WO2003048187A3 - Peptides and use thereof in therapeutic agents against hiv infection - Google Patents

Peptides and use thereof in therapeutic agents against hiv infection Download PDF

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Publication number
WO2003048187A3
WO2003048187A3 PCT/US2002/038152 US0238152W WO03048187A3 WO 2003048187 A3 WO2003048187 A3 WO 2003048187A3 US 0238152 W US0238152 W US 0238152W WO 03048187 A3 WO03048187 A3 WO 03048187A3
Authority
WO
WIPO (PCT)
Prior art keywords
amino acids
group
acid selected
peptides
amino acid
Prior art date
Application number
PCT/US2002/038152
Other languages
French (fr)
Other versions
WO2003048187A2 (en
Inventor
Pierre-Francois Serre
Original Assignee
Mymetics Corp
Pierre-Francois Serre
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0115423A external-priority patent/FR2832715A1/en
Application filed by Mymetics Corp, Pierre-Francois Serre filed Critical Mymetics Corp
Priority to AU2002351176A priority Critical patent/AU2002351176A1/en
Publication of WO2003048187A2 publication Critical patent/WO2003048187A2/en
Publication of WO2003048187A3 publication Critical patent/WO2003048187A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides novel peptides A peptide containing from 25 to 40 amino acids and comprising a sequence π corresponding to formula (I) WX1X2WX3X4EX5X6NYT, wherein X1 represents an amino acid selected from the group consisting of amino acids M, I, L and Q; X2 represents an amino acid selected from the group consisting of amino acids E, K, R, and Q; X3 represents an amino acid selected from the group consisting of amino acids D and E; X4 represents an amino acid selected from the group consisting of amino acids K, R, and Q; X5 represents an amino acid selected from the group consisting of amino acids V, I, and L; and X6 represents an amino acid selected from the group consisting of amino acids D, S, N, and E; and wherein letters in formula (I) other than X represent amino acids according to conventional nomenclature.
PCT/US2002/038152 2001-11-29 2002-11-27 Peptides and use thereof in therapeutic agents against hiv infection WO2003048187A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002351176A AU2002351176A1 (en) 2001-11-29 2002-11-27 Peptides and use thereof in therapeutic agents against hiv infection

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0115423A FR2832715A1 (en) 2001-11-29 2001-11-29 New peptide containing 25 - 40 amino acids and a sequence useful as therapeutic agents in the treatment of HIV virus infections
FR0115423 2001-11-29
US34049201P 2001-12-18 2001-12-18
US60/340,492 2001-12-18

Publications (2)

Publication Number Publication Date
WO2003048187A2 WO2003048187A2 (en) 2003-06-12
WO2003048187A3 true WO2003048187A3 (en) 2004-04-29

Family

ID=26213281

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038152 WO2003048187A2 (en) 2001-11-29 2002-11-27 Peptides and use thereof in therapeutic agents against hiv infection

Country Status (2)

Country Link
AU (1) AU2002351176A1 (en)
WO (1) WO2003048187A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140335119A1 (en) * 2004-02-06 2014-11-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) POLYPEPTIDE DERIVED FROM gp41, A VACCINE COMPOSITION COMPRISING SAID POLYPEPTIDE, AND USES FOR TREATING AN INFECTION BY AN HIV VIRUS IN AN INDIVIDUAL
US20150175666A1 (en) * 2012-06-27 2015-06-25 Yeda Research And Development Co. Ltd. Peptides derived from hiv gp41 for treating t-cell mediated pathologies

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US5656480A (en) * 1992-07-20 1997-08-12 Duke University Compounds which inhibit HIV replication
US5840843A (en) * 1992-03-26 1998-11-24 The New York Blood Center Synthetic polypeptides as inhibitors of HIV-1

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840843A (en) * 1992-03-26 1998-11-24 The New York Blood Center Synthetic polypeptides as inhibitors of HIV-1
US5656480A (en) * 1992-07-20 1997-08-12 Duke University Compounds which inhibit HIV replication
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission

Also Published As

Publication number Publication date
AU2002351176A1 (en) 2003-06-17
WO2003048187A2 (en) 2003-06-12
AU2002351176A8 (en) 2003-06-17

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