DK0673418T3 - Monoklonale antistoffer rettet mod mikrotubulusassocieret tau-protein, hybridomaer, der secernerer disse antistoffer, antig - Google Patents

Monoklonale antistoffer rettet mod mikrotubulusassocieret tau-protein, hybridomaer, der secernerer disse antistoffer, antig

Info

Publication number
DK0673418T3
DK0673418T3 DK94903752T DK94903752T DK0673418T3 DK 0673418 T3 DK0673418 T3 DK 0673418T3 DK 94903752 T DK94903752 T DK 94903752T DK 94903752 T DK94903752 T DK 94903752T DK 0673418 T3 DK0673418 T3 DK 0673418T3
Authority
DK
Denmark
Prior art keywords
tau protein
pct
antigen
monoclonal antibodies
directed against
Prior art date
Application number
DK94903752T
Other languages
Danish (da)
English (en)
Inventor
Marc Mercken
De Voorde Andre Van
Marc Vandermeeren
Eugeen Vanmechelen
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Application granted granted Critical
Publication of DK0673418T3 publication Critical patent/DK0673418T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK94903752T 1992-12-14 1993-12-10 Monoklonale antistoffer rettet mod mikrotubulusassocieret tau-protein, hybridomaer, der secernerer disse antistoffer, antig DK0673418T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92403403 1992-12-14
PCT/EP1993/003499 WO1994013795A1 (en) 1992-12-14 1993-12-10 Monoclonal antibodies directed against the microtubule-associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and their applications

Publications (1)

Publication Number Publication Date
DK0673418T3 true DK0673418T3 (da) 1999-03-01

Family

ID=8211736

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94903752T DK0673418T3 (da) 1992-12-14 1993-12-10 Monoklonale antistoffer rettet mod mikrotubulusassocieret tau-protein, hybridomaer, der secernerer disse antistoffer, antig

Country Status (9)

Country Link
US (1) US5843779A (ja)
EP (1) EP0673418B1 (ja)
JP (1) JP2879975B2 (ja)
AT (1) ATE165866T1 (ja)
AU (1) AU690092B2 (ja)
DE (1) DE69318420T2 (ja)
DK (1) DK0673418T3 (ja)
ES (1) ES2118373T3 (ja)
WO (1) WO1994013795A1 (ja)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811310A (en) * 1986-09-30 1998-09-22 Albert Einstein College Of Medicine Of Yeshiva Univ. The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease
WO1993008302A1 (en) * 1991-10-25 1993-04-29 Itt Automotive Europe Gmbh Monoclonal antibodies directed against the microtubule-associated protein tau
DE69529906D1 (de) * 1994-07-29 2003-04-17 Innogenetics Nv Monoklonale antikörper gegen ein epitop einer gewissen unterklasse oder form von phosphoryliertem tau, hybridome die diese sezernieren,antigenerkennung durch diese antikörper und deren verwendung
US6797478B1 (en) 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
BR9913112A (pt) * 1998-09-08 2001-05-08 Innogenetics Nv Tau como um marcador para dano inicial de cns
WO2000043791A2 (en) 1999-01-25 2000-07-27 Minerva Biotechnologies Corporation Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
WO2001023894A1 (de) * 1999-09-28 2001-04-05 Evotec Oai Ag Quantitative analyse und typisierung subzellulärer partikel
ES2274869T3 (es) * 2000-01-24 2007-06-01 Innogenetics N.V. Diagnostico de tauopatias determinando la relacion tau/fosfotau.
US20030162230A1 (en) * 2000-09-27 2003-08-28 Reagan Kevin J. Method for quantifying phosphokinase activity on proteins
WO2004081534A2 (en) * 2003-03-12 2004-09-23 Assay Designs, Inc. Phosphokinase assay
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
WO2005080986A1 (en) * 2004-02-18 2005-09-01 University Of Iowa Research Foundation Antibodies to phosphorylated tau, methods of making and methods of use
US20070178447A1 (en) * 2006-01-31 2007-08-02 Bethyl Laboratories, Inc. Method for decreasing interference in results of immunochemical methods
CN102428101B (zh) * 2009-03-18 2016-03-02 Ac免疫有限公司 用于治疗用途的方法
UA107571C2 (xx) * 2009-04-03 2015-01-26 Фармацевтична композиція
CN103339146B (zh) 2010-10-11 2017-09-01 比奥根国际神经科学公司 人抗tau抗体
GB201111361D0 (en) 2011-07-04 2011-08-17 Nordic Bioscience As Biochemical markers for neurodegenerative conditions
JP6293731B2 (ja) 2012-04-05 2018-03-14 エーシー イミューン エス．エー． ヒト化タウ抗体
PL2885010T3 (pl) 2012-08-16 2020-11-16 Ipierian, Inc. Metody leczenia tauopatii
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
LT2935326T (lt) 2012-12-21 2020-12-10 Biogen Ma Inc. Žmogaus antikūnai prieš tau baltymą
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
SG10201707855YA (en) 2013-03-13 2017-10-30 Prothena Biosciences Ltd Tau immunotherapy
WO2014150877A2 (en) 2013-03-15 2014-09-25 Ac Immune S.A. Anti-tau antibodies and methods of use
CN105939722A (zh) 2014-02-14 2016-09-14 伊皮埃里安股份有限公司 Tau肽，抗Tau抗体，及其使用方法
EP3452507B1 (en) 2016-05-02 2022-10-19 Prothena Biosciences Limited Tau immunotherapy
EP3452508A1 (en) 2016-05-02 2019-03-13 Prothena Biosciences Limited Antibodies recognizing tau
SG11201910066QA (en) 2017-05-02 2019-11-28 Prothena Biosciences Ltd Antibodies recognizing tau
KR20200077543A (ko) 2017-10-25 2020-06-30 얀센 파마슈티칼즈, 인코포레이티드 인산화 타우 펩티드의 조성물 및 이의 용도
EP3885362A4 (en) 2018-11-22 2022-08-17 Fujirebio Inc. ANTIBODY CONJUGATE
WO2020163730A2 (en) 2019-02-08 2020-08-13 Ac Immune S.A. Method of safe administration of phosphorylated tau peptide vaccine
WO2020180819A1 (en) 2019-03-03 2020-09-10 Prothena Biosciences Limited Antibodies recognizing tau
EP3965817A4 (en) 2019-04-24 2023-11-22 Janssen Pharmaceuticals, Inc. HETEROLOGUE ADMINISTRATION OF TAU VACCINES
US20220365102A1 (en) * 2019-09-30 2022-11-17 Nipro Corporation Tau protein detection method using blood sample as test specimen
JP2023523401A (ja) 2020-04-15 2023-06-05 ボイジャー セラピューティクス インコーポレイテッド タウ結合化合物
CN111349617B (zh) * 2020-05-25 2020-09-22 苏州仁端生物医药科技有限公司 一种分泌抗Tau或pTau-181/231/396单克隆抗体杂交瘤细胞株及其应用
AU2021403010A1 (en) 2020-12-16 2023-07-13 Voyager Therapeutics, Inc. Tau binding compounds
EP4271708A1 (en) 2020-12-29 2023-11-08 Neurimmune AG Human anti-tau antibodies
CN113005096B (zh) * 2021-01-19 2022-10-14 华中科技大学 分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株
CN114539400B (zh) * 2022-02-15 2024-06-07 武汉天德生物科技有限公司 一种磷酸化Tau pT217蛋白单克隆抗体、ELISA试剂盒及其应用
WO2023250388A1 (en) 2022-06-22 2023-12-28 Voyager Therapeutics, Inc. Tau binding compounds
WO2024059739A1 (en) 2022-09-15 2024-03-21 Voyager Therapeutics, Inc. Tau binding compounds

