YU89392A - Novi postupak za dobijanje 4-supstituisanih-1,4-dihidropiridina - Google Patents
Novi postupak za dobijanje 4-supstituisanih-1,4-dihidropiridinaInfo
- Publication number
- YU89392A YU89392A YU89392A YU89392A YU89392A YU 89392 A YU89392 A YU 89392A YU 89392 A YU89392 A YU 89392A YU 89392 A YU89392 A YU 89392A YU 89392 A YU89392 A YU 89392A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- substituted
- reaction
- dihydropyridine
- obtaining
- new procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
NOVI POSTUPAK ZA DOBIJANJE 4-SUPSTITUISANIH-1,4-DIHIDROPIRIDINA, 4-supstituisani-1,4-dihidropiridini se dobijaju cikloadicionom reakcijom u kojoj se ciklizacija dovodi do kraja, posle toplotne reakcije, dodatkom kiseline. Felodipin, vazodilatator, se dobija cikloadicionom reakcijom etil 3-aminokrotonata sa pogodnim supstituisanim dihlorobenzilidinom pod reakcionim uslovima, pri čemu se proizvod iskristalisava iz reakcionog rastvora i može da se direktno izoluje filtracijom.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75902691A | 1991-09-13 | 1991-09-13 | |
US07/920,701 US5310917A (en) | 1991-09-13 | 1992-07-28 | Process for the preparation of 4-substituted-1,4-dihydropydrines |
Publications (2)
Publication Number | Publication Date |
---|---|
YU89392A true YU89392A (sh) | 1995-03-27 |
YU48424B YU48424B (sh) | 1998-07-10 |
Family
ID=25054110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU89392A YU48424B (sh) | 1991-09-13 | 1992-10-07 | Postupak za dobijanje 4-supstituisanih-1,4-dihidropiridina |
Country Status (4)
Country | Link |
---|---|
US (1) | US5310917A (sh) |
KR (1) | KR930005979A (sh) |
YU (1) | YU48424B (sh) |
ZA (1) | ZA926935B (sh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE59410255D1 (de) | 1993-12-10 | 2003-04-17 | Bayer Ag | Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität |
US5977369A (en) * | 1995-12-28 | 1999-11-02 | Napp Technologies, Inc. | Process to prepare dihydropyridine and derivatives thereof |
SE9600086D0 (sv) * | 1996-01-10 | 1996-01-10 | Astra Ab | New manufacturing process |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
US6451814B1 (en) * | 2000-07-17 | 2002-09-17 | Wyeth | Heterocyclic β-3 adrenergic receptor agonists |
CA2425561C (en) * | 2003-04-14 | 2007-09-18 | Brantford Chemicals Inc. | Process to prepare 1,4-dihydropyridine intermediates and derivatives thereof |
CN102143948B (zh) * | 2008-09-04 | 2013-07-31 | 安国药品株式会社 | (s)-(-)-非洛地平的制备方法 |
WO2012123966A1 (en) | 2011-03-04 | 2012-09-20 | Arch Pharmalabs Limited | Process for the preparation of 4 -substituted -1, 4-dihydropyridines |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE429652B (sv) * | 1978-06-30 | 1983-09-19 | Haessle Ab | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
IL68524A0 (en) * | 1982-05-21 | 1983-07-31 | Haessle Ab | Novel dihydropyridines |
AU561213B2 (en) * | 1983-06-02 | 1987-04-30 | Teijin Limited | 1, 4-dihydropyridine derivative |
ZA863578B (en) * | 1985-06-21 | 1987-02-25 | Hoffmann La Roche | Dihydropyridine derivatives |
US4772596A (en) * | 1986-10-09 | 1988-09-20 | Sankyo Company Limited | Dihydropyridine derivatives, their preparation and their use |
DE3741540A1 (de) * | 1987-12-08 | 1989-06-22 | Bayer Ag | Verfahren zur herstellung von unsymmetrischen dihydropyridinen |
AT391471B (de) * | 1988-05-13 | 1990-10-10 | Gerot Pharmazeutika | Neue derivate von 5-aminomethyl-2-furanmethanol, ihre herstellung und verwendung |
US5047543A (en) * | 1988-11-24 | 1991-09-10 | Taisho Pharmaceutical Co., Ltd. | 1,4-dihydropyridine derivatives |
JPH02149563A (ja) * | 1988-11-30 | 1990-06-08 | Nisshin Flour Milling Co Ltd | 2−ハロエトキシカルボニル基を含有する1,4−ジヒドロピリジン誘導体の製造法 |
JPH04211060A (ja) * | 1990-03-07 | 1992-08-03 | Tokawa Tetsuo | 2,6−ジメチル−4−(m−ニトロフェニル)−1,4−ジヒドロピリジン−3,5−ジカルボン酸−3−メチルエステル−5−β−(N−ベンジル−N−メチルアミノ)エチルエステルの新規製造方法 |
DE4011695A1 (de) * | 1990-04-11 | 1991-10-17 | Bayer Ag | Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung |
-
1992
- 1992-07-28 US US07/920,701 patent/US5310917A/en not_active Expired - Fee Related
- 1992-09-09 KR KR1019920016535A patent/KR930005979A/ko active IP Right Grant
- 1992-09-11 ZA ZA926935A patent/ZA926935B/xx unknown
- 1992-10-07 YU YU89392A patent/YU48424B/sh unknown
Also Published As
Publication number | Publication date |
---|---|
YU48424B (sh) | 1998-07-10 |
US5310917A (en) | 1994-05-10 |
ZA926935B (en) | 1993-04-28 |
KR930005979A (ko) | 1993-04-20 |
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