DK0534520T3 - Fremgangsmåde til fremstilling af 4-substituerede 1,4-dihydropyridiner - Google Patents

Fremgangsmåde til fremstilling af 4-substituerede 1,4-dihydropyridiner

Info

Publication number
DK0534520T3
DK0534520T3 DK92202690.1T DK92202690T DK0534520T3 DK 0534520 T3 DK0534520 T3 DK 0534520T3 DK 92202690 T DK92202690 T DK 92202690T DK 0534520 T3 DK0534520 T3 DK 0534520T3
Authority
DK
Denmark
Prior art keywords
substituted
reaction
dihydropyridines
preparation
prepared
Prior art date
Application number
DK92202690.1T
Other languages
Danish (da)
English (en)
Inventor
Joseph Auerbach
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/920,701 external-priority patent/US5310917A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0534520T3 publication Critical patent/DK0534520T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK92202690.1T 1991-09-13 1992-09-05 Fremgangsmåde til fremstilling af 4-substituerede 1,4-dihydropyridiner DK0534520T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75902691A 1991-09-13 1991-09-13
US07/920,701 US5310917A (en) 1991-09-13 1992-07-28 Process for the preparation of 4-substituted-1,4-dihydropydrines

Publications (1)

Publication Number Publication Date
DK0534520T3 true DK0534520T3 (da) 1997-09-08

Family

ID=27116618

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92202690.1T DK0534520T3 (da) 1991-09-13 1992-09-05 Fremgangsmåde til fremstilling af 4-substituerede 1,4-dihydropyridiner

Country Status (15)

Country Link
EP (1) EP0534520B1 (fr)
JP (1) JPH0751562B2 (fr)
CN (1) CN1070907A (fr)
AT (1) ATE150456T1 (fr)
AU (1) AU654387B2 (fr)
CA (1) CA2077919A1 (fr)
DE (1) DE69218330T2 (fr)
DK (1) DK0534520T3 (fr)
ES (1) ES2101027T3 (fr)
GR (1) GR3022877T3 (fr)
IL (1) IL103010A (fr)
LV (1) LV12072B (fr)
MX (1) MX9205215A (fr)
NZ (1) NZ244130A (fr)
WO (1) WO1993006082A1 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
PT657432E (pt) * 1993-12-10 2003-07-31 Bayer Ag 1,4-di-hidropiridinas fenil-substituidas com actividade cerebral
DE4423445A1 (de) * 1994-07-05 1996-01-11 Bayer Ag Katalysatorverfahren zur Herstellung von Nifedipin
US5554621A (en) * 1995-06-07 1996-09-10 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
US5668151A (en) * 1995-06-07 1997-09-16 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: piperidine derivatives
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
IT1283793B1 (it) * 1996-08-23 1998-04-30 Lusochimica Spa Processo per la preparazione di diidropiridine
US5889016A (en) * 1997-06-26 1999-03-30 Bristol-Myers Squibb Company Dihydropyrimidone derivatives as NPY antagonists
HUP9900353A3 (en) * 1999-02-15 2002-01-28 Egis Gyogyszergyar Nyilvanosan Process for producing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acids
AU764627B2 (en) 1999-06-21 2003-08-28 Bristol-Myers Squibb Company Dihydropyrazine derivatives as NPY antagonists
EP1309554A1 (fr) 2000-12-29 2003-05-14 Synthon Licensing, Ltd. Derive d'amide d'amlodipine
EP1309556B1 (fr) 2000-12-29 2004-11-24 Pfizer Limited Fumarate d'amlodipine
BR0116553A (pt) 2000-12-29 2004-02-03 Pfizer Ltd Composto, composição farmacêutica para tratamento de angina ou hipertensão, processo, processo para tratamento ou prevenção de angina ou hipertensão, composição de ingredientes farmaceuticamente ativos, composição farmacêutica para tratamento ou prevenção de angina ou hipertensão e processo para tratar ou prevenir angina ou hipertensão
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
ATE315026T1 (de) 2000-12-29 2006-02-15 Pfizer Ltd Amlodipin-hemimaleat
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
WO2002054062A2 (fr) 2000-12-29 2002-07-11 Pfizer Limited Standards de reference destines a la determination de la purete ou de la stabilite de maleate d'amlodipine et procedes correspondants
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
CN1272319C (zh) 2000-12-29 2006-08-30 辉瑞有限公司 制备氨氯地平马来酸盐的工艺、所制得的氨氯地平马来酸盐、其药物组合物和用途
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
US8378107B2 (en) 2008-10-01 2013-02-19 Panmira Pharmaceuticals, Llc Heteroaryl antagonists of prostaglandin D2 receptors
CN101613280B (zh) * 2009-05-13 2012-10-17 合肥立方制药股份有限公司 非洛地平合成中间体2,3-二氯亚苄基乙酰乙酸甲酯的制备方法
CN101987833B (zh) * 2009-08-04 2014-07-30 北京利乐生制药科技有限公司 尼伐地平晶型及其制备方法
WO2012123966A1 (fr) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Procédé pour la préparation de 1,4-dihydropyridines substituées en position 4
CN102285911B (zh) * 2011-07-12 2015-06-17 绍兴文理学院 非洛地平的制备方法
CN102304079B (zh) * 2011-09-29 2013-09-25 合肥立方制药股份有限公司 一种非洛地平环合反应液直接水析纯化方法
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2905242C (fr) 2013-03-15 2016-11-29 Pfizer Inc. Composes indoliques activant l'ampk

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK224786A (da) * 1985-06-21 1986-12-22 Hoffmann La Roche Dihydropyridinderivater
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
FR2596760B1 (fr) * 1986-04-02 1988-12-09 Sori Soc Rech Ind Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique
JPH02149563A (ja) * 1988-11-30 1990-06-08 Nisshin Flour Milling Co Ltd ２−ハロエトキシカルボニル基を含有する１，４−ジヒドロピリジン誘導体の製造法
JPH04211060A (ja) * 1990-03-07 1992-08-03 Tokawa Tetsuo ２，６−ジメチル−４−（ｍ−ニトロフェニル）−１，４−ジヒドロピリジン−３，５−ジカルボン酸−３−メチルエステル−５−β−（Ｎ−ベンジル−Ｎ−メチルアミノ）エチルエステルの新規製造方法
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0534520A2 (fr) 1993-03-31
IL103010A0 (en) 1993-02-21
JPH05221984A (ja) 1993-08-31
DE69218330D1 (de) 1997-04-24
ATE150456T1 (de) 1997-04-15
MX9205215A (es) 1993-03-01
LV12072A (lv) 1998-06-20
IL103010A (en) 1996-10-31
LV12072B (en) 1998-09-20
CA2077919A1 (fr) 1993-03-14
WO1993006082A1 (fr) 1993-04-01
EP0534520A3 (en) 1993-05-05
AU2355292A (en) 1993-03-18
AU654387B2 (en) 1994-11-03
DE69218330T2 (de) 1997-09-18
CN1070907A (zh) 1993-04-14
NZ244130A (en) 1994-10-26
ES2101027T3 (es) 1997-07-01
EP0534520B1 (fr) 1997-03-19
JPH0751562B2 (ja) 1995-06-05
GR3022877T3 (en) 1997-06-30

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