRAVES DE UNA COLUMNA EMPAQUETADA CON UNA RESINA DE INTERCAMBIO DE IONES FUERTEMENTE ACIDICA (DEL TIPO H+) Y LUEGO A TRAVES DE OTRA COLUMNA EMPAQUETADA CON UNA RESINA DE INTERCAMBIO DE IONES FUERTEMENTE ALCALINA (DEL TIPO OH-) PARA PREPARAR UN PRODUCTO NEUTRO QUE CONTIENE D-QUIRO-INOSITOL, POSTERIORMENTE, SE CONCENTRA EL PRODUCTO PARA EFECTUAR LA DEPOSICION DE LOS CRISTALES DE D-QUIRO-INOSITOL.
ES94923085T 1993-08-11 1994-08-08 Proceso para producir d-(quiro)-inositol. Expired - Lifetime ES2130440T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5217926A JP3053510B2 (ja) 1993-08-11 1993-08-11 Ｄ−キロ−イノシトールの製造法
JP05288827A JP3113770B2 (ja) 1993-10-26 1993-10-26 Ｄ−キロ−イノシトールの製造方法
JP06152181A JP3113776B2 (ja) 1994-07-04 1994-07-04 Ｄ−キロ−イノシトールの製造方法

Publications (1)

Publication Number Publication Date
ES2130440T3 true ES2130440T3 (es) 1999-07-01

Family

ID=27320233

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94923085T Expired - Lifetime ES2130440T3 (es) 1993-08-11 1994-08-08 Proceso para producir d-(quiro)-inositol.

Country Status (11)

Country Link
US (1) US5714643A (es)
EP (1) EP0712827B1 (es)
KR (1) KR100332144B1 (es)
CN (1) CN1072637C (es)
AT (1) ATE176779T1 (es)
CA (1) CA2168953A1 (es)
DE (1) DE69416594T2 (es)
DK (1) DK0712827T3 (es)
ES (1) ES2130440T3 (es)
TW (1) TW350837B (es)
WO (1) WO1995004711A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE181048T1 (de) * 1994-11-10 1999-06-15 Abbott Lab Verbessertes verfahren zur herstellung von d- chiroinositol
US5932774A (en) * 1995-11-06 1999-08-03 Abbott Laboratories Processes for the preparation of D-chiro-inositol
JP2001215294A (ja) * 1999-11-22 2001-08-10 Japan Organo Co Ltd 復水脱塩装置
US6342645B2 (en) * 1999-12-30 2002-01-29 Insmed Pharmaceuticals, Inc. Methods for the production and isolation of D-chiro-inositol from kasugamycin and the use of D-chiro-inositol obtained therefrom
US6660891B2 (en) 2000-05-15 2003-12-09 Insmed Incorporated Methods for the production of D-chiro-inositol and the use of D-chiro inositol obtained therefrom
US6408277B1 (en) * 2000-06-21 2002-06-18 Banter Limited System and method for automatic task prioritization
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
EP1824496A4 (en) * 2004-11-17 2008-07-16 Joanne Mclaurin COMPOSITIONS OF SCYLLO-INOSITOL DERIVATIVES AND METHOD FOR THE TREATMENT OF PROTEIN AGGREGATION DISORDERS
US20090170957A1 (en) * 2005-10-13 2009-07-02 Antonio Cruz Scyllo-inositol derivatives and their use in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence
US20070197452A1 (en) * 2006-02-17 2007-08-23 Mclaurin Joanne Treatment of amyloid-related diseases
EA200801967A1 (ru) * 2006-03-09 2009-04-28 Ворэта Фармэсьютиклз Инк. Дозированная лекарственная форма на основе циклогексанового полиола (варианты), способ ее получения, способ лечения болезни альцгеймера с ее помощью и циклогексановый полиол в качестве средства при изготовлении лекарственного средства
CA2652449A1 (en) * 2006-05-19 2007-11-29 Waratah Pharmaceuticals Inc. Screening methods for amyloid beta modulators
WO2008034244A1 (en) * 2006-09-21 2008-03-27 Waratah Pharmaceuticals Inc. The combination of a cyclohexanehexol and a nsaid for the treatment of neurodegenerative diseases
US20090214474A1 (en) * 2006-11-01 2009-08-27 Barbara Brooke Jennings Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US20080103116A1 (en) * 2006-11-01 2008-05-01 Jennings-Spring Barbara L Method of treatment and compositions of D-chiro inositol and phosphates thereof
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2091566A4 (en) * 2006-11-24 2011-07-06 Waratah Pharmaceuticals Inc COMBINATION THERAPIES AGAINST ALZHEIMER DISEASE AND SIMILAR ILLNESSES
US20100144891A1 (en) * 2007-04-12 2010-06-10 Mclaurin Joanne Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis
CA2683548A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases
CA2683546A1 (en) * 2007-04-12 2008-10-23 Joanne Mclaurin Use of cyclohexanehexol derivatives in the treatment of .alpha.-synucleinopathies
WO2008124940A1 (en) * 2007-04-12 2008-10-23 Waratah Pharmaceuticals Inc. Use of cyclohexanehexol derivatives in the treatment of ocular diseases
AU2009301603A1 (en) * 2008-10-09 2010-04-15 Waratah Pharmaceuticals Inc. Use of scyllo-inositols for the treatment of macular degeneration-related disorders
KR101447579B1 (ko) 2012-09-26 2014-10-15 주식회사 디와이내츄럴 미생물을 이용한 ｄ-카이로 이노시톨의 생산 방법
CN104961628A (zh) * 2015-06-30 2015-10-07 天津科技大学 一种由d-松醇转化为d-手性肌醇的方法
CN105669376B (zh) * 2016-02-27 2019-03-12 诸城市浩天药业有限公司 制备高结晶度、粒径大的肌醇的结晶工艺及应用
KR102291223B1 (ko) * 2017-12-21 2021-08-19 오르가노 코포레이션 비수액상 물질의 정제방법 및 외기차단부재 부착 이온교환수지 충전 카트리지
US20220177396A1 (en) * 2019-05-03 2022-06-09 Bono & Ditta S.P.A. Process for the separation of pinitol from a carob extract

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS572381B2 (es) * 1974-11-18 1982-01-16
US5091596A (en) * 1990-12-20 1992-02-25 Univ. Of Va. Alumni Patents Foundation Method for producing chiro-inositol

Also Published As

Publication number Publication date
DE69416594D1 (de) 1999-03-25
US5714643A (en) 1998-02-03
WO1995004711A1 (fr) 1995-02-16
DK0712827T3 (da) 1999-09-20
DE69416594T2 (de) 1999-09-23
CN1072637C (zh) 2001-10-10
EP0712827A4 (en) 1996-11-06
ATE176779T1 (de) 1999-03-15
EP0712827B1 (en) 1999-02-17
KR960703836A (ko) 1996-08-31
TW350837B (en) 1999-01-21
EP0712827A1 (en) 1996-05-22
CA2168953A1 (en) 1995-02-16
KR100332144B1 (ko) 2002-11-13
CN1128986A (zh) 1996-08-14

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