DK0481008T3 - Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopiintegration af en ekspressionsvektor. - Google Patents
Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopiintegration af en ekspressionsvektor.Info
- Publication number
- DK0481008T3 DK0481008T3 DK90911878.8T DK90911878T DK0481008T3 DK 0481008 T3 DK0481008 T3 DK 0481008T3 DK 90911878 T DK90911878 T DK 90911878T DK 0481008 T3 DK0481008 T3 DK 0481008T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- expression vector
- multicopy integration
- integration
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898915659A GB8915659D0 (en) | 1989-07-07 | 1989-07-07 | Enzymes,their production and use |
EP90201007 | 1990-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0481008T3 true DK0481008T3 (da) | 1998-05-04 |
Family
ID=26125849
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97200631T DK0778348T3 (da) | 1989-07-07 | 1990-07-09 | Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopi-integration af en ekspr |
DK90911878.8T DK0481008T3 (da) | 1989-07-07 | 1990-07-09 | Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopiintegration af en ekspressionsvektor. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97200631T DK0778348T3 (da) | 1989-07-07 | 1990-07-09 | Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopi-integration af en ekspr |
Country Status (10)
Country | Link |
---|---|
US (1) | US6090574A (fr) |
EP (2) | EP0778348B1 (fr) |
JP (1) | JP3273609B2 (fr) |
AT (2) | ATE196505T1 (fr) |
CA (1) | CA2063592C (fr) |
DE (2) | DE69033633T2 (fr) |
DK (2) | DK0778348T3 (fr) |
ES (2) | ES2150188T3 (fr) |
IE (1) | IE81016B1 (fr) |
WO (1) | WO1991000920A2 (fr) |
Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991014781A1 (fr) * | 1990-03-19 | 1991-10-03 | Henkel Research Corporation | METHODE POUR AUGMENTER L'ACTIVITE D'OMEGA-HYDROXYLASE CHEZ LE $i(CANDIDA TROPICALIS) |
JP3133774B2 (ja) * | 1990-10-04 | 2001-02-13 | 日本食品化工株式会社 | 新規な宿主−ベクター系 |
ATE140974T1 (de) * | 1990-10-04 | 1996-08-15 | Japan Maize Prod | Wirt-vektor-system |
IT1251435B (it) * | 1991-09-04 | 1995-05-09 | Sclavo Spa | Vettore genetico per la integrazione multipla stabile di sequenze di dna nel genoma dei lieviti kluyveromyces lactis e saccharomyces cerevisiae e plasmidi che lo contengono. |
WO1994013821A1 (fr) * | 1992-12-11 | 1994-06-23 | Quest International B.V. | Utilisation du promoteur du gene d'inulinase de kluyveromyces marxianus dans la production de proteines |
US6936289B2 (en) | 1995-06-07 | 2005-08-30 | Danisco A/S | Method of improving the properties of a flour dough, a flour dough improving composition and improved food products |
CA2265519A1 (fr) * | 1996-09-24 | 1998-04-02 | Plant Genetic Systems N.V. | Produits de synthese d'adn et procedes pour produire des proteines a l'aide de ces produits de synthese d'adn |
US7883872B2 (en) | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
US6255115B1 (en) | 1997-04-07 | 2001-07-03 | Unilever Patent Holdings Bv | Agrobacterium mediated transformation of moulds, in particular those belonging to the genus Aspergillus |
EP0870835A1 (fr) * | 1997-04-07 | 1998-10-14 | Unilever N.V. | Transformation de moissures induite par agrobacterium, en particulier appartenant au genre aspergillus |
US6265186B1 (en) | 1997-04-11 | 2001-07-24 | Dsm N.V. | Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces |
