DK0624594T3 - Monomere galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemiddel - Google Patents
Monomere galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemiddelInfo
- Publication number
- DK0624594T3 DK0624594T3 DK94106845T DK94106845T DK0624594T3 DK 0624594 T3 DK0624594 T3 DK 0624594T3 DK 94106845 T DK94106845 T DK 94106845T DK 94106845 T DK94106845 T DK 94106845T DK 0624594 T3 DK0624594 T3 DK 0624594T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- processes
- preparation
- acid derivatives
- bile acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4315439 | 1993-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0624594T3 true DK0624594T3 (da) | 1999-12-13 |
Family
ID=6487634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94106845T DK0624594T3 (da) | 1993-05-08 | 1994-05-02 | Monomere galdesyrederivater, fremgangsmåde til deres fremstilling og anvendelse af disse forbindelser som lægemiddel |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5610151A (zh) |
| EP (1) | EP0624594B1 (zh) |
| JP (1) | JP3424978B2 (zh) |
| KR (1) | KR100333151B1 (zh) |
| AT (1) | ATE183191T1 (zh) |
| AU (1) | AU673419B2 (zh) |
| CA (1) | CA2123052C (zh) |
| CZ (1) | CZ289209B6 (zh) |
| DE (1) | DE59408602D1 (zh) |
| DK (1) | DK0624594T3 (zh) |
| ES (1) | ES2136677T3 (zh) |
| FI (1) | FI942077A (zh) |
| GR (1) | GR3031541T3 (zh) |
| HU (1) | HUT67574A (zh) |
| IL (1) | IL109580A (zh) |
| NO (1) | NO304794B1 (zh) |
| NZ (1) | NZ260471A (zh) |
| TW (1) | TW289021B (zh) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0573848B1 (de) * | 1992-06-12 | 1997-12-03 | Hoechst Aktiengesellschaft | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel |
| TW289020B (zh) * | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6107494A (en) * | 1994-09-13 | 2000-08-22 | G.D. Searle And Company | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| DE19845403B4 (de) | 1998-10-02 | 2005-02-10 | Aventis Pharma Deutschland Gmbh | Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE19849722A1 (de) * | 1998-10-28 | 2000-05-04 | Aventis Pharma Gmbh | Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DK1140185T3 (da) | 1998-12-23 | 2003-09-29 | Searle Llc | Kombinationer af cholesterylestertransferhæmmere og galdesyre kompleksdannende forbindelser til hjertekar indikationer |
| EA004231B1 (ru) * | 1998-12-23 | 2004-02-26 | Джи.Ди.Сирл Ллс | Сочетание ингибиторов белка, переносящего эфир холестерила, и производных фибриновой кислоты для сердечно-сосудистых показаний |
| PT1140189E (pt) | 1998-12-23 | 2003-09-30 | Searle Llc | Combinacoes de inibidores do transporte do acido biliar ileal e de derivados do acido fibrico para indicacoes cardiovasculares |
| EA200100704A1 (ru) * | 1998-12-23 | 2002-02-28 | Джи.Ди.Сирл Ллс | Комбинация для применения по сердечно-сосудистым показаниям |
| US6462091B1 (en) | 1998-12-23 | 2002-10-08 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications |
| ES2201822T3 (es) * | 1998-12-23 | 2004-03-16 | G.D. Searle Llc | Combinaciones de inhibididores de la proteina de transferencia de ester de colesterilo y de derivados de acido nicotinico para indicaciones cardiovasculares. |
| NZ512535A (en) | 1998-12-23 | 2003-12-19 | G | Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications |
| EA005815B1 (ru) | 1998-12-23 | 2005-06-30 | Джи.Ди.Сирл Ллс | Комбинация ингибиторов транспорта желчных кислот в подвздошной кишке и ингибиторов белка, переносящего эфиры холестерина, для сердечно-сосудистых показаний |
| DE19941764A1 (de) | 1999-09-02 | 2001-03-15 | Aventis Pharma Gmbh | Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente |
| HUP0203045A3 (en) * | 1999-09-22 | 2004-06-28 | Sanofi Aventis Deutschland | 4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use |
| AU2001247331A1 (en) * | 2000-03-10 | 2001-09-24 | Pharmacia Corporation | Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders |
| JP2003528830A (ja) | 2000-03-10 | 2003-09-30 | ファルマシア・コーポレーション | テトラヒドロベンゾチエピン類の製造方法 |
| US6624155B2 (en) * | 2001-05-01 | 2003-09-23 | Board Of Trustees Of The University Of Arkansas | Hybrid cholinergic agents and compositions |
| US20040077625A1 (en) * | 2001-07-25 | 2004-04-22 | Tremont Samuel J. | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake |
