DK0681580T3 - Prolægemidler af anti-inflammatoriske 3-acyl-2-oxindol-1-carboxamider - Google Patents

Prolægemidler af anti-inflammatoriske 3-acyl-2-oxindol-1-carboxamider

Info

Publication number
DK0681580T3
DK0681580T3 DK93923879.6T DK93923879T DK0681580T3 DK 0681580 T3 DK0681580 T3 DK 0681580T3 DK 93923879 T DK93923879 T DK 93923879T DK 0681580 T3 DK0681580 T3 DK 0681580T3
Authority
DK
Denmark
Prior art keywords
oxindole
carboxamides
prodrugs
acyl
inflammatory
Prior art date
Application number
DK93923879.6T
Other languages
Danish (da)
English (en)
Inventor
Lawrence A Reiter
Kelvin Cooper
Wayne E Barth
Edward F Kleinman
Ralph P Robinson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0681580T3 publication Critical patent/DK0681580T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DK93923879.6T 1993-01-26 1993-10-20 Prolægemidler af anti-inflammatoriske 3-acyl-2-oxindol-1-carboxamider DK0681580T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/009,188 US5270331A (en) 1993-01-26 1993-01-26 Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Publications (1)

Publication Number Publication Date
DK0681580T3 true DK0681580T3 (da) 1997-08-18

Family

ID=21736103

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93923879.6T DK0681580T3 (da) 1993-01-26 1993-10-20 Prolægemidler af anti-inflammatoriske 3-acyl-2-oxindol-1-carboxamider

Country Status (35)

Country Link
US (1) US5270331A (sv)
EP (1) EP0681580B1 (sv)
JP (1) JP2703825B2 (sv)
KR (1) KR0169827B1 (sv)
CN (1) CN1052003C (sv)
AP (1) AP443A (sv)
AT (1) ATE155137T1 (sv)
AU (1) AU678187B2 (sv)
BR (1) BR9307768A (sv)
CA (1) CA2152919C (sv)
CZ (1) CZ281046B6 (sv)
DE (1) DE69312093T2 (sv)
DK (1) DK0681580T3 (sv)
EG (1) EG20302A (sv)
ES (1) ES2104187T3 (sv)
FI (1) FI940365A (sv)
GR (1) GR3024591T3 (sv)
HR (1) HRP940034B1 (sv)
HU (1) HUT69689A (sv)
IL (1) IL108384A (sv)
MA (1) MA23096A1 (sv)
MX (1) MX9400677A (sv)
MY (1) MY138629A (sv)
NO (1) NO952949D0 (sv)
NZ (1) NZ257278A (sv)
OA (1) OA10563A (sv)
PL (1) PL178857B1 (sv)
RU (1) RU2124514C1 (sv)
SI (1) SI9300567A (sv)
SK (1) SK280929B6 (sv)
TW (1) TW330935B (sv)
UA (1) UA41348C2 (sv)
WO (1) WO1994017061A1 (sv)
YU (1) YU48796B (sv)
ZA (1) ZA94463B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69305999T2 (de) * 1993-02-09 1997-03-06 Pfizer Inc., New York, N.Y. Oxindol 1-[n-(alkoxycarbonyl)]carboxamide und 1-[n-carboxamido]carboxamide als antiinflammatorische wirkstoffe
WO1997013767A1 (de) * 1995-10-09 1997-04-17 Chemisch Pharmazeutische Forschungsgesellschaft Mbh Heterocyclisch substituierte 1-indolcarboxamide als cyclooxygenase-2 inhibitoren
US6906090B1 (en) * 1998-03-06 2005-06-14 Astrazeneca Ab Compositions and methods for treating mycobacterial diseases
EP0984012A3 (en) * 1998-08-31 2001-01-10 Pfizer Products Inc. Nitric oxide releasing oxindole prodrugs with analgesic and anti-inflammatory properties
WO2003016259A2 (de) * 2001-08-16 2003-02-27 Pharmacon-Forschung Und Beratung Gmbh Milchsäureelemente enthaltende verbindungen, deren herstellung sowie deren verwendung als pharmazeutische wirkstoffe
CN101628842A (zh) * 2009-08-27 2010-01-20 中国人民解放军防化指挥工程学院 烷氧羰基甲氧基作为羧基保护基

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556672A (en) * 1984-03-19 1985-12-03 Pfizer Inc. 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
WO1990004393A1 (en) * 1988-10-18 1990-05-03 Pfizer Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides
EP0365194B1 (en) * 1988-10-18 1995-08-02 Pfizer Inc. Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides

Also Published As

Publication number Publication date
BR9307768A (pt) 1995-11-21
US5270331A (en) 1993-12-14
YU2994A (sh) 1997-01-08
IL108384A0 (en) 1994-04-12
PL309989A1 (en) 1995-11-13
WO1994017061A1 (en) 1994-08-04
CN1052003C (zh) 2000-05-03
HUT69689A (en) 1995-09-28
FI940365A (sv) 1994-07-27
KR0169827B1 (en) 1999-01-15
CZ181995A3 (en) 1996-06-12
GR3024591T3 (en) 1997-12-31
RU2124514C1 (ru) 1999-01-10
EG20302A (en) 1998-10-31
MX9400677A (es) 1994-08-31
KR960700244A (ko) 1996-01-19
ZA94463B (en) 1995-07-24
UA41348C2 (uk) 2001-09-17
SI9300567A (en) 1994-09-30
CN1097740A (zh) 1995-01-25
CZ281046B6 (cs) 1996-06-12
NZ257278A (en) 1996-09-25
AU5359894A (en) 1994-08-15
MA23096A1 (fr) 1994-10-01
NO952949L (no) 1995-07-25
PL178857B1 (pl) 2000-06-30
IL108384A (en) 1998-12-27
SK280929B6 (sk) 2000-09-12
HRP940034B1 (en) 2000-10-31
HRP940034A2 (en) 1996-08-31
DE69312093T2 (de) 1997-10-30
SK91295A3 (en) 1995-12-06
AP9300583A0 (en) 1993-10-31
AU678187B2 (en) 1997-05-22
YU48796B (sh) 2000-03-21
TW330935B (en) 1998-05-01
JPH08501316A (ja) 1996-02-13
CA2152919A1 (en) 1994-08-04
ES2104187T3 (es) 1997-10-01
HU9400209D0 (en) 1994-05-30
EP0681580B1 (en) 1997-07-09
JP2703825B2 (ja) 1998-01-26
EP0681580A1 (en) 1995-11-15
NO952949D0 (no) 1995-07-25
ATE155137T1 (de) 1997-07-15
MY138629A (en) 2009-07-31
AP443A (en) 1996-01-03
RU95117091A (ru) 1997-06-27
OA10563A (en) 2002-06-05
DE69312093D1 (de) 1997-08-14
CA2152919C (en) 1999-01-05
FI940365A0 (sv) 1994-01-25

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