DK0979294T3 (en) * | 1997-04-11 | 2015-08-31 | Dsm Ip Assets Bv | Gene conversion AS A TOOL FOR CONSTRUCTION OF RECOMBINANT INDUSTRIAL filamentous fungi |
ES2308805T3 (es) * | 1997-04-11 | 2008-12-01 | Dsm Ip Assets B.V. | Celulas de levadura que comprenden al menos dos copias de un gen deseado integradas en el genoma cromosomico en mas de un domicio que codifica el arn no ribosomico particularmente con kluyveromyces. |
EP1015612B1 (fr) * | 1997-05-27 | 2005-01-26 | Hanil Synthetic Fiber Co., Ltd. | Technique de mise au point de proteines de recombinaison faisant intervenir un vecteur d'expression des plus efficace issu de saccharomyces cerevisiae |
US6228583B1 (en) * | 1997-08-04 | 2001-05-08 | Massachusetts Institute Of Technology | Assays for compounds which extend life span |
CN1284998A (zh) * | 1997-12-22 | 2001-02-21 | 尤尼利弗公司 | 多拷贝基因在霉菌中的定点整合方法 |
PL341760A1 (en) * | 1997-12-22 | 2001-05-07 | Dsm Nv | Expression cloning in mildew fungi |
WO1999055885A2 (fr) * | 1998-04-28 | 1999-11-04 | Axys Pharmaceuticals, Inc. | Nouvelle serine protease apte au clivage selectif de la proteine de liaison du facteur de croissance insuline-like |
AU771539C (en) | 1998-10-06 | 2005-01-13 | Dyadic International (Usa), Inc. | Transformation system in the field of filamentous fungal hosts |
US7220542B2 (en) | 2000-07-17 | 2007-05-22 | Van Den Brink Johannes Maarten | Expression cloning in filamentous fungi |
AU7398100A (en) * | 1999-09-13 | 2001-04-17 | Concordia University | A multifunctional system for the efficient manipulation of protein expression infilamentous fungi and method using same |
DE19963690A1 (de) * | 1999-11-23 | 2001-06-13 | Rhein Biotech Proz & Prod Gmbh | Vektoren und Verfahren zur Herstellung rekombinanter Proteine in Pilzen |
WO2002092757A2 (fr) * | 2000-11-15 | 2002-11-21 | Kemin Industries, Inc. | Enzyme surproduisant des micro-organismes transgeniques |
ZA200303353B (en) * | 2000-12-13 | 2004-04-30 | Unilever Plc | Method for the production of a heterologous protein by a fungus. |
AU2002226307A1 (en) * | 2001-01-25 | 2002-08-06 | Evolva Biotech A/S | Artificial chromosomes comprising concatemers of expressible nucleotide sequences |
EP1356037B1 (fr) | 2001-01-25 | 2011-03-09 | Evolva Ltd. | Echantillothèque pour collection de cellules |
AU2002339115B2 (en) | 2001-05-18 | 2007-03-15 | Dupont Nutrition Biosciences Aps | Method of preparing a dough with an enzyme |
ITMI20011728A1 (it) * | 2001-08-06 | 2003-02-06 | Consorzio Per Le Ricerche E Lo | Vettore per l'integrazione sito-specifica di sequenze di dna eterologhe in lieviti metilotrofi |
WO2004072225A2 (fr) * | 2003-02-12 | 2004-08-26 | Ramot At Tel Aviv University Ltd. | Champignons transgeniques exprimant bcl-2 et procedes d'utilisation de bcl-2 ou de parties de celui-ci aux fins d'amelioration de la production, survie, longevite, resistance au stress de la biomasse et de la pathogenicite des champignons |
CN101818177A (zh) | 2004-07-16 | 2010-09-01 | 丹尼斯科公司 | 脂肪分解酶及其在食品工业中的应用 |
EP2102366A4 (fr) | 2006-12-10 | 2010-01-27 | Dyadic International Inc | Expression et criblage a haut debit de bibliotheques d'adn exprime complexes dans les champignons filamenteux |
EP2197893B1 (fr) | 2007-09-07 | 2013-07-24 | Dyadic International, Inc. | Enzymes fongiques inédites |
