ES2090156T3 - Procedimiento para la preparacion de castanoespermina. - Google Patents

Procedimiento para la preparacion de castanoespermina.

Info

Publication number
ES2090156T3
ES2090156T3 ES91103682T ES91103682T ES2090156T3 ES 2090156 T3 ES2090156 T3 ES 2090156T3 ES 91103682 T ES91103682 T ES 91103682T ES 91103682 T ES91103682 T ES 91103682T ES 2090156 T3 ES2090156 T3 ES 2090156T3
Authority
ES
Spain
Prior art keywords
castanospermine
substituted
castanoespermina
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91103682T
Other languages
English (en)
Inventor
Peter B Anzeveno
Laura J Creemer
Paul T Angell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2090156T3 publication Critical patent/ES2090156T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LA CASTANOSPERMINA SE PREPARA A PARTIR DE 5-(T-BOC) AMINO-5-DEOXI-1,2-0-ISOPROPILIDINA-ALFA-D-GLUCORONOLACTONA. DOS CARBONOS ADICIONALES SE AÑADEN AL MATERIAL DE COMIENZO USANDO ACETATO DE ETIL Y UNA BASE FUERTE Y EL HEMIQUETAL CICLICO RESULTANTE SE EXPONE A UNA SERIE DE REDUCCIONES, CON SEPARACION DE LOS GRUPOS PROTECTORES, PARA DAR COMO RESULTADO LA CASTANOSPERMINA. UNA HIDROXIPIRROLIDINONA SUBSTITUIDA Y UNA HIDROXIPIRROLIDINA SUBSTITUIDA SIRVEN COMO INTERMEDIARIOS DEL PROCESO.
ES91103682T 1990-03-12 1991-03-11 Procedimiento para la preparacion de castanoespermina. Expired - Lifetime ES2090156T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/492,507 US5066807A (en) 1990-03-12 1990-03-12 Process for the preparation of castanospermine

Publications (1)

Publication Number Publication Date
ES2090156T3 true ES2090156T3 (es) 1996-10-16

Family

ID=23956525

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91103682T Expired - Lifetime ES2090156T3 (es) 1990-03-12 1991-03-11 Procedimiento para la preparacion de castanoespermina.

Country Status (15)

Country Link
US (1) US5066807A (es)
EP (1) EP0446832B1 (es)
JP (1) JP3019269B2 (es)
KR (1) KR0160136B1 (es)
AT (1) ATE139231T1 (es)
AU (1) AU630543B2 (es)
CA (1) CA2037608C (es)
DE (1) DE69120108T2 (es)
DK (1) DK0446832T3 (es)
ES (1) ES2090156T3 (es)
GR (1) GR3020707T3 (es)
HU (1) HU210048B (es)
IE (1) IE910803A1 (es)
IL (1) IL97487A (es)
ZA (1) ZA911742B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288875A (en) * 1991-08-14 1994-02-22 Cha Jin K Synthesis of (-)-swainsonine and intermediate compounds employed in such synthesis
US5435991A (en) * 1991-08-09 1995-07-25 Nycomed Innovation Ab Use of persistent heterocyclic free-radicals in magnetic resonance imaging
GB0110832D0 (en) * 2001-05-03 2001-06-27 Virogen Ltd Antiviral compounds
KR20070061879A (ko) * 2004-10-06 2007-06-14 미게닉스 인코포레이티드 카스타노스페르민을 포함하는 조합 항-바이러스 조성물 및그의 사용 방법
US10377818B2 (en) 2015-01-30 2019-08-13 The Board Of Trustees Of The Leland Stanford Junior University Method of treating glioma
KR101966101B1 (ko) 2017-11-27 2019-04-05 주식회사 인트켐 결정성장 촉진형 하이브리드 자기치유 혼화재의 제조방법과 그 자기치유 혼화재를 이용한 시멘트 결합재 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1315276C (en) * 1987-07-02 1993-03-30 Paul S. Liu Castanospermine esters and glycosides
US4970317A (en) * 1989-08-08 1990-11-13 Merrell Dow Pharmaceuticals Inc. Process for the preparation of castanospermine esters
US5227479A (en) * 1989-12-20 1993-07-13 Merrell Dow Pharmaceuticals Inc. Process for the preparation of nojirimycin and related compounds

Also Published As

Publication number Publication date
KR0160136B1 (ko) 1998-12-01
IL97487A0 (en) 1992-06-21
DE69120108T2 (de) 1997-02-06
CA2037608C (en) 2000-11-21
HU210048B (en) 1995-01-30
EP0446832A2 (en) 1991-09-18
AU7264091A (en) 1991-09-12
ATE139231T1 (de) 1996-06-15
DE69120108D1 (de) 1996-07-18
AU630543B2 (en) 1992-10-29
GR3020707T3 (en) 1996-11-30
CA2037608A1 (en) 1991-09-13
HUT57208A (en) 1991-11-28
US5066807A (en) 1991-11-19
IE910803A1 (en) 1991-09-25
ZA911742B (en) 1991-12-24
KR910016749A (ko) 1991-11-05
HU910790D0 (en) 1991-09-30
JP3019269B2 (ja) 2000-03-13
DK0446832T3 (da) 1996-07-01
EP0446832B1 (en) 1996-06-12
IL97487A (en) 1995-05-26
JPH04217978A (ja) 1992-08-07
EP0446832A3 (en) 1992-03-25

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