DK0670845T3 - Fremgangsmåde til fremstilling af fludarabinphosphat ud fra guanosin - Google Patents

Fremgangsmåde til fremstilling af fludarabinphosphat ud fra guanosin

Info

Publication number
DK0670845T3
DK0670845T3 DK94902410T DK94902410T DK0670845T3 DK 0670845 T3 DK0670845 T3 DK 0670845T3 DK 94902410 T DK94902410 T DK 94902410T DK 94902410 T DK94902410 T DK 94902410T DK 0670845 T3 DK0670845 T3 DK 0670845T3
Authority
DK
Denmark
Prior art keywords
guanosine
fludarabine phosphate
producing
conversion
fludarabine
Prior art date
Application number
DK94902410T
Other languages
English (en)
Inventor
John G Bauman
Randolph C Wirsching
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0670845T3 publication Critical patent/DK0670845T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK94902410T 1992-11-25 1993-11-24 Fremgangsmåde til fremstilling af fludarabinphosphat ud fra guanosin DK0670845T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/981,114 US5602246A (en) 1992-11-25 1992-11-25 Process for the preparation of fludarabine or fludarabine phosphate from guanosine
PCT/US1993/011472 WO1994012514A1 (en) 1992-11-25 1993-11-24 Process for the preparation of fludarabine phosphate from guanosine

Publications (1)

Publication Number Publication Date
DK0670845T3 true DK0670845T3 (da) 1998-09-14

Family

ID=25528119

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94902410T DK0670845T3 (da) 1992-11-25 1993-11-24 Fremgangsmåde til fremstilling af fludarabinphosphat ud fra guanosin

Country Status (11)

Country Link
US (2) US5602246A (da)
EP (1) EP0670845B1 (da)
JP (1) JP3523870B2 (da)
AT (1) ATE162197T1 (da)
AU (1) AU676874B2 (da)
CA (1) CA2149117A1 (da)
DE (1) DE69316391T2 (da)
DK (1) DK0670845T3 (da)
ES (1) ES2114173T3 (da)
GR (1) GR3026499T3 (da)
WO (1) WO1994012514A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009244A1 (de) * 1993-09-28 1995-04-06 Schering Aktiengesellschaft Verfahren zur herstellung von arabinonukleotiden
DE69638137D1 (de) * 1995-09-07 2010-04-15 Univ Georgia Therapeutische azidverbindungen
PL195712B1 (pl) 1997-12-11 2007-10-31 Schering Ag Sposób wytwarzania soli litowych, sodowych, potasowych, wapniowych i magnezowych fosforanu fludarabiny oraz sposób wytwarzania fosforanu fludarabiny
JP2000040679A (ja) * 1998-07-24 2000-02-08 Hitachi Ltd 半導体集積回路装置の製造方法
EP1556400B1 (en) * 2002-09-25 2013-05-01 Brigham Young University Method for the preparation of 2-halo-2 -deoxyadenosine compounds from 2 -deoxyguanosine
EP1464708A1 (en) * 2003-04-03 2004-10-06 Pro. Bio. Sint. S.p.A. A process for the preparation of fludarabine phosphate from 2-fluoroadenine
MX2007015595A (es) * 2005-06-10 2008-03-07 Univ Florida State Res Found Procesos para la produccion de compuestos de anillo fusionado policiclico.
JP5113745B2 (ja) * 2005-06-10 2013-01-09 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド ドセタキセルの製造法
CN101092441A (zh) * 2007-07-17 2007-12-26 北京本草天源药物研究院 一种奈拉滨的合成方法
FR2926079B1 (fr) 2008-01-03 2012-12-28 Commissariat Energie Atomique Procede de preparation d'un derive de purine marque, ledit derive et ses utilisations
CN101830955B (zh) * 2009-03-13 2013-09-11 浙江海正药业股份有限公司 抗肿瘤药物氯法拉宾的合成工艺
US20120220762A1 (en) * 2009-05-12 2012-08-30 Mathias Berwe Method for the manufacture of 2-fluoro-ara-adenine
CN101735296B (zh) * 2009-12-18 2013-03-27 天津市炜杰科技有限公司 一种氟达拉滨的制备方法
CN102311472B (zh) 2010-07-09 2014-09-03 神隆(昆山)生化科技有限公司 2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备
EP2428201A1 (en) 2010-09-08 2012-03-14 Merck Serono S.A. Oral administration of nucleoside monophosphates
CN102485738A (zh) * 2011-10-18 2012-06-06 连云港盛和生物科技有限公司 氟达拉滨中间体2-氟-2′,3′,5′-三-o-乙酰基腺苷合成方法
CN102911230A (zh) * 2012-04-16 2013-02-06 淮海工学院 一种氟达拉滨的合成方法
CN103333215A (zh) * 2013-07-01 2013-10-02 淮海工学院 一种合成2-氟腺苷的方法
CN107556356B (zh) * 2017-09-27 2020-07-10 新乡拓新药业股份有限公司 一种合成阿糖腺苷的方法
CN108640960A (zh) * 2018-06-14 2018-10-12 慎终（上海）生物科技有限公司 氟达拉滨碱的合成工艺
CN109776639B (zh) * 2019-03-05 2022-04-08 重庆海腾制药有限公司 一种阿糖苷类化合物杂质的合成方法

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US2719843A (en) * 1951-10-24 1955-10-04 Davoll John Method of synthesizing nucleosides and analogous compounds and compounds prepared thereby
US3074930A (en) * 1955-08-11 1963-01-22 Burroughs Wellcome Co 6-mercaptopurine nucleosides and method of preparing them
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CH443312A (fr) * 1963-10-29 1967-09-15 Ajinomoto Kk Procédé de préparation du 1-N-oxyde d'hypoxanthine et du 1-N-oxyde d'inosine substituée ou non, et utilisation des produits obtenus par ce procédé poutilisation des produits obtenus par ce procédé pour la préparation de la 2,6-dichloro-purine et 9-B-D-ribofuranosyl purine substitua ée ou non
US3309358A (en) * 1965-09-20 1967-03-14 Upjohn Co 7-deazaadenine 2', 5'-and 3', 5'-dinucleoside phosphate and process therefor
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Also Published As

Publication number Publication date
JP3523870B2 (ja) 2004-04-26
DE69316391T2 (de) 1998-08-13
AU5679294A (en) 1994-06-22
ES2114173T3 (es) 1998-05-16
AU676874B2 (en) 1997-03-27
CA2149117A1 (en) 1994-06-09
JPH08505608A (ja) 1996-06-18
EP0670845B1 (en) 1998-01-14
EP0670845A1 (en) 1995-09-13
DE69316391D1 (de) 1998-02-19
WO1994012514A1 (en) 1994-06-09
US5668270A (en) 1997-09-16
ATE162197T1 (de) 1998-01-15
US5602246A (en) 1997-02-11
GR3026499T3 (en) 1998-07-31

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