US20110318795A1 (en) | 2007-11-20 | 2011-12-29 | Verwaal Rene | Dicarboxylic acid production in a filamentous fungus |
CN101896606B (zh) | 2007-11-20 | 2016-12-21 | 帝斯曼知识产权资产管理有限公司 | 在重组酵母中生产二羧酸 |
BRPI0819275B8 (pt) | 2007-11-20 | 2022-07-19 | Dsm Ip Assets Bv | Célula eucariótica recombinante produtora de ácido succínico e processo para a preparação de ácido succínico |
EP2116136A1 (fr) | 2008-05-08 | 2009-11-11 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Nouvelles phytases |
US8546645B2 (en) | 2008-10-03 | 2013-10-01 | Agrisoma Biosciences Inc. | Production of modified fatty acids in plants through rDNA targeted integration of heterologous genes |
EP2408907B8 (fr) | 2009-03-17 | 2018-04-18 | Dutch DNA Biotech B.V. | Utilisation des protéines actives sur cellulose et lignocellulose |
US9353387B2 (en) | 2009-04-15 | 2016-05-31 | Dsm Ip Assets B.V. | Dicarboxylic acid production process |
UA108853C2 (uk) | 2009-07-10 | 2015-06-25 | Спосіб ферментації галактози | |
DE102009035671A1 (de) * | 2009-07-30 | 2011-02-03 | Dechema Gesellschaft Für Chemische Technik Und Biotechnologie E.V. | Verfahren zur Expression von homologen Proteinen und/oder Peptiden in Pilzen der Klasse Dothideomycetes |
WO2011131667A1 (fr) | 2010-04-21 | 2011-10-27 | Dsm Ip Assets B.V. | Cellule adaptée pour la fermentation d'une composition de sucre mélangé |
EP2388331A1 (fr) | 2010-05-21 | 2011-11-23 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Promoteur constitutif |
US9353376B2 (en) | 2010-10-13 | 2016-05-31 | Dsm Ip Assets, B.V. | Pentose and glucose fermenting yeast cell |
EP2699589A2 (fr) | 2011-04-22 | 2014-02-26 | DSM IP Assets B.V. | Cellule de levure pouvant convertir des sucres comprenant l'arabinose et le xylose |
EP2554668A1 (fr) | 2011-08-04 | 2013-02-06 | DSM IP Assets B.V. | Cellule de fermentation de sucre de pentose |
AR087423A1 (es) | 2011-08-04 | 2014-03-19 | Dsm Ip Assets Bv | Celula capaz de fermentar azucares pentosas |
DK2806754T3 (en) | 2012-01-23 | 2019-02-18 | Dsm Ip Assets Bv | Diterpene PREPARATION |
US20130273619A1 (en) | 2012-04-16 | 2013-10-17 | Basf Se | Process for the Preparation of (3E, 7E)-Homofarnesol |
WO2014060377A1 (fr) | 2012-10-16 | 2014-04-24 | Dsm Ip Assets B.V. | Cellules à conversion de pentose améliorée |
EP2772545A1 (fr) | 2013-03-01 | 2014-09-03 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Protéines d'amidon actives |
EP2992105A1 (fr) | 2013-05-02 | 2016-03-09 | Dutch DNA Biotech B.V. | Nouvelle voie de l'acide organique |
DK3004366T3 (da) | 2013-05-31 | 2019-05-20 | Dsm Ip Assets Bv | Mikroorganismer til diterpenproduktion |
CN108064135A (zh) | 2013-07-15 | 2018-05-22 | 帝斯曼知识产权资产管理有限公司 | 二萜的生产 |
DK3027632T3 (da) | 2013-07-31 | 2019-06-17 | Dsm Ip Assets Bv | Indvinding af steviolglycosider fra et fermenteringsmedium |
WO2016131818A1 (fr) | 2015-02-16 | 2016-08-25 | Dsm Ip Assets B.V. | Processus de production d'acide itaconique en conditions anaérobies |
CA2980090A1 (fr) | 2015-04-03 | 2016-10-06 | Dsm Ip Assets B.V. | Glycosides de steviol |
WO2016172282A1 (fr) | 2015-04-21 | 2016-10-27 | Dsm Ip Assets B.V. | Production microbienne de terpénoïdes |
PL3298133T3 (pl) | 2015-05-22 | 2020-03-31 | Dsm Ip Assets B.V. | Komórki drożdży zużywające octan |
EP3320104B1 (fr) | 2015-07-10 | 2021-11-10 | DSM IP Assets B.V. | Procédé de préparation d'une composition de glycoside de stéviol |
