BR9913112A - Tau como um marcador para dano inicial de cns - Google Patents

Tau como um marcador para dano inicial de cns

Info

Publication number
BR9913112A
BR9913112A BR9913112-9A BR9913112A BR9913112A BR 9913112 A BR9913112 A BR 9913112A BR 9913112 A BR9913112 A BR 9913112A BR 9913112 A BR9913112 A BR 9913112A
Authority
BR
Brazil
Prior art keywords
cns
tau
marker
initial damage
individual
Prior art date
Application number
BR9913112-9A
Other languages
English (en)
Inventor
Frank Hulstaert
Eugeen Vanmechelen
Hugo Vanderstichele
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Publication of BR9913112A publication Critical patent/BR9913112A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Devices That Are Associated With Refrigeration Equipment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

"TAU COMO UM MARCADOR PARA DANO INICIAL DE CNS" A presente invenção provê um novo processo para o diagnóstico precoce de dano de CNS em um indivíduo, o dito dano de CNS sendo causado por lesões ocupantes de espaço do CNS, por invasão ou metástase do CNS, por organismos, por anoxia ou isquemia, por agentes químicos, por agentes físicos, ou por uma combinação destes mecanismos. O novo processo compreende a etapa de determinação e/ou quantificação do nível de tau no dito indivíduo e comparando o mesmo aonível de tau em indivíduos controles saudáveis.
BR9913112-9A 1998-09-08 1999-09-07 Tau como um marcador para dano inicial de cns BR9913112A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98870190 1998-09-08
PCT/EP1999/006592 WO2000014546A1 (en) 1998-09-08 1999-09-07 Tau as a marker for early cns damage

Publications (1)

Publication Number Publication Date
BR9913112A true BR9913112A (pt) 2001-05-08

Family

ID=8237090

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9913112-9A BR9913112A (pt) 1998-09-08 1999-09-07 Tau como um marcador para dano inicial de cns

Country Status (11)

Country Link
EP (1) EP1112500B1 (pt)
JP (1) JP4624559B2 (pt)
CN (2) CN1325491A (pt)
AT (1) ATE277353T1 (pt)
AU (1) AU772151B2 (pt)
BR (1) BR9913112A (pt)
CA (1) CA2340433A1 (pt)
DE (1) DE69920487T2 (pt)
ES (1) ES2229817T3 (pt)
HK (1) HK1040429B (pt)
WO (1) WO2000014546A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004016655A1 (ja) 2002-08-14 2004-02-26 Mitsubishi Chemical Corporation 中枢性タウ蛋白質特異的抗体
NZ539734A (en) 2002-10-09 2011-07-29 Dmi Biosciences Inc Diagnosis and monitoring of inflammation, ischemia and appendicitis
JP5721426B2 (ja) 2007-04-05 2015-05-20 ザ ジェイ．ディヴィッド グラッドストン インスティテューツ 神経の過度な興奮を緩和する薬剤を識別する方法
AU2009282117B2 (en) 2008-08-11 2016-05-12 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
ES2687469T3 (es) * 2009-09-14 2018-10-25 Banyan Biomarkers, Inc. Marcadores autoanticuerpos para el diagnóstico de traumatismo craneoencefálico
RU2449287C1 (ru) * 2011-03-17 2012-04-27 Государственное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГОУ ВПО СибГМУ Минздравсоцразвития) Способ антенатального прогнозирования последствий перинатальных поражений нервной системы у детей
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
SG11201408626YA (en) 2012-07-03 2015-03-30 Univ Washington Antibodies to tau
KR101582387B1 (ko) * 2013-12-12 2016-01-05 서울대학교산학협력단 뇌전이암 원인종양 진단용 조성물 및 그의 용도
TWI734975B (zh) 2014-06-27 2021-08-01 美商Ｃ２Ｎ醫療診斷有限責任公司 人類化抗-tau抗體
RU2568914C1 (ru) * 2014-07-31 2015-11-20 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский институт акушерства и педиатрии" Министерства здравоохранения Российской Федерации Способ прогнозирования перинатального поражения цнс у недоношенных новорожденных
CN110366558A (zh) 2016-10-28 2019-10-22 班扬生物标记公司 针对泛素c末端水解酶l1(uch-l1)和胶质纤维酸性蛋白(gfap)的抗体及相关方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0610330B1 (en) * 1991-10-25 1997-06-18 N.V. Innogenetics S.A. Monoclonal antibodies directed against the microtubule-associated protein tau
DE69318420T2 (de) * 1992-12-14 1999-01-28 Naamloze Vennootschap Innogenetics S.A., Gent Monoklonale antikörper gegen das mikrotubulusassoziierte tauprotein,hybridomen, die diese antikörper sezernieren, antigenerkennung durch diese monoklonalen antikörper und deren verwendung
JPH06239899A (ja) * 1993-02-12 1994-08-30 Teijin Ltd ヒトタウ蛋白に対する抗体、並びに該抗体を利用する体液中のヒトタウ蛋白の測定方法
JPH10506381A (ja) * 1994-07-29 1998-06-23 イノジェネティックス・ナムローゼ・フェンノートシャップ 特定のサブクラスまたは形態のホスホリレーションされたｔａｕのエピトープに特異的なモノクローナル抗体、それらを分泌するハイブリドーマ、これらの抗体の抗原認識およびそれらの応用
US7427392B1 (en) * 1994-11-14 2008-09-23 Elan Pharmaceuticals, Inc. Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau

Also Published As

Publication number Publication date
HK1040429A1 (en) 2002-06-07
AU772151B2 (en) 2004-04-08
JP2002524740A (ja) 2002-08-06
EP1112500B1 (en) 2004-09-22
CA2340433A1 (en) 2000-03-16
CN1325491A (zh) 2001-12-05
ATE277353T1 (de) 2004-10-15
DE69920487D1 (de) 2004-10-28
JP4624559B2 (ja) 2011-02-02
ES2229817T3 (es) 2005-04-16
AU5974699A (en) 2000-03-27
EP1112500A1 (en) 2001-07-04
HK1040429B (zh) 2005-08-12
DE69920487T2 (de) 2006-03-09
CN101046476A (zh) 2007-10-03
CN101046476B (zh) 2013-04-10
WO2000014546A1 (en) 2000-03-16

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A, 7A E 8A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007.