DK0474126T3 - - Google Patents

Info

Publication number
DK0474126T3
DK0474126T3 DK91114598.5T DK91114598T DK0474126T3 DK 0474126 T3 DK0474126 T3 DK 0474126T3 DK 91114598 T DK91114598 T DK 91114598T DK 0474126 T3 DK0474126 T3 DK 0474126T3
Authority
DK
Denmark
Prior art keywords
ointment
octacos
tetraone
azatricyclo
methoxycyclohexyl
Prior art date
Application number
DK91114598.5T
Other languages
Danish (da)
English (en)
Inventor
Sotoo Asakura
Yoshio Murakami
Nobuto Kanagawa
Toshiomi Nakate
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16982211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0474126(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of DK0474126T3 publication Critical patent/DK0474126T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK91114598.5T 1990-09-04 1991-08-30 DK0474126T3 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23517790 1990-09-04

Publications (1)

Publication Number Publication Date
DK0474126T3 true DK0474126T3 (fr) 1997-04-07

Family

ID=16982211

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91114598.5T DK0474126T3 (fr) 1990-09-04 1991-08-30

Country Status (20)

Country Link
US (1) US5385907A (fr)
EP (1) EP0474126B1 (fr)
JP (1) JP2526752B2 (fr)
KR (1) KR100194240B1 (fr)
CN (1) CN1069193C (fr)
AT (1) ATE150304T1 (fr)
AU (1) AU656145B2 (fr)
CA (1) CA2050623C (fr)
DE (1) DE69125230T2 (fr)
DK (1) DK0474126T3 (fr)
ES (1) ES2099112T3 (fr)
GR (1) GR3022883T3 (fr)
HK (1) HK1000006A1 (fr)
HU (2) HUT59002A (fr)
IE (1) IE913085A1 (fr)
PH (1) PH31282A (fr)
PT (1) PT98862B (fr)
RU (1) RU2079303C1 (fr)
SG (1) SG46547A1 (fr)
ZA (1) ZA916983B (fr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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ATE183083T1 (de) * 1992-11-18 1999-08-15 Fujisawa Pharmaceutical Co Pharmazeutische zubereitung mit verlängerter wirkung
JPH06345646A (ja) * 1993-06-08 1994-12-20 Fujisawa Pharmaceut Co Ltd ローション剤
CZ289773B6 (cs) * 1994-10-26 2002-04-17 Novartis Ag Farmaceutický prostředek pro místní aplikaci
AU735106B2 (en) * 1994-10-26 2001-06-28 Novartis Ag Pharmaceutical compositions
GB2327611B (en) * 1994-10-26 1999-06-02 Novartis Ag Macrolide compositions
DE19549794B4 (de) * 1994-10-26 2009-07-30 Novartis Ag Pharmazeutische Zusammensetzungen
GB2327610B (en) * 1994-11-04 1999-06-02 Novartis Ag Macrolide compositions
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
US5993787A (en) * 1996-09-13 1999-11-30 Johnson & Johnson Consumer Products, Inc. Composition base for topical therapeutic and cosmetic preparations
WO1998029136A1 (fr) * 1996-12-27 1998-07-09 Takeda Chemical Industries, Ltd. Compose tricyclique stabilise
TW450810B (en) 1997-02-20 2001-08-21 Fujisawa Pharmaceutical Co Macrolides antibiotic pharmaceutical composition for preventing and treating skin diseases
GB9723669D0 (en) * 1997-11-07 1998-01-07 Univ Aberdeen Skin penetration enhancing components
KR100406823B1 (ko) 1998-04-27 2003-11-21 후지사와 야꾸힝 고교 가부시키가이샤 의약 조성물
GB9817064D0 (en) * 1998-08-05 1998-10-07 Fujisawa Pharmaceutical Co New use
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
GB9826656D0 (en) * 1998-12-03 1999-01-27 Novartis Ag Organic compounds
AUPR529701A0 (en) * 2001-05-28 2001-06-21 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition
WO2003004098A1 (fr) 2001-07-06 2003-01-16 Sucampo Ag Composition pour administration directe comprenant un inhibiteur de l'interleukine 2 et un agent antimicrobien
PE20030828A1 (es) * 2002-03-04 2003-11-04 Novartis Ag Composicion oftalmica que comprende ascomicina
AU2003254566A1 (en) * 2002-07-23 2004-02-09 Novartis Ag Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent
GB0218996D0 (en) * 2002-08-14 2002-09-25 Novartis Ag Organic compounds
ZA200702216B (en) * 2004-08-18 2008-11-26 Ace Aps Cosmetic and pharmaceutical compositions comprising ACE inhibitors and/or angiotensin II receptor antagonists
AU2005232248B2 (en) * 2005-01-04 2011-08-04 Texas United Chemical Company, Llc Compounded hydrocarbon oil and oil base drilling fluids prepared therefrom
US7888392B2 (en) * 2005-02-14 2011-02-15 Taisho Pharmaceutical Co., Ltd. Ointment
US20090012051A1 (en) * 2005-03-15 2009-01-08 Kyowa Hakko Kogyo Co., Ltd. External preparation
CN101389612B (zh) 2006-02-21 2011-09-21 卫材R&D管理有限公司 喹唑啉衍生物
AU2008215411B2 (en) 2007-02-16 2012-11-22 Eisai R & D Management Co., Ltd. Crystal, amorphous form and salt of methyl N-[3-(6,7-dimethoxy- 2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid
US10265265B2 (en) 2007-03-15 2019-04-23 Drug Delivery Solutions Limited Topical composition
US8513269B2 (en) 2007-08-17 2013-08-20 Eisai R&D Management Co., Ltd. Preparation for external use
WO2009025238A1 (fr) 2007-08-17 2009-02-26 Eisai R & D Management Co., Ltd. Procédé de fabrication d'un dérivé de quinazoline
EP2345414B1 (fr) * 2008-10-08 2014-06-25 Takata Seiyaku Co., Ltd. Préparation de tacrolimus pour applications externes
JP2010132607A (ja) * 2008-12-05 2010-06-17 Taisho Pharm Ind Ltd アトピー性皮膚炎治療用軟膏剤
JP2010202546A (ja) * 2009-03-02 2010-09-16 Taisho Pharm Ind Ltd アトピー性皮膚炎の治療用軟膏製剤
EP2671583A4 (fr) * 2011-01-31 2014-09-03 Univ Osaka Médicament à usage externe pour traiter un trouble cutané et procédé pour produire celui-ci
CN102885761B (zh) * 2012-09-24 2015-08-05 浙江万晟药业有限公司 一种制备他克莫司软膏的方法
RU2538680C2 (ru) * 2013-03-12 2015-01-10 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения атопического дерматита и способ ее получения
RU2553600C2 (ru) * 2013-05-16 2015-06-20 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения заболеваний кожи
CN104127369A (zh) * 2014-07-02 2014-11-05 人福医药集团股份公司 他克莫司软膏及其制备方法
ES2898849T3 (es) 2014-10-28 2022-03-09 Koushi Yamaguchi Medicamento para mejorar el síndrome de hipertensión inducida por el embarazo
CN106309353A (zh) * 2015-06-19 2017-01-11 江苏吉贝尔药业股份有限公司 一种治疗银屑病的软膏剂及其制备方法
JP6932180B2 (ja) 2016-04-04 2021-09-08 エムシー２・セラピューティクス・リミテッドＭＣ２ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ タクロリムスを含む局所組成物
CN105769752B (zh) * 2016-04-08 2018-12-11 湖北人福成田药业有限公司 制备他克莫司软膏的方法及他克莫司软膏
EP3542788A1 (fr) 2018-03-19 2019-09-25 MC2 Therapeutics Limited Composition topique comprenant calcipotriol et dipropionate de bétaméthasone
JP7465806B2 (ja) 2018-08-10 2024-04-11 晃史 山口 母体と胎児との関係における液性免疫関連疾患の治療薬
EP3930713A4 (fr) 2018-12-04 2022-11-16 Ilko Ilaç Sanayi Ve Ticaret Anonim Sirketi Formulation de pommade à base de tacrolimus stable pour le traitement topique d'affections cutanées
WO2020129348A1 (fr) 2018-12-18 2020-06-25 晃史 山口 Agent permettant de traiter l'infertilité, les fausses couches récurrentes et d'améliorer la grossesse
CN114767688A (zh) * 2019-09-04 2022-07-22 武汉科福新药有限责任公司 透皮促渗组合物及其在噻吗洛尔制剂中的应用
WO2021176263A1 (fr) * 2020-03-02 2021-09-10 Shanghai Aucta Pharmaceuticals Co., Ltd. Formulations topiques contenant des inhibiteurs de mtor
CN112022798B (zh) * 2020-08-11 2022-04-29 四川大学华西医院 一种速效他克莫司软膏、制备方法及应用