CA2993744A1 (fr) | 2015-08-13 | 2017-02-16 | Dsm Ip Assets B.V. | Transport de glycoside de steviol |
WO2017050652A1 (fr) | 2015-09-25 | 2017-03-30 | Dsm Ip Assets B.V. | Asparaginase |
US11136600B2 (en) | 2015-10-06 | 2021-10-05 | Dsm Ip Assets B.V. | Eukaryotic cell with increased production of fermentation product |
EP3435771A1 (fr) | 2016-03-31 | 2019-02-06 | DSM IP Assets B.V. | Composition enzymatique et préparation d'un produit laitier ayant des propriétés améliorées |
EP3435772A1 (fr) | 2016-03-31 | 2019-02-06 | DSM IP Assets B.V. | Composition enzymatique et préparation d'un produit laitier aux propriétés améliorées |
WO2017167847A1 (fr) | 2016-03-31 | 2017-10-05 | Dsm Ip Assets B.V. | Production de lait à faible teneur en lactose |
US10689670B2 (en) | 2016-06-14 | 2020-06-23 | Dsm Ip Assets B.V. | Recombinant yeast cell |
US10787649B2 (en) | 2016-07-13 | 2020-09-29 | Dsm Ip Assets B.V. | Malate dehyrogenases |
BR112019002417B1 (pt) | 2016-08-09 | 2023-05-02 | Dsm Ip Assets B.V. | Cristalização de glicosídeos de esteviol |
WO2018029274A1 (fr) | 2016-08-09 | 2018-02-15 | Dsm Ip Assets B.V. | Cristallisation de glycosides de stéviol |
CN110036114B (zh) | 2016-08-26 | 2023-09-29 | 勒萨弗尔公司 | 提高的衣康酸生产 |
WO2018073107A1 (fr) | 2016-10-19 | 2018-04-26 | Dsm Ip Assets B.V. | Cellule eucaryote comprenant de la xylose isomérase |
WO2018114912A1 (fr) | 2016-12-21 | 2018-06-28 | Dsm Ip Assets B.V. | Variants d'enzyme lipolytique |
CA3046153A1 (fr) | 2016-12-21 | 2018-06-28 | Dsm Ip Assets B.V. | Variants d'enzyme lipolytique |
WO2018114938A1 (fr) | 2016-12-21 | 2018-06-28 | Dsm Ip Assets B.V. | Variants d'enzyme lipolytique |
EP3559222A1 (fr) | 2016-12-21 | 2019-10-30 | DSM IP Assets B.V. | Variants d'enzyme lipolytique |
WO2018114995A1 (fr) | 2016-12-22 | 2018-06-28 | Dsm Ip Assets B.V. | Procédés de fermentation pour la production de glycosides de stéviol |
US11667886B2 (en) | 2017-06-13 | 2023-06-06 | Dsm Ip Assets B.V. | Recombinant yeast cell |
JP2020530271A (ja) * | 2017-06-30 | 2020-10-22 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | 安定化されたコピー数の機能性dna配列を有する微生物及び関連方法 |
US11414683B2 (en) | 2017-09-26 | 2022-08-16 | Dsm Ip Assets B.V. | Acetic acid consuming strain |
EP3533878A1 (fr) | 2018-02-28 | 2019-09-04 | Dutch DNA Biotech B.V. | Procédé de production d'acide 2-hydroxy-2-méthylsuccinique en utilisant d'aspergillus |
BR112020025589A2 (pt) | 2018-06-19 | 2021-03-23 | Dsm Ip Assets B.V. | variantes de enzima lipolítica |
CN111254127B (zh) * | 2018-11-30 | 2022-06-10 | 康码(上海)生物科技有限公司 | 蛋白激酶a催化亚基tpk2基因改造方法及其应用 |
CN111254128A (zh) * | 2018-11-30 | 2020-06-09 | 康码(上海)生物科技有限公司 | 蛋白激酶a催化亚基tpk1基因改造方法及其应用 |
AU2021367159A1 (en) | 2020-10-22 | 2023-05-04 | Cargill, Incorporated | Microorganisms for diterpene production |
FR3122436A1 (fr) * | 2021-04-30 | 2022-11-04 | IFP Energies Nouvelles | Insertion multicopies d’un gène d’intérêt dans le génome d’un champignon |
CA3225417A1 (fr) | 2021-06-24 | 2022-12-29 | Fonterra Co-Operative Group Limited | Proteines de recombinaison |
EP4370690A1 (fr) | 2021-07-12 | 2024-05-22 | Danisco Us Inc | Cellule de levure recombinée |
WO2023285279A1 (fr) | 2021-07-12 | 2023-01-19 | Dsm Ip Assets B.V. | Cellule de levure recombinée |
EP4370692A1 (fr) | 2021-07-12 | 2024-05-22 | Danisco Us Inc | Cellule de levure recombinée |
