ATE150456T1 - Verfahren zur herstellung von an 4-position substituierten 1,4-dihydropyridinen - Google Patents

Verfahren zur herstellung von an 4-position substituierten 1,4-dihydropyridinen

Info

Publication number
ATE150456T1
ATE150456T1 AT92202690T AT92202690T ATE150456T1 AT E150456 T1 ATE150456 T1 AT E150456T1 AT 92202690 T AT92202690 T AT 92202690T AT 92202690 T AT92202690 T AT 92202690T AT E150456 T1 ATE150456 T1 AT E150456T1
Authority
AT
Austria
Prior art keywords
reaction
substituted
producing
dihydropyridines
prepared
Prior art date
Application number
AT92202690T
Other languages
English (en)
Inventor
Joseph Auerbach
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/920,701 external-priority patent/US5310917A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE150456T1 publication Critical patent/ATE150456T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT92202690T 1991-09-13 1992-09-05 Verfahren zur herstellung von an 4-position substituierten 1,4-dihydropyridinen ATE150456T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75902691A 1991-09-13 1991-09-13
US07/920,701 US5310917A (en) 1991-09-13 1992-07-28 Process for the preparation of 4-substituted-1,4-dihydropydrines

Publications (1)

Publication Number Publication Date
ATE150456T1 true ATE150456T1 (de) 1997-04-15

Family

ID=27116618

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92202690T ATE150456T1 (de) 1991-09-13 1992-09-05 Verfahren zur herstellung von an 4-position substituierten 1,4-dihydropyridinen

Country Status (15)

