DE69331434D1 - Mutanter AOX2 Promotor, diesen enthaltender Vektor, transformierte Zellen und Herstellung von heterologen Proteinen - Google Patents

Mutanter AOX2 Promotor, diesen enthaltender Vektor, transformierte Zellen und Herstellung von heterologen Proteinen

Info

Publication number
DE69331434D1
DE69331434D1 DE69331434T DE69331434T DE69331434D1 DE 69331434 D1 DE69331434 D1 DE 69331434D1 DE 69331434 T DE69331434 T DE 69331434T DE 69331434 T DE69331434 T DE 69331434T DE 69331434 D1 DE69331434 D1 DE 69331434D1
Authority
DE
Germany
Prior art keywords
production
vector containing
transformed cells
heterologous proteins
aox2 promoter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69331434T
Other languages
English (en)
Other versions
DE69331434T2 (de
Inventor
Hideyuki Ohi
Masami Miura
Shusei Uno
Masako Chuganji
Ryuji Hiramatsu
Takao Ohmura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Pharma Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Publication of DE69331434D1 publication Critical patent/DE69331434D1/de
Application granted granted Critical
Publication of DE69331434T2 publication Critical patent/DE69331434T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69331434T 1992-10-30 1993-10-28 Mutanter AOX2 Promotor, diesen enthaltender Vektor, transformierte Zellen und Herstellung von heterologen Proteinen Expired - Lifetime DE69331434T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP29331592 1992-10-30
JP5215306A JPH06189769A (ja) 1992-10-30 1993-08-06 変異型ａｏｘ２プロモーター、それを担持するベクター、形質転換体および異種蛋白質の製造方法

Publications (2)

Publication Number Publication Date
DE69331434D1 true DE69331434D1 (de) 2002-02-14
DE69331434T2 DE69331434T2 (de) 2002-09-05

Family

ID=26520803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69331434T Expired - Lifetime DE69331434T2 (de) 1992-10-30 1993-10-28 Mutanter AOX2 Promotor, diesen enthaltender Vektor, transformierte Zellen und Herstellung von heterologen Proteinen

Country Status (9)

Country Link
US (1) US5683893A (de)
EP (1) EP0595334B1 (de)
JP (1) JPH06189769A (de)
KR (1) KR100393297B1 (de)
CA (1) CA2102043C (de)
DE (1) DE69331434T2 (de)
DK (1) DK0595334T3 (de)
ES (1) ES2170751T3 (de)
TW (1) TW343997B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3505743B2 (ja) * 1993-07-27 2004-03-15 三菱ウェルファーマ株式会社 変異型ａｏｘ２プロモーター、それを担持するベクター、形質転換体および異種蛋白質の製造方法
US6183953B1 (en) 1997-09-15 2001-02-06 Zymogenetics, Inc. Chromosomal mutagenesis in Pichia methanolica
EP1326991A2 (de) * 2000-10-20 2003-07-16 Whitehead Institute For Biomedical Research Expressionsvektoren und deren verwendungen
CA2442935A1 (en) * 2001-04-05 2002-10-17 The Board Of Regents Of The University Of Nebraska Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast
CN1308452C (zh) * 2004-09-14 2007-04-04 上海永业农科生物工程有限公司 一种含有改组乙醇氧化酶启动子的毕赤酵母植酸酶表达系统
AU2006331649B2 (en) 2005-12-20 2012-09-27 University Of Central Florida Research Foundation Isolated MCPIP and methods of use
JP7014774B2 (ja) * 2016-05-04 2022-02-01 シェンチェン、プロトゲン、リミテッド 組換えヒト血清アルブミンの高発現のための遺伝子工学操作された細菌の構築

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2063890C (en) * 1991-03-27 2007-03-13 Masami Miura Mutant aox2 promoter, microorganism carrying same, method of preparation thereof and production of heterologous protein using such microorganism

Also Published As

Publication number Publication date
EP0595334A2 (de) 1994-05-04
US5683893A (en) 1997-11-04
ES2170751T3 (es) 2002-08-16
KR940009334A (ko) 1994-05-20
TW343997B (en) 1998-11-01
CA2102043C (en) 2007-09-18
EP0595334B1 (de) 2002-01-09
CA2102043A1 (en) 1994-05-01
KR100393297B1 (ko) 2004-10-20
EP0595334A3 (de) 1995-05-31
DE69331434T2 (de) 2002-09-05
DK0595334T3 (da) 2002-04-29
JPH06189769A (ja) 1994-07-12

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: MITSUBISHI PHARMA CORP., OSAKA, JP

8364 No opposition during term of opposition