WO2023285297A1 (fr) | 2021-07-12 | 2023-01-19 | Dsm Ip Assets B.V. | Cellule de levure recombinée |
CN117940570A (zh) | 2021-07-12 | 2024-04-26 | 丹尼斯科美国公司 | 重组酵母细胞 |
EP4370689A1 (fr) | 2021-07-12 | 2024-05-22 | Danisco Us Inc | Cellule de levure recombinante |
CN113564206B (zh) * | 2021-07-29 | 2023-09-26 | 山东大学 | 一种目的基因多拷贝整合到酿酒酵母染色体rDNA的方法 |
WO2023079048A1 (fr) | 2021-11-04 | 2023-05-11 | Dsm Ip Assets B.V. | Procédé de production d'éthanol et cellule de levure recombinante |
WO2023079049A1 (fr) | 2021-11-04 | 2023-05-11 | Dsm Ip Assets B.V. | Polypeptide variant et cellule de levure recombinée |
WO2023079050A1 (fr) | 2021-11-04 | 2023-05-11 | Dsm Ip Assets B.V. | Cellule de levure recombinée |
AU2022388727A1 (en) | 2021-11-09 | 2024-05-16 | Amgen Inc. | Production of therapeutic proteins |
WO2023222614A1 (fr) | 2022-05-16 | 2023-11-23 | Dsm Ip Assets B.V. | Variants d'enzymes lipolytiques |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU600885B2 (en) * | 1984-05-25 | 1990-08-30 | Zymogenetics Inc. | Stable DNA constructs |
GB8415186D0 (en) * | 1984-06-14 | 1984-07-18 | Ciba Geigy Ag | Polypeptides |
EP0173378B1 (fr) * | 1984-07-27 | 1991-06-12 | Unilever N.V. | Procédé de préparation d'un polypeptide par culture des micro-organismes transformés, micro-organisme correspondant et séquences d'ADN utiles pour la préparation d'un tel micro-organisme. |
JPS61134325A (ja) * | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
JPH0614865B2 (ja) * | 1985-12-13 | 1994-03-02 | 麒麟麦酒株式会社 | α―アセト乳酸脱炭酸酵素をコードするDNA鎖およびこのDNA鎖により形質転換された酵母 |
KR910002604B1 (ko) | 1986-05-28 | 1991-04-27 | 미쓰비시덴기 가부시기가이샤 | 영상 재생 장치 |
CA1339101C (fr) * | 1986-06-03 | 1997-07-29 | Nicolaas Overbeeke | Obtention d'alpha-galactosidase de guar et d'alpha-galactisidase apparente du point de vue immunitaire a l'aide d'organismes hotes transformes par des methodes a adn recombinant |
GB8629536D0 (en) | 1986-12-10 | 1987-01-21 | Unilever Plc | Enzymatic detergent composition |
PT88556B (pt) * | 1987-09-28 | 1992-11-30 | Smithkline Biolog | Processo de integracao genomica estavel e de expressao de uma sequencia de cadificacao estranha, em leveduras |
DK571587D0 (da) | 1987-11-02 | 1987-11-02 | Novo Industri As | Enzymatisk detergentsammensaetning |
EP0318775B1 (fr) * | 1987-12-03 | 1994-02-02 | Chisso Corporation | Gène codant pour une lipase |
US5001230A (en) * | 1988-02-18 | 1991-03-19 | Schering Corporation | T cell activation markers |
JP3079276B2 (ja) * | 1988-02-28 | 2000-08-21 | 天野製薬株式会社 | 組換え体dna、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法 |
JP2639677B2 (ja) * | 1988-03-14 | 1997-08-13 | 旭化成工業株式会社 | リパーゼの遺伝情報を有するdna |
-
1990
- 1990-07-09 AT AT97200631T patent/ATE196505T1/de not_active IP Right Cessation
- 1990-07-09 EP EP97200631A patent/EP0778348B1/fr not_active Expired - Lifetime
- 1990-07-09 DK DK97200631T patent/DK0778348T3/da active
- 1990-07-09 WO PCT/EP1990/001138 patent/WO1991000920A2/fr active IP Right Grant
- 1990-07-09 ES ES97200631T patent/ES2150188T3/es not_active Expired - Lifetime
- 1990-07-09 AT AT90911878T patent/ATE160176T1/de not_active IP Right Cessation
- 1990-07-09 DE DE69033633T patent/DE69033633T2/de not_active Expired - Lifetime
- 1990-07-09 EP EP90911878A patent/EP0481008B1/fr not_active Expired - Lifetime
