DK0506040T3 - Mutant AOX2 promotor, mikroorganismer indeholdende denne, fremgangsmåde til fremstilling deraf og produktion af heterologt - Google Patents

Mutant AOX2 promotor, mikroorganismer indeholdende denne, fremgangsmåde til fremstilling deraf og produktion af heterologt

Info

Publication number
DK0506040T3
DK0506040T3 DK92105201T DK92105201T DK0506040T3 DK 0506040 T3 DK0506040 T3 DK 0506040T3 DK 92105201 T DK92105201 T DK 92105201T DK 92105201 T DK92105201 T DK 92105201T DK 0506040 T3 DK0506040 T3 DK 0506040T3
Authority
DK
Denmark
Prior art keywords
heterologous
preparation
production
microorganisms containing
aox2 promoter
Prior art date
Application number
DK92105201T
Other languages
Danish (da)
English (en)
Inventor
Masami Miura
Yataka Ishida
Hideyuki Oi
Koji Murakami
Yukimitsu Nakagawa
Haruhide Kawabe
Original Assignee
Yoshitomi Pharmaceutical
Green Cross Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3063599A external-priority patent/JPH07106153B2/ja
Priority claimed from JP3063598A external-priority patent/JPH0829102B2/ja
Application filed by Yoshitomi Pharmaceutical, Green Cross Corp filed Critical Yoshitomi Pharmaceutical
Application granted granted Critical
Publication of DK0506040T3 publication Critical patent/DK0506040T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK92105201T 1991-03-27 1992-03-26 Mutant AOX2 promotor, mikroorganismer indeholdende denne, fremgangsmåde til fremstilling deraf og produktion af heterologt DK0506040T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP3063599A JPH07106153B2 (ja) 1991-03-27 1991-03-27 変異型ａｏｘ２プロモーターを担持するプラスミド、形質転換体および異種蛋白質の製造方法
JP3063598A JPH0829102B2 (ja) 1991-03-27 1991-03-27 変異型ａｏｘ２プロモーター、当該プロモーターを担持する菌株、その取得方法およびその菌株を利用した異種蛋白質の製造方法

Publications (1)

Publication Number Publication Date
DK0506040T3 true DK0506040T3 (da) 1999-02-08

Family

ID=26404726

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92105201T DK0506040T3 (da) 1991-03-27 1992-03-26 Mutant AOX2 promotor, mikroorganismer indeholdende denne, fremgangsmåde til fremstilling deraf og produktion af heterologt

Country Status (8)

Country Link
US (1) US5610036A (fr)
EP (1) EP0506040B1 (fr)
KR (1) KR100237953B1 (fr)
CA (1) CA2063890C (fr)
DE (1) DE69226028T2 (fr)
DK (1) DK0506040T3 (fr)
ES (1) ES2118762T3 (fr)
TW (1) TW204370B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06189769A (ja) * 1992-10-30 1994-07-12 Green Cross Corp:The 変異型ａｏｘ２プロモーター、それを担持するベクター、形質転換体および異種蛋白質の製造方法
JPH06209763A (ja) * 1993-01-13 1994-08-02 Green Cross Corp:The 変異株
JP3505743B2 (ja) * 1993-07-27 2004-03-15 三菱ウェルファーマ株式会社 変異型ａｏｘ２プロモーター、それを担持するベクター、形質転換体および異種蛋白質の製造方法
JPH07308199A (ja) 1994-05-18 1995-11-28 Green Cross Corp:The ヒト血清アルブミンの製造方法
KR100428998B1 (ko) * 2001-09-10 2004-04-28 한국과학기술원 모체 단백질과는 크기와 서열이 다른 단백질의 변이집단을생산하는 방법
CN1308452C (zh) * 2004-09-14 2007-04-04 上海永业农科生物工程有限公司 一种含有改组乙醇氧化酶启动子的毕赤酵母植酸酶表达系统
AT501955B1 (de) * 2005-02-23 2007-08-15 Univ Graz Tech Mutierte aox1-promotoren
US20110065642A1 (en) * 2008-05-15 2011-03-17 R-Tech Ueno, Ltd. Pharmaceutical composition for the treatment of dry eye and/or corneal and conjunctival lesion
US9034840B2 (en) * 2010-12-17 2015-05-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nucleic acids targeting TCTP for use in the treatment of chemo- or hormone-resistant cancers
USD704961S1 (en) 2013-07-03 2014-05-20 Wearwell Studded molded mat

