DK0528312T3 - Cykliske peptider og anvendelse deraf - Google Patents

Cykliske peptider og anvendelse deraf

Info

Publication number
DK0528312T3
DK0528312T3 DK92113568.7T DK92113568T DK0528312T3 DK 0528312 T3 DK0528312 T3 DK 0528312T3 DK 92113568 T DK92113568 T DK 92113568T DK 0528312 T3 DK0528312 T3 DK 0528312T3
Authority
DK
Denmark
Prior art keywords
alpha
amino acid
acid residue
formula
cyclic peptides
Prior art date
Application number
DK92113568.7T
Other languages
Danish (da)
English (en)
Inventor
Mitsuhiro Wakimasu
Takashi Kikuchi
Akira Kawada
Hideo Shirahuji
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DK0528312T3 publication Critical patent/DK0528312T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK92113568.7T 1991-08-13 1992-08-08 Cykliske peptider og anvendelse deraf DK0528312T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP20303291 1991-08-13
JP30363591 1991-11-19
JP3543692 1992-02-21
JP11179292 1992-04-30

Publications (1)

Publication Number Publication Date
DK0528312T3 true DK0528312T3 (da) 1997-12-29

Family

ID=27460093

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92113568.7T DK0528312T3 (da) 1991-08-13 1992-08-08 Cykliske peptider og anvendelse deraf

Country Status (11)

Country Link
US (2) US5616684A (ja)
EP (1) EP0528312B1 (ja)
JP (2) JP2677489B2 (ja)
AT (1) ATE155486T1 (ja)
CA (1) CA2075878C (ja)
DE (1) DE69220861T2 (ja)
DK (1) DK0528312T3 (ja)
ES (1) ES2103857T3 (ja)
FI (1) FI106031B (ja)
GR (1) GR3024495T3 (ja)
NO (1) NO310295B1 (ja)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767310A (en) * 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
CA2121724A1 (en) 1993-04-21 1994-10-22 Toshifumi Watanabe Methods and compositions for the prophylactic and/or therapeutic treatment of organ hypofunction
US6087324A (en) 1993-06-24 2000-07-11 Takeda Chemical Industries, Ltd. Sustained-release preparation
EP0647449A1 (en) * 1993-06-24 1995-04-12 Takeda Chemical Industries, Ltd. Sustained-release preparation of anti-endothelin substance
US5811218A (en) * 1993-07-28 1998-09-22 Hitachi Chemical Company, Ltd. Photoinitiator compositions including amino acids, coumarin and titanocene and photosensitive materials using the same
CA2135151A1 (en) * 1993-11-08 1995-05-09 Mitsuhiro Wakimasu Cyclic hexapeptides, their production and use
US5521156A (en) * 1994-02-03 1996-05-28 Merrell Pharmaceuticals Inc. Cyclic neurokinin A antagonists
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
EP0714909A1 (en) * 1994-12-01 1996-06-05 Takeda Chemical Industries, Ltd. Composition for prophylaxis or treatment of pulmonary circulatory diseases
US6136781A (en) * 1995-04-28 2000-10-24 Takeda Chemical Industries, Ltd. LH-RH receptor antagonists
US6251861B1 (en) 1996-06-27 2001-06-26 Takeda Chemical Industries, Ltd. Treatment of cerebral infarction using cyclic hexapeptides
IT1304888B1 (it) * 1998-08-05 2001-04-05 Menarini Ricerche Spa Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
ES2304345T3 (es) 1999-03-29 2008-10-16 THE PROCTER & GAMBLE COMPANY Ligandos del receptor de melanocortina.
WO2003006041A1 (fr) * 2001-07-12 2003-01-23 Takeda Chemical Industries, Ltd. Agents prophylactiques/therapeutiques contre les tumeurs malignes
GB0326632D0 (en) 2003-11-14 2003-12-17 Jagotec Ag Dry powder formulations
WO2005085277A1 (en) * 2004-02-06 2005-09-15 Concepcion Gisela P Cyclic hexapeptides, process and use thereof
US7838102B2 (en) * 2004-10-28 2010-11-23 E. I. Du Pont De Nemours And Company Filled polyvinyl butyral sheeting for decorative laminated glass and a process for making same
KR20080111137A (ko) * 2006-04-13 2008-12-22 액테리온 파마슈티칼 리미티드 초기 단계 특발성 폐 섬유증을 위한 엔도텔린 수용체 대항제
JP5649825B2 (ja) 2007-01-31 2015-01-07 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 安定化させたｐ５３ペプチドおよびその使用法
KR20160061439A (ko) 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
US20130177651A1 (en) 2010-09-03 2013-07-11 Pharmaterials Limited Pharmaceutical Composition Suitable for Use in a Dry Powder Inhaler
US9486273B2 (en) 2011-01-21 2016-11-08 Kardium Inc. High-density electrode-based medical device system
KR20140100937A (ko) 2011-10-18 2014-08-18 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
CN107216380A (zh) 2012-02-15 2017-09-29 爱勒让治疗公司 拟肽大环化合物
CN104144695A (zh) 2012-02-15 2014-11-12 爱勒让治疗公司 三唑交联的和硫醚交联的拟肽大环化合物
US9605047B2 (en) 2012-04-04 2017-03-28 The Brigham And Womens's Hospital, Inc. Compositions and methods for treating hypertension
KR20150082307A (ko) 2012-11-01 2015-07-15 에일러론 테라퓨틱스 인코포레이티드 이치환 아미노산 및 이의 제조 및 사용 방법
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
SG10201902598VA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
EP3294318A4 (en) 2015-03-20 2019-04-03 Aileron Therapeutics, Inc. PEPTIDOMIMETIC MACROCYCLES AND USES THEREOF
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
KR102389725B1 (ko) * 2020-02-14 2022-04-25 서울대학교산학협력단 피페라진산을 함유하는 사이클릭 펩티드 화합물, 이의 생산 방법, 및 이의 용도
WO2024114782A1 (en) * 2022-12-01 2024-06-06 National Institute Of Biological Sciences, Beijing Small-molecule modulators of spike protein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2032559C (en) * 1989-12-28 2001-11-06 Kiyofumi Ishikawa Endothelin antagonistic cyclic pentapeptides
IT1241761B (it) * 1990-08-03 1994-02-01 Menarini Farma Ind Peptidi di sintesi antagonisti della neurochinina a, loro sali e relativi procedimenti di fabbricazione
US5260276A (en) * 1991-06-14 1993-11-09 Warner-Lambert Company Linear and monocyclic endothelin antagonists

