RU93055875A - Новый способ получения производных n*994-ацил-5'-дезокси-5-флюороцитидина - Google Patents

Новый способ получения производных n*994-ацил-5'-дезокси-5-флюороцитидина

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Publication number
RU93055875A
RU93055875A RU93055875/04A RU93055875A RU93055875A RU 93055875 A RU93055875 A RU 93055875A RU 93055875/04 A RU93055875/04 A RU 93055875/04A RU 93055875 A RU93055875 A RU 93055875A RU 93055875 A RU93055875 A RU 93055875A
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RU
Russia
Prior art keywords
deoxy
acyl
derivatives
fluorocytidine
producing
Prior art date
Application number
RU93055875/04A
Other languages
English (en)
Other versions
RU2131879C1 (ru
Inventor
Камийя Такаши
Ишидука Макото
Накайма Хироши
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Фуджи Кагаку Когио
Кабушики Кайша
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Ф.Хоффманн-Ля Рош Аг, Фуджи Кагаку Когио, Кабушики Кайша filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of RU93055875A publication Critical patent/RU93055875A/ru
Application granted granted Critical
Publication of RU2131879C1 publication Critical patent/RU2131879C1/ru

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Claims (1)

  1. Предусматривается новый способ получения N4-ацил-5'-деокси-5-фтороцитидиновых производных с использованием новых 5'-деокси-5-фторо-N4,2'-О,3-О-триацилцитидиновых производных. 5-Деокси-1,2,3-три-О-ацил-β-D-рибофуранозид химически взаимодействует с 5-фтороцитозином, в результате чего получают 5'-деокси-2', 3' -ди-О-ацил-5-фтороцитидин, после чего происходит ацилирование. Ациловые радикалы полученного 5'-деокси-5-фторо-N4,2'-О,3'-О-триацилцитидиновых производных избирательно де-О-ацилируются, в результате чего получаются N-ацил-5'-деокси-5-фтороцитидиновые производные. Из фтороцитозина могут быть получены N4-ацил-5'-деокси-5-фтороцитидиновые производные при осуществлении очень небольшого числа этапов и с высокими выходами.
RU93055875A 1992-12-18 1993-12-16 Способы получения производных n4-ацил-5'-дезокси-5-фторцитидина RU2131879C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92121539.8 1992-12-18
EP92121539 1992-12-18

Publications (2)

Publication Number Publication Date
RU93055875A true RU93055875A (ru) 1997-03-27
RU2131879C1 RU2131879C1 (ru) 1999-06-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU93055875A RU2131879C1 (ru) 1992-12-18 1993-12-16 Способы получения производных n4-ацил-5'-дезокси-5-фторцитидина

Country Status (13)

Country Link
US (1) US5453497A (ru)
EP (1) EP0602478B1 (ru)
JP (2) JP3530218B2 (ru)
KR (1) KR100343481B1 (ru)
CN (1) CN1035675C (ru)
AT (1) ATE140923T1 (ru)
CA (1) CA2110335C (ru)
CY (1) CY2154B1 (ru)
DE (1) DE69303879T2 (ru)
DK (1) DK0602478T3 (ru)
ES (1) ES2093905T3 (ru)
RU (1) RU2131879C1 (ru)
TW (1) TW254946B (ru)

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