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882279A (en) * 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US5032516A (en) * 1985-10-25 1991-07-16 Phillips Petroleum Company Pichia pastoris alcohol oxidase II regulatory region
US4895800A (en) * 1985-11-26 1990-01-23 Phillips Petroleum Company Yeast production of hepatitis B surface antigen
IL81817A0 (en) * 1986-03-14 1987-10-20 Phillips Petroleum Co Methanol and glucose responsive yeast regulatory regions
IL89992A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of human serum albumin in methylotrophic yeasts
DE3908019C1 (fr) * 1989-03-11 1990-06-13 Metallgesellschaft Ag, 6000 Frankfurt, De

Also Published As

Publication number Publication date
ES2118762T3 (es) 1998-10-01
US5610036A (en) 1997-03-11
DE69226028D1 (de) 1998-08-06
CA2063890A1 (fr) 1992-09-28
DE69226028T2 (de) 1998-12-10
TW204370B (fr) 1993-04-21
KR100237953B1 (ko) 2000-01-15
CA2063890C (fr) 2007-03-13
EP0506040B1 (fr) 1998-07-01
EP0506040A1 (fr) 1992-09-30
KR920018224A (ko) 1992-10-21

Similar Documents

Publication Publication Date Title
NO944644D0 (no) Fremstilling av 3,4,4-trisubstituert-piperidinyl-N-alkylkarboksylater og mellomprodukter
AU581835B2 (en) Adsorbent for separation - recovery of CO, preparing method thereof and process for separation - recovery of high purity CO, using the adsorbent
AU1702192A (en) Process for the purification of the inert gases
GR3022734T3 (en) Method for the purification of chlorofluorohydrocarbons
DK0506040T3 (da) Mutant AOX2 promotor, mikroorganismer indeholdende denne, fremgangsmåde til fremstilling deraf og produktion af heterologt
DK0595334T3 (da) Mutant AOX2-promotor, vektor indeholdende denne, transformant og produktion af heterologt protein
AU4142889A (en) Novel pyrazole compounds, method for production thereof, use thereof and intermediates for production thereof
GR80553B (en) Novel process for the preparation of derivatives from the 17a-hydroxy 19-nor -progesterone series
BG96511A (en) Microbiological method of preparing 5-hydroxypyrazinecarbonic acid
DK211189D0 (da) Fremgangsmaade til fremstilling af 5-chlor-3-chlorsulfonyl-2-thiophencarboxylsyreestere
DE3663661D1 (en) Process for synthesizing n-acetylglycine using novel promoters
IS3694A7 (is) Aðferð til framleiðslu malaðs kornmetis og matvæla unnum þar úr
HU9200728D0 (en) Process for the production of 1-lizin by fermentation
DK0508343T3 (da) Fremgangsmåde til kontinuerlig modning af øl
ZA921763B (en) Process for the recovery of platinum of high purity
GB2224726B (en) Process for preparing potassium persulfate of high purity
AU8872191A (en) Method of inhibiting viral production
AU586626B2 (en) Process for the production of low-calorie alcoholic beverages
HUT33999A (en) Process for producing amino-nitril-derivatives utilizable as intermediates for producing herbicide compounds
HUT65256A (en) Process for producing 2-mercapto methylene-tetrahydronaphtalene-2-carboxamide derivatives and pharmaceutical preparations containing them
CS8807889A2 (en) Method of beer production by means of high-percentage strain brewing
PL255845A1 (en) Method of obtaining novel concentrated derivatives of as-triazines
CS845687A1 (en) Method of benzyl acetate production by means of alkalineacetates benzylation
AU2860384A (en) Cloning vector,method of constructing such,and method of concentrating and purifying product proteins produced by the cloning vector
BG45561A1 (en) Method for accelerated development and increase of production from grown under glass cultivation, especially tomatoes