DE69218330D1 - Verfahren zur Herstellung von an 4-Position substituierten 1,4-Dihydropyridinen - Google Patents

Verfahren zur Herstellung von an 4-Position substituierten 1,4-Dihydropyridinen

Info

Publication number
DE69218330D1
DE69218330D1 DE69218330T DE69218330T DE69218330D1 DE 69218330 D1 DE69218330 D1 DE 69218330D1 DE 69218330 T DE69218330 T DE 69218330T DE 69218330 T DE69218330 T DE 69218330T DE 69218330 D1 DE69218330 D1 DE 69218330D1
Authority
DE
Germany
Prior art keywords
reaction
substituted
preparation
dihydropyridines
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69218330T
Other languages
English (en)
Other versions
DE69218330T2 (de
Inventor
Joseph Auerbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/920,701 external-priority patent/US5310917A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69218330D1 publication Critical patent/DE69218330D1/de
Publication of DE69218330T2 publication Critical patent/DE69218330T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
DE69218330T 1991-09-13 1992-09-05 Verfahren zur Herstellung von an 4-Position substituierten 1,4-Dihydropyridinen Expired - Fee Related DE69218330T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75902691A 1991-09-13 1991-09-13
US07/920,701 US5310917A (en) 1991-09-13 1992-07-28 Process for the preparation of 4-substituted-1,4-dihydropydrines

Publications (2)

Publication Number Publication Date
DE69218330D1 true DE69218330D1 (de) 1997-04-24
DE69218330T2 DE69218330T2 (de) 1997-09-18

Family

ID=27116618

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69218330T Expired - Fee Related DE69218330T2 (de) 1991-09-13 1992-09-05 Verfahren zur Herstellung von an 4-Position substituierten 1,4-Dihydropyridinen

Country Status (15)

Country Link
EP (1) EP0534520B1 (de)
JP (1) JPH0751562B2 (de)
CN (1) CN1070907A (de)
AT (1) ATE150456T1 (de)
AU (1) AU654387B2 (de)
CA (1) CA2077919A1 (de)
DE (1) DE69218330T2 (de)
DK (1) DK0534520T3 (de)
ES (1) ES2101027T3 (de)
GR (1) GR3022877T3 (de)
IL (1) IL103010A (de)
LV (1) LV12072B (de)
MX (1) MX9205215A (de)
NZ (1) NZ244130A (de)
WO (1) WO1993006082A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
DK0657432T3 (da) 1993-12-10 2003-07-07 Bayer Ag Phenylsubstituerede 1,4-dihydropyridiner med cerebral aktivitet
DE4423445A1 (de) * 1994-07-05 1996-01-11 Bayer Ag Katalysatorverfahren zur Herstellung von Nifedipin
US5668151A (en) * 1995-06-07 1997-09-16 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: piperidine derivatives
US5554621A (en) * 1995-06-07 1996-09-10 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
IT1283793B1 (it) * 1996-08-23 1998-04-30 Lusochimica Spa Processo per la preparazione di diidropiridine
US5889016A (en) * 1997-06-26 1999-03-30 Bristol-Myers Squibb Company Dihydropyrimidone derivatives as NPY antagonists
HUP9900353A3 (en) * 1999-02-15 2002-01-28 Egis Gyogyszergyar Nyilvanosan Process for producing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acids
CA2377698A1 (en) 1999-06-21 2000-12-28 Bristol-Myers Squibb Company Dihydropyrazine derivatives as npy antagonists
WO2002053538A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Amlodipine fumarate
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
WO2002053540A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Aspartate derivative of amlodipine as calcium channel antagonist
CA2433193C (en) 2000-12-29 2006-01-31 Pfizer Limited Amide derivative of amlodipine
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
MXPA03005885A (es) 2000-12-29 2005-04-19 Pfizer Ltd Procedimiento para fabricar maleato de amlodipina.
GB2371862B (en) 2000-12-29 2004-07-14 Bioorg Bv Reference standards for determining the purity or stability of amlodipine maleate and processes therefor
ES2254495T4 (es) 2000-12-29 2007-06-16 Pfizer Limited Hemimaleato de amlodipina.
WO2010039977A2 (en) 2008-10-01 2010-04-08 Amira Pharmaceuticals, Inc. Heteroaryl antagonists of prostaglandin d2 receptors
CN101613280B (zh) * 2009-05-13 2012-10-17 合肥立方制药股份有限公司 非洛地平合成中间体2,3-二氯亚苄基乙酰乙酸甲酯的制备方法
CN101987833B (zh) * 2009-08-04 2014-07-30 北京利乐生制药科技有限公司 尼伐地平晶型及其制备方法
WO2012123966A1 (en) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Process for the preparation of 4 -substituted -1, 4-dihydropyridines
CN102285911B (zh) * 2011-07-12 2015-06-17 绍兴文理学院 非洛地平的制备方法
CN102304079B (zh) * 2011-09-29 2013-09-25 合肥立方制药股份有限公司 一种非洛地平环合反应液直接水析纯化方法
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA863578B (en) * 1985-06-21 1987-02-25 Hoffmann La Roche Dihydropyridine derivatives
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
FR2596760B1 (fr) * 1986-04-02 1988-12-09 Sori Soc Rech Ind Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique
JPH02149563A (ja) * 1988-11-30 1990-06-08 Nisshin Flour Milling Co Ltd ２−ハロエトキシカルボニル基を含有する１，４−ジヒドロピリジン誘導体の製造法
JPH04211060A (ja) * 1990-03-07 1992-08-03 Tokawa Tetsuo ２，６−ジメチル−４−（ｍ−ニトロフェニル）−１，４−ジヒドロピリジン−３，５−ジカルボン酸−３−メチルエステル−５−β−（Ｎ−ベンジル−Ｎ−メチルアミノ）エチルエステルの新規製造方法
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
AU2355292A (en) 1993-03-18
DE69218330T2 (de) 1997-09-18
ATE150456T1 (de) 1997-04-15
EP0534520A3 (en) 1993-05-05
GR3022877T3 (en) 1997-06-30
AU654387B2 (en) 1994-11-03
ES2101027T3 (es) 1997-07-01
LV12072B (en) 1998-09-20
EP0534520B1 (de) 1997-03-19
IL103010A0 (en) 1993-02-21
DK0534520T3 (da) 1997-09-08
EP0534520A2 (de) 1993-03-31
JPH05221984A (ja) 1993-08-31
WO1993006082A1 (en) 1993-04-01
NZ244130A (en) 1994-10-26
JPH0751562B2 (ja) 1995-06-05
CA2077919A1 (en) 1993-03-14
MX9205215A (es) 1993-03-01
CN1070907A (zh) 1993-04-14
LV12072A (lv) 1998-06-20
IL103010A (en) 1996-10-31

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee