DK0595334T3 - Mutant AOX2-promotor, vektor indeholdende denne, transformant og produktion af heterologt protein - Google Patents

Mutant AOX2-promotor, vektor indeholdende denne, transformant og produktion af heterologt protein

Info

Publication number
DK0595334T3
DK0595334T3 DK93117527T DK93117527T DK0595334T3 DK 0595334 T3 DK0595334 T3 DK 0595334T3 DK 93117527 T DK93117527 T DK 93117527T DK 93117527 T DK93117527 T DK 93117527T DK 0595334 T3 DK0595334 T3 DK 0595334T3
Authority
DK
Denmark
Prior art keywords
transformant
production
vector containing
heterologous protein
aox2 promoter
Prior art date
Application number
DK93117527T
Other languages
English (en)
Inventor
Hideyuki C O The Green Cro Ohi
Masami C O The Green Cro Miura
Shusei C O The Green Cross Uno
Masako C Othe Green C Chuganji
Ryuji C Othe Green C Hiramatsu
Takao C O The Green Cro Ohmura
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of DK0595334T3 publication Critical patent/DK0595334T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK93117527T 1992-10-30 1993-10-28 Mutant AOX2-promotor, vektor indeholdende denne, transformant og produktion af heterologt protein DK0595334T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29331592 1992-10-30
JP5215306A JPH06189769A (ja) 1992-10-30 1993-08-06 変異型ａｏｘ２プロモーター、それを担持するベクター、形質転換体および異種蛋白質の製造方法

Publications (1)

Publication Number Publication Date
DK0595334T3 true DK0595334T3 (da) 2002-04-29

Family

ID=26520803

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93117527T DK0595334T3 (da) 1992-10-30 1993-10-28 Mutant AOX2-promotor, vektor indeholdende denne, transformant og produktion af heterologt protein

Country Status (9)

Country Link
US (1) US5683893A (da)
EP (1) EP0595334B1 (da)
JP (1) JPH06189769A (da)
KR (1) KR100393297B1 (da)
CA (1) CA2102043C (da)
DE (1) DE69331434T2 (da)
DK (1) DK0595334T3 (da)
ES (1) ES2170751T3 (da)
TW (1) TW343997B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3505743B2 (ja) * 1993-07-27 2004-03-15 三菱ウェルファーマ株式会社 変異型ａｏｘ２プロモーター、それを担持するベクター、形質転換体および異種蛋白質の製造方法
US6183953B1 (en) 1997-09-15 2001-02-06 Zymogenetics, Inc. Chromosomal mutagenesis in Pichia methanolica
EP1326991A2 (en) * 2000-10-20 2003-07-16 Whitehead Institute For Biomedical Research Expression vectors and uses thereof
CA2442935A1 (en) * 2001-04-05 2002-10-17 The Board Of Regents Of The University Of Nebraska Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast
CN1308452C (zh) * 2004-09-14 2007-04-04 上海永业农科生物工程有限公司 一种含有改组乙醇氧化酶启动子的毕赤酵母植酸酶表达系统
AU2006331649B2 (en) 2005-12-20 2012-09-27 University Of Central Florida Research Foundation Isolated MCPIP and methods of use
JP7014774B2 (ja) * 2016-05-04 2022-02-01 シェンチェン、プロトゲン、リミテッド 組換えヒト血清アルブミンの高発現のための遺伝子工学操作された細菌の構築

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2063890C (en) * 1991-03-27 2007-03-13 Masami Miura Mutant aox2 promoter, microorganism carrying same, method of preparation thereof and production of heterologous protein using such microorganism

Also Published As

Publication number Publication date
EP0595334A2 (en) 1994-05-04
US5683893A (en) 1997-11-04
ES2170751T3 (es) 2002-08-16
DE69331434D1 (de) 2002-02-14
KR940009334A (ko) 1994-05-20
TW343997B (en) 1998-11-01
CA2102043C (en) 2007-09-18
EP0595334B1 (en) 2002-01-09
CA2102043A1 (en) 1994-05-01
KR100393297B1 (ko) 2004-10-20
EP0595334A3 (en) 1995-05-31
DE69331434T2 (de) 2002-09-05
JPH06189769A (ja) 1994-07-12

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