DK0567448T4 - Fremgangsmåde til fremstilling af faktor VIII - Google Patents

Fremgangsmåde til fremstilling af faktor VIII

Info

Publication number
DK0567448T4
DK0567448T4 DK93890076T DK93890076T DK0567448T4 DK 0567448 T4 DK0567448 T4 DK 0567448T4 DK 93890076 T DK93890076 T DK 93890076T DK 93890076 T DK93890076 T DK 93890076T DK 0567448 T4 DK0567448 T4 DK 0567448T4
Authority
DK
Denmark
Prior art keywords
factor viii
preparation
surfactant
preparing factor
preparing
Prior art date
Application number
DK93890076T
Other languages
Danish (da)
English (en)
Other versions
DK0567448T3 (da
Inventor
Friedrich Dr Elsinger
Herbert Gritsch
Yendra Dr Linnau
Otto Dr Schwarz
Peter Dr Turecek
Guenther Prof Dr Woeber
Johann Dr Eibl
Original Assignee
Immuno Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3501200&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0567448(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immuno Ag filed Critical Immuno Ag
Publication of DK0567448T3 publication Critical patent/DK0567448T3/da
Application granted granted Critical
Publication of DK0567448T4 publication Critical patent/DK0567448T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y10S530/831—Cohn fractions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK93890076T 1992-04-24 1993-04-07 Fremgangsmåde til fremstilling af faktor VIII DK0567448T4 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0084992A AT399818B (de) 1992-04-24 1992-04-24 Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation

Publications (2)

Publication Number Publication Date
DK0567448T3 DK0567448T3 (da) 1999-03-22
DK0567448T4 true DK0567448T4 (da) 2005-05-02

Family

ID=3501200

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93890076T DK0567448T4 (da) 1992-04-24 1993-04-07 Fremgangsmåde til fremstilling af faktor VIII

Country Status (18)

Country Link
US (1) US5410022A (fr)
EP (1) EP0567448B2 (fr)
JP (1) JP2511631B2 (fr)
AT (2) AT399818B (fr)
AU (1) AU659301B2 (fr)
BR (1) BR9301641A (fr)
CA (1) CA2094347C (fr)
CZ (1) CZ279979B6 (fr)
DE (1) DE59308628D1 (fr)
DK (1) DK0567448T4 (fr)
ES (1) ES2117703T5 (fr)
FI (1) FI106468B (fr)
HU (1) HU210632B (fr)
MX (1) MX9302279A (fr)
NO (1) NO307465B1 (fr)
PL (1) PL172462B1 (fr)
SK (1) SK279750B6 (fr)
ZA (1) ZA932843B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013329A1 (fr) * 1992-12-16 1994-06-23 Immuno Aktiengesellschaft Procede de preparation de compositions biologiques exemptes de virus
DE4320294A1 (de) * 1993-06-18 1994-12-22 Immuno Ag Verwendung von humanem Protein C zur Verhinderung und Behandlung von Thrombozytenablagerungen
DE4325872C1 (de) * 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
AT402788B (de) * 1993-08-03 1997-08-25 Immuno Ag Virussichere blutgerinnungsfaktor xiii-präparation
DE4337573C1 (de) * 1993-11-04 1995-05-18 Octapharma Ag Verfahren zur Herstellung einer virusinaktivierten Faktor VIII enthaltenden Fraktion mittels chromatographischer Methoden
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
AT403764B (de) 1996-03-15 1998-05-25 Immuno Ag Stabiler faktor viii/vwf-komplex
DE19623293C2 (de) * 1996-06-11 1998-10-22 Biotest Pharma Gmbh Nicht-immunogene Faktor VIII-enthaltende Zusammensetzung und ein Verfahren zu ihrer Herstellung
AT404358B (de) 1997-02-04 1998-11-25 Immuno Ag Verfahren zur chromatographischen reinigung bzw. fraktionierung von von willebrand-faktor aus einem vwf-hältigen ausgangsmaterial
US6586573B1 (en) 1999-02-22 2003-07-01 Baxter International Inc. Albumin-free Factor VIII formulations
US20040117862A1 (en) * 2002-03-11 2004-06-17 Cooper Julian D. Production of high levels of transgenic factor VII with engineered stability and its therapeutic uses
US20060110788A1 (en) * 2004-10-01 2006-05-25 Invitrogen Corporation Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
AU2009313325B2 (en) * 2008-11-07 2014-05-01 Takeda Pharmaceutical Company Limited Factor VIII formulations
CN101967188B (zh) * 2010-11-08 2012-11-28 江西博雅生物制药股份有限公司 一种人凝血因子ⅷ的制备工艺
CN107073084B (zh) * 2014-11-05 2022-03-25 雅培制药股份有限公司 用于生产具有改善的安全特性的具有脂肪酶活性的组合物和适用于药物用途的组合物的方法