| BR0213501A (pt) * | 2001-11-02 | 2004-08-24 | Searle Llc | Compostos de benzotiepina mono- e di-fluorada como inibidores de transporte de ácido biliar co-dependente de sódio apical (asbt) e captação de taurocolato |
| WO2003061604A2 (en) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
| DE10259374A1 (de) * | 2002-12-18 | 2004-07-08 | Atto-Tec Gmbh | Carboxamid-substituierte Farbstoffe für analytische Anwendungen |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| US7344701B2 (en) * | 2004-02-03 | 2008-03-18 | Biosearch Technologies, Inc. | Xanthene dyes |
| EP1750776A2 (en) | 2004-04-30 | 2007-02-14 | Alnylam Pharmaceuticals Inc. | Oligonucleotides comprising a c5-modified pyrimidine |
| US8391785B2 (en) * | 2005-04-29 | 2013-03-05 | Impinj, Inc. | Interference rejection in RFID tags |
| JP4913561B2 (ja) * | 2006-11-17 | 2012-04-11 | 株式会社リコー | コロナ帯電装置及び画像形成装置 |
| EP3593802A3 (en) | 2010-05-26 | 2020-03-25 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| BR112013010157B1 (pt) | 2010-11-08 | 2020-02-04 | Albireo Ab | iinibidores do ibat, seus usos, e composição e combinações farmacêuticas |
| SG190433A1 (en) | 2010-11-08 | 2013-06-28 | Albireo Ab | A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
| US20140243281A1 (en) | 2011-10-28 | 2014-08-28 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| SG10201406155QA (en) | 2011-10-28 | 2014-11-27 | Lumena Pharmaceuticals Inc | Bile Acid Recycling Inhibitors For Treatment Of Pediatric Cholestatic Liver Diseases |
| AU2014229050A1 (en) | 2013-03-15 | 2015-10-22 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of Barrett's esophagus and gastroesophageal reflux disease |
| JP2016514684A (ja) | 2013-03-15 | 2016-05-23 | ルメナ ファーマシューティカルズ エルエルシー | 原発性硬化性胆管炎および炎症性腸疾患の処置のための胆汁酸再循環阻害剤 |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| CA2952406A1 (en) | 2014-06-25 | 2015-12-30 | Ea Pharma Co., Ltd. | Solid formulation and method for preventing or reducing coloration thereof |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| JP6954926B2 (ja) | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | 経口コレスチラミン製剤及びその使用 |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| JP6954927B2 (ja) | 2016-02-09 | 2021-10-27 | アルビレオ・アクチボラグ | 経口コレスチラミン製剤及びその使用 |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| JP2018199648A (ja) * | 2017-05-29 | 2018-12-20 | 五稜化薬株式会社 | 新規トランスポーター機能解析用蛍光物質 |
| JP2020530448A (ja) | 2017-08-09 | 2020-10-22 | アルビレオ・アクチボラグ | コレスチラミン顆粒、経口コレスチラミン製剤、及びそれらの使用 |
| CN110996915B (zh) | 2017-08-09 | 2023-10-03 | 阿尔比里奥公司 | 考来烯胺丸粒、口服考来烯胺制剂及其用途 |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JP7391048B2 (ja) | 2018-06-05 | 2023-12-04 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| MX2020013839A (es) | 2018-06-20 | 2021-03-25 | Albireo Ab | Formulacion farmaceutica de odevixibat. |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| ES2955799T3 (es) | 2019-02-06 | 2023-12-07 | Albireo Ab | Compuestos de benzotiazepina y su uso como moduladores de los ácidos biliares |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| UA127911C2 (uk) | 2019-02-06 | 2024-02-07 | Альбірео Аб | Сполуки бензотіадіазепіну та їх застосування як модуляторів жовчних кислот |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| MX2021009625A (es) | 2019-02-12 | 2021-11-04 | Mirum Pharmaceuticals Inc | Métodos para incrementar el crecimiento en sujetos pediátricos que tienen enfermedad de hígado colestásico. |
| WO2021110885A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| AR120683A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como ácido biliar |
| DK4069360T3 (da) | 2019-12-04 | 2024-02-26 | Albireo Ab | Benzothia(di)azepinforbindelser og anvendelse deraf som galdesyremodulatorer |
| AR120679A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores ácido biliar |
| TW202134220A (zh) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| JP2023504643A (ja) | 2019-12-04 | 2023-02-06 | アルビレオ・アクチボラグ | ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用 |
| AR120674A1 (es) | 2019-12-04 | 2022-03-09 | Albireo Ab | Compuestos de benzotiazepina y su uso como ácido biliar |