- 1990-07-09 DE DE69031710T patent/DE69031710T2/de not_active Expired - Lifetime
- 1990-07-09 IE IE249690A patent/IE81016B1/en not_active IP Right Cessation
- 1990-07-09 DK DK90911878.8T patent/DK0481008T3/da active
- 1990-07-09 ES ES90911878T patent/ES2109238T3/es not_active Expired - Lifetime
- 1990-07-09 JP JP51119190A patent/JP3273609B2/ja not_active Expired - Fee Related
- 1990-07-09 CA CA002063592A patent/CA2063592C/fr not_active Expired - Lifetime
-
1994
- 1994-12-27 US US08/364,010 patent/US6090574A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK0778348T3 (da) | 2000-12-04 |
IE81016B1 (en) | 1999-09-22 |
ATE160176T1 (de) | 1997-11-15 |
ES2150188T3 (es) | 2000-11-16 |
DE69031710T2 (de) | 1998-03-05 |
EP0481008A1 (fr) | 1992-04-22 |
CA2063592A1 (fr) | 1991-01-08 |
WO1991000920A3 (fr) | 1991-03-07 |
WO1991000920A2 (fr) | 1991-01-24 |
ES2109238T3 (es) | 1998-01-16 |
EP0778348B1 (fr) | 2000-09-20 |
DE69033633D1 (de) | 2000-10-26 |
EP0481008B1 (fr) | 1997-11-12 |
DE69031710D1 (de) | 1997-12-18 |
ATE196505T1 (de) | 2000-10-15 |
US6090574A (en) | 2000-07-18 |
JP3273609B2 (ja) | 2002-04-08 |
DE69033633T2 (de) | 2001-05-03 |
CA2063592C (fr) | 2003-01-21 |
EP0778348A1 (fr) | 1997-06-11 |
IE902496A1 (en) | 1991-02-13 |
JPH05501949A (ja) | 1993-04-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0481008T3 (da) | Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopiintegration af en ekspressionsvektor. | |
MX165920B (es) | Un procedimiento para producir glucoamilasa | |
KR950701348A (ko) | 재조합 사람 락토페린 생산방법 | |
BR8200191A (pt) | Celula viva renina preprorrenina prorrenina processo para obter expressao de preporrenina prorrenina e renina gene de prorrenina preprorrenina e renina e coli material dna recombinador saccharomyces cerevisiae polipetidio processo para exprimir um gene | |
DE3584149D1 (de) | Verfahren zur herstellung von alkohol. | |
PT670896E (pt) | Clonagem e expressao de alfa-galactosidase biologicamente activa | |
DE69939947D1 (de) | Verfahren zur herstellung von polypeptiden in mutierten aspergillus zellen | |
EP0312121A3 (fr) | Souches de levure produisant des enzyms cellulolytiques et procédés et mécanismes pour former celles-ci | |
DK0527758T3 (da) | Rekombinante gær indeholdende DNA-sekvenserne kodende for xylosereductase- og xylitoldehydrogenaseenzymer | |
ATE321142T1 (de) | Verbesserter einbau exogener dna in pflanzenzellen | |
IE802742L (en) | Alpha-galactosidase | |
GB2191491A (en) | Dna segment coding for a specific lipase, vectors for the expression thereof, microorganisms transformed by these vectors and use of these microorganisms for the production of the lipase | |
EP0128743A3 (fr) | Expression de gènes étrangers dans la levure | |
DE69409354D1 (de) | Dextranase, Herstellungsverfahren und dafür kodierende DNS | |
PT81052B (pt) | Processo de preparacao de saccharomyces recombinantes | |
ATE266733T1 (de) | Verfahren zur herstellung von heterologen polypeptiden in transformierten hefezellen | |
CA2286395A1 (fr) | Proteine heterologue et sa methode de production | |
FI871584A (fi) | Uppbyggande av nya -galaktosidas producerande jaeststammar och foerfaranden foer industriellt utnyttjande av dylika jaeststammar. | |
EP0323838A3 (fr) | Vecteur d'expression et procédé de préparation réglable des protéins en eucaryotes | |
ATE212669T1 (de) | Verfahren zur herstellung einer substanz |