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US3920625A (en) * 1973-06-19 1975-11-18 Kabi Ab Isolation of coagulation factors from biological material using cross linked sulfated, sulfonated carbohydrates
AT350726B (de) * 1976-08-30 1979-06-11 Immuno Ag Verfahren zur herstellung einer blut- gerinnungsfoerdernden praeperation aus menschlichem blutplasma
FR2435832A1 (fr) * 1978-07-21 1980-04-04 Alsthom Cgee Dispositif de connexion electrique
US4250139A (en) * 1979-02-01 1981-02-10 Collagen Corporation Microwave sterilization of dry protein
DE2916711A1 (de) * 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
EP0035204B2 (fr) * 1980-03-05 1991-05-22 Miles Inc. Compositions pasteurisées de protéines thérapeutiquement actives
US4314997A (en) * 1980-10-06 1982-02-09 Edward Shanbrom Purification of plasma protein products
EP0050061B2 (fr) * 1980-10-06 1990-06-20 New York Blood Center, Inc. Procédé pour réduire les activités indésirables de produits biologiques et pharmaceutiques
DE3043857A1 (de) * 1980-11-21 1982-07-08 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ii und vii
DE3045153A1 (de) * 1980-11-29 1982-07-08 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ix und x
US4495278A (en) * 1981-04-27 1985-01-22 Baxter Travenol Laboratories, Inc. Process for making novel blood clotting enzyme compositions
US4456590B2 (en) * 1981-11-02 1989-05-30 Heat treatment of lyphilized blood clotting factor viii concentrate
US4481189A (en) * 1982-04-14 1984-11-06 New York Blood Center Inc. Process for preparing sterilized plasma and plasma derivatives
US4379085A (en) * 1982-05-14 1983-04-05 American National Red Cross Heat stabilization of plasma proteins
US4511556A (en) * 1982-06-10 1985-04-16 The United States Of America As Represented By The Department Of Health And Human Services Inactivation of a lipid virus
JPS59134730A (ja) * 1983-01-20 1984-08-02 Green Cross Corp:The 血液凝固第８因子の加熱処理法
CA1213827A (fr) * 1983-04-29 1986-11-12 Ricardo H. Landaburu Procede de pasteurisation de la fibronectine
DE3473407D1 (en) * 1983-05-02 1988-09-22 Immuno Ag Method of inactivating pathogens
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
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DE3432083A1 (de) * 1984-08-31 1986-03-06 Behringwerke Ag, 3550 Marburg Pasteurisierte, isoagglutininfreie faktor viii-praeparation und verfahren zu ihrer herstellung
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JPH0825902B2 (ja) * 1985-02-21 1996-03-13 株式会社ミドリ十字 γ−グロブリンの加熱処理方法
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AT391808B (de) * 1986-11-03 1990-12-10 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion
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AU2251288A (en) * 1987-05-15 1988-12-06 Alan I. Rubinstein Sequential improved method for treatment of human blood- clotting factor products
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AT391809B (de) * 1988-01-12 1990-12-10 Immuno Ag Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutplasmaprodukten
FR2630115B1 (fr) * 1988-04-14 1994-10-28 Merieux Inst Procede de stabilisation des solutions d'albumine humaine et solution obtenue
ATE85220T1 (de) * 1988-05-27 1993-02-15 Centre Regional De Transfusion Verfahren zur herstellung eines hochreinen, virusfreien antihaemophiliefaktors mittels chromatographie.
AT397203B (de) * 1988-05-31 1994-02-25 Immuno Ag Gewebeklebstoff
FR2632309B1 (fr) * 1988-06-07 1990-08-24 Lille Transfusion Sanguine Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus
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DE3843126C3 (de) * 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
EP0378208B2 (fr) * 1989-01-13 2003-01-15 Mitsubishi Pharma Corporation Procédé pour la production d'une composition contenant une protéine
DK0431129T3 (da) * 1989-06-15 1996-06-17 Rorer Int Overseas Fremgangsmåder til inaktivering af virus i viruskontaminerede farmaceutiske præparater
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
US5217737A (en) * 1991-05-20 1993-06-08 Abbott Laboratories Plastic containers capable of surviving sterilization
AT402891B (de) * 1991-06-20 1997-09-25 Immuno Ag Verfahren zur herstellung eines inaktivierten blutproduktes
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
FR2681867B1 (fr) * 1991-09-26 1993-12-31 Pasteur Merieux Serums Vaccins Procede de purification du facteur viii et preparations obtenues.
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
FR2841484B1 (fr) * 2002-06-26 2004-09-10 Boucq De Beaudignies Ghisla Le Dispositif et procede de filtration de l'air et des gaz avec regeneration des particules captees

Also Published As

Publication number Publication date
DE59308628D1 (de) 1998-07-09
HU210632B (en) 1995-06-28
MX9302279A (es) 1994-08-31
BR9301641A (pt) 1993-10-26
EP0567448B1 (fr) 1998-06-03
SK279750B6 (sk) 1999-03-12
ATA84992A (de) 1994-12-15
ATE166881T1 (de) 1998-06-15
EP0567448A1 (fr) 1993-10-27
CA2094347A1 (fr) 1993-10-25
NO931476D0 (no) 1993-04-22
ES2117703T5 (es) 2005-07-16
HUT64777A (en) 1994-02-28
NO307465B1 (no) 2000-04-10
NO931476L (no) 1993-10-25
JP2511631B2 (ja) 1996-07-03
DK0567448T3 (da) 1999-03-22
FI106468B (fi) 2001-02-15
US5410022A (en) 1995-04-25
HU9301038D0 (en) 1993-06-28
ES2117703T3 (es) 1998-08-16
PL172462B1 (pl) 1997-09-30
CA2094347C (fr) 2002-06-25
JPH069694A (ja) 1994-01-18
CZ69293A3 (en) 1993-12-15
FI931826A (fi) 1993-10-25
AT399818B (de) 1995-07-25
EP0567448B2 (fr) 2005-01-05
AU3687593A (en) 1993-10-28
AU659301B2 (en) 1995-05-11
CZ279979B6 (cs) 1995-09-13
FI931826A0 (fi) 1993-04-22
SK39193A3 (en) 1993-11-10
ZA932843B (en) 1993-11-23
PL298670A1 (en) 1994-04-05

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