Country Link
EP (1) EP0534520B1 (de)
JP (1) JPH0751562B2 (de)
CN (1) CN1070907A (de)
AT (1) ATE150456T1 (de)
AU (1) AU654387B2 (de)
CA (1) CA2077919A1 (de)
DE (1) DE69218330T2 (de)
DK (1) DK0534520T3 (de)
ES (1) ES2101027T3 (de)
GR (1) GR3022877T3 (de)
IL (1) IL103010A (de)
LV (1) LV12072B (de)
MX (1) MX9205215A (de)
NZ (1) NZ244130A (de)
WO (1) WO1993006082A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4342196A1 (de) * 1993-12-10 1995-06-14 Bayer Ag Neue 4-Phenyl-substituierte 1,4-Dihydropyridine
ES2193148T3 (es) 1993-12-10 2003-11-01 Bayer Ag 1,4-dihidropiridinas sustituidas con fenilo con actividad cerebral.
DE4423445A1 (de) * 1994-07-05 1996-01-11 Bayer Ag Katalysatorverfahren zur Herstellung von Nifedipin
US5554621A (en) * 1995-06-07 1996-09-10 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives
US5668151A (en) * 1995-06-07 1997-09-16 Bristol-Myers Squibb Company Dihydropyridine NPY antagonists: piperidine derivatives
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
IT1283793B1 (it) * 1996-08-23 1998-04-30 Lusochimica Spa Processo per la preparazione di diidropiridine
US5889016A (en) * 1997-06-26 1999-03-30 Bristol-Myers Squibb Company Dihydropyrimidone derivatives as NPY antagonists
HUP9900353A3 (en) * 1999-02-15 2002-01-28 Egis Gyogyszergyar Nyilvanosan Process for producing asymmetric esters of 1,4-dihydropyridine-dicarboxylic acids
JP2003502374A (ja) 1999-06-21 2003-01-21 ブリストルーマイヤーズ スクイブ カンパニー Ｎｐｙ拮抗薬としてのジヒドロピラジン誘導体
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
BR0116557A (pt) 2000-12-29 2003-10-28 Pfizer Ltd Processo, processo para fabricação de um sal de maleato de amlodipina substancialmente livre de aspartato de amlodipina, processo para purificação, maleato de amlodipina, composição farmacêutica para tratar ou prevenir angina ou hipertenção, método para tratar hipertenção, angina ou ataque cardìaco, benzeno sulfonato de amlodipina, hidrocloreto de amlodipina e uso de maleato de amlodipina substancialmente livre de aspartato de amlodipina
WO2002053541A1 (en) 2000-12-29 2002-07-11 Pfizer Limited Amide derivative of amlodipine
GB2372036B (en) 2000-12-29 2004-05-19 Bioorg Bv Aspartate derivative of amlodipine
EP1309557B9 (de) 2000-12-29 2006-11-15 Pfizer Limited Amlodipin-hemimaleat
EP1309556B1 (de) 2000-12-29 2004-11-24 Pfizer Limited Amlodipinfumarat
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
GB2371862B (en) 2000-12-29 2004-07-14 Bioorg Bv Reference standards for determining the purity or stability of amlodipine maleate and processes therefor
WO2010039977A2 (en) 2008-10-01 2010-04-08 Amira Pharmaceuticals, Inc. Heteroaryl antagonists of prostaglandin d2 receptors
CN101613280B (zh) * 2009-05-13 2012-10-17 合肥立方制药股份有限公司 非洛地平合成中间体2,3-二氯亚苄基乙酰乙酸甲酯的制备方法
CN101987833B (zh) * 2009-08-04 2014-07-30 北京利乐生制药科技有限公司 尼伐地平晶型及其制备方法
WO2012123966A1 (en) 2011-03-04 2012-09-20 Arch Pharmalabs Limited Process for the preparation of 4 -substituted -1, 4-dihydropyridines
CN102285911B (zh) * 2011-07-12 2015-06-17 绍兴文理学院 非洛地平的制备方法
CN102304079B (zh) * 2011-09-29 2013-09-25 合肥立方制药股份有限公司 一种非洛地平环合反应液直接水析纯化方法
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA863578B (en) * 1985-06-21 1987-02-25 Hoffmann La Roche Dihydropyridine derivatives
US4780538A (en) * 1986-02-12 1988-10-25 Merck & Co., Inc. Process for 1,4-dihydropyridine compounds using a titanamine catalyst
FR2596760B1 (fr) * 1986-04-02 1988-12-09 Sori Soc Rech Ind Derives dissymetriques de l'acide 1,4-dihydropyridine-3,5-dicarboxylique, procedes de preparation et utilisation en therapeutique
JPH02149563A (ja) * 1988-11-30 1990-06-08 Nisshin Flour Milling Co Ltd ２−ハロエトキシカルボニル基を含有する１，４−ジヒドロピリジン誘導体の製造法
JPH04211060A (ja) * 1990-03-07 1992-08-03 Tokawa Tetsuo ２，６−ジメチル−４−（ｍ−ニトロフェニル）−１，４−ジヒドロピリジン−３，５−ジカルボン酸−３−メチルエステル−５−β−（Ｎ−ベンジル−Ｎ−メチルアミノ）エチルエステルの新規製造方法
DE4011695A1 (de) * 1990-04-11 1991-10-17 Bayer Ag Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
JPH0751562B2 (ja) 1995-06-05
DK0534520T3 (da) 1997-09-08
GR3022877T3 (en) 1997-06-30
WO1993006082A1 (en) 1993-04-01
ES2101027T3 (es) 1997-07-01
AU2355292A (en) 1993-03-18
LV12072B (en) 1998-09-20
LV12072A (lv) 1998-06-20
EP0534520A3 (en) 1993-05-05
CA2077919A1 (en) 1993-03-14
EP0534520B1 (de) 1997-03-19
DE69218330T2 (de) 1997-09-18
DE69218330D1 (de) 1997-04-24
MX9205215A (es) 1993-03-01
IL103010A0 (en) 1993-02-21
NZ244130A (en) 1994-10-26
CN1070907A (zh) 1993-04-14
EP0534520A2 (de) 1993-03-31
JPH05221984A (ja) 1993-08-31
AU654387B2 (en) 1994-11-03
IL103010A (en) 1996-10-31

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