DK0535152T3 - Bis-benzo- eller benzopyrido-cyclohepta-piperiden, -piperidyliden- og -piperazin-forbindelser og -præparater - Google Patents

Bis-benzo- eller benzopyrido-cyclohepta-piperiden, -piperidyliden- og -piperazin-forbindelser og -præparater

Info

Publication number
DK0535152T3
DK0535152T3 DK91913317.3T DK91913317T DK0535152T3 DK 0535152 T3 DK0535152 T3 DK 0535152T3 DK 91913317 T DK91913317 T DK 91913317T DK 0535152 T3 DK0535152 T3 DK 0535152T3
Authority
DK
Denmark
Prior art keywords
benzopyrido
piperidylidene
benzo
bis
pct
Prior art date
Application number
DK91913317.3T
Other languages
Danish (da)
English (en)
Inventor
John J Piwinski
Michael J Green
Jesse Wong
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK0535152T3 publication Critical patent/DK0535152T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK91913317.3T 1990-06-22 1991-06-21 Bis-benzo- eller benzopyrido-cyclohepta-piperiden, -piperidyliden- og -piperazin-forbindelser og -præparater DK0535152T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54228090A 1990-06-22 1990-06-22

Publications (1)

Publication Number Publication Date
DK0535152T3 true DK0535152T3 (da) 1995-09-25

Family

ID=24163110

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91913317.3T DK0535152T3 (da) 1990-06-22 1991-06-21 Bis-benzo- eller benzopyrido-cyclohepta-piperiden, -piperidyliden- og -piperazin-forbindelser og -præparater

Country Status (26)

Country Link
US (1) US5422351A (fr)
EP (1) EP0535152B1 (fr)
JP (1) JPH0761998B2 (fr)
KR (1) KR960012368B1 (fr)
AT (1) ATE126226T1 (fr)
AU (1) AU646878B2 (fr)
CA (1) CA2085878C (fr)
CZ (1) CZ284610B6 (fr)
DE (2) DE69112061T2 (fr)
DK (1) DK0535152T3 (fr)
ES (1) ES2096657T3 (fr)
FI (1) FI925820A0 (fr)
GR (1) GR3017924T3 (fr)
HK (1) HK186496A (fr)
HU (1) HU220622B1 (fr)
IE (1) IE68935B1 (fr)
IL (1) IL98572A (fr)
NL (1) NL300378I2 (fr)
NO (1) NO303223B1 (fr)
NZ (1) NZ238629A (fr)
OA (1) OA10032A (fr)
PL (1) PL173224B1 (fr)
RU (1) RU2086549C1 (fr)
SK (1) SK280717B6 (fr)
WO (1) WO1992000293A1 (fr)
ZA (1) ZA914764B (fr)