Also Published As

Publication number Publication date
JP2726647B2 (ja) 1998-03-11
NO923142D0 (no) 1992-08-12
FI923619A (fi) 1993-02-14
GR3024495T3 (en) 1997-11-28
US5616684A (en) 1997-04-01
NO310295B1 (no) 2001-06-18
FI106031B (fi) 2000-11-15
CA2075878C (en) 2002-12-24
DE69220861D1 (de) 1997-08-21
ATE155486T1 (de) 1997-08-15
EP0528312B1 (en) 1997-07-16
JPH069689A (ja) 1994-01-18
NO923142L (no) 1993-02-15
EP0528312A3 (en) 1993-04-14
ES2103857T3 (es) 1997-10-01
CA2075878A1 (en) 1993-02-14
JPH08225595A (ja) 1996-09-03
JP2677489B2 (ja) 1997-11-17
US5883075A (en) 1999-03-16
DE69220861T2 (de) 1997-11-20
EP0528312A2 (en) 1993-02-24
FI923619A0 (fi) 1992-08-12

Similar Documents

Publication Publication Date Title
DK0528312T3 (da) Cykliske peptider og anvendelse deraf
MY121908A (en) 3-amidopyrazole derivatives, process for preparing these and pharmaceutical compositions containing them.
LU91225I2 (fr) Plenaxis
DK0951474T3 (da) Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf
DK0644199T3 (da) Cykliske antimikrobielle peptider og fremstilling deraf
PL344599A1 (en) Novel cyclosporins
HUP0004234A2 (hu) Dolasztatin-15-származékok
HUT61780A (en) Process for producing new peptides and pharmaceutical compositions comprising same as active ingredient
DK515489D0 (da) Dispergerbar laegemiddelformulering
SE9101838D0 (sv) Novel peptides and their use
ES2133295T3 (es) Peptidos ciclicos y su uso.
IT1299583B1 (it) Uso di proteine hmg-i per la preparazione di medicamenti ad attivita' citotossica
DK0502198T3 (da) Nye polypeptider og anti-HIV-lægemidler fremstillet deraf
DE69002881D1 (de) Peptide und deren Benutzung.
WO2003048187A3 (en) Peptides and use thereof in therapeutic agents against hiv infection
DK163661C (da) 2,5-pyrrolidindionderivater og farmaceutisk acceptable syreadditionssalte deraf