Also Published As

Publication number Publication date
ATE165866T1 (de) 1998-05-15
AU690092B2 (en) 1998-04-23
ES2118373T3 (es) 1998-09-16
EP0673418B1 (en) 1998-05-06
JPH08502898A (ja) 1996-04-02
AU5809794A (en) 1994-07-04
DE69318420T2 (de) 1999-01-28
EP0673418A1 (en) 1995-09-27
US5843779A (en) 1998-12-01
DE69318420D1 (de) 1998-06-10
JP2879975B2 (ja) 1999-04-05
WO1994013795A1 (en) 1994-06-23

Similar Documents

Publication Publication Date Title
DK0673418T3 (da) Monoklonale antistoffer rettet mod mikrotubulusassocieret tau-protein, hybridomaer, der secernerer disse antistoffer, antig
DK0610330T3 (da) Monoklonale antistoffer mod microtubulus-associeret protein tau
Hamsten et al. Identification of galactose‐α‐1, 3‐galactose in the gastrointestinal tract of the tick I xodes ricinus; possible relationship with red meat allergy
Fu et al. Occurrence of surface IgM, IgD, and free light chains on human lymphocytes
ATE302411T1 (de) Diagnose, prophylaxe und behandlung von morbus crohn durch die verwendung des ompc antigens
ATE208820T1 (de) Humanisierte antikoerper
FI834530A (fi) Affinitetsreningsfoerfarande medelst monoklonala anti-kroppar.
DK0476226T3 (da) Monoklonalt antistof mod humant IgE
DK0635132T3 (da) Bredt reaktive opsoniske antistoffer, som reagerer med fælles stafylokok-antigener
KR900701318A (ko) 항-사람 고분자량- 흑색종 관련 항원에 대한 항-이디오 타입 항체
Mageed et al. Restricted light chain subgroup expression on human rheumatoid factor paraproteins determined by monoclonal antibodies.
NO972522L (no) Monoklonale antistoffer med immunoundertrykkende aktivitet
Cooper et al. Quantitation of surface-membrane and intracellular gamma, mu and kappa chains of normal and neoplastic human lymphocytes
ATE111606T1 (de) Ein gattungsspezifisches listeria-antigen, identifiziert durch monoklonale antikörper.
D'Amelio et al. Detection and partial characterization of circulating immune complexes in hydatid disease
Dziarski Anti-immunoglobulin autoantibodies are not preferentially induced in polyclonal activation of human and mouse lymphocytes, and more anti-DNA and anti-erythrocyte autoantibodies are induced in polyclonal activation of mouse than human lymphocytes.
CA2150816A1 (en) Monoclonal antibodies directed against the microtubule- associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and theirapplications
Evans et al. Investigation of the idiotypic determinants of IgM monoclonal proteins associated with neuropathy.
Brown et al. Detection of antibody, idiotype, and anti-idiotype forming cells by in situ immunocytochemical staining
Grov et al. AN EXAMINATION OF THE “STAR‐PHENOMENON”, A THREE COMPONENT IMMUNOPRECIPITATION INVOLVING STAPHYLOCOCCAL PROTEIN A
Süsal et al. Role of anti-IgG autoantibodies in kidney transplantation
DK0513565T3 (da) Monoklonale antistoffer mod plasmin-antiplasmin-komplekset, fremgangsmåde til deres fremstilling og deres anvendelse
Williams Jr et al. Expression of F4, 8.12, 3I, and 16/6 Anti-DNA Idiotype-Related Antigens on Cationic Human IgG Myeloma Proteins
Waller et al. The hydrolysis of human IgG with subtilisin
Sluis et al. Inhibition of idiotype-anti-idiotype reaction in particle counting immunoassay as a tentative assay of IgE