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US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6365588B1 (en) 1993-10-15 2002-04-02 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6075025A (en) * 1993-10-15 2000-06-13 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
ES2087818B1 (es) * 1993-11-24 1997-03-16 Uriach & Cia Sa J 8-cloro-11-(1-((5-metil-3-piridil)metil)-4-piperidiliden)-6,11-dihidro-5h-benzo-(5,6)cicloheptal(1,2-b)piridina, fumarato.
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US5684013A (en) * 1995-03-24 1997-11-04 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
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US5801175A (en) * 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
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US5874442A (en) 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
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US5965570A (en) * 1996-09-13 1999-10-12 Schering Corporation Tricyclic piperidinyl compounds useful as inhibitors of farnesyl-protein transferase
JP2001500507A (ja) * 1996-09-13 2001-01-16 シェーリング コーポレイション ファルネシルタンパク質トランスフェラーゼのインヒビターとして有用な新規三環式ピペリジニル化合物
JP2001502307A (ja) * 1996-10-04 2001-02-20 ノボ ノルディスク アクティーゼルスカブ １，４―ジ置換ピペラジン
US5900421A (en) * 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
US5958940A (en) * 1997-09-11 1999-09-28 Schering Corporation Tricyclic compounds useful as inhibitors of farnesyl-protein transferase
CA2305801A1 (fr) * 1997-10-10 1999-04-22 Schering Corporation Polymorphe d'ethyl 4-(8-chloro-5, 6,-dihydro-11h- benzo[5,6]cyclohepta [1,2-b]pyridine -11-ylidene)-1- piperidene carboxylate
US6100274A (en) * 1999-07-07 2000-08-08 Schering Corporation 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions
US6114346A (en) * 1999-10-22 2000-09-05 Schering Corporation Treating sleep disorders using desloratadine
WO2001045676A2 (fr) 1999-12-20 2001-06-28 Schering Corporation Composition de dose orale a liberation prolongee
SK287684B6 (sk) 1999-12-20 2011-06-06 Schering Corporation Pevná orálna farmaceutická dávková forma s predĺženým uvoľňovaním
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
JP4901474B2 (ja) * 2003-05-30 2012-03-21 ランバクシー ラボラトリーズ リミテッド 置換ピロール誘導体
US7901190B2 (en) * 2004-07-28 2011-03-08 Ian Gray Pump control system
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CN103113348B (zh) * 2013-02-18 2015-03-25 扬子江药业集团江苏海慈生物药业有限公司 枸地氯雷他定的假多晶型及其制备方法
CN106588761B (zh) * 2016-11-22 2018-12-14 宜昌东阳光药业股份有限公司 一种氯雷他定中间体的合成方法
CN109608438A (zh) * 2018-12-05 2019-04-12 杭州澳医保灵药业有限公司 中间体化合物、其制备方法和应用、以及富马酸卢帕他定杂质j的制备方法
CN113004245B (zh) * 2019-12-20 2022-04-15 南京亿华药业有限公司 一种地氯雷他定制备方法
CN113880801A (zh) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 一类三环化合物、其制备方法及其医药用途
CN113880808A (zh) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 一类三唑类化合物、制备方法及其医药用途
CN115433123B (zh) * 2022-10-08 2024-06-28 上海壮铭生物医药有限公司 一种氯雷他定中间体的制备方法

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Also Published As

Publication number Publication date
GR3017924T3 (en) 1996-01-31
AU646878B2 (en) 1994-03-10
ATE126226T1 (de) 1995-08-15
DE122008000047I2 (de) 2011-06-16
OA10032A (en) 1996-10-14
IL98572A0 (en) 1992-07-15
JPH0761998B2 (ja) 1995-07-05
RU2086549C1 (ru) 1997-08-10
NZ238629A (en) 1993-09-27
US5422351A (en) 1995-06-06
SK374892A3 (en) 2000-06-12
DE69112061T2 (de) 1995-12-14
EP0535152A1 (fr) 1993-04-07
WO1992000293A1 (fr) 1992-01-09
JPH05507092A (ja) 1993-10-14
IL98572A (en) 1995-07-31
CZ284610B6 (cs) 1999-01-13
NL300378I2 (nl) 2009-09-01
FI925820A (fi) 1992-12-22
HK186496A (en) 1996-10-11
NL300378I1 (nl) 2009-05-06
ES2096657T3 (es) 1997-03-16
PL173224B1 (pl) 1998-02-27
AU8225291A (en) 1992-01-23
SK280717B6 (sk) 2000-06-12
NO924955L (no) 1993-02-22
DE69112061D1 (de) 1995-09-14
CZ374892A3 (en) 1993-10-13
CA2085878C (fr) 2000-06-13
FI925820A0 (fi) 1992-12-22
CA2085878A1 (fr) 1991-12-23
NO303223B1 (no) 1998-06-15
ZA914764B (en) 1992-03-25
EP0535152B1 (fr) 1995-08-09
HUT63161A (en) 1993-07-28
HU220622B1 (hu) 2002-03-28
NO924955D0 (no) 1992-12-21
IE912124A1 (en) 1992-01-01
PL297300A1 (fr) 1992-07-13
HU9204079D0 (en) 1993-03-29
KR960012368B1 (ko) 1996-09-20
IE68935B1 (en) 1996-07-24

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