| EP4069247A1 (en) | 2019-12-04 | 2022-10-12 | Albireo AB | Benzothiadiazepine compounds and their use as bile acid modulators |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| CN114786772B (zh) | 2019-12-04 | 2024-04-09 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| EP4188541A1 (en) | 2020-08-03 | 2023-06-07 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JP7217384B2 (ja) | 2020-10-09 | 2023-02-02 | ポリプラスチックス株式会社 | ポリアセタール樹脂組成物及び自動車部品 |
| JP7078687B2 (ja) | 2020-10-09 | 2022-05-31 | ポリプラスチックス株式会社 | ポリアセタール樹脂組成物及び自動車部品 |
| EP4243831A1 (en) | 2020-11-12 | 2023-09-20 | Albireo AB | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| BR112023010799A2 (pt) | 2020-12-04 | 2023-10-03 | Albireo Ab | Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| US20230338392A1 (en) | 2022-04-22 | 2023-10-26 | Albireo Ab | Subcutaneous administration of an asbt inhibitor |
| US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
| US20240067617A1 (en) | 2022-07-05 | 2024-02-29 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US489423A (en) * | 1893-01-03 | Electric time-alarm | ||
| US417725A (en) * | 1889-12-24 | Coffin | ||
| DE1119263B (de) * | 1959-07-09 | 1961-12-14 | Riedel De Haeen Ag | Verfahren zur Herstellung neuer Sulfonylurethane |
| US3859437A (en) * | 1972-06-02 | 1975-01-07 | Intellectual Property Dev Corp | Reducing cholesterol levels |
| US4217279A (en) * | 1978-12-18 | 1980-08-12 | Kaiser Emil T | Synthesis of steroids |
| US4848349A (en) * | 1987-04-29 | 1989-07-18 | Sherman Igor A | Substance and method for measuring hepatic blood flow |
| DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| FI106800B (fi) * | 1990-12-06 | 2001-04-12 | Hoechst Ag | Menetelmä uusien terapeuttisesti käyttökelpoisten dimeeristen sappihappojohdannaisten valmistamiseksi |
| AU664059B2 (en) * | 1991-12-20 | 1995-11-02 | Hoechst Aktiengesellschaft | Ethylenically unsaturated bile acid derivatives, processes for their preparation and precursors |
-
1993
- 1993-11-23 TW TW082109828A patent/TW289021B/zh active
-
1994
- 1994-05-02 DE DE59408602T patent/DE59408602D1/de not_active Expired - Lifetime
- 1994-05-02 ES ES94106845T patent/ES2136677T3/es not_active Expired - Lifetime
- 1994-05-02 AT AT94106845T patent/ATE183191T1/de not_active IP Right Cessation
- 1994-05-02 EP EP94106845A patent/EP0624594B1/de not_active Expired - Lifetime
- 1994-05-02 DK DK94106845T patent/DK0624594T3/da active
- 1994-05-05 FI FI942077A patent/FI942077A/fi unknown
- 1994-05-05 US US08/238,749 patent/US5610151A/en not_active Expired - Lifetime
- 1994-05-06 NZ NZ260471A patent/NZ260471A/en unknown
- 1994-05-06 IL IL10958094A patent/IL109580A/en not_active IP Right Cessation
- 1994-05-06 NO NO941678A patent/NO304794B1/no not_active IP Right Cessation
- 1994-05-06 HU HU9401408A patent/HUT67574A/hu unknown
- 1994-05-06 AU AU61949/94A patent/AU673419B2/en not_active Ceased
- 1994-05-06 CZ CZ19941137A patent/CZ289209B6/cs not_active IP Right Cessation
- 1994-05-06 JP JP09411494A patent/JP3424978B2/ja not_active Expired - Lifetime
- 1994-05-06 CA CA002123052A patent/CA2123052C/en not_active Expired - Lifetime
- 1994-05-07 KR KR1019940009974A patent/KR100333151B1/ko not_active IP Right Cessation
-
1999
- 1999-10-15 GR GR990402628T patent/GR3031541T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE59408602D1 (de) | 1999-09-16 |
| NO941680D0 (no) | 1994-05-06 |
| IL109580A (en) | 1999-03-12 |
| NO941680L (no) | 1994-11-09 |
| KR100333151B1 (ko) | 2002-09-04 |
| JP3424978B2 (ja) | 2003-07-07 |
| TW289021B (zh) | 1996-10-21 |
| CA2123052C (en) | 2005-04-26 |
| HU9401408D0 (en) | 1994-08-29 |
| NO304794B1 (no) | 1999-02-15 |
| HUT67574A (en) | 1995-04-28 |
| CZ289209B6 (cs) | 2001-12-12 |
| EP0624594B1 (de) | 1999-08-11 |
| US5610151A (en) | 1997-03-11 |
| ATE183191T1 (de) | 1999-08-15 |
| ES2136677T3 (es) | 1999-12-01 |
| NZ260471A (en) | 1995-04-27 |
| CZ113794A3 (en) | 1994-11-16 |
| GR3031541T3 (en) | 2000-01-31 |
| AU673419B2 (en) | 1996-11-07 |
| FI942077A (fi) | 1994-11-09 |
| IL109580A0 (en) | 1994-08-26 |
| JPH072891A (ja) | 1995-01-06 |
| EP0624594A2 (de) | 1994-11-17 |
| FI942077A0 (fi) | 1994-05-05 |
| EP0624594A3 (de) | 1996-05-01 |
| AU6194994A (en) | 1994-11-10 |
| CA2123052A1 (en) | 1994-11-09 |
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