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GB2212061B (en) * 1987-11-09 1991-08-28 Sandoz Ltd Topical compositions comprising 11,28-dioxa-4-azatricyclo [22.3.1.0(4,9)] octacos-18-ene derivatives
KR0159766B1 (ko) * 1989-10-16 1998-12-01 후지사와 토모키치로 양모제 조성물
US5061700A (en) * 1989-11-16 1991-10-29 Gordon Jay Dow Glyceryl acetate ointment vehicles

Also Published As

Publication number Publication date
PT98862B (pt) 1999-02-26
ATE150304T1 (de) 1997-04-15
RU2079303C1 (ru) 1997-05-20
PT98862A (pt) 1992-08-31
CA2050623C (fr) 2002-02-05
CN1059468A (zh) 1992-03-18
CA2050623A1 (fr) 1992-03-05
KR920005987A (ko) 1992-04-27
US5385907A (en) 1995-01-31
IE913085A1 (en) 1992-03-11
ES2099112T3 (es) 1997-05-16
AU656145B2 (en) 1995-01-27
ZA916983B (en) 1992-05-27
JP2526752B2 (ja) 1996-08-21
DE69125230T2 (de) 1997-07-10
GR3022883T3 (en) 1997-06-30
SG46547A1 (en) 1998-02-20
EP0474126A1 (fr) 1992-03-11
HK1000006A1 (en) 1997-10-03
CN1069193C (zh) 2001-08-08
DE69125230D1 (de) 1997-04-24
PH31282A (en) 1998-07-06
KR100194240B1 (ko) 1999-06-15
HU211470A9 (en) 1995-11-28
EP0474126B1 (fr) 1997-03-19
JPH0517481A (ja) 1993-01-26
AU8351591A (en) 1992-03-12
HUT59002A (en